Toxicology, 1998, Vol.131(2), pp.73-91
Time course of enzyme induction was measured in Fischer344 rats treated daily at 150 and 600 mg 1,4-dichlorobenzene (1,4-DCB)/kg p.o. up to 28 days. The monoxygenases 7-ethoxycoumarin O-deethylase (ECOD), 7-ethoxyresorufin O-deethylase (EROD) and aldrin epoxidase (ALD) as well as the phase II enzymes; epoxide hydrolase (EH), glutathione S-transferase (GS-T) and glucuronyl transferase (GLU-T) were dose-dependently induced in the liver of males and females. A pronounced induction in the kidneys was measured at 600 mg/kg only for ECOD. After single oral administration of 100 and 1000 mg/kg bw and feeding of 100 and 1000 ppm (corresponding to ≈10 and 100 mg/kg bw) to male Wistar rats for 28 days, the time course of 1,4-DCB and 2,5-DCP concentrations was investigated in plasma, adipose, hepatic and renal tissue. In addition, total urinary excretion of 2,5-DCP was determined. After single application, 1,4-DCB and 2,5-DCP were rapidly eliminated from the plasma and tissues, 40–60%...
1,4-Dichlorobenzene ; Enzyme Induction ; Liver ; Kidneys ; Absorption ; Distribution ; 2,5-Dichlorophenol ; 1,4-Dichlorobenzene ; Enzyme Induction ; Liver ; Kidneys ; Absorption ; Distribution ; 2,5-Dichlorophenol ; ALD, Aldrin Epoxidase ; Cet, Central European Time ; Cyp, Cytochrome P 450 ; 1,4-Dcb, 1,4-Dichlorobenzene ; 2,5-Dcp, 2,5-Dichlorophenol ; Ecod, 7-Ethoxycoumarin O-Deethylase
Permalink to record
View record in ScienceDirect (Access to full text may be restricted)