placeholder
and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Proceed order?

Export
Filter
Document type
Language
Year
  • 1
    Language: English
    In: Journal of demographic economics, 2021-03, Vol.87 (1), p.1-31
    Description: Pensions may be provided for in a modern society by a mix of several methods, namely by voluntary individual savings, mandatory fully-funded occupational pension systems, mandatory social security financed by pay-as-you-go, and old-fashioned hoarding in cash. We call a specific mixture of the four systems a pension composition. We assume that individual workers decide on their own individual savings, that the fully-funded occupational system is decided upon by the age cohort of the median worker (MW), and that social security is decided upon by the median voter (MV). We assume that individual and collective pension savings are the only sources of capital supply. When capital supply equals demand from industry there is equilibrium in the capital market with a corresponding equilibrium interest rate and pension composition. In this paper we assume a demography with one hundred age brackets and we investigate how changes in the birth rates, survival rates, and the retirement age affect the pension composition and the capital market equilibrium. Our conclusion is that for a given technology the pension composition and the interest rate are determined by the demography and cannot be modified at will as a long-term political instrument.
    ISSN: 2054-0892
    E-ISSN: 2054-0906
    Source: Cambridge Journals
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Gerontology and geriatric medicine, 2015-07-31, Vol.1, p.2333721415607833-2333721415607833
    Description: Objective: To explore the value of day services at green care farms (GCFs) in terms of social participation for people with dementia. Method: Semi-structured interviews were conducted with people with dementia who attended day services at a GCF (GCF group, n = 21), were on a waiting list (WL) for day services at a GCF (WL group, n = 12), or attended day services in a regular day care facility (RDCF group, n = 17) and with their family caregivers. Results: People with dementia in the GCF and WL group were primarily males, with an average age of 71 and 76 years, respectively, who almost all had a spousal caregiver. People with dementia in the RDCF group were mostly females with an average age of 85 years, most of whom had a non-spousal caregiver. For both the GCF and RDCF groups, it was indicated that day services made people with dementia feel part of society. The most important domains of social participation addressed by RDCFs were social interactions and recreational activities. GCFs additionally addressed the domains “paid employment” and “volunteer work.” Conclusion: GCFs are valuable in terms of social participation for a particular group of people with dementia. Matching characteristics of adult day services (ADS) centers to the preferences and capacities of people with dementia is of importance. Diversity in ADS centers is therefore desirable.
    Subject(s): Health and Society ; Animal Production Systems ; WASS ; Leerstoelgroep Dierlijke productiesystemen ; Gezondheid en Maatschappij ; Dierlijke Productiesystemen
    ISSN: 2333-7214
    E-ISSN: 2333-7214
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Gerontology and geriatric medicine, 2015-10-01, Vol.1
    Description: Objective: To explore the value of day services at green care farms (GCFs) in terms of social participation for people with dementia. Method: Semi-structured interviews were conducted with people with dementia who attended day services at a GCF (GCF group, n = 21), were on a waiting list (WL) for day services at a GCF (WL group, n = 12), or attended day services in a regular day care facility (RDCF group, n = 17) and with their family caregivers. Results: People with dementia in the GCF and WL group were primarily males, with an average age of 71 and 76 years, respectively, who almost all had a spousal caregiver. People with dementia in the RDCF group were mostly females with an average age of 85 years, most of whom had a non-spousal caregiver. For both the GCF and RDCF groups, it was indicated that day services made people with dementia feel part of society. The most important domains of social participation addressed by RDCFs were social interactions and recreational activities. GCFs additionally addressed the domains “paid employment” and “volunteer work.” Conclusion: GCFs are valuable in terms of social participation for a particular group of people with dementia. Matching characteristics of adult day services (ADS) centers to the preferences and capacities of people with dementia is of importance. Diversity in ADS centers is therefore desirable.
    E-ISSN: 2333-7214
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Computer Science in Economics and Management, 1992-08, Vol.5 (3), p.183-220
    ISSN: 0921-2736
    E-ISSN: 1572-9974
    Source: Springer Online Journal Archives (DFG Nationallizenzen)
    Source: Springer Online Journal Archives (Through 1996)
    Source: Springer Online Journal Archives Complete
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Journal of the Royal Statistical Society. Series D (The Statistician), 1987-01-01, Vol.36 (2/3), p.83-90
    Description: In earlier work (van Dijk, 1984, Chapter 3) one of the authors discussed the use of Monte Carlo integration methods for the computation of the multivariate integrals that are defined in the posterior moments and densities of the parameters of interest of econometric models. In the present paper we describe the computational steps of one Monte Carlo method, which is known in the literature as importance sampling. Further, a set of standard programs is available, which may be used for the implementation of a simple case of importance sampling. The computer programs have been written in FORTRAN 77.
