disco – ULB Münster

1

Article

Vectorcardiography analysis of the repolarization response to pharmacologically induced autonomic nervous system modulation in healthy subjects

Vahedi, Farzad ; Odenstedt, Jacob ; Hartford, Marianne ; [et al.]

2012

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Language: English

In: Journal of applied physiology (Bethesda, Md. : 1985), August 2012, Vol.113(3), pp.368-76

Description: Autonomic nervous system activity is essential for regulation of ventricular repolarization (VR) and plays an important role in several arrhythmogenic conditions. This study in 31 healthy adult subjects (16 men, 15 women) evaluated the VR response to pharmacologically modulated autonomic nervous system activity applying vectorcardiography (VCG) analysis. During continuous VCG recording, 0.01-0.1 μg·kg(-1)·min(-1) isoprenaline (Iso) was infused at an increasing flow rate until three targeted heart rates (HR) were reached. After Iso washout, one intravenous bolus of 0.04 mg/kg atropine was given followed by an intravenous bolus of 0.2 mg/kg propranolol. A 5-min steady-state VCG recording was analyzed for each of the seven phases (including baseline 1 and 2). Furthermore, during the first 4 min following atropine, six periods of 10-s VCG were selected for subanalysis to evaluate the time course of change. The analysis included QRS, QT, and T-peak to T-end intervals, measures of the QRS and T vectors and their relation, as well as T-loop morphology parameters. By increasing HR, Iso infusion decreased HR dependent parameters reflecting total heterogeneity of VR (T area) and action potential morphology (ventricular gradient). In contrast, Iso prolonged QT HR corrected according to Bazett and increased the T-peak to T-end-to-QT ratio to levels observed in arrhythmogenic conditions. HR acceleration after atropine was accompanied by a transient paradoxical QT prolongation and delayed HR adaptation of T area and ventricular gradient. In addition to the expected HR adaptation, the VR response to β-adrenoceptor stimulation with Iso and to muscarinic receptor blockade with atropine thus included alterations previously observed in congenital and acquired long QT syndromes, demonstrating substantial overlap between physiological and pathophysiological electrophysiology.

Subject(s): Adaptation, Physiological ; Autonomic Nervous System -- Drug Effects ; Heart Rate -- Drug Effects ; Vectorcardiography -- Methods

E-ISSN: 1522-1601

DOI: 10.1152/japplphysiol.01190.2011

URL: View this record in MEDLINE/PubMed

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2

Article

TCT-51 Prognostic impact of chronic total occlusion in patients with different severity of coronary artery disease - A report from the Swedish Coronary Angiography and Angioplasty Registry

Råmunddal, Truls ; Hoebers, Loes ; Henriques, Jose P ; [et al.]

2013

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 29 October 2013, Vol.62(18), pp.B17-B17

Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2013.08.783 Byline: Truls Ramunddal, Loes Hoebers, Jose P. Henriques, Christian Dworeck, Mkael Aasa, Per Albertsson, Oskar Angeras, Jan Harnek, Dan Ioanes, Ulf J. Jensen, Risto Jussila, Goran Olivecrona, Jacob Odenstedt, Goran Matejka, Elmir Omerovic Author Affiliation: (1) Department of Cardiology, Sahlgrenska University Hospital, GOTHENBURG, GOTHENBURG, Sweden (2) Academic Medical Center, Amsterdam, Netherlands (3) Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands (4) Department of Cardiology, Sahlgrenska University Hospital, GOTHENBURG, Sweden (5) Stockholm South General Hospital, Stockholm, Sweden (6) Sahlgrenska University Hospital, Gothenburg, Sweden (7) Skane University Hospital, Malmo, Sweden (8) Karolinska University Hospital, Stockholm, Sweden (9) Skane University Hospital, Lund, Sweden

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2013.08.783

URL: View full text in ScienceDirect

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3

Article

DIFFERENT RISK FACTOR PROFILE IN YOUNG VERSUS OLDER PATIENTS WITH ACUTE CORONARY SYNDROME: A SWEDISH CORONARY ANGIOGRAPHY AND ANGIOPLASTY REGISTRY STUDY

Lindholm, Daniel ; James, Stefan ; Odenstedt, Jacob ; [et al.]

