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1

Article

Outcome of children with high-risk acute myeloid leukemia given autologous or allogeneic hematopoietic cell transplantation in the aieop AML-2002/01 study

Locatelli, F ; Masetti, R ; Rondelli, R ; [et al.]

2015

ISSN: 0268-3369

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Language: English

In: Bone marrow transplantation (Basingstoke), 2015-02, Vol.50 (2), p.181-188

Description: We analyzed the outcome of 243 children with high-risk (HR) AML in first CR1 enrolled in the AIEOP-2002/01 protocol, who were given either allogeneic (ALLO; n=141) or autologous (AUTO; n=102) hematopoietic SCT (HSCT), depending on the availability of a HLA-compatible sibling. Infants, patients with AML-M7, or complex karyotype or those with FLT3-ITD, were eligible to be transplanted also from alternative donors. All patients received a myeloablative regimen combining busulfan, cyclophosphamide and melphalan; [corrected] AUTO-HSCT patients received BM cells in most cases, while in children given ALLO-HSCT stem cell source was BM in 96, peripheral blood in 19 and cord blood in 26. With a median follow-up of 57 months (range 12-130), the probability of disease-free survival (DFS) was 73% and 63% in patients given either ALLO- or AUTO-HSCT, respectively (P=NS). Although the cumulative incidence (CI) of relapse was lower in ALLO- than in AUTO-HSCT recipients (17% vs 28%, respectively; P=0.043), the CI of TRM was 7% in both groups. Patients transplanted with unrelated donor cord blood had a remarkable 92.3% 8-year DFS probability. Altogether, these data confirm that HSCT is a suitable option for preventing leukemia recurrence in HR children with CR1 AML.

Subject(s): Autografts ; Follow-Up Studies ; Leukemia, Myeloid, Acute - pathology ; Humans ; Child, Preschool ; Hematopoietic Stem Cell Transplantation ; Infant ; Male ; Survival Rate ; Abnormal Karyotype ; Cord Blood Stem Cell Transplantation ; Leukemia, Myeloid, Acute - mortality ; fms-Like Tyrosine Kinase 3 - genetics ; Disease-Free Survival ; Allografts ; Adolescent ; Myeloablative Agonists - administration & dosage ; Female ; Transplantation Conditioning - methods ; Child ; Leukemia, Myeloid, Acute - therapy ; Leukemia, Myeloid, Acute - genetics ; Transplantation ; Health aspects ; Patient outcomes ; Hematopoietic stem cells ; Index Medicus

ISSN: 0268-3369

E-ISSN: 1476-5365

DOI: 10.1038/bmt.2014.246

Source: Nature Open Access

Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Source: Academic Search Ultimate

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2

Article

Does External Accountability Affect Student Outcomes? A Cross-State Analysis

Martin Carnoy ; Susanna Loeb

2002

ISSN: 0162-3737

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Language: English

In: Educational evaluation and policy analysis, 2002-12-01, Vol.24 (4), p.305-331

Description: We developed a zero-to-five index of the strength of accountability in 50 states based on the use of high-stakes testing to sanction and reward schools, and analyzed whether that index is related to student gains on the NAEP mathematics test in 1996-2000. The study also relates the index to changes in student retention in the 9th grade and to changes in high school completion rates over the same period. The results show that students in high-accountability states averaged significantly greater gains on the NAEP 8th-grade math test than students in states with little or no state measures to improve student performance. Furthermore, students in high-accountability states do not have significantly higher retention or lower high school completion rates.

Subject(s): Outcomes of education ; Grade repetition ; High school students ; Basic skills ; Test scores ; Mathematics ; High schools ; Coefficients ; Survival rates ; Hispanics

ISSN: 0162-3737

E-ISSN: 1935-1062

DOI: 10.3102/01623737024004305

Source: JSTOR Arts & Sciences IV

Source: Alma/SFX Local Collection

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3

Article

Stress-Induced Deficits in Working Memory and Visuo-Constructive Abilities in Special Operations Soldiers

Morgan, Charles A ; Doran, Anthony ; Steffian, George ; [et al.]

