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  • 1
    Language: English
    In: The New England journal of medicine, 1953-02-12, Vol.248 (7), p.295-297
    Description: SIMPLE methods for the qualitative and roughly quantitative determination of serum acetone have been known for some time. 1 Duncan, 2 , 3 particularly, has pointed out the value of these simple tests in the early diagnosis and treatment of diabetic acidosis. Perhaps because of their very simplicity, the tests have failed to gain the wide recognition they deserve. A limited experience with one of these simple tests is herewith reported in the hope that others may be encouraged to use it in situations in which more elaborate determinations are unavailable. Method Because of its convenience the nitroprusside method has been found to serve . . .
    Subject(s): Acetone ; Diabetes Mellitus - diagnosis ; Hematologic Tests ; Humans ; Old Medline
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 2
    Language: English
    In: Obstetrical & gynecological survey, 1963-12, Vol.18 (6), p.878-879
    ISSN: 0029-7828
    E-ISSN: 1533-9866
    Source: Hellenic Academic Libraries Link
    Source: Alma/SFX Local Collection
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  • 3
    Language: English
    In: The Journal of pediatrics, 1960, Vol.56 (1), p.66-74
    Description: Forty-six electrocardiograms taken on 21 newborn infants of diabetic mothers (30 tracings during the first week of life) fell within the limits of normal as described by Zigler except for S-T abnormalities occurring in one infant during the first day of life and one tracing with a main T axis of −20 degrees at 8 days. The ECG abnormalities occurring in a case of complete transposition of the great vessels are described separately. The evidence that electrocardiographic abnormalities described by others in newborn infants of diabetic mothers may be due to potassium depletion is discussed, and the possibility is presented that these abnormalities may be due to an exaggeration of the increased load on the left ventricle secondary to circulatory changes occurring following delivery. From this small series we would conclude that abnormal electrocardiograms are uncommon in newborn infants of diabetic mothers and that the explanation of such abnormalities remains speculative.
    ISSN: 0022-3476
    E-ISSN: 1097-6833
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 4
    Language: English
    In: The New England journal of medicine, 1957-01-10, Vol.256 (2), p.74-76
    Description: SINCE 1954 the hypoglycemic sulfonamide, carbutamide (l-butyl-3-sulfanilylurea)∥ has been undergoing extensive clinical trial in the treatment of diabetes mellitus. In preliminary reports of these studies, few toxic reactions were described. 1 2 3 These included several cases of drug fever and rash that cleared promptly on discontinuance of the drug. A case of hepatitis that occurred in Germany concomitant with the administration of carbutamide was believed to be on an infectious basis. In more recent reports, Ridolfo and Kirtley 4 and Kinsell 5 have described cases of progressive leukopenia that necessitated termination of therapy. In our series of 48 cases side reactions were considerably more . . .
    Subject(s): Anuria - etiology ; Bone Marrow - drug effects ; Carbutamide ; Depression ; Sulfanilamides - analogs & derivatives ; Urea - analogs & derivatives
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 5
    Language: English
    In: Journal of the American Medical Association, 1956-05-19, Vol.161 (3), p.224-226
    Description: Dr. Priscilla White1 has, through the years, evolved a routine for the management of the pregnant diabetic woman that has been most successful in her hands. With this system she has handled the largest number of diabetic pregnancies and, though many occurred in women with diabetes of long duration, often with signs of vascular disease, there has been an excellent fetal survival rate. In spite of the excellence of her results, some practitioners have recorded disagreement with some of the measures used in handling the diabetic pregnancies. Given and co-workers2 do not advocate strict chemical control of the diabetes, some3 do not believe in premature delivery by cesarean section, while others4 disagree with the need for sex hormone replacement therapy. Late in 1951 it was decided that an attempt should be made to evaluate White's routine to determine, where possible, those features likely to contribute to
    Subject(s): Diabetes Mellitus ; Disease Management ; Female ; Hormone Replacement Therapy ; Humans ; Old Medline ; Pregnancy
    ISSN: 0002-9955
    Source: American Medical Association Journals
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  • 6
    Language: English
    In: Journal of the American College of Cardiology, 2013-05-28, Vol.61 (21), p.2194-2196
    Subject(s): Abridged Index Medicus ; Atrial Fibrillation - etiology ; Atrial Fibrillation - prevention & control ; Cardiac Surgical Procedures - adverse effects ; Fish Oils - therapeutic use ; Humans ; Postoperative Care - methods ; Postoperative Complications ; Randomized Controlled Trials as Topic
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: Microbial genomics, 2016-08, Vol.2 (8), p.e000083-e000083
    Description: The rapidly reducing cost of bacterial genome sequencing has lead to its routine use in large-scale microbial analysis. Though mapping approaches can be used to find differences relative to the reference, many bacteria are subject to constant evolutionary pressures resulting in events such as the loss and gain of mobile genetic elements, horizontal gene transfer through recombination and genomic rearrangements. assembly is the reconstruction of the underlying genome sequence, an essential step to understanding bacterial genome diversity. Here we present a high-throughput bacterial assembly and improvement pipeline that has been used to generate nearly 20 000 annotated draft genome assemblies in public databases. We demonstrate its performance on a public data set of 9404 genomes. We find all the genes used in multi-locus sequence typing schema present in 99.6 % of assembled genomes. When tested on low-, neutral- and high-GC organisms, more than 94 % of genes were present and completely intact. The pipeline has been proven to be scalable and robust with a wide variety of datasets without requiring human intervention. All of the software is available on GitHub under the GNU GPL open source license.