2015

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 17 March 2015, Vol.65(10), pp.A74-A74

Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0735-1097(15)60074-2 Byline: Daniel Lindholm, Stefan James, Jacob Odenstedt, Nina Johnston, Jonas Persson, Dimitrios Venetsanos, Bo Lagerqvist, Christoph Varenhorst Author Affiliation: Dept. of Medical Sciences, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala, Sweden Article Note: (footnote) Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m. Session Title: Insights from Subgroups: Age, Gender and Diabetes Abstract Category: 2. Acute Coronary Syndromes: Clinical Presentation Number: 1138-053

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/S0735-1097(15)60074-2

URL: View full text in ScienceDirect

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4

Article

TCT-3 Pretreatment with P2Y12 receptor antagonists is not associated with improved patency of infarct related-artery in STEMI – A report from SCAAR

Dworeck, Christian ; Haraldsson, Inger ; Angeras, Oscar ; [et al.]

2016

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 01 November 2016, Vol.68(18), pp.B1-B2

Description: The following variables were used to adjust for differences in patient's characteristics: age; gender; hypertension; hyperlipidemia; smoking status; diabetes; calendar year; prior myocardial infarction, coronary by-pass surgery and/or PCI; cardiogenic shock; severity of coronary artery disease; pretreatment with ASA, heparin; type of P2Y12 agent, clopidogrel, ticagrelor, prasugrel.

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2016.09.009

URL: View full text in ScienceDirect

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5

Article

TCT-446 Effect of Intra-Aortic Balloon Counterpulsation on Short-Term Survival in Cardiogenic Shock due to Acute Coronary Syndromes

Råmunddal, Truls ; Angerås, Oskar ; Dworeck, Christian ; [et al.]

2013

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 29 October 2013, Vol.62(18), pp.B137-B137

Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2013.08.1188 Byline: Truls Ramunddal, Oskar Angeras, Christian Dworeck, Inger Haraldsson, Dan Ioanes, Berglind Libungan, Goran Matejka, Jacob Odenstedt, Petur Petursson, Wilhelm Ridderstrale, Elmir Omerovic Author Affiliation: (1) Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Gothenburg, Sweden (2) Sahlgrenska University Hospital, Gothenburg, Sweden (3) Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2013.08.1188

URL: View full text in ScienceDirect

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6

Article

TCT-112 Pretreatment with P2Y12 receptor antagonists is not associated with improved patency of infarct related-artery in NSTEMI – A report from SCAAR

Dworeck, Christian ; Haraldsson, Inger ; Angeras, Oscar ; [et al.]

2016

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 01 November 2016, Vol.68(18), pp.B45-B45

Description: [...]there is no clear evidence from randomized clinical trials that pretreatment with P2Y12 in myocardial infarction reduces ischemic events and improves prognosis.

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2016.09.356

URL: View full text in ScienceDirect

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7

Article

TCT-107 Ticagelor is not superior to clopidogrel in patients with acute coronary syndrome – A report from SCAAR

Redfors, Björn ; Volz, Sebastian ; Angeras, Oscar ; [et al.]

2016

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 01 November 2016, Vol.68(18), pp.B43-B43

Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2016.09.351 Byline: Bjorn Redfors, Sebastian Volz, Oscar Angeras, Inger Haraldsson, Dan Ioanes, Jacob Odenstedt, Petur Petursson, Lotta Robertsson, Jason Stewart, Magnus Wahlin, Per Albertsson, Truls Ramunddal, Elmir Omerovic Author Affiliation: (1) Sahlgrenska University Hospital, Gothenburg, Sweden (2) Sahlgrenska University Hospital, Gothenburg, Sweden (3) Mayo Clinic Arizona (4) University of Verona, Gothenburg, Sweden (5) Kullavik (6) Sahlgrenska University Hospital, Gothenburg, Sweden (7) Sahglrenska University Hospital, Gothenburg, Sweden (8) Boras Hospital, BorAA[yen]s, Sweden (9) Cardiology, SkAAEA[paragraph]vde, Sweden (10) Nu sjukvAA[yen]rden, Trollhattan, Sweden (11) Unknown, GA[paragraph]teborg, Sweden (12) Sahlgrenska university hospital, Goteborg, Sweden (13) Department of Cardiology, Hisings Backa, Sweden

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2016.09.351

URL: View full text in ScienceDirect

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8

Article

TCT-310 Comparative efficacy of drug-eluting stents in chronic total occlusions: A report from the SCAAR

Råmunddal, Truls ; Dworeck, Christian ; Angeras, Oscar ; [et al.]