2006

ISSN: 0006-3223

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Language: English

In: Biological psychiatry (1969), 2006, Vol.60 (7), p.722-729

Description: Pre-clinical and clinical studies have shown acute stress may impair working memory and visuo-spatial ability. This study was designed to clarify the nature of stress-induced cognitive deficits in soldiers and how such deficits may contribute to operational or battlefield errors. One hundred eighty-four Special Operations warfighters enrolled in Survival School completed pre-stress measures of dissociation and trauma exposure. Subjects were randomized to one of three assessment groups (Pre-stress, Stress, Post-stress) and were administered the Rey Ostereith Complex Figure (ROCF). All subjects completed post-stress measures of dissociation. ROCF copy and recall were normal in the Pre- and Post-stress groups. ROCF copy and recall were significantly impaired in the Stress Group. Stress group ROCF copy performance was piecemeal, and ROCF recall was impaired. Symptoms of dissociation were negatively associated with ROCF recall in the Stress group. Baseline dissociation and history of traumatic stress predicted cognitive impairment during stress. Stress exposure impaired visuo-spatial capacity and working memory. In rats, monkeys, and humans, high dopamine and NE turnover in the PFC induce deficits in cognition and spatial working memory. Improved understanding of stress-induced cognitive deficits may assist in identification of soldiers at risk and lead to the development of better countermeasures.

Subject(s): survival school ; pre-frontal cortex ; Cognition ; military performance ; trauma exposure ; dissociation ; Fundamental and applied biological sciences. Psychology ; Human ; Psychology. Psychoanalysis. Psychiatry ; Memory ; Psychology. Psychophysiology ; Biological and medical sciences ; Learning. Memory ; Humans ; Military Personnel - psychology ; Male ; Dissociative Disorders - etiology ; Memory Disorders - etiology ; Space Perception ; Adult ; Female ; Form Perception ; Pattern Recognition, Visual ; Memory, Short-Term ; Stress, Psychological - complications ; Training ; Medical colleges ; Soldiers ; Military personnel ; Short-term memory ; Index Medicus

ISSN: 0006-3223

E-ISSN: 1873-2402

DOI: 10.1016/j.biopsych.2006.04.021

Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]

URL: http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18164343$$DView record in Pascal Francis

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4

Article

Livelihood and survival strategies among Gweru urban teachers and their implications on pupils’ performance in the current Zimbabwe’s flopping economy

Muzvondiwa, Eresi

2020

ISSN: 2668-7798

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Language: English

In: Technium Social Sciences Journal, 2020-04-26, Vol.7, p.74-85

Description: Currently, teachers’ salaries in Zimbabwe are insufficient to sustain the harsh economic situation yet teachers seem to be meeting their monthly livelihood demands. A study to explore different survival strategies engaged by teachers under this current flopping economy was conducted in the Gweru urban. A total of 55 participants were randomly selected from five different schools. Questionnaires and in-depth interviews were used to collect data. Descriptive statistics and Chi-Square test for association (SPSS version 21) were used to analyse the data. Findings revealed that teachers have adopted 15 survival strategies to augment their meagre salaries. Over 50% of the teachers indicated that borrowing money from banks/microfinance institutions, conducting extra lessons, poultry production, cross border trading, part-time teaching at private schools, production of horticultural produce and selling of goods (maputi “dried corn”, sweets, peanut butter, snacks etc...) were pillars to their survival in this collapsing economy. Gender influenced the adoption of cross border trading (χ2 = 4.558; p 〈0.05) and hair dressing (χ2 = 10.102; p 〈0.005). Delivery of extra lesson was significantly associated with job title (χ2 = 5.026; p 〈0.05) constituting 70% teachers and 20% headmasters. It was observed that teachers with higher qualifications had a greater chances of being hired as part time private tutors in private schools. A greater proportion of the respondents (70.91%) agreed that venturing into these survival strategies impacted seriously on pupils’ overall performance. Thus teachers are recommended to balance their profession and private business to ensure that pupils’ performance is not compromised.

Subject(s): flopping economy, survival strategies, teachers, school, livelihood

ISSN: 2668-7798

E-ISSN: 2668-7798

DOI: 10.47577/tssj.v7i1.356

Source: HeinOnline Law Journal Library

Source: Directory of Open Access Journals

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5

Article

Livelihood and survival strategies among Gweru urban teachers and their implications on pupils’ performance in the current Zimbabwe’s flopping economy