    Subject(s): assembly ; Genome, Bacterial - genetics ; Genomics - economics ; Genomics - methods ; high-throughput ; High-Throughput Nucleotide Sequencing ; illumina ; Methods Paper ; Multilocus Sequence Typing ; prokaryotic ; Prokaryotic Cells ; Sequence Analysis, DNA - methods ; Software
    ISSN: 2057-5858
    E-ISSN: 2057-5858
    Source: PubMed Central
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  • 8
    Language: English
    In: Reviews of geophysics (1985), 2016-03, Vol.54 (1), p.162-219
    Description: Interglacials, including the present (Holocene) period, are warm, low land ice extent (high sea level), end‐members of glacial cycles. Based on a sea level definition, we identify eleven interglacials in the last 800,000 years, a result that is robust to alternative definitions. Data compilations suggest that despite spatial heterogeneity, Marine Isotope Stages (MIS) 5e (last interglacial) and 11c (~400 ka ago) were globally strong (warm), while MIS 13a (~500 ka ago) was cool at many locations. A step change in strength of interglacials at 450 ka is apparent only in atmospheric CO2 and in Antarctic and deep ocean temperature. The onset of an interglacial (glacial termination) seems to require a reducing precession parameter (increasing Northern Hemisphere summer insolation), but this condition alone is insufficient. Terminations involve rapid, nonlinear, reactions of ice volume, CO2, and temperature to external astronomical forcing. The precise timing of events may be modulated by millennial‐scale climate change that can lead to a contrasting timing of maximum interglacial intensity in each hemisphere. A variety of temporal trends is observed, such that maxima in the main records are observed either early or late in different interglacials. The end of an interglacial (glacial inception) is a slower process involving a global sequence of changes. Interglacials have been typically 10–30 ka long. The combination of minimal reduction in northern summer insolation over the next few orbital cycles, owing to low eccentricity, and high atmospheric greenhouse gas concentrations implies that the next glacial inception is many tens of millennia in the future. Key Points We have reviewed the occurrence, strength, shape, and timing of interglacials Despite spatial variability, MIS 5 and 11 stand out as strong/warm The current interglacial is expected to be longer than any of those reviewed
    Subject(s): Climatology ; Earth Sciences ; interglacials ; quaternary ; review ; Sciences of the Universe
    ISSN: 8755-1209
    E-ISSN: 1944-9208
    Source: Wiley Online Library All Backfiles
    Source: Wiley Online Library All Journals
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  • 9
    Language: English
    In: Journal of the American College of Cardiology, 2008-09-23, Vol.52 (13), p.e1-142
    Description: Task Force Members Sidney C. Smith, Jr, MD, FACC, FAHA, Chair Alice K. Jacobs, MD, FACC, FAHA, Vice-Chair Christopher E. Buller, MD, FACC Mark A. Creager, MD, FACC, FAHA Steven M. Ettinger, MD, FACC David P. Faxon, MD, FACC, FAHA[dagger] Jonathan L. Halperin, MD, FACC, FAHA[dagger] Harlan M. Krumholz, MD, FACC, FAHA Frederick G. Kushner, MD, FACC, FAHA Bruce W. Lytle, MD, FACC, FAHA[dagger] Rick A. Nishimura, MD, FACC, FAHA Richard L. Page, MD, FACC, FAHA Lynn G. Tarkington, RN Clyde W. Yancy, Jr, MD, FACC, FAHA Table of Contents PREAMBLE (UPDATED)...e5 INTRODUCTION...e6 Evidence Review (UPDATED)...e6 Scope of the Document (UPDATED)...e7 Review and Approval (NEW)...e8 GENERAL PRINCIPLES...e8 Evaluation of the Patient With a Cardiac Murmur...e8 Introduction (UPDATED)...e8 Classification of Murmurs...e8 Dynamic Cardiac Auscultation...e9 