    Subject(s): Economic models ; Random numbers ; Approximation ; Economic modeling ; Computer software ; Mathematical independent variables ; Econometrics ; Parametric models ; Estimators ; Fortran ; computational methods ; FORTRAN ; computer language ; Monte Carlo models ; sampling ; Mathematics ; Probability and statistics ; Sampling theory, sample surveys ; Statistics ; Exact sciences and technology ; Sciences and techniques of general use
    ISSN: 0039-0526
    E-ISSN: 1467-9884
    Source: JSTOR Arts & Sciences I
    Source: Wiley Online Library All Backfiles
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: The lancet oncology, 2013, Vol.14 (3), p.210-218
    Description: Summary Background Laparoscopic surgery as an alternative to open surgery in patients with rectal cancer has not yet been shown to be oncologically safe. The aim in the COlorectal cancer Laparoscopic or Open Resection (COLOR II) trial was to compare laparoscopic and open surgery in patients with rectal cancer. Methods A non-inferiority phase 3 trial was undertaken at 30 centres and hospitals in eight countries. Patients (aged ≥18 years) with rectal cancer within 15 cm from the anal verge without evidence of distant metastases were randomly assigned to either laparoscopic or open surgery in a 2:1 ratio, stratified by centre, location of tumour, and preoperative radiotherapy. The study was not masked. Secondary (short-term) outcomes—including operative findings, complications, mortality, and results at pathological examination—are reported here. Analysis was by modified intention to treat, excluding those patients with post-randomisation exclusion criteria and for whom data were not available. This study is registered with ClinicalTrials.gov , number NCT00297791. Findings The study was undertaken between Jan 20, 2004, and May 4, 2010. 1103 patients were randomly assigned to the laparoscopic (n=739) and open surgery groups (n=364), and 1044 were eligible for analyses (699 and 345, respectively). Patients in the laparoscopic surgery group lost less blood than did those in the open surgery group (median 200 mL [IQR 100–400] vs 400 mL [200–700], p〈0·0001); however, laparoscopic procedures took longer (240 min [184–300] vs 188 min [150–240]; p〈0·0001). In the laparoscopic surgery group, bowel function returned sooner (2·0 days [1·0–3·0] vs 3·0 days [2·0–4·0]; p〈0·0001) and hospital stay was shorter (8·0 days [6·0–13·0] vs 9·0 days [7·0–14·0]; p=0·036). Macroscopically, completeness of the resection was not different between groups (589 [88%] of 666 vs 303 [92%] of 331; p=0·250). Positive circumferential resection margin (〈2 mm) was noted in 56 (10%) of 588 patients in the laparoscopic surgery group and 30 (10%) of 300 in the open surgery group (p=0·850). Median tumour distance to distal resection margin did not differ significantly between the groups (3·0 cm [IQR 2·0–4·8] vs 3·0 cm [1·8–5·0], respectively; p=0·676). In the laparoscopic and open surgery groups, morbidity (278 [40%] of 697 vs 128 [37%] of 345, respectively; p=0·424) and mortality (eight [1%] of 699 vs six [2%] of 345, respectively; p=0·409) within 28 days after surgery were similar. Interpretation In selected patients with rectal cancer treated by skilled surgeons, laparoscopic surgery resulted in similar safety, resection margins, and completeness of resection to that of open surgery, and recovery was improved after laparoscopic surgery. Results for the primary endpoint—locoregional recurrence—are expected by the end of 2013. Funding Ethicon Endo-Surgery Europe, Swedish Cancer Foundation, West Gothia Region, Sahlgrenska University Hospital.
