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  • 1
    Language: English
    In: Educational evaluation and policy analysis, 2002-12-01, Vol.24 (4), p.305-331
    Description: We developed a zero-to-five index of the strength of accountability in 50 states based on the use of high-stakes testing to sanction and reward schools, and analyzed whether that index is related to student gains on the NAEP mathematics test in 1996-2000. The study also relates the index to changes in student retention in the 9th grade and to changes in high school completion rates over the same period. The results show that students in high-accountability states averaged significantly greater gains on the NAEP 8th-grade math test than students in states with little or no state measures to improve student performance. Furthermore, students in high-accountability states do not have significantly higher retention or lower high school completion rates.
    Subject(s): Basic skills ; Coefficients ; Grade repetition ; High school students ; High schools ; Hispanics ; Mathematics ; Outcomes of education ; Survival rates ; Test scores
    ISSN: 0162-3737
    E-ISSN: 1935-1062
    Source: JSTOR Arts & Sciences IV
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: Biological psychiatry (1969), 2006, Vol.60 (7), p.722-729
    Description: Pre-clinical and clinical studies have shown acute stress may impair working memory and visuo-spatial ability. This study was designed to clarify the nature of stress-induced cognitive deficits in soldiers and how such deficits may contribute to operational or battlefield errors. One hundred eighty-four Special Operations warfighters enrolled in Survival School completed pre-stress measures of dissociation and trauma exposure. Subjects were randomized to one of three assessment groups (Pre-stress, Stress, Post-stress) and were administered the Rey Ostereith Complex Figure (ROCF). All subjects completed post-stress measures of dissociation. ROCF copy and recall were normal in the Pre- and Post-stress groups. ROCF copy and recall were significantly impaired in the Stress Group. Stress group ROCF copy performance was piecemeal, and ROCF recall was impaired. Symptoms of dissociation were negatively associated with ROCF recall in the Stress group. Baseline dissociation and history of traumatic stress predicted cognitive impairment during stress. Stress exposure impaired visuo-spatial capacity and working memory. In rats, monkeys, and humans, high dopamine and NE turnover in the PFC induce deficits in cognition and spatial working memory. Improved understanding of stress-induced cognitive deficits may assist in identification of soldiers at risk and lead to the development of better countermeasures.
    Subject(s): Adult ; Biological and medical sciences ; Cognition ; dissociation ; Dissociative Disorders - etiology ; Female ; Form Perception ; Fundamental and applied biological sciences. Psychology ; Human ; Humans ; Learning. Memory ; Male ; Medical colleges ; Memory ; Memory Disorders - etiology ; Memory, Short-Term ; military performance ; Military personnel ; Military Personnel - psychology ; Pattern Recognition, Visual ; pre-frontal cortex ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Short-term memory ; Soldiers ; Space Perception ; Stress, Psychological - complications ; survival school ; Training ; trauma exposure
    ISSN: 0006-3223
    E-ISSN: 1873-2402
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 3
    Language: English
    In: Technium Social Sciences Journal, 2020-04-01, Vol.7, p.74-85
    Description: Currently, teachers’ salaries in Zimbabwe are insufficient to sustain the harsh economic situation yet teachers seem to be meeting their monthly livelihood demands. A study to explore different survival strategies engaged by teachers under this current flopping economy was conducted in the Gweru urban. A total of 55 participants were randomly selected from five different schools. Questionnaires and in-depth interviews were used to collect data. Descriptive statistics and Chi-Square test for association (SPSS version 21) were used to analyse the data. Findings revealed that teachers have adopted 15 survival strategies to augment their meagre salaries. Over 50% of the teachers indicated that borrowing money from banks/microfinance institutions, conducting extra lessons, poultry production, cross border trading, part-time teaching at private schools, