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  • 1
    Language: English
    In: The New England journal of medicine, 1957-01-10, Vol.256 (2), p.74-76
    Description: SINCE 1954 the hypoglycemic sulfonamide, carbutamide (l-butyl-3-sulfanilylurea)∥ has been undergoing extensive clinical trial in the treatment of diabetes mellitus. In preliminary reports of these studies, few toxic reactions were described. 1 2 3 These included several cases of drug fever and rash that cleared promptly on discontinuance of the drug. A case of hepatitis that occurred in Germany concomitant with the administration of carbutamide was believed to be on an infectious basis. In more recent reports, Ridolfo and Kirtley 4 and Kinsell 5 have described cases of progressive leukopenia that necessitated termination of therapy. In our series of 48 cases side reactions were considerably more . . .
    Subject(s): Carbutamide ; Depression ; Anuria - etiology ; Sulfanilamides - analogs & derivatives ; Urea - analogs & derivatives ; Bone Marrow - drug effects
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Single Journals
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