2016

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 01 November 2016, Vol.68(18), pp.B128-B128

Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2016.09.440 Byline: Truls Ramunddal, Christian Dworeck, Oscar Angeras, Jacob Odenstedt, Dan Ioanes, Goran Olivecrona, Ulf Jensen, Mikael Aasa, Per Albertsson, Elmir Omerovic Author Affiliation: (1) Sahlgrenska university hospital, Goteborg, Sweden (2) Hospital, trollhattan, Sweden (3) Mayo Clinic Arizona (4) Sahlgrenska University Hospital, Gothenburg, Sweden (5) Sahlgrenska Sweden, Viken, Sweden (6) Skane University Hospital, Lund, Sweden (7) Sodersjukhuset, Stockholm, Sweden (8) Sodersjukhuset, Stockholm, Sweden (9) Unknown, Goteborg, Sweden (10) Department of Cardiology, Hisings Backa, Sweden

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2016.09.440

URL: View full text in ScienceDirect

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9

Article

TCT-157 Pretreatment with heparins and glycoprotein IIb/IIIa receptor inhibitors is associated with improved patency of infarct related-artery in STEMI – A report from SCAAR

Angeras, Oscar ; Dworeck, Christian ; Haraldsson, Inger ; [et al.]

2016

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 01 November 2016, Vol.68(18), pp.B64-B65

Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2016.09.299 Byline: Oscar Angeras, Christian Dworeck, Inger Haraldsson, Jacob Odenstedt, Dan Ioanes, Petur Petursson, Sebastian Volz, Per Albertsson, Jonas Persson, Sasha Koul, Bjorn Redfors, David Erlinge, Truls Ramunddal, Elmir Omerovic Author Affiliation: (1) Mayo Clinic Arizona (2) Hospital, trollhattan, Sweden (3) University of Verona, Gothenburg, Sweden (4) Sahlgrenska University Hospital, Gothenburg, Sweden (5) Sahlgrenska Sweden, Viken, Sweden (6) Sahlgrenska University Hospital, Gothenburg, Sweden (7) Sahlgrenska University Hospital, Gothenburg, Sweden (8) University of Gothenburg, Gothenburg, Sweden (9) Hjartmedicin/Medicinkliniken, Stockholm, Sweden (10) Hospital Ramon y Cajal (11) Sahlgrenska University Hospital, Gothenburg, Sweden (12) Skane University Hospital, Lund, Sweden (13) Sahlgrenska university hospital, Goteborg, Sweden (14) Department of Cardiology, Hisings Backa, Sweden

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2016.09.299

URL: View full text in ScienceDirect

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10

Article

TCT-477 Long-term risk of stent thrombosis and restenosis after treatment with drug-eluting stents: A report from SCAAR

Dworeck, Christian ; Angeras, Oscar ; Haraldsson, Inger ; [et al.]

2016

ISSN: 0735-1097

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Language: English

In: Journal of the American College of Cardiology, 01 November 2016, Vol.68(18), pp.B191-B192

Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2016.09.613 Byline: Christian Dworeck, Oscar Angeras, Inger Haraldsson, Dan Ioanes, Jacob Odenstedt, Petur Petursson, Lotta Robertsson, Jason Stewart, Sebastian Volz, Per Albertsson, Truls Ramunddal, Elmir Omerovic Author Affiliation: (1) Hospital, trollhattan, Sweden (2) Mayo Clinic Arizona (3) University of Verona, Gothenburg, Sweden (4) Sahlgrenska Sweden, Viken, Sweden (5) Sahlgrenska University Hospital, Gothenburg, Sweden (6) Sahglrenska University Hospital, Gothenburg, Sweden (7) Boras Hospital, BorAA[yen]s, Sweden (8) Cardiology, Skovde, Sweden (9) Sahlgrenska University Hospital, Gothenburg, Sweden (10) Unknown, Goteborg, Sweden (11) Sahlgrenska university hospital, Goteborg, Sweden (12) Department of Cardiology, Hisings Backa, Sweden

Subject(s): Medicine

ISSN: 0735-1097

E-ISSN: 1558-3597

DOI: 10.1016/j.jacc.2016.09.613

URL: View full text in ScienceDirect

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