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  • 1
    Article
    Article
    1990
    ISSN: 0006-1972 
    Language: English
    In: Bibliotheksdienst, 1990-12, Vol.24 (12), p.1655-1656
    ISSN: 0006-1972
    E-ISSN: 2194-9646
    Source: De Gruyter Online
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  • 2
    Article
    Article
    1985
    ISSN: 0006-1972 
    Language: English
    In: Bibliotheksdienst, 1985-01, Vol.19 (12)
    ISSN: 0006-1972
    E-ISSN: 2194-9646
    Source: De Gruyter Online
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  • 3
    Language: English
    In: Journal of Virology, 1999-02-01, Vol.73 (2), p.939-947
    Description: Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
    Subject(s): Amino Acid Sequence ; Animals ; Base Sequence ; Capsid - genetics ; Dependovirus - classification ; Dependovirus - genetics ; DNA, Viral ; DNA-Binding Proteins - genetics ; Genome, Viral ; HeLa Cells ; Helper Viruses - classification ; Helper Viruses - genetics ; Humans ; Molecular Sequence Data ; Parvovirus - classification ; Parvovirus - genetics ; Primates ; Recombination and Evolution ; Sequence Homology, Amino Acid ; Viral Proteins - genetics
    ISSN: 0022-538X
    E-ISSN: 1098-5514
    Source: HighWire Press (Free Journals)
    Source: Hellenic Academic Libraries Link
    Source: PubMed Central
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  • 4
    Language: English
    In: International journal of cancer, 2021-03-15, Vol.148 (6), p.1478-1488
    Description: Few data exist on health‐related quality of life (QoL) in patients with metastatic pancreatic cancer (mPC) receiving first‐line chemotherapy (Awad L ZE, Mesbah M Boston, MA. Applying survival data methodology to analyze quality of life data, in Mesbah M, Cole BF, Ting Lee M‐L (eds): Statistical Methods for Quality of Life Studies: Design, Measurements and Analysis. Kluwer Academic Publishers 2002). The QOLIXANE study is a prospective, noninterventional, multicenter substudy of the Platform for Outcome, Quality of Life and Translational Research on Pancreatic Cancer (PARAGON) registry, which evaluated QoL in patients with mPC receiving first‐line gemcitabine and nab‐paclitaxel chemotherapy in real‐life setting. QoL was prospectively measured via EORTC QLQ‐C30 questionnaires at baseline and every month thereafter. Therapy and efficacy parameters were prospectively collected. Main objectives were the rate of patients without deterioration of Global Health Status/QoL (GHS/QoL) at 3 and 6 months. Six hundred patients were enrolled in 95 German study sites. Median progression‐free survival was 5.9 months (95% confidence interval [CI], 5.2‐6.3). Median overall survival (OS) was 8.9 months (95% CI, 7.9‐10.2), while median time to deterioration of GHS/QoL was 4.7 months (95% CI, 4.0‐5.6). With a baseline GHS/QoL score of 46 (SD, 22.8), baseline QoL of the patients was severely impaired, in most cases due to loss in role functioning and fatigue. In the Kaplan‐Meier analysis, 61% and 41% of patients had maintained GHS/QoL after 3 and 6 months, respectively. However, in the QoL response analysis, 35% and 19% of patients had maintained (improved or stable) GHS/QoL after 3 and 6 months, respectively, while 14% and 9% had deteriorated GHS/QoL with the remaining patients being nonevaluable. In the Cox regression analysis, GHS/QoL scores strongly predicted survival with a hazard ratio of 0.86 (P 〈 .0001). Patients with mPC have poor QoL at baseline that deteriorates within a median of 4.7 months. Treatment with gemcitabine and nab‐paclitaxel is associated with maintained QoL in relevant proportions of patients. However, overall, results remain poor, reflecting the aggressive nature of the disease. What's new? In metastatic pancreatic cancer (mPC), chemotherapy with nab‐paclitaxel plus gemcitabine has shown significant survival benefits. However, less attention has been paid to quality of life (QoL) for these patients. In this prospective study, the authors found that, due to the aggressive nature of mPC, QoL declined rapidly for most patients. But surprisingly, as many as 41% of patients were able to maintain their baseline QoL at six months. Thus, while overall results remain poor, it does appear possible to stabilize QoL for a subset of patients receiving this first‐line combination chemotherapy.
