placeholder
and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Proceed order?

Export
Filter
Language
Year
  • 1
    In: Water Resources Research, 2012, Vol.48(4), pp.n/a
    ISSN: 00431397
    Source: VU University Amsterdam
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: Krisis, 2011, pp.31-45
    ISSN: 0168275X
    Source: VU University Amsterdam
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: PLoS ONE, 2013, Vol.8(8)
    Description: Moraxella catarrhalis is a mucosal pathogen that causes childhood otitis media and exacerbations of chronic obstructive pulmonary disease in adults. During the course of infection, M. catarrhalis needs to adhere to epithelial cells of different host niches such as the nasopharynx and lungs, and consequently, efficient adhesion to epithelial cells is considered an important virulence trait of M. catarrhalis . By using Tn-seq, a genome-wide negative selection screenings technology, we identified 15 genes potentially required for adherence of M. catarrhalis BBH18 to pharyngeal epithelial Detroit 562 and lung epithelial A549 cells. Validation with directed deletion mutants confirmed the importance of aroA (3-phosphoshikimate 1-carboxyvinyl-transferase), ecnAB (entericidin EcnAB), lgt1 (glucosyltransferase), and MCR_1483 (outer membrane lipoprotein) for cellular adherence, with ΔMCR_1483 being most severely attenuated in adherence to both cell lines. Expression profiling of M. catarrhalis BBH18 during adherence to Detroit 562 cells showed increased expression of 34 genes in cell-attached versus planktonic bacteria, among which ABC transporters for molybdate and sulfate, while reduced expression of 16 genes was observed. Notably, neither the newly identified genes affecting adhesion nor known adhesion genes were differentially expressed during adhesion, but appeared to be constitutively expressed at a high level. Profiling of the transcriptional response of Detroit 562 cells upon adherence of M. catarrhalis BBH18 showed induction of a panel of pro-inflammatory genes as well as genes involved in the prevention of damage of the epithelial barrier. In conclusion, this study provides new insight into the molecular interplay between M. catarrhalis and host epithelial cells during the process of adherence.
    Subject(s): Research Article
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    In: Water Resources Research, April 2012, Vol.48(4), pp.n/a-n/a
    Description: A lack of empirical evidence impedes assessment of the spatial and temporal extent of critical conditions for recurring high turbidity in large wind‐exposed shallow lakes. Here spatiotemporal variation in total suspended matter (TSM) concentration was captured by processing 30 Envisat Medium Resolution Imaging Spectrometer (MERIS) images of a shallow lake (Markermeer) with a spectral matching algorithm. The TSM maps showed elevated downwind concentrations for moderate winds (from 4 to 9 m s), which occur 68% of the time. Regressions confirmed the relationship between hourly averaged wind speed and TSM. To explore critical conditions for resuspension, wind speed, linear fetch, and water depth were combined in a spatial model based on simplified linear wave equations. Remotely sensed TSM patterns matched predicted areas of resuspension from these wave equations. On average, over 70% of cells were true positive or negative, with elevated TSM matching the predicted resuspending bottom area and background TSM matching no resuspension. Images acquired during moderate winds register local resuspension. This implies that under these conditions, a critical shear stress threshold for resuspension is passed, followed by upward mixing over the few meters of water column. Images acquired during low wind speeds (≤3 m s) either do not show a TSM pattern or display settling because it takes several hours of low wind before all particles are removed from the visible top layer. Because of the good spatial matching, the resuspension model can also be used for future verification of the retrieval capacity of the spectral matching algorithm. Images acquired during moderate wind speeds (4 to 9 m/s) register resuspension Retrieved surface TSM maps from remote sensing match predicted resuspension maps Spatial patterns in turbidity can be well explained from water depth and wind
    Subject(s): Markermeer ; Seston ; Spatial Modeling ; Total Suspended Solids ; Turbidity ; Wave Equations
    ISSN: 0043-1397
    E-ISSN: 1944-7973
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: British Journal of Anaesthesia, May 2018, Vol.120(5), pp.942-959
    Description: Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a desired target concentration in a central or effect-site compartment. Our aim was to develop a PK–PD model for propofol that can predict the bispectral index (BIS) for a broad population, suitable for TCI applications. Propofol PK data were obtained from 30 previously published studies, five of which also contained BIS observations. A PK–PD model was developed using NONM. Weight, age, post-menstrual age (PMA), height, sex, BMI, and presence/absence of concomitant anaesthetic drugs were explored as covariates. The predictive performance was measured across young children, children, adults, elderly, and high-BMI individuals, and in simulated TCI applications. Overall, 15 433 propofol concentration and 28 639 BIS observations from 1033 individuals (672 males and 361 females) were...
