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  • 1
    Language: English
    In: Chemie ingenieur technik, 1997-02, Vol.69 (1‐2), p.103-107
    ISSN: 0009-286X
    E-ISSN: 1522-2640
    Source: Wiley Online Library All Backfiles
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  • 2
    Article
    Article
    1978
    ISSN: 0025-584X 
    Language: English
    In: Mathematische Nachrichten, 1978, Vol.84 (1), p.123-144
    ISSN: 0025-584X
    E-ISSN: 1522-2616
    Source: Wiley Online Library All Backfiles
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  • 3
    Article
    Article
    1978
    ISSN: 0025-584X 
    Language: German
    In: Mathematische Nachrichten, 1978, Vol.84 (1), p.123-144
    ISSN: 0025-584X
    E-ISSN: 1522-2616
    Source: Wiley Online Library All Backfiles
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  • 4
    Audio
    Audio
    1976
    Language: English
    Description: Provider: Europeana Sounds - Institution: Österreichische Mediathek - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
    Subject(s): Politik ; Gesellschaft ; Radiosendung-Mitschnitt
    Source: Europeana Collections
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  • 5
    Language: English
    In: Zeitschrift für Tierpsychologie, 1980-01, Vol.52 (1), p.1-18
    Description: In poikilothermal animals, modes of behaviour as well as other physiological functions are dependent on the environmental temperature. Individual adaptation can decrease or cancel out this dependency. In experiments involving abrupt and slow temperature changes, we were able to prove temperature compensations and stress effects in the courting behaviour of the male Poecilia reticulata.
    ISSN: 0044-3573
    E-ISSN: 1439-0310
    Source: Alma/SFX Local Collection
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  • 6
    Language: English
    In: Zeitschrift für Tierpsychologie, 1980-01-12, Vol.52 (1), p.1-18
    ISSN: 0044-3573
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: European heart journal, 2008-05, Vol.29 (9), p.1168-1180
    Description: Aims Despite recent advances in medical therapy, heart failure remains a leading cause for cardiovascular mortality, and its complex pathogenesis is incompletely understood. This study was performed to identify possible new therapeutic targets in dilated cardiomyopathy (DCM). Methods and results Oligonucleotide microarray analysis was performed on endomyocardial biopsies (EMBs) from patients with early DCM (LVEDD ≥ 55 mm, LVEF ≤ 55%, n = 5) and control subjects (LVEDD 〈 55 mm, LVEF 〉 60%, no cardiac pathology, n = 4). Adiponectin, an adipocytokine involved in cellular metabolism, survival, and immunmodulation, was six-fold downregulated in DCM patients. Microarray data for adiponectin were confirmed by TaqMan-PCR (9.2-fold downregulation, control n= 9 vs. DCM n= 9, respectively, P 〈 0.05). Immunohistological analysis of EMBs showed significant downregulation of cardiac adiponectin protein expression independent of serum adiponectin (P = 0.36, ns) or serum TNFα concentrations (P = 0.46, ns). Neither the adiponectin receptor 1 (adipo-R1) nor adipo-R2 was deregulated in early DCM. Adiponectin mRNA and protein downregulation were confirmed in explanted hearts of patients with advanced DCM (LVEF 〈 25%, n= 8). In vitro, adiponectin incubation of neonatal rat ventricular myocytes led to activation of the pro-survival kinase PKB/Akt, increased eNOS-phosphorylation, and prevented stress-induced apoptosis of cardiomyocytes in an Akt-dependent manner. Moreover, inhibition of adiponectin secretion was accompanied by an increase in the expression of the cytokine and its receptors. Conclusion These data indicate the existence of a local cardiac adiponectin system regulated independent of adiponectin and TNFα serum levels and its disturbance in cardiac pathology. The study suggests a role for adiponectin in the pathogenesis of DCM and implicates the adipocytokine as a possible future therapeutic target in DCM.
