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  • 1
    Language: English
    In: Biogeosciences, 2016, Vol.13 (17), p.4959-4973
    Description: Phytoplankton spring bloom phenology was derived from a 15-year time series (2000-2014) of ship-of-opportunity chlorophyll a fluorescence observations collected in the Baltic Sea through the Alg@line network. Decadal trends were analysed against inter-annual variability in bloom timing and intensity, and environmental drivers (nutrient concentration, temperature, radiation level, wind speed). Spring blooms developed from the south to the north, with the first blooms peaking mid-March in the Bay of Mecklenburg and the latest bloom peaks occurring mid-April in the Gulf of Finland. Bloom duration was similar between sea areas (43 ± 2 day), except for shorter bloom duration in the Bay of Mecklenburg (36 ± 11 day). Variability in bloom timing increased towards the south. Bloom peak chlorophyll a concentrations were highest (and most variable) in the Gulf of Finland (20.2 ± 5.7 mg m
    Subject(s): Chlorophyll
    ISSN: 1726-4170
    ISSN: 1726-4189
    E-ISSN: 1726-4189
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: Political studies, 2016-04, Vol.64 (1_suppl), p.70-87
    Description: Most scholars engaged in ideational analysis agree that the availability of new ideas may cause existing welfare state policies and institutions to alter. This article considers the extent to which the open functional approach and constructivist approaches are able to explain the role of ideas in policy and institutional change. Notwithstanding their contribution to the study of the role of ideas in policy and institutional change, these approaches suffer from some shortcomings as they fail to view ideas as non-stable entities. In order to address these shortcomings, an alternative poststructuralist discourse theoretical explanatory model is presented. Applying this model to the case of the rise and fall of Dutch life course policy, the article shows how a discourse theoretical view of ideas as floating signifiers contributes to the study of the role of ideas in welfare state change.
    ISSN: 0032-3217
    E-ISSN: 1467-9248
    Source: SAGE Complete A-Z List
    Source: Academic Search Ultimate
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  • 3
    Language: English
    In: Clinical pharmacokinetics, 2019-01-01, Vol.58 (6), p.767-780
    Description: Abstract Background and Objectives Uncertainty exists regarding the optimal dosing regimen for vancomycin in diferent patient populations, leading to a plethora of subgroup-specifc pharmacokinetic models and derived dosing regimens. We aimed to investigate whether a single model for vancomycin could be developed based on a broad dataset covering the extremes of patient characteristics. Furthermore, as a benchmark for current dosing recommendations, we evaluated and optimised the expected vancomycin exposure throughout life and for specifc patient subgroups. Methods A pooled population-pharmacokinetic model was built in NONMEM based on data from 14 diferent studies in diferent patient populations. Steady-state exposure was simulated and compared across patient subgro
    Subject(s): Pharmacotherapy ; Internal Medicine ; Medicine & Public Health ; Pharmacology/Toxicology ; Studies ; Staphylococcus infections ; Antibiotics ; Patients ; Drug dosages ; Age ; Life Sciences ; Santé publique et épidémiologie
    ISSN: 0312-5963
    E-ISSN: 1179-1926
    Source: Alma/SFX Local Collection
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  • 4
    Language: English
    In: British journal of anaesthesia : BJA, 2018-05, Vol.120 (5), p.942-959
    Description: Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a desired target concentration in a central or effect-site compartment. Our aim was to develop a PK–PD model for propofol that can predict the bispectral index (BIS) for a broad population, suitable for TCI applications. Propofol PK data were obtained from 30 previously published studies, five of which also contained BIS observations. A PK–PD model was developed using NONMEM. Weight, age, post-menstrual age (PMA), height, sex, BMI, and presence/absence of concomitant anaesthetic drugs were explored as covariates. The predictive performance was measured across young children, children, adults, elderly, and high-BMI individuals, and in simulated TCI applications. Overall, 15 433 propofol concentration and 28 639 BIS observations from 1033 individuals (672 males and 361 females) were analysed. The age range was from 27 weeks PMA to 88 yr, and the weight range was 0.68–160 kg. The final model uses age, PMA, weight, height, sex, and presence/absence of concomitant anaesthetic drugs as covariates. A 35-yr-old, 170 cm, 70 kg male (without concomitant anaesthetic drugs) has a V1, V2, V3, CL, Q2, Q3, and ke0 of 6.28, 25.5, 273 litres, 1.79, 1.75, 1.11 litres min−1, and 0.146 min−1, respectively. The propofol TCI administration using the model matches well with recommendations for all age groups considered for both anaesthesia and sedation. We developed a PK–PD model to predict the propofol concentrations and BIS for broad, diverse population. This should be useful for TCI in anaesthesia and sedation.