Eresi Muzvondiwa

2020

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Language: English

In: Technium Social Sciences Journal, 2020-04-01, Vol.7, p.74-85

Description: Currently, teachers’ salaries in Zimbabwe are insufficient to sustain the harsh economic situation yet teachers seem to be meeting their monthly livelihood demands. A study to explore different survival strategies engaged by teachers under this current flopping economy was conducted in the Gweru urban. A total of 55 participants were randomly selected from five different schools. Questionnaires and in-depth interviews were used to collect data. Descriptive statistics and Chi-Square test for association (SPSS version 21) were used to analyse the data. Findings revealed that teachers have adopted 15 survival strategies to augment their meagre salaries. Over 50% of the teachers indicated that borrowing money from banks/microfinance institutions, conducting extra lessons, poultry production, cross border trading, part-time teaching at private schools, production of horticultural produce and selling of goods (maputi “dried corn”, sweets, peanut butter, snacks etc...) were pillars to their survival in this collapsing economy. Gender influenced the adoption of cross border trading (χ2 = 4.558; p 〈0.05) and hair dressing (χ2 = 10.102; p 〈0.005). Delivery of extra lesson was significantly associated with job title (χ2 = 5.026; p 〈0.05) constituting 70% teachers and 20% headmasters. It was observed that teachers with higher qualifications had a greater chances of being hired as part time private tutors in private schools. A greater proportion of the respondents (70.91%) agreed that venturing into these survival strategies impacted seriously on pupils’ overall performance. Thus teachers are recommended to balance their profession and private business to ensure that pupils’ performance is not compromised.

Subject(s): flopping economy, survival strategies, teachers, school, livelihood

E-ISSN: 2668-7798

DOI: 10.47577/tssj.v7i1.356

Source: HeinOnline Law Journal Library

Source: Directory of Open Access Journals

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6

Article

Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease

Kröger, Nicolaus ; Solano, Carlos ; Wolschke, Christine ; [et al.]

2016

ISSN: 0028-4793

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Language: English

In: The New England journal of medicine, 2016-01-07, Vol.374 (1), p.43-53

Description: Antilymphocyte globulin (ATG) added to the conditioning regimen before allogeneic hematopoietic stem-cell transplantation resulted in a lower rate of chronic graft-versus-host disease at 2 years than the rate without ATG (32% vs. 68%), with no apparent increased risk of relapse. Chronic graft-versus-host disease (GVHD) is a major complication of allogeneic stem-cell transplantation that results in later illness and death and a reduction in quality of life. 1 , 2 Risk factors for chronic GVHD are the use of peripheral blood as a source of stem cells, a history of acute GVHD, and the use of donated stem cells with high numbers of T cells. 3 – 7 In a meta-analysis, the Stem Cell Trialists’ Collaborative Group reported an incidence of extensive chronic GVHD of 47% after peripheral-blood stem-cell transplantation from an HLA-identical sibling. 4 In 2012, more than 70% of the stem-cell transplantations performed in . . .

Subject(s): Graft vs Host Disease - epidemiology ; Prospective Studies ; Humans ; Immunosuppressive Agents - therapeutic use ; Middle Aged ; Proportional Hazards Models ; Child, Preschool ; Male ; Survival Rate ; Transplantation, Homologous ; Incidence ; Young Adult ; Disease-Free Survival ; Graft vs Host Disease - mortality ; Adolescent ; Antilymphocyte Serum - therapeutic use ; Adult ; Female ; Graft vs Host Disease - prevention & control ; T-Lymphocytes - immunology ; Child ; Chronic Disease ; Prevention ; Treatment outcome ; Graft versus host reaction ; Immunoglobulins ; Dosage and administration ; Analysis ; Graft-versus-host reaction ; Transplants & implants ; Leukemia ; Stem cell transplantation ; Lymphocytes T ; Preventive medicine ; Hemopoiesis ; Globulins ; Risk assessment ; Peripheral blood ; Stem cells ; Bone marrow ; Histocompatibility antigen HLA ; Index Medicus ; Abridged Index Medicus

ISSN: 0028-4793

E-ISSN: 1533-4406

DOI: 10.1056/NEJMoa1506002

Source: Single Journals

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7

Article

Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study

Sun, Weili ; Malvar, Jemily ; Sposto, Richard ; [et al.]

2018

ISSN: 0887-6924

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Language: English

In: Leukemia, 2018-11, Vol.32 (11), p.2316-2325

Description: The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the outcome of multiply R/R childhood B-ALL treated at 24 TACL institutions between 2005 and 2013. Patient information, treatment, and response were collected. Prognostic factors influencing the complete remission (CR) rate and event-free survival (EFS) were analyzed. The analytic set included 578 salvage treatment attempts among 325 patients. CR rates (mean ± SE) were 51 ± 4% for patients with bone marrow R/R B-ALL who underwent a second salvage attempt, 37 ± 6% for a third attempt, and 31 ± 6% for the fourth through eighth attempts combined. For patients achieving a CR after their second, third, and fourth through eighth attempts, the 2 year EFS was 41 ± 6%, 13 ± 7%, and 27 ± 13% respectively. Our results showed slight improvement when compared to previous studies. This is the largest and most recent study to date that evaluates the outcome of this patient population. Our data will provide detailed reference for the evaluation of new agents being developed for childhood B-ALL.