    Subject(s): Cardiology. Vascular system ; Heart ; Biological and medical sciences ; Myocarditis. Cardiomyopathies ; Medical sciences ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Tumor Necrosis Factor-alpha - metabolism ; Cardiomyopathy, Dilated - pathology ; Oligonucleotide Array Sequence Analysis ; Signal Transduction ; Humans ; Middle Aged ; Cells, Cultured ; Rats ; Receptors, Adiponectin - metabolism ; Male ; Myocardium - pathology ; RNA, Messenger - metabolism ; Cardiomyopathy, Dilated - metabolism ; Down-Regulation - physiology ; Animals ; Myocardium - metabolism ; Adiponectin - metabolism ; Adult ; Female ; Aged ; Heart Failure - etiology ; Index Medicus
    ISSN: 0195-668X
    E-ISSN: 1522-9645
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 8
    Language: English
    In: eLife, 2015-12-09, Vol.4
    Description: Calcium in the flagellum controls sperm navigation. In sperm of marine invertebrates and mammals, Ca2+ signalling has been intensely studied, whereas for fish little is known. In sea urchin sperm, a cyclic nucleotide-gated K+ channel (CNGK) mediates a cGMP-induced hyperpolarization that evokes Ca2+ influx. Here, we identify in sperm of the freshwater fish Danio rerio a novel CNGK family member featuring non-canonical properties. It is located in the sperm head rather than the flagellum and is controlled by intracellular pH, but not cyclic nucleotides. Alkalization hyperpolarizes sperm and produces Ca2+ entry. Ca2+ induces spinning-like swimming, different from swimming of sperm from other species. The “spinning” mode probably guides sperm into the micropyle, a narrow entrance on the surface of fish eggs. A picture is emerging of sperm channel orthologues that employ different activation mechanisms and serve different functions. The channel inventories probably reflect adaptations to species-specific challenges during fertilization. Mammalian sperm cells fertilize egg cells inside the female’s body; while for fish and other marine animals it is common for fertilization to take place outside in the environment. In general, sperm cells become attracted to egg cells by various chemical or physical signals. Sperm detect these cues and generate electrical signals that control their own movements and eventually guide sperm to the egg.In 2009, researchers identified a potassium ion channel, called CNGK, that starts the electrical signal in the sperm cells of sea urchins. This channel is activated by signalling molecules inside cells, called ‘cyclic nucleotides’, and its activity ultimately leads to calcium ions flowing into the sperm cell’s tail. This influx of calcium ions in turn controls the beating of the tail and, thereby, steers the sperm cell towards the egg.It was previously thought that this CNGK channel is found only in animals without a backbone (i.e. in invertebrates). However, Fechner et al. – including some of the researchers involved in the 2009 work – now report that the CNGK channel also exists in the sperm cells of a freshwater fish, the zebrafish. Unexpectedly, the CNGK channel is located in the heads of this fish’s sperm cells rather than in the tails.Electrophysiological experiments then revealed that the fish version of CNGK is not activated by cyclic nucleotides, but is activated when the inside of the cell becomes more alkaline. In zebrafish sperm, a more alkaline pH inside the cell causes calcium ions to flow in and this influx of calcium ions triggers a unique spinning-like swimming movement that is different from the swimming of other sperm from other species. Fechner et al. suspect that this unusual swimming behaviour guides sperm through a small hole in the protective coating of fish eggs, which eventually leads to fertilization.These findings suggest that while channel proteins found in sperm cells from different species look similar and serve similar roles, they are activated in ways that can be very different.
    Subject(s): potassium channel ; Zebrafish ; sperm signalling ; fertilization ; Biophysics and Structural Biology ; Cell Biology
    ISSN: 2050-084X
    E-ISSN: 2050-084X
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Molecules (Basel, Switzerland), 2011-10-11, Vol.16 (10), p.8475-8503
    Description: Subtype B coxsackieviruses (CVB) represent the most commonly identified infectious agents associated with acute and chronic myocarditis, with CVB3 being the most common variant. Damage to the heart is induced both directly by virally mediated cell destruction and indirectly due to the immune and autoimmune processes reacting to virus infection. This review addresses antiviral therapeutics for cardiac coxsackievirus infections discovered over the last 25 years. One group represents pharmacologically active low molecular weight substances that inhibit virus uptake by binding to the virus capsid (e.g., pleconaril) or inactivate viral proteins (e.g., NO-metoprolol and ribavirin) or inhibit cellular proteins which are essential for viral replication (e.g., ubiquitination inhibitors). A second important group of substances are interferons. They have antiviral but also immunomodulating activities. The third and most recently discovered group includes biological and cellular therapeutics. Soluble receptor analogues (e.g., sCAR-Fc) bind to the virus capsid and block virus uptake. Small interfering RNAs, short hairpin RNAs and antisense oligonucleotides bind to and led to degradation of the viral RNA genome or cellular RNAs, thereby preventing their translation and viral replication. Most recently mesenchymal stem cell transplantation has been shown to possess antiviral activity in CVB3 infections. Taken together, a number of antiviral therapeutics has been developed for the treatment of myocardial CVB infection in recent years. In addition to low molecular weight inhibitors, biological therapeutics have become promising anti-viral agents.