    Subject(s): Hematology, Oncology and Palliative Medicine ; Lymph Nodes - surgery ; Rectal Neoplasms - surgery ; Europe ; Humans ; Middle Aged ; Male ; Treatment Outcome ; Neoplasm Recurrence, Local - surgery ; Rectal Neoplasms - radiotherapy ; Laparoscopy - methods ; Aged, 80 and over ; Adult ; Female ; Aged ; Rectal Neoplasms - pathology ; Neoplasm Staging ; Laparoscopic surgery ; Laparoscopy ; Colorectal cancer
    ISSN: 1470-2045
    E-ISSN: 1474-5488
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: The Lancet (British edition), 2007, Vol.370 (9605), p.2112-2117
    Description: Summary Background Mechanical bowel preparation is a common practice before elective colorectal surgery. We aimed to compare the rate of anastomotic leakage after elective colorectal resections and primary anastomoses between patients who did or did not have mechanical bowel preparation. Methods We did a multicentre randomised non-inferiority study at 13 hospitals. We randomly assigned 1431 patients who were going to have elective colorectal surgery to either receive mechanical bowel preparation or not. Patients who did not have mechanical bowel preparation had a normal meal on the day before the operation. Those who did were given a fluid diet, and mechanical bowel preparation with either polyethylene glycol or sodium phosphate. The primary endpoint was anastomotic leakage, and the study was designed to test the hypothesis that patients who are given mechanical bowel preparation before colorectal surgery do not have a lower risk of anastomotic leakage than those who are not. The median follow-up was 24 days (IQR 17–34). We analysed patients who were treated as per protocol. This study is registered with ClinicalTrials.gov , number NCT00288496. Findings 77 patients were excluded: 46 who did not have a bowel resection; 21 because of missing outcome data; and 10 who withdrew, cancelled, or were excluded for other reasons. The rate of anastomotic leakage did not differ between both groups: 32/670 (4·8%) patients who had mechanical bowel preparation and 37/684 (5·4%) in those who did not (difference 0·6%, 95% CI −1·7% to 2·9%, p=0·69). Patients who had mechanical bowel preparation had fewer abscesses after anastomotic leakage than those who did not (2/670 [0·3%] vs 17/684 [2·5%], p=0·001). Other septic complications, fascia dehiscence, and mortality did not differ between groups. Interpretation We advise that mechanical bowel preparation before elective colorectal surgery can safely be abandoned.
    Subject(s): Internal Medicine ; Length of Stay ; Humans ; Anastomosis, Surgical - classification ; Anastomosis, Surgical - adverse effects ; Female ; Male ; Aged ; Colorectal Surgery - methods ; Postoperative Complications ; Elective Surgical Procedures ; Preoperative Care - methods ; Surgical anastomosis ; Medical tests ; Colon (Anatomy) ; Health aspects ; Surgery ; Anastomosis ; Abridged Index Medicus
    ISSN: 0140-6736
    E-ISSN: 1474-547X
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: American journal of respiratory and critical care medicine, 2012-05-15, Vol.185 (10), p.1096-1103
    Description: Rationale: Up to one-third of patients with cystic fibrosis (CF) awaiting lung transplantation (LTX) die while waiting. Inclusion of computed tomography (CT) scores may improve survival prediction models such as the lung allocation score (LAS). Objectives: This study investigated the association between CT and survival in patients with CF screened for LTX. Methods: Clinical data and chest CTs of 411 patients with CF screened for LTX between 1990 and 2005 were collected from 17 centers. CTs were scored with the Severe Advanced Lung Disease (SALD) four-category scoring system, including the components infection/inflammation (INF), air trapping/hypoperfusion (AT), normal/hyperperfusion (NOR), and bulla/cysts (BUL). The volume of each componentwas computed using semiautomated software. Survival analysis included Kaplan-Meier curves and Cox regression models. Measurements and Main Results: Three hundred and sixty-six (186 males) of 411 patients entered the waiting list (median age, 23 yr; range, 5-58 yr). Subsequently, 67 of 366 (18%) died while waiting, 263 of 366 (72%) underwent LTX, and 36 of 366 (10%) were awaiting LTX at the census date. INF and LAS were significantly associated with waiting list mortality in univariate analyses. The multivariate Cox model including INF and LAS grouped in tertiles, and comparing tertiles 2 and 3 with tertile 1, showed waiting list mortality hazard ratios of 1.62 (95% confidence interval [95% CI], 0.78-3.36; P=0.19) and 2.65 (95% CI, 1.35-5.20; P = 0.005) for INF, and 1.42 (95% CI, 0.63-3.24; P=0.40), and 2.32 (95% CI, 1.17-4.60; P=0.016) for LAS, respectively. These results indicated that INF and LAS had significant, independent predictive value for survival. Conclusions: CT score INF correlates with survival, and adds to the predictive value of LAS. Copyright
