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  • 1
    Article
    Article
    2010
    ISSN: 1758-2679 
    In: Evangelou, Angelos (2010) Georges Bataille’s ‘Ethics of Violence’. Skepsi, 3 (2). pp. 51-64.
    Description: In this article I will focus on Georges Bataille’s understanding of violence, whose position and reaction to fascism and Nazi violence in particular have been questioned, and his political engagement has been characterised as ambiguous to say the least. This article focuses on Battaille’s understanding of violence. His position vis-à-vis and reaction to fascism in general and Nazi violence in particular has been questioned, and his political engagement has been characterised as ambiguous, to say the least. The article endeavours to throw some light on the thought of a philosopher whose attraction to violence, horror, anguish and death as equally as to love and life may easily allow his project to be misread. How can Bataille,imbued within the Nietzschean tradition of beyond good and evil, both call for a hypermorality of ‘holding nothing back!’ and make sense of Auschwitz as something humanly possible, yet resist any direct accusations of being a Nazi politics supporter? The article first contextualises Bataille’s ‘ethics of violence’ within his discussion of the heterogeneous and the science of heterology, then explains the nature of his fascination with violence and horror and finally considers his reaction to the reproaches mentioned above. In other words, this discussion can be read as revolving around a question and the attempt to answer it: what, according to Bataille, is one to make of or do with violence, and why? Is one to deny it as one does an enemy and a threat, come to terms with it as something inevitable or go after it as something necessary? But are these options easily distinguished, if one sees violence, indeed as a pharmakon?
    ISSN: 1758-2679
    Source: University of Kent
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  • 2
    Language: English
    In: PQDT - UK & Ireland
    Description: The shortage of fossil fuels and the emergence of renewable energy technologies have increased the demand for a more variable and efficient power output from conventional gas turbine units. Single crystal Ni-based superalloys have long been the materials of choice for high temperature, gas turbine blade, applications due to their excellent fatigue, creep and oxidation resistance. However, the increased number of start-ups and shut downs, produce complex, unpredictable, cyclic loadings even at moderate temperatures, where the fatigue - oxidation behaviour of such materials is less well understood. The gas turbine industry has significant economic incentives to optimise maintenance scheduling and determine the useful lifetime of such components and thus a substantial effort is put in the development of damage tolerant, life assessment methods. This thesis aims to elucidate the mechanisms of oxidation - fatigue damage at moderate service temperatures, in single crystal, Ni-based superalloy...
    Subject(s): Https://Eprints.Soton.Ac.Uk/420749/ ; (Umi)Aai13854745 ; Social Sciences
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Source: ProQuest Dissertations & Theses A&I
    Source: ProQuest Dissertations & Theses: Global
    Source: ProQuest One Academic
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  • 3
    In: Journal of Scientific Exploration, 09/30/2018, Vol.32(3), pp.495-513
    Description: The effect of location and its geophysical properties on biology has been known since ancient times. This paper makes an attempt to define geophysical anomalies and analyze the various parameters that constitute them. Furthermore, the mechanisms through which these anomalies interact with human biology, flora and fauna are analyzed.
    Subject(s): Sciences (General);
    ISSN: 08923310
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  • 4
    Language: English
    In: The open medical informatics journal, 2012, Vol.6, pp.15-25
    Description: This work describes a hysteroscopy surgery management application that was designed based on the medical information standard SNOMED. We describe how the application fulfils the needs of this procedure and the way in which existing handwritten medical information is effectively transmitted to the application's database.
    Subject(s): Conceptual Database Design ; Snomed. ; Hysteroscopy ; Interoperability ; Medical Information Management
    ISSN: 1874-4311
    E-ISSN: 1874-4311
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  • 5
    Language: English
    In: British Journal of Oral & Maxillofacial Surgery, 2011, Vol.49(7), pp.538-541
    Description: The use of titanium implants and osteosynthesis materials in orthopaedics, neurosurgery, and maxillofacial surgery has increased considerably, and they may be retained in patients for a long time. We could find no papers in English that provided data about the effect of titanium osteosynthesis materials on platelet function, and the purpose of this study was to evaluate those effects. Platelet function was tested in 33 patients with titanium maxillofacial implants using the PFA-100 (platelet function analyser) system and these results were compared with those of a control group of 34 healthy volunteer blood donors. Platelet function was measured in each group using collagen/adrenaline and collagen/adenosine diphosphate (ADP) as agonists for assessment of platelet function. There were no significant differences between the groups (collagen/adrenaline p = 0.1, collagen/ADP p = 0.09). Titanium maxillofacial osteosynthesis materials have no significant effect on...