    Subject(s): Antiviral Agents - pharmacology ; Oligonucleotides, Antisense - pharmacology ; Enterovirus - drug effects ; Antiviral Agents - therapeutic use ; Interferons - pharmacology ; Humans ; Myocarditis - drug therapy ; RNA, Small Interfering - pharmacology ; Interferons - therapeutic use ; Coxsackievirus Infections - drug therapy ; Coxsackievirus Infections - therapy ; Myocarditis - virology ; Animals ; Ubiquitination - drug effects ; RNA, Small Interfering - therapeutic use ; Oligonucleotides, Antisense - therapeutic use ; Enterovirus - immunology ; Mice ; Myocarditis - immunology ; Coxsackievirus Infections - immunology ; Mesenchymal Stem Cell Transplantation ; Index Medicus ; coxsackievirus ; antiviral drugs ; RNA interference ; Review ; myocarditis ; soluble receptors
    ISSN: 1420-3049
    E-ISSN: 1420-3049
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Directory of Open Access Journals
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  • 10
    Language: English
    In: Molecular pain, 2018-01, Vol.14, p.1744806917749669-1744806917749669
    Description: Activation of the neuronal potassium channel Kv7.2 encoded by the KCNQ2 gene has recently been shown to be an attractive mechanism to inhibit nociceptive transmission. However, potent, selective, and clinically proven activators of Kv7.2/Kv7.3 currents with analgesic properties are still lacking. An important prerequisite for the development of new drugs is a model to test the selectivity of novel agonists by abrogating Kv7.2/Kv7.3 function. Since constitutive knockout mice are not viable, we developed a model based on RNA interference-mediated silencing of KCNQ2. By delivery of a KCNQ2-specific short hairpin RNA with adeno-associated virus vectors, we completely abolished the activity of the specific Kv7.2/Kv7.3-opener ICA-27243 in rat sensory neurons. Results obtained in the silencing experiments were consistent between freshly prepared and cryopreserved dorsal root ganglion neurons, as well as in dorsal root ganglion neurons dissociated and cultured after in vivo administration of the silencing vector by intrathecal injections into rats. Interestingly, the tested associated virus serotypes substantially differed with respect to their transduction capability in cultured neuronal cell lines and primary dorsal root ganglion neurons and the in vivo transfer of transgenes by intrathecal injection of associated virus vectors. However, our study provides the proof-of-concept that RNA interference-mediated silencing of KCNQ2 is a suitable approach to create an ex vivo model for testing the specificity of novel Kv7.2/Kv7.3 agonists.
    Subject(s): Gene Transfer Techniques ; Dependovirus - metabolism ; Humans ; Cells, Cultured ; Fluorescence ; Genetic Vectors - metabolism ; Male ; Rats, Sprague-Dawley ; Gene Knockdown Techniques ; Animals ; KCNQ2 Potassium Channel - metabolism ; RNA Interference ; Time Factors ; HEK293 Cells ; Benzamides - pharmacology ; Neurons - metabolism ; Pyridines - pharmacology ; Ganglia, Spinal - drug effects ; Neurons - drug effects ; Action Potentials - drug effects ; Serotyping ; Ganglia, Spinal - metabolism ; RNA, Small Interfering - metabolism ; Index Medicus ; adeno-associated virus ; Methodology ; electrophysiology ; Dorsal root ganglion ; Kv7.2 ; KCNQ2
    ISSN: 1744-8069
    E-ISSN: 1744-8069
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: EBSCOhost EJS
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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