ISSN: 0887-6924

E-ISSN: 1476-5551

DOI: 10.1038/s41375-018-0094-0

Source: Nature Open Access

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8

Article

Characterization of children with FLT3-ITD acute myeloid leukemia: a report from the AIEOP AML-2002 study group

Manara, E ; Basso, G ; Zampini, M ; [et al.]

2017

ISSN: 0887-6924

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Language: English

In: Leukemia, 2017-01, Vol.31 (1), p.18-25

Description: Recurrent molecular markers have been routinely used in acute myeloid leukemia (AML) for risk assessment at diagnosis, whereas their post-induction monitoring still represents a debated issue. We evaluated the prognostic value and biological impact of minimal residual disease (MRD) and of the allelic ratio (AR) of FLT3-internal-tandem duplication (ITD) in childhood AML. We retrospectively screened 494 children with de novo AML for FLT3-ITD mutation, identifying 54 harboring the mutation; 51% of them presented high ITD-AR at diagnosis and had worse event-free survival (EFS, 19.2 versus 63.5% for low ITD-AR, 〈0.05). Forty-one percent of children with high levels of MRD after the 1st induction course, measured by a patient-specific real-time-PCR, had worse EFS (22.2 versus 59.4% in low-MRD patients, P〈0.05). Next, we correlated these parameters with gene expression, showing that patients with high ITD-AR or persistent MRD had characteristic expression profiles with deregulated genes involved in methylation and acetylation. Moreover, patients with high CyclinA1 expression presented an unfavorable EFS (20.3 versus 51.2% in low CyclinA1 group, P〈0.01). Our results suggest that ITD-AR levels and molecular MRD should be considered in planning clinical management of FLT3-ITD patients. Different transcriptional activation of epigenetic and oncogenic profiles may explain variability in outcome among these patients, for whom novel therapeutic approaches are desirable.

Subject(s): fms-Like Tyrosine Kinase 3 - genetics ; Disease-Free Survival ; Leukemia, Myeloid, Acute - diagnosis ; Prognosis ; Epigenesis, Genetic - genetics ; Humans ; Child, Preschool ; Retrospective Studies ; Gene Expression Regulation, Leukemic ; Child ; Neoplasm, Residual - genetics ; Leukemia, Myeloid, Acute - genetics ; Molecular targeted therapy ; Gene mutations ; Gene expression ; Health aspects ; Innovations ; Index Medicus

ISSN: 0887-6924

E-ISSN: 1476-5551

DOI: 10.1038/leu.2016.177

Source: Nature Open Access

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9

Article

Neoadjuvant Chemotherapy With Methotrexate, Cisplatin, and Doxorubicin With or Without Ifosfamide in Nonmetastatic Osteosarcoma of the Extremity: An Italian Sarcoma Group Trial ISG/OS-1

Stefano Ferrari ; Pietro Ruggieri ; Graziella Cefalo ; [et al.]

2012

ISSN: 0732-183X

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Language: English

In: Journal of clinical oncology, 2012-06-10, Vol.30 (17), p.2112-2118

Description: We compared two chemotherapy regimens that included methotrexate (MTX), cisplatin (CDP), and doxorubicin (ADM) with or without ifosfamide (IFO) in patients with nonmetastatic osteosarcoma of the extremity. Patients age ≤ 40 years randomly received regimens with the same cumulative doses of drugs (ADM 420 mg/m(2), MTX 120 g/m(2), CDP 600 mg/m(2), and IFO 30 g/m(2)) but with different durations (arm A, 44 weeks; arm B, 34 weeks). IFO was given postoperatively when pathologic response to MTX-CDP-ADM was poor (arm A) or given in the primary phase of chemotherapy with MTX-CDP-ADM (arm B). End points of the study included pathologic response to preoperative chemotherapy, toxicity, and survival. Given the feasibility of accrual, the statistical plan only permitted detection of a 15% difference in 5-year overall survival (OS). From April 2001 to December 2006, 246 patients were enrolled. Two hundred thirty patients (94%) underwent limb salvage surgery (arm A, 92%; arm B, 96%; P = .5). Chemotherapy-induced necrosis was good in 45% of patients (48% in arm A, 42% in arm B; P = .3). Four patients died of treatment-related toxicity (arm A, n = 1; arm B, n = 3). A significantly higher incidence of hematologic toxicity was reported in arm B. With a median follow-up of 66 months (range, 1 to 104 months), 5-year OS and event-free survival (EFS) rates were not significantly different between arm A and arm B, with OS being 73% (95% CI, 65% to 81%) in arm A and 74% (95% CI, 66% to 82%) in arm B and EFS being 64% (95% CI, 56% to 73%) in arm A and 55% (95% CI, 46% to 64%) in arm B. IFO added to MTX, CDP, and ADM from the preoperative phase does not improve the good responder rate and increases hematologic toxicity. IFO should only be considered in patients who have a poor histologic response to MTX, CDP, and ADM.