    Subject(s): Titanium Osteosynthesis Materials ; Platelet Function ; Pfa-100 System ; Titanium Osteosynthesis Materials ; Platelet Function ; Pfa-100 System ; Dentistry
    ISSN: 0266-4356
    E-ISSN: 1532-1940
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  • 6
    Language: English
    In: Movement Disorders, 15 May 2008, Vol.23(7), pp.950-957
    Description: The aim of the present study was to investigate the course of levodopa induced dyskinesia (LID) development in parkinsonian rats treated with several different levodopa dosing regiments. Administration of 6.25 mg/kg levodopa once daily did not induce any dyskinesia for the first 12.5 ± 2.5 days. Then, LID gradually increased in intensity reaching an AIMs score on day 40 of 6.3 ± 0.9. Treatment with 6.25 mg/kg of levodopa qid resulted in the rapid appearance of LID with a mean latency of 2 days and an AIMs score of 19.9 ± 2.9 on day 10. Levodopa (25 mg/kg) once daily induced severe LID from the second day of treatment reaching an AIMs score of 35 ± 3.2. In summary, the worst way for delivering levodopa was through intermittent administration of high doses. The daily cumulative dose of levodopa was found more important for LID induction than the total amount of levodopa received. In contrast, the best way to administer levodopa in respect to prevention/delay of LID was “low dopaminergic stimulation” with one low daily dose, instead of trying to achieve “continuous dopaminergic stimulation” using several levodopa doses throughout the day. The benefits of this strategy offered protection against severe dyskinesia even if subsequently subjects were switched to high dose levodopa. © 2007 Movement Disorder Society
    Subject(s): Parkinson'S Disease ; Continuous Dopaminergic Stimulation ; Motor Response Complications ; Priming ; Abnormal Involuntary Movements ; Basal Ganglia.
    ISSN: 0885-3185
    E-ISSN: 1531-8257
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  • 7
    Language: English
    In: Psychopharmacology, 2006, Vol.185(3), pp.369-377
    Description: Tardive dyskinesia is a syndrome of abnormal, involuntary movements, which occurs as a complication of long-term neuroleptic therapy. The pathophysiology of this potentially irreversible syndrome is still an enigma. The objective of the present study was to elucidate the role of N-methyl-D-aspartate (NMDA) receptor involvement in neuroleptic-induced orofacial dyskinesia in rats. Animals chronically treated with haloperidol for a period of 40 weeks exhibited significantly more vacuous chewing movements (VCMs), as compared to vehicle-treated controls. In a series of acute experiments, rats received: amantadine (10, 20, and 40 mg/kg i.p.), a low-affinity, uncompetitive NMDA-receptor antagonist (open channel blocker); dextrorphan (5, 10, and 20 mg/kg i.p.), an NMDA receptor channel antagonist; ifenprodil (2.5, 5, and 10 mg/kg i.p.), a noncompetitive allosteric NMDA receptor antagonist acting at the polyamine site; and Ro 25-6981 (2.5, 5, and 10 mg/kg i.p.), a potent and selective blocker of NMDA receptors which contain the NR2B subunit. All the drugs tested, except dextrorphan, reduced VCMs and tongue protrusions with varying efficacies and side effects profiles. Ro 25-6981 was found significantly more potent than amantadine and ifenprodil in reducing VCMs and tongue protrusions at all doses tested, and at the higher dose, it completely eliminated orofacial dyskinesia (p〈0.05). These results suggest that NMDA receptors may play a significant role in the pathophysiology of tardive dyskinesia. Furthermore, antagonists showing selectivity for NMDA receptors containing the NR2B subunit may be particularly efficacious as novel therapeutic agents for the treatment of tardive dyskinesia and deserve further testing.
    Subject(s): Tardive dyskinesia ; Vacuous chewing movements ; NMDA ; NMDA receptor antagonist ; Amantadine ; Orofacial dyskinesia ; Tongue protrusions ; Jaw tremor
    ISSN: 0033-3158
    E-ISSN: 1432-2072
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  • 8
    Language: English
    In: International Urology and Nephrology, 2013, Vol.45(4), pp.1137-1144
    Description: Byline: Georgios Boudouris (1,2), Ioannis I. Verginadis (1), Yannis V. Simos (1), Andreas Zouridakis (1,3), Vasilios Ragos (4), Spyridon Ch. Karkabounas (1), Angelos M. Evangelou (1) Keywords: Oxidative stress; Peritoneal dialysis; Antioxidants; Ascorbic acid; a-tocopherol Abstract: Purpose Chronic renal failure patients undergoing peritoneal dialysis (PD) are characterized by increased oxidative stress (OS), which is associated with enhanced cardiovascular risk. Moreover, oxidative stress also contributes to peritoneal membrane changes and ultrafiltration failure. The aim of this study was to evaluate OS in PD patients and the effect of treatment with ascorbic acid and [alpha]-tocopherol. Methods Plasma, erythrocyte, urine, and peritoneal effluent samples from 20 patients on PD were evaluated for glutathione peroxidase and superoxide dismutase activity, total antioxidant capacity (TAC) and malondialdehyde (MDA) levels, as well as protein carbonyl formation, before and after administration of vitamin C, alone or in combination with vitamin E, in comparison with 10 apparently healthy control individuals. Results All studied markers showed enhanced OS in the PD group, compared to controls. The supplementation of vitamin C and E resulted in improvements of all the OS markers, as indicated by increased erythrocyte antioxidant enzymes activity and TAC levels, as well as decreased MDA concentration and carbonyl compound formation. Conclusions The oral supplementation of antioxidant vitamins C and E, in combination, can lead to decreased OS, thus providing a useful and cost-effective therapeutic option in PD patients. Author Affiliation: (1) Laboratory of Physiology, Faculty of Medicine, University of Ioannina, 45110, Ioannina, Greece (2) 4th Department of Internal Medicine, Hippokration General Hospital, Thessaloniki, Greece (3) Renal Unit, General Hospital, 46300, Filiates, Greece (4) Department of Maxillofacial Surgery, University Hospital of Ioannina, Ioannina, Greece Article History: Registration Date: 10/11/2012 Received Date: 01/04/2012 Accepted Date: 09/11/2012 Online Date: 02/12/2012
    Subject(s): Oxidative stress ; Peritoneal dialysis ; Antioxidants ; Ascorbic acid ; a-tocopherol
    ISSN: 0301-1623
    E-ISSN: 1573-2584
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  • 9
    Language: English
    In: The open cardiovascular medicine journal, 2015, Vol.9, pp.5-17
    Description: The purpose of this study was to examine the associations between resting blood pressure (BP), smoking, physical activity (PA) and body mass index (BMI) in Greek young adults. A standardised questionnaire and the Greek version of IPAQ-short were given to 1500 randomly selected health science students, in order to record smoking behaviour, PA status, BMI and resting BP. All healthy young adults aged 19-30 years old were eligible. The final size of the study cohort was 1249 students (522 men). Males' BP was 129.2/77.0 mmHg, significantly higher than the females' values of 119.9/73.4 mmHg. Approximately 17% of the total population were classified as overweight and 3% as obese. In the overall population, smoking prevalence was 35.2%, with 15.3% being heavy smokers (≥21 cigs/d). Smoking prevalence did not differ significantly between sexes. The prevalence of health-enhancing PA (high PAclass) was only 14.0%, while 42.8% of the study population were classified as insufficiently active (low PAclass). Of the three lifestyle risk factors examined, only BMI was significantly and directly associated with systolic and diastolic BP levels. The prevalence of hypertension (≥140/90 mmHg) was significantly higher in men compared to women, and in obese and overweight participants compared to normal-weight subjects. Smoking and categorical PA (PAclass) were not correlated with BP. Continuous vigorous PAscore was significantly and directly associated with systolic BP, but only in males. BMI was significantly and directly associated with resting BP in both sexes. Smoking prevalence and PA status were not associated with BP in this sample of Greek young adults.
    Subject(s): Blood Pressure ; Body Mass Index ; Obesity ; Physical Activity ; Risk Factors ; Smoking
    ISSN: 1874-1924
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  • 10
    Language: English
    In: European Journal of Preventive Cardiology, August 2010, Vol.17(4), pp.380-386
    Description: Background Self-reported physical activity (PA) is well associated with cardiorespiratory fitness and exercise capacity. The short International Physical Activity Questionnaire (IPAQ-short) is a frequently used instrument for cross-national assessments of PA in adults. The purpose of this study was to validate IPAQ-short against exercise capacity in Greek young adults. Design and methods One hundred and thirteen men and 105 women, aged 20-29 years, were randomly selected from a larger population of young health-science students. A Greek version of IPAQ-short (IPAQ-Gr) was administered to all participants before their exercise capacity evaluation with a maximal Bruce treadmill test. Multiple regression and correlation analyses were used to examine the associations between all IPAQ-Gr outcomes with exercise capacity based on maximal treadmill time. Results Spearman's correlations for total and vigorous...
    Subject(s): Exercise Capacity ; International Physical Activity Questionnaire ; Ipaq ; Physical Activity ; Physical Activity Questionnaires ; Validity ; Medicine
    ISSN: 2047-4873
    ISSN: 17418267
    E-ISSN: 2047-4881
    E-ISSN: 17418275
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