    Subject(s): Cancer ; chemotherapy ; Metastasis ; Oncology, Experimental ; Pancreatic cancer ; PARAGON ; Patient outcomes ; QOLIXANE ; quality of life ; registry ; Research
    ISSN: 0020-7136
    E-ISSN: 1097-0215
    Source: Alma/SFX Local Collection
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  • 5
    Language: English
    In: Human reproduction (Oxford), 2002, Vol.17 (4), p.912-915
    Description: We report on a pair of dizygotic twin boys born after ICSI. One twin was affected with maternal meiosis I-derived free trisomy 21. The other had multiple congenital malformations including a complex heart defect and oesophageal atresia. The advanced maternal age of 37 years predisposed for chromosome 21 meiosis I non-disjunction in twin A. Each of the multiple congenital anomalies in twin B has been described in trisomy 21. However, due to dizygosity demonstrated by a panel of molecular markers mapped on chromosome 21 as well as the results of investigations with 16 short tandem repeat markers localized on various other chromosomes, low level mosaicism or chimerism for this aneuploidy in twin B is unlikely. In addition, the twinning process, which by itself is associated with an increased rate of congenital malformations particularly affecting heart and oesophagus, might be responsible for the multiple congenital anomalies in twin B. Thus, in agreement with the results of several population-based studies from the literature, it appears unlikely that the micromanipulation of ICSI is causally responsible for the different anomalies found in these two boys.
    Subject(s): Abnormalities, Multiple - etiology ; Biological and medical sciences ; Chromosome aberrations ; Down Syndrome - etiology ; Humans ; Infant, Newborn ; Male ; Medical genetics ; Medical sciences ; Sperm Injections, Intracytoplasmic - adverse effects ; Twins, Dizygotic
    ISSN: 0268-1161
    E-ISSN: 1460-2350
    Source: Alma/SFX Local Collection
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
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  • 6
    Language: English
    In: Human reproduction (Oxford), 2002-04, Vol.17 (4), p.912-915
    Description: We report on a pair of dizygotic twin boys born after ICSI. One twin was affected with maternal meiosis I-derived free trisomy 21. The other had multiple congenital malformations including a complex heart defect and oesophageal atresia. The advanced maternal age of 37 years predisposed for chromosome 21 meiosis I non-disjunction in twin A. Each of the multiple congenital anomalies in twin B has been described in trisomy 21. However, due to dizygosity demonstrated by a panel of molecular markers mapped on chromosome 21 as well as the results of investigations with 16 short tandem repeat markers localized on various other chromosomes, low level mosaicism or chimerism for this aneuploidy in twin B is unlikely. In addition, the twinning process, which by itself is associated with an increased rate of congenital malformations particularly affecting heart and oesophagus, might be responsible for the multiple congenital anomalies in twin B. Thus, in agreement with the results of several population-based studies from the literature, it appears unlikely that the micromanipulation of ICSI is causally responsible for the different anomalies found in these two boys.
    Subject(s): ICSI ; multiple congenital anomalies ; oesophageal atresia ; trisomy 21 ; twins
    ISSN: 0268-1161
    ISSN: 1460-2350
    E-ISSN: 1460-2350
    Source: Alma/SFX Local Collection
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
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  • 7
    Language: English
    In: Proceedings of the National Academy of Sciences - PNAS, 1983-01-15, Vol.80 (2), p.560-563
    Description: Human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papillomavirus (HPV) 6 and HPV 11 sequences. HPV 11 DNA was found in 7 of 14 laryngeal papillomas; in the 7 other tumors no HPV DNA was demonstrated. HPV 11 DNA was also found in all five atypical condylomata of the cervix included in this study. Condylomata acuminata mainly contained HPV 6 DNA. From 63 biopsy specimens, 41 clearly harbored HPV 6 DNA and 13 harbored HPV 11 DNA. In three tumors accurate typing was impossible, and in six additional ones neither HPV 6 nor HPV 11 DNA could be demonstrated. The data support a genital origin of laryngeal papillomavirus infections. In 4 of 24 malignant tumors, HPV 11 DNA or related sequences were demonstrated; 2 of the 4 were biopsy specimens from invasive cancer, and the other 2 originated from carcinomata in situ. A possible role of this or related papillomavirus types in the induction of malignant genital tumors remains to be elucidated.
    Subject(s): Biopsies ; Cancer ; Carcinoma, Squamous Cell - microbiology ; Cervix uteri ; Condylomata acuminata ; DNA, Viral - genetics ; DNA, Viral - isolation & purification ; Female ; Genital Neoplasms, Female - microbiology ; Genitalia ; Genomes ; Humans ; Infections ; Laryngeal Neoplasms - microbiology ; Molecular Weight ; Nucleic Acid Hybridization ; Papilloma ; Papilloma - microbiology ; Papillomaviridae - genetics ; Tumors ; Uterine Cervical Neoplasms - microbiology ; Viruses
    ISSN: 0027-8424
    E-ISSN: 1091-6490
    Source: JSTOR Life Sciences
    Source: HighWire Press (Free Journals)
    Source: Hellenic Academic Libraries Link
    Source: PubMed Central
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  • 8
    Language: English
    In: Journal of embryology and experimental morphology, 1985, Vol.89, p.17-34
    Description: The internal structure of the Xenopus oocyte is reorganized during the hormone-induced egg maturation. A cytological survey of the intracellular movements and changes is described. The behaviour of the nuclear lamina protein and of three nucleoplasmic proteins during these processes was studied by immunocytology. The proteins are finally deposited in the egg in different patterns brought about by their differential behaviour during the process of maturation.
    Subject(s): Animals ; Antibodies, Monoclonal ; Biological and medical sciences ; Cell Nucleus - analysis ; Early stages. Segmentation. Gastrulation. Neurulation ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Lamins ; Nuclear Proteins ; Nucleoplasmins ; Nucleoproteins - analysis ; Oocytes - analysis ; Phosphoproteins ; Xenopus - embryology ; Xenopus - metabolism
    ISSN: 0022-0752
    Source: Free Medical Journals
    Source: Alma/SFX Local Collection
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  • 9
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    1993
    Language: German
    Description: Provider: Deutsche Digitale Bibliothek - Institution: GESIS - Leibniz-Institut für Sozialwissenschaften. Bibliothek Köln - Data provided by Europeana Collections- Welche Rolle übernimmt der Staat bei der Umverteilung von Erwerbsarbeit und der Durchsetzung von beruflichen Flexibilisierungsstrategien? Ausgehend von dieser Frage schildert die Autorin am historischen Beispiel für den staatlichen Arbeitgeber Post, wie dieser spätestens seit 1898 ungeschützte Beschäftigungsverhältnisse für Frauen und Flexibilisierungsstrategien dazu nutzte, Personalkosten zu dämpfen und zugleich das Einkommen der männlichen Beamten als "Familienlohn" zu sichern. Teilzeitarbeit und kapazitätsorientierte variable Arbeitszeitregelungen (Kapovaz) seien damit keine aktuelle Erfindung, sondern bereits im Kaiserreich und in der Weimarer Republik erprobt, wie die Autorin aufzeigt. Es wäre an der Zeit, so eine abschließende Forderung der Autorin, das staatliche "Entgegenkommen" der Teilzeitregelungen heute stärker auch auf Männer zu beziehen. (rk)- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
    Subject(s): alte Bundesländer ; Arbeitsmarkt- und Berufsforschung ; Berufsforschung ; Bundesrepublik Deutschland ; Frauen- und Geschlechterforschung ; Frauenerwerbstätigkeit ; Frauenforschung ; Geschichte ; geschlechtsspezifische Faktoren ; historische Entwicklung ; Post ; Sozialgeschichte, historische Sozialforschung ; Sozialwissenschaften, Soziologie ; Teilzeitarbeit ; Wirtschaft
    Source: Europeana Collections
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  • 10
    Language: English
    In: Wilhelm Roux's archives of developmental biology, 1981-07, Vol.190 (4), p.197-207
    Description: A library of hybridoma cell lines has been established which produce monoclonal antibodies against antigens from the germinal vesicle ofXenopus laevis oocytes. Many of the antigens are also found in the nuclei ofXenopus embryonic cells in culture. The fate of two of these antigens during embryogenesis was traced by immunofluorescence on embryo and tadpole sections. Early in development these antigens appear to be evenly distributed in the nuclei of all cells. In later stages they gradually disappear from most embryonic structures but are strongly accumulated in the nuclei of some specific cell types and organs.
    ISSN: 0340-0794
    E-ISSN: 1432-041X
    Source: Springer Online Journal Archives (DFG Nationallizenzen)
    Source: Springer Online Journal Archives (Through 1996)
    Source: Alma/SFX Local Collection
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