Subject(s): Biological and medical sciences ; Medical sciences ; Diseases of the osteoarticular system ; Tumors of striated muscle and skeleton ; Tumors ; Osteosarcoma - drug therapy ; Femur - pathology ; Humans ; Child, Preschool ; Male ; Tibia - pathology ; Cisplatin - administration & dosage ; Humerus - pathology ; Disease-Free Survival ; Ifosfamide - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Chemotherapy, Adjuvant - methods ; Adolescent ; Adult ; Female ; Methotrexate - administration & dosage ; Bone Neoplasms - drug therapy ; Child ; Doxorubicin - administration & dosage

ISSN: 0732-183X

E-ISSN: 1527-7755

DOI: 10.1200/JCO.2011.38.4420

Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

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10

Article

Outcome of children with acute myeloid leukaemia (AML) experiencing primary induction failure in the AIEOP AML 2002/01 clinical trial

Quarello, Paola ; Fagioli, Franca ; Basso, Giuseppe ; [et al.]

2015

ISSN: 0007-1048

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Language: English

In: British journal of haematology, 2015-11, Vol.171 (4), p.566-573

Description: Summary Paediatric patients with acute myeloid leukaemia (AML) who fail induction due to primary resistance to chemotherapy account for a significant proportion of cases and have a particularly dismal prognosis. We report the clinical and biological data, and final outcome of 48 paediatric patients with primary‐resistant AML enrolled in the Associazione Italiana di Ematologia e Oncologia Pediatrica AML 2002/01 clinical trial. These patients had a significantly higher white blood cell count at diagnosis compared to other AML patients. Cytogenetic and molecular features did not differ between patients with primary induction failure and patients allocated to the high‐risk group. For the whole patient population, the probability of overall survival, event‐free survival (EFS) and disease‐free survival (DFS) was 21·8% ± 6·2, 20·4% ± 5·9, and 49·5% ± 11·3, respectively. Twenty‐eight (58%) patients received haematopoietic stem cell transplantation (HSCT); 3 were autologous and 25 were allogeneic. Patients who underwent HSCT had improved EFS (31·2% vs. 5%, P 〈 0·0001). Only one of the 20 patients who did not receive HSCT is alive and disease free. The 19 patients in complete remission at time of HSCT showed significantly better DFS than the 9 with active disease (46% vs. 0%, P = 0·02). This study represents one of the largest series with long‐term follow up of paediatric AML patients with primary refractory disease. Children who underwent transplantation had an encouraging long‐term outcome. Disease recurrence remains the major cause of treatment failure; a better understanding of the disease biology is desirable to develop more effective treatment strategies.

Subject(s): childhood leukaemia ; acute myeloid leukaemia ; relapse ; stem cell transplantation ; induction failure ; Recurrence ; Graft vs Host Disease - epidemiology ; Prognosis ; Follow-Up Studies ; Humans ; Child, Preschool ; Infant ; Male ; Transplantation, Autologous ; Incidence ; Allografts ; Treatment Failure ; Leukemia, Myeloid, Acute - drug therapy ; Female ; Child ; Infant, Newborn ; Leukemia, Myeloid, Acute - therapy ; Kaplan-Meier Estimate ; Hematopoietic Stem Cell Transplantation ; Remission Induction ; Leukemia, Myeloid, Acute - mortality ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Adolescent ; Transplantation Conditioning ; Clinical trials ; Chemotherapy ; Transplantation ; Hematopoietic stem cells ; Cancer ; Index Medicus

ISSN: 0007-1048

E-ISSN: 1365-2141

DOI: 10.1111/bjh.13611

Source: Alma/SFX Local Collection

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