Other Physical Findings...e9 Associated Symptoms...e10 Electrocardiography and Chest Roentgenography...e11 Echocardiography...e11 Cardiac Catheterization...e12 Exercise Testing...e12 Approach to the Patient...e12 Valve Disease Severity Table...e13 Endocarditis and Rheumatic Fever Prophylaxis (UPDATED)...e13 Endocarditis Prophylaxis (UPDATED)...e13 Table 5 (DELETED) Table 6(UPDATED) Table 7(UPDATED) Table 8 (DELETED) Rheumatic Fever Prophylaxis...e17 General Considerations...e17 Primary Prevention...e17 Secondary Prevention...e17 SPECIFIC VALVE LESIONS...e18 Aortic Stenosis...e18 Introduction...e18 Grading the Degree of Stenosis...e18 Pathophysiology...e18 Natural History...e19 Management of the Asymptomatic Patient...e19 Echocardiography (Imaging, Spectral, and Color Doppler) in Aortic Stenosis...e19 Exercise Testing...e21 Serial Evaluations...e21 Medical Therapy (UPDATED)...e21 Physical Activity and Exercise...e22 Indications for Cardiac Catheterization...e22 Low-Flow/Low-Gradient Aortic Stenosis...e22 Indications for Aortic Valve Replacement...e23 Symptomatic Patients...e23 Asymptomatic Patients...e24 Patients Undergoing Coronary Artery Bypass or Other Cardiac Surgery...e25 Aortic Balloon Valvotomy...e25 Medical Therapy for the Inoperable Patient...e25 Evaluation After Aortic Valve Replacement...e26 Special Considerations in the Elderly...e26 Aortic Regurgitation...e26 Etiology...e26 Acute Aortic Regurgitation...e26 Pathophysiology...e26 Diagnosis...e27 Treatment...e27 Chronic Aortic Regurgitation...e27 Pathophysiology...e27 Natural History...e29 Asymptomatic Patients With Normal Left Ventricular Function...e29 Asymptomatic Patients With Depressed Systolic Function...e30 Symptomatic Patients...e30 Diagnosis and Initial Evaluation...e30 Medical Therapy...e31 Physical Activity and Exercise...e33 Serial Testing...e33 Indications for Cardiac Catheterization...e34 Indications for Aortic Valve Replacement or Aortic Valve Repair...e35 Symptomatic Patients With Normal Left Ventricular Systolic Function...e35 Symptomatic Patients With Left Ventricular Dysfunction...e35 Asymptomatic Patients...e36 Concomitant Aortic Root Disease...e37 Evaluation of Patients After Aortic Valve Replacement...e37 Special Considerations in the Elderly...e38 Bicuspid Aortic Valve With Dilated Ascending Aorta...e38 Mitral Stenosis...e39 Pathophysiology and Natural History...e39 Indications for Echocardiography in Mitral Stenosis...e40 Medical Therapy...e42 Medical Therapy: General (UPDATED)...e42 Medical Therapy: Atrial Fibrillation...e43 Medical Therapy: Prevention of Systemic Embolization...e43 Recommendations Regarding Physical Activity and Exercise...e44 Serial Testing...e44 Evaluation of the Symptomatic Patient...e44 Indications for Invasive Hemodynamic Evaluation...e45 Indications for Percutaneous Mitral Balloon Valvotomy...e47 Indications for Surgery for Mitral Stenosis...e50 Management of Patients After Valvotomy or Commissurotomy...e51 Special Considerations...e52 Pregnant Patients...e52 Older Patients...e52 Mitral Valve Prolapse...e52 Pathophysiology and Natural History...e52 Evaluation and Management of the Asymptomatic Patient (UPDATED)...e53 Evaluation and Management of the Symptomatic Patient (UPDATED)...e54 Surgical Considerations...e55 Mitral Regurgitation...e55 Etiology...e55 Acute Severe Mitral Regurgitation...e56 Pathophysiology...e56 Diagnosis...e56 Medical Therapy...e56 Chronic Asymptomatic Mitral Regurgitation...e56 Pathophysiology and Natural History...e56 Diagnosis...e57 Indications for Transthoracic Echocardiography...e57 Indications for Transesophageal Echocardiography...e58 Serial Testing...e58 Guidelines for Physical Activity and Exercise...e58 Medical