    Subject(s): pharmacokinetics ; propofol ; pharmacology ; MAINTENANCE ; PERFORMANCE ; SIZE ; VS. SEQUENTIAL-ANALYSIS ; REMIFENTANIL ; LARYNGOSCOPY ; TARGET-CONTROLLED INFUSION ; PAEDFUSOR ; BISPECTRAL INDEX ; CHILDREN ; Anesthesia - methods ; Humans ; Middle Aged ; Child, Preschool ; Propofol - pharmacology ; Infant ; Male ; Young Adult ; Anesthetics, Intravenous - pharmacology ; Anesthetics, Intravenous - administration & dosage ; Models, Biological ; Adolescent ; Aged, 80 and over ; Anesthetics, Intravenous - pharmacokinetics ; Adult ; Female ; Propofol - pharmacokinetics ; Aged ; Infusions, Intravenous ; Propofol - administration & dosage ; Child ; Index Medicus
    ISSN: 0007-0912
    E-ISSN: 1471-6771
    Source: Alma/SFX Local Collection
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  • 5
    Language: English
    In: Scientific reports, 2021-01-13, Vol.11 (1), p.1214-1214
    Description: Chimpanzees are genetically and physiologically similar to humans. Several pharmacokinetic models of propofol are available and target controlled infusion (TCI) of propofol is established in humans, but not in chimpanzees. The purpose of this study was to investigate if human pharmacokinetic models can accurately predict propofol plasma concentration (Cp) in chimpanzees and if it is feasible to perform TCI in chimpanzees. Ten chimpanzees were anaesthetized for regular veterinary examinations. Propofol was used as an induction or maintenance agent. Blood samples were collected from a catheter in a cephalic vein at 3-7 time points between 1 and 100 min following the propofol bolus and/or infusion in five chimpanzees, or TCI in six chimpanzees. Cp was measured using high-performance liquid chromatography. The Marsh, Schnider and Eleveld human pharmacokinetic models were used to predict Cp for each case and we examined the predictive performances of these models using the Varvel criteria Median PE and Median APE. Median PE and Median APE for Marsh, Schnider and Eleveld models were within or close to the acceptable range. A human TCI pump was successfully maintained propofol Cp during general anesthesia in six chimpanzees. Human propofol pharmacokinetic models and TCI pumps can be applied in chimpanzees.
    Subject(s): Anesthesia ; Models ; Propofol ; Pharmacokinetics ; High-performance liquid chromatography ; Monkeys & apes ; Catheters ; Index Medicus
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 6
    Language: English
    In: Public administration (London), 2016-12, Vol.94 (4), p.1159-1161
    ISSN: 0033-3298
    E-ISSN: 1467-9299
    Source: Business Source Ultimate
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: Acta anaesthesiologica Scandinavica, 2019-04, Vol.63 (4), p.422-423
    Subject(s): PROPOFOL ; Anesthetics - pharmacokinetics ; Anesthesia, Intravenous - instrumentation ; Humans ; Infusions, Intravenous - instrumentation ; Anesthetics, Intravenous ; Infusions, Intravenous - methods ; Anesthesia, Intravenous - methods ; Anesthetics - administration & dosage ; Index Medicus
    ISSN: 0001-5172
    E-ISSN: 1399-6576
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
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  • 8
    Language: English
    Description: With welfare to work programmes under intense scrutiny, this book ranges widely across Europe to review existing policies and explore future ones. It shows how many schemes do not adequately address social rights and lived experiences, and consider alternatives based on theories of non-domination.
    Subject(s): Public welfare-Europe
    ISBN: 1447340019
    ISBN: 9781447340010
    Source: Cambridge Core All Books
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  • 9
    Language: English
    In: Public administration (London), 2016, Vol.94 (4), p.1159-1161
    ISSN: 0033-3298
    E-ISSN: 1467-9299
    Source: Business Source Ultimate
    Source: Alma/SFX Local Collection
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  • 10
    Language: English
    In: Water resources research, 2012-04, Vol.48 (4), p.n/a
    Description: A lack of empirical evidence impedes assessment of the spatial and temporal extent of critical conditions for recurring high turbidity in large wind-exposed shallow lakes. Here spatiotemporal variation in total suspended matter (TSM) concentration was captured by processing 30 Envisat Medium Resolution Imaging Spectrometer (MERIS) images of a shallow lake (Markermeer) with a spectral matching algorithm. The TSM maps showed elevated downwind concentrations for moderate winds (from 4 to 9 m s
    Subject(s): seston ; wave equations ; turbidity ; spatial modeling ; total suspended solids ; Markermeer
    ISSN: 0043-1397
    E-ISSN: 1944-7973
    Source: Wiley Online Library All Backfiles
    Source: Alma/SFX Local Collection
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