    Subject(s): Lung disease ; Cystic fibrosis ; Tomography X-ray computed ; Lung transplantation ; Waiting list survival ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Investigative techniques, diagnostic techniques (general aspects) ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Intensive care medicine ; Medical sciences ; Respiratory system ; Severity of Illness Index ; Waiting Lists - mortality ; Multivariate Analysis ; Prognosis ; Humans ; Middle Aged ; Decision Support Techniques ; Kaplan-Meier Estimate ; Proportional Hazards Models ; Child, Preschool ; Male ; Tomography, X-Ray Computed ; Cystic Fibrosis - diagnostic imaging ; Young Adult ; Lung Transplantation ; Cystic Fibrosis - surgery ; Adolescent ; Adult ; Female ; Cystic Fibrosis - mortality ; Child ; Cohort Studies ; Abridged Index Medicus
    ISSN: 1073-449X
    E-ISSN: 1535-4970
    Source: ProQuest Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Pediatric pulmonology, 2013-08, Vol.48 (8), p.789-796
    Description: BACKGROUND: Invasive pulmonary aspergillosis (IPA) is a life-threatening complication in immunocompromised patients. Early diagnosis and therapy improves outcome. Assessment of galactomannan (GM) in bronchoalveolar lavage (BAL) fluid is a proposed tool to diagnose IPA. Little is known about the diagnostic value of BAL GM in children. MATERIALS AND METHODS: Retrospectively, 72 bronchoscopies were analyzed for GM in patients fulfilling the host factor criteria as defined by the EORTC/MSG. A cut-off index value GM of 〉/=0.5 was used. Clinical data, results of chest CT-scans and BAL cultures were collected. RESULTS: Sensitivity, specificity, PPV, and NPV of BAL GM for a diagnosis of proven and probable IPA (n = 41) were 82.4%, 87.5%, 82.4%, and 87.5% respectively. A significant relation was found for BAL GM and abnormal chest CT (P = 0.01). No significant relationship was observed between BAL Aspergillus sp. culture and chest CT (n = 47). BAL GM and serum GM correlated significantly. In 9 out of 12 patients classified as possible IPA, antifungal therapy was continued or started, despite a negative BAL GM. CONCLUSIONS: BAL GM test had good diagnostic value in children suspected of IPA. However, the decision to continue or start antifungal therapy was mainly determined by the clinical suspicion of IPA based on chest CT-outcome, serum GM index values and failure of antibiotic therapy.
    Subject(s): galactomannan ; children ; bronchoalveolar lavage ; aspergillosis ; Bronchoscopy ; Diagnosis, Differential ; Reproducibility of Results ; Follow-Up Studies ; Humans ; Child, Preschool ; Infant ; Male ; Bronchoalveolar Lavage - methods ; Invasive Pulmonary Aspergillosis - diagnosis ; Bronchoalveolar Lavage Fluid - microbiology ; Mannans ; Invasive Pulmonary Aspergillosis - microbiology ; Adolescent ; Aspergillus - isolation & purification ; Female ; Retrospective Studies ; Child ; Early Diagnosis ; Cross infection ; Diagnosis ; Nosocomial infections ; Children ; Pulmonary aspergillosis ; Juvenile offenders
    ISSN: 8755-6863
    E-ISSN: 1099-0496
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Clinical cancer research, 2012, Vol.18 (14), p.3846-3855
    Description: Immunodeficient mice transplanted with subcutaneous tumors (xenograft or allograft) are widely used as a model of preclinical activity for the discovery and development of anticancer drug candidates. Despite their widespread use, there is a widely held view that these models provide minimal predictive value for discerning clinically active versus inactive agents. To improve the predictive nature of these models, we have carried out a retrospective population pharmacokinetic-pharmacodynamic (PK-PD) analysis of relevant xenograft/allograft efficacy data for eight agents (molecularly targeted and cytotoxic) with known clinical outcome. PK-PD modeling was carried out to first characterize the relationship between drug concentration and antitumor activity for each agent in dose-ranging xenograft or allograft experiments. Next, simulations of tumor growth inhibition (TGI) in xenografts/allografts at clinically relevant doses and schedules were carried out by replacing the murine pharmacokinetics, which were used to build the PK-PD model with human pharmacokinetics obtained from literature to account for species differences in pharmacokinetics. A significant correlation (r = 0.91, P = 0.0008) was observed between simulated xenograft/allograft TGI driven by human pharmacokinetics and clinical response but not when TGI observed at maximum tolerated doses in mice was correlated with clinical response (r = 0.36, P = 0.34). On the basis of these analyses, agents that led to greater than 60% TGI in preclinical models, at clinically relevant exposures, are more likely to lead to responses in the clinic. A proposed strategy for the use of murine subcutaneous models for compound selection in anticancer drug discovery is discussed.
    Subject(s): Biological and medical sciences ; Medical sciences ; Antineoplastic agents ; Pharmacology. Drug treatments ; Predictive Value of Tests ; Humans ; Antineoplastic Agents - administration & dosage ; Dose-Response Relationship, Drug ; Xenograft Model Antitumor Assays ; Animals ; Mice, Nude ; Cell Line, Tumor ; Antineoplastic Agents - pharmacokinetics ; Mice ; Retrospective Studies ; Neoplasms, Experimental - drug therapy ; Disease Models, Animal
    ISSN: 1078-0432
    E-ISSN: 1557-3265
    Source: HighWire Press (Free Journals)
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...