Therapy...e58 Indications for Cardiac Catheterization...e59 Indications for Surgery...e59 Types of Surgery...e59 Indications for Mitral Valve Operation...e60 Symptomatic Patients With Normal Left Ventricular Function...e61 Asymptomatic or Symptomatic Patients With Left Ventricular Dysfunction...e61 Asymptomatic Patients With Normal Left Ventricular Function...e62 Atrial Fibrillation...e63 Ischemic Mitral Regurgitation...e63 Evaluation of Patients After Mitral Valve Replacement or Repair...e63 Special Considerations in the Elderly...e64 Multiple Valve Disease...e64 Introduction...e64 Mixed Single Valve Disease...e64 Pathophysiology...e64 Diagnosis...e64 Two-Dimensional and Doppler Echocardiographic Studies...e64 Cardiac Catheterization...e64 Management...e65 Combined Mitral Stenosis and Aortic Regurgitation...e65 Pathophysiology...e65 Management...e65 Combined Mitral Stenosis and Tricuspid Regurgitation...e65 Pathophysiology...e65 Diagnosis...e65 Management...e65 Combined Mitral Regurgitation and Aortic Regurgitation...e66 Pathophysiology...e66 Diagnosis and Therapy...e66 Combined Mitral Stenosis and Aortic Stenosis...e66 Pathophysiology...e66 Diagnosis and Therapy...e66 Combined Aortic Stenosis and Mitral Regurgitation...e66 Pathophysiology...e66 Diagnosis and Therapy...e66 Tricuspid Valve Disease...e66 Pathophysiology...e66 Diagnosis...e67 Management...e67 Drug-Related Valvular Heart Disease...e68 Radiation Heart Disease...e68 EVALUATION AND MANAGEMENT OF INFECTIVE ENDOCARDITIS...e69 Antimicrobial Therapy...e69 Culture-Negative Endocarditis...e71 Endocarditis in HIV-Seropositive Patients...e71 Indications for Echocardiography in Suspected or Known Endocarditis...e71 Transthoracic Echocardiography in Endocarditis...e73 Transesophageal Echocardiography in Endocarditis...e73 Outpatient Treatment...e74 Indications for Surgery in Patients With Acute Infective Endocarditis...e75 Surgery for Native Valve Endocarditis...e75 Surgery for Prosthetic Valve Endocarditis...e77 MANAGEMENT OF VALVULAR DISEASE IN PREGNANCY...e77 Physiological Changes of Pregnancy...e77 Physical Examination...e77 Echocardiography...e78 General Management Guidelines...e78 Specific Lesions...e80 Mitral Stenosis...e80 Mitral Regurgitation...e80 Aortic Stenosis...e80 Aortic Regurgitation...e80 Pulmonic Stenosis...e80 Tricuspid Valve Disease...e81 Marfan Syndrome...e81 Endocarditis Prophylaxis (UPDATED)...e81 Cardiac Valve Surgery...e81 Anticoagulation During Pregnancy...e81 Warfarin...e81 Unfractionated Heparin...e82 Low-Molecular-Weight Heparins...e82 Selection of Anticoagulation Regimen in Pregnant Patients With Mechanical Prosthetic Valves...e82 Selection of Valve Prostheses in Young Women...e84 MANAGEMENT OF CONGENITAL VALVULAR HEART DISEASE IN ADOLESCENTS AND YOUNG ADULTS (UPDATED)...e84 Aortic Stenosis...e84 Pathophysiology...e84 Evaluation of Asymptomatic Adolescents or Young Adults With Aortic Stenosis...e85 Indications for Aortic Balloon Valvotomy in Adolescents and Young Adults...e85 Aortic Regurgitation...e86 Mitral Regurgitation...e87 Mitral Stenosis...e87 Tricuspid Valve Disease...e88 Pathophysiology...e88 Evaluation of Tricuspid Valve Disease in Adolescents and Young Adults...e89 Indications for Intervention in Tricuspid Regurgitation...e89 Pulmonic Stenosis...e89 Pathophysiology...e89 Evaluation of Pulmonic Stenosis in Adolescents and Young Adults...e90 Indications for Balloon Valvotomy in Pulmonic Stenosis (UPDATED)...e90 Pulmonary Regurgitation...e91 SURGICAL CONSIDERATIONS...e91 American Association for Thoracic Surgery/Society of Thoracic Surgeons Guidelines for Clinical Reporting of Heart Valve Complications...e92 Aortic Valve Surgery...e93 Risks and Strategies in Aortic Valve