    Subject(s): Propofol ; Pharmacokinetics ; Pharmacology ; Propofol ; Pharmacokinetics ; Pharmacology
    ISSN: 0007-0912
    E-ISSN: 1471-6771
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: Anesthesia & Analgesia, 2014, Vol.118(6), pp.1221-1237
    Description: BACKGROUND:: Pharmacokinetic (PK) models are used to predict drug concentrations for infusion regimens for intraoperative displays and to calculate infusion rates in target-controlled infusion systems. For propofol, the PK models available in the literature were mostly developed from particular patient groups or anesthetic techniques, and there is uncertainty of the accuracy of the models under differing patient and clinical conditions. Our goal was to determine a PK model with robust predictive performance for a wide range of patient groups and clinical conditions. METHODS:: We aggregated and analyzed 21 previously published propofol datasets containing data from young children, children, adults, elderly, and obese individuals. A 3-compartmental allometric model was estimated with NONMEM software using weight, age, sex, and patient status as covariates. A predictive performance metric focused on intraoperative conditions was devised and used along with the Akaike information criteria to guide model development. RESULTS:: The dataset contains 10,927 drug concentration observations from 660 individuals (age range 0.25–88 years; weight range 5.2–160 kg). The final model uses weight, age, sex, and patient versus healthy volunteer as covariates. Parameter estimates for a 35-year, 70-kg male patient were: 9.77, 29.0, 134 L, 1.53, 1.42, and 0.608 L/min for V1, V2, V3, CL, Q2, and Q3, respectively. Predictive performance is better than or similar to that of specialized models, even for the subpopulations on which those models were derived. CONCLUSIONS:: We have developed a single propofol PK model that performed well for a wide range of patient groups and clinical conditions. Further prospective evaluation of the model is needed.
    Subject(s): Anesthetics, Intravenous -- Pharmacokinetics ; Propofol -- Pharmacokinetics;
    ISSN: 0003-2999
    E-ISSN: 15267598
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: European Journal of Social Security, September 2014, Vol.16(3), pp.204-224
    Description: Since the rise of the activation paradigm in the 1990s, the duty to work without a wage has become widespread in European social assistance legislation. This paper investigates in a precise way the extent to which the duty to work without a wage follows the legal logic of a contractual relationship and how this duty is related to the fundamental right to an adequate standard of living. A comparison between German, Dutch and British social assistance legislation shows that the duty to work without a wage increasingly takes the form of a reciprocity requirement. That is, instead of re-integrating into regular paid work, recipients of social assistance are required to show that they are worthy of attaining basic social rights, not only by improving their capability to work but, above all, by showing a willingness to work. It concludes that the duty to work without a wage enhances governmental control over recipients of social assistance rather than improving their employability...
    Subject(s): Activation Policies ; Legal Comparison ; Social Assistance ; Social Rights ; Workfare ; Political Science ; Economics
    ISSN: 1388-2627
    E-ISSN: 2399-2948
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Article
    Article
    2015
    ISSN: 0957-8536 
    Language: English
    In: Law and Critique, 2015, Vol.26(1), pp.83-100
    Description: This paper investigates how a performative understanding of a woman’s right to care can become part of a feminist politics which is able to transcend the well-worn dichotomies we find both within and without feminist literature, such as difference versus equality, difference versus repronormativity, and rights as freedom versus rights as domination. Drawing on my own research, I argue that claiming the right to care does not simply push women more deeply into motherhood resulting in even more control and regulation of their lives, but that claiming care rights enables women to speak for themselves. Following the work of Linda Zerilli this paper argues that claiming women’s rights should, above all, be viewed as performative activities which contribute to democratic practices.
    Subject(s): Biopolitics ; Care ; Foucault ; Performative rights ; Zerilli
    ISSN: 0957-8536
    E-ISSN: 1572-8617
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Political Studies, April 2016, Vol.64(1_suppl), pp.70-87
    Description: Most scholars engaged in ideational analysis agree that the availability of new ideas may cause existing welfare state policies and institutions to alter. This article considers the extent to which the open functional approach and constructivist approaches are able to explain the role of ideas in policy and institutional change. Notwithstanding their contribution to the study of the role of ideas in policy and institutional change, these approaches suffer from some shortcomings as they fail to view ideas as non-stable entities. In order to address these shortcomings, an alternative poststructuralist discourse theoretical explanatory model is presented. Applying this model to the case of the rise and fall of Dutch life course policy, the article shows how a discourse theoretical view of ideas as floating signifiers contributes to the study of the role of ideas in welfare state change.
    Subject(s): Poststructuralist Discourse Theory ; Ideational Analysis ; Welfare State ; Constructivism ; David Howarth ; Government ; Political Science
    ISSN: 0032-3217
    E-ISSN: 1467-9248
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Anesthesia and Analgesia, 9 April 2014
    ISSN: 00032999
    E-ISSN: 15267598
    Source: ScienceDirect (Elsevier B.V.)〈img src="http://exlibris-pub.s3.amazonaws.com/Scopus.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...