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  • 1
    Conference Proceeding
    Conference Proceeding
    2018
    ISSN: 1755-1307 
    Language: English
    In: IOP conference series. Earth and environmental science, 2018-07-01, Vol.170 (3), p.32159
    Description: Based on literature data, expert interviews, questionnaires, data monitoring and other methods, taking Tibetan Plateau's environmental characteristics as an entry point, conduct the empirical research of physical exercise on health in Gansu Tibetan Plateau. Conclusion: the promotion strategy of physical exercise on health under plateau environment should be scientifically designed from three aspects: the scientific time of physical exercise, the safety environment and the appropriate exercise prescription.
    ISSN: 1755-1307
    E-ISSN: 1755-1315
    Source: IOPscience extra
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: Nucleic acids research, 2019-01-08, Vol.47 (D1), p.D886-D894
    Description: Abstract Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders. CADD is an integrative annotation built from more than 60 genomic features, and can score human single nucleotide variants and short insertion and deletions anywhere in the reference assembly. CADD uses a machine learning model trained on a binary distinction between simulated de novo variants and variants that have arisen and become fixed in human populations since the split between humans and chimpanzees; the former are free of selective pressure and may thus include both neutral and deleterious alleles, while the latter are overwhelmingly neutral (or, at most, weakly deleterious) by virtue of having survived millions of years of purifying selection. Here we review the latest updates to CADD, including the most recent version, 1.4, which supports the human genome build GRCh38. We also present updates to our website that include simplified variant lookup, extended documentation, an Application Program Interface and improved mechanisms for integrating CADD scores into other tools or applications. CADD scores, software and documentation are available at https://cadd.gs.washington.edu.
    Subject(s): Genetic Variation ; Genome, Human ; Databases, Nucleic Acid ; Machine Learning ; Humans ; Molecular Sequence Annotation ; Database Issue
    ISSN: 0305-1048
    E-ISSN: 1362-4962
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 3
    Language: English
    Description: This richly illustrated book offers correlation of gross and microscopic pathology with abnormal radiologic images. Taking advantage of all imaging modalities, the authors give detailed descriptions and critical assessments of radiologic presentations of a broad spectrum of diseases from most organ systems, including the nervous system, head and neck, chest, abdomen, urogenital system, musculoskeletal system and breast. Some chapters are based on a very successful lecture series offered recently at the European Congress of Radiology in Vienna, with additional important topics added. The book helps the clinician to apply the principles of radiologic--pathologic correlation to the interpretation of radiologic studies, to understand the clinical and pathologic implications of the radiologic appearance and to refine the differential diagnosis in various entities and organ systems, based on specific cross-correlated features. Authoritative reviews, written by leading experts, are provided on all of the important clinical entities.
    Subject(s): Orthopedics
    ISBN: 3540043950
    ISBN: 9783540043959
    Source: Springer Medicine eBooks 2005 English/International
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  • 4
    Language: English
    In: Cell reports (Cambridge), 2016-05-31, Vol.15 (9), p.1945-1956
    Description: Antibiotics, though remarkably useful, can also cause certain adverse effects. We detected that treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention. Reconstitution with normal gut flora (SPF) did not completely reverse the deficits in neurogenesis unless the mice also had access to a running wheel or received probiotics. In parallel to an increase in neurogenesis and memory retention, both SPF-reconstituted mice that ran and mice supplemented with probiotics exhibited higher numbers of Ly6Chi monocytes in the brain than antibiotic-treated mice. Elimination of Ly6Chi monocytes by antibody depletion or the use of knockout mice resulted in decreased neurogenesis, whereas adoptive transfer of Ly6Chi monocytes rescued neurogenesis after antibiotic treatment. We propose that the rescue of neurogenesis and behavior deficits in antibiotic-treated mice by exercise and probiotics is partially mediated by Ly6Chi monocytes. [Display omitted] •Antibiotics decrease neurogenesis and cognitive function•Probiotics or exercise rescues neurogenesis and cognitive function•Ly6Chi monocytes are crucial for brain homeostasis Möhle et al. show the impact of prolonged antibiotic treatment on brain cell plasticity and cognitive function. They were able to rescue the decrease in neurogenesis by probiotic treatment, physical exercise, or transfer of Ly6Cpos monocytes. They propose that the Ly6Chi population is crucial for brain homeostasis and plasticity.
    ISSN: 2211-1247
    E-ISSN: 2211-1247
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 5
    Language: German
    Subject(s): 150 Psychologie ; 610 Medizin ; Gesundheit
    ISSN: 0306-4530
    ISSN: 1873-3360
    E-ISSN: 1873-3360
    Source: MADOC Publikationsserver
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  • 6
    Language: English
    In: Toxicological sciences, 2012-04, Vol.126 (2), p.457-468
    Description: In the body, nanoparticles can be systemically distributed and then may affect secondary target organs, such as the central nervous system (CNS). Putative adverse effects on the CNS are rarely investigated to date. Here, we used a mixed primary cell model consisting mainly of neurons and astrocytes and a minor proportion of oligodendrocytes to analyze the effects of well-characterized 20 and 40 nm silver nanoparticles (SNP). Similar gold nanoparticles served as control and proved inert for all endpoints tested. SNP induced a strong size-dependent cytotoxicity. Additionally, in the low concentration range (up to 10 μg/ml of SNP), the further differentiated cultures were more sensitive to SNP treatment. For detailed studies, we used low/medium dose concentrations (up to 20 μg/ml) and found strong oxidative stress responses. Reactive oxygen species (ROS) were detected along with the formation of protein carbonyls and the induction of heme oxygenase-1. We observed an acute calcium response, which clearly preceded oxidative stress responses. ROS formation was reduced by antioxidants, whereas the calcium response could not be alleviated by antioxidants. Finally, we looked into the responses of neurons and astrocytes separately. Astrocytes were much more vulnerable to SNP treatment compared with neurons. Consistently, SNP were mainly taken up by astrocytes and not by neurons. Immunofluorescence studies of mixed cell cultures indicated stronger effects on astrocyte morphology. Altogether, we can demonstrate strong effects of SNP associated with calcium dysregulation and ROS formation in primary neural cells, which were detectable already at moderate dosages.