Surgery...e94 Mechanical Aortic Valve Prostheses...e94 Antithrombotic Therapy for Patients With Aortic Mechanical Heart Valves...e94 Stented and Nonstented Heterografts...e94 Aortic Valve Replacement With Stented Heterografts...e94 Aortic Valve Replacement With Stentless Heterografts...e95 Aortic Valve Homografts...e96 Pulmonic Valve Autotransplantation...e96 Aortic Valve Repair...e97 Left Ventricle-to-Descending Aorta Shunt...e97 Comparative Trials and Selection of Aortic Valve Prostheses...e97 Major Criteria for Aortic Valve Selection...e98 Mitral Valve Surgery...e98 Mitral Valve Repair...e99 Myxomatous Mitral Valve...e99 Rheumatic Heart Disease...e99 Ischemic Mitral Valve Disease...e99 Mitral Valve Endocarditis...e100 Mitral Valve Prostheses (Mechanical or Bioprostheses)...e100 Selection of a Mitral Valve Prosthesis...e100 Choice of Mitral Valve Operation...e100 Tricuspid Valve Surgery...e101 Valve Selection for Women of Childbearing Age...e101 INTRAOPERATIVE ASSESSMENT...e101 Specific Valve Lesions...e102 Aortic Stenosis...e102 Aortic Regurgitation...e102 Mitral Stenosis...e103 Mitral Regurgitation...e103 Tricuspid Regurgitation...e103 Tricuspid Stenosis...e103 Pulmonic Valve Lesions...e103 Specific Clinical Scenarios...e104 Previously Undetected Aortic Stenosis During CABG...e104 Previously Undetected Mitral Regurgitation During CABG...e104 MANAGEMENT OF PATIENTS WITH PROSTHETIC HEART VALVES...e104 Antibiotic Prophylaxis...e104 Infective Endocarditis...e104 Recurrence of Rheumatic Carditis...e104 Antithrombotic Therapy...
    Subject(s): Abridged Index Medicus ; Adolescent ; Adult ; Cardiology ; Cardiovascular disease ; Children & youth ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - therapy ; Coronary vessels ; Disease prevention ; Endocarditis, Bacterial - diagnosis ; Endocarditis, Bacterial - therapy ; Exercise ; Female ; Heart Defects, Congenital - therapy ; Heart failure ; Heart surgery ; Heart Valve Diseases - complications ; Heart Valve Diseases - diagnosis ; Heart Valve Diseases - therapy ; Heart Valve Prosthesis - adverse effects ; Humans ; Intraoperative Period ; Intubation ; Older people ; Patients ; Pediatrics ; Physical fitness ; Pregnancy ; Pregnancy Complications, Cardiovascular - diagnosis ; Pregnancy Complications, Cardiovascular - therapy ; Prostheses ; Rheumatic fever ; Task forces ; Teenagers ; Thoracic surgery ; Young adults
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Source: Alma/SFX Local Collection
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  • 10
    Language: English
    In: Analytical biochemistry, 2009, Vol.386 (2), p.194-216
    Description: To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used.
    Subject(s): Agriculture ; Analysis ; Antibodies, Catalytic - analysis ; Antigens ; Ballistic missiles ; Benchmarking ; Biacore ; Binding Sites ; Biochemistry and Molecular Biology ; Biokemi och molekylärbiologi ; Biological products ; Biological Sciences ; Biologiska vetenskaper ; Biosensing Techniques - methods ; Biosensing Techniques - statistics & numerical data ; Blood clot ; Cancer ; Detectors ; Engineering schools ; EWI-16945 ; Glutathione ; Glutathione transferase ; Glutathione Transferase - analysis ; Human health and pathology ; IR-68798 ; Kinetics ; Life Sciences ; Ligands ; Medical colleges ; Medical equipment ; Natural Sciences ; Naturvetenskap ; Neurosciences ; Oncology, Experimental ; Optical biosensor ; Physiological apparatus ; Proteins ; Proteins - analysis ; Research ; Surface plasmon resonance ; Thrombosis
    ISSN: 0003-2697
    ISSN: 1096-0309
    E-ISSN: 1096-0309
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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