    Subject(s): Microscopy, Electron, Transmission ; Animals ; Reactive Oxygen Species - metabolism ; Oxidative Stress ; Calcium - metabolism ; Cells, Cultured ; Silver - chemistry ; Rats ; Neurons - cytology ; Neurons - metabolism ; Neurons - drug effects ; Metal Nanoparticles ; calcium ; silver nanoparticles ; Nanotoxicology ; protein carbonyls ; neurons ; oxidative stress
    ISSN: 1096-6080
    E-ISSN: 1096-0929
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
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  • 7
    Article
    Article
    2020
    ISSN: 1468-0327  ISSN: 0266-4658 
    Language: German
    Description: Bulimia Nervosa (BN) is a detrimental persistent eating disorder that impacts millions of women, and imposes serious costs on the economy in terms of physical health, treatment costs, absence from work, and reduced human capital accumulation. One important issue in treating BN is that it is often undiagnosed, especially among disadvantaged girls. The failures to diagnose BN occur, in part, because many cases of BN are unobservable to others, and asking girls about their bingeing and purging behavior can be considered invasive. Using data on eating disorder behaviors from the National Heart, Lung, and Blood Institute Growth and Health Study, we show that information on a girl’s personality traits, along with information on her family’s socioeconomic status, can be used to impute the unobservable BN behavior. In particular, we find that personality traits are significant determinants of bulimic behavior, even after controlling for socioeconomic status. These results suggest a way to target those who are likely to suffer from BN based on identifiable personality traits. Given the costs involved in BN, and the number of individuals affected, our research suggests a practical direction for public health policy to reduce the number of undiagnosed cases.
    Subject(s): 330 Wirtschaft ; 610 Medizin ; Gesundheit
    ISSN: 1468-0327
    ISSN: 0266-4658
    E-ISSN: 1468-0327
    Source: Business Source Ultimate
    Source: EconLit with Full Text
    Source: MADOC Publikationsserver
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  • 8
    Article
    Article
    2020
    ISSN: 1757-8981  ISSN: 1757-899X 
    Language: English
    In: IOP conference series. Materials Science and Engineering, 2020-03-01, Vol.768 (7), p.72113
    Description: School bullying has frequently appeared in major primary and secondary schools and even universities. It has become a topic of great concern to all sectors of society. Campus safety issues have greatly affected the physical and mental health of young people, and even have an indelible shadow on their future. The rapid development of technology has provided a powerful help for studying the factors affecting contemporary students' school bullying. This paper uses the factor analysis model to compare the dominant factors affecting school bullying from the horizontal aspect, which can provide reference for parents and schools to judge potential campus bullying, and has positive significance for preventing and controlling campus bullying.
    ISSN: 1757-8981
    ISSN: 1757-899X
    E-ISSN: 1757-899X
    Source: IOPscience extra
    Source: Alma/SFX Local Collection
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  • 9
    Language: English
    In: Scientific reports, 2019-06-11, Vol.9 (1), p.8495-8495
    Description: We applied deep convolutional neural networks (CNNs) to detect periodontal bone loss (PBL) on panoramic dental radiographs. We synthesized a set of 2001 image segments from panoramic radiographs. Our reference test was the measured % of PBL. A deep feed-forward CNN was trained and validated via 10-times repeated group shuffling. Model architectures and hyperparameters were tuned using grid search. The final model was a seven-layer deep neural network, parameterized by a total number of 4,299,651 weights. For comparison, six dentists assessed the image segments for PBL. Averaged over 10 validation folds the mean (SD) classification accuracy of the CNN was 0.81 (0.02). Mean (SD) sensitivity and specificity were 0.81 (0.04), 0.81 (0.05), respectively. The mean (SD) accuracy of the dentists was 0.76 (0.06), but the CNN was not statistically significant superior compared to the examiners (p = 0.067/t-test). Mean sensitivity and specificity of the dentists was 0.92 (0.02) and 0.63 (0.14), respectively. A CNN trained on a limited amount of radiographic image segments showed at least similar discrimination ability as dentists for assessing PBL on panoramic radiographs. Dentists' diagnostic efforts when using radiographs may be reduced by applying machine-learning based technologies.
    Subject(s): Radiography ; Periodontics ; Learning algorithms ; Statistical analysis ; Neural networks ; Bone loss ; Dentists
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 10
    Language: English
    In: IOP conference series. Materials Science and Engineering, 2020-02-01, Vol.753 (4), p.42050
    Description: Vibration and it's high background bring a danger to human health. According to the intensity of fluctuations in the urban environment transport, especially trams, trains, including metro bring the greatest impact on human. This article investigates the reaction of high-rise building on microseismic influence of the motion of the external transport. There are determined the minimum reserves of dynamic comfort for different frequencies of impacts, as well as potentially dangerous average frequencies for the studied building. A comparison of the results of the calculation of the building using explicit and implicit schemes of integration of the equations of motion is made. Conclusions about the feasibility of using implicit integration schemes for solving problems of this type are made.
    ISSN: 1757-8981
    ISSN: 1757-899X
    E-ISSN: 1757-899X
    Source: IOPscience extra
    Source: Alma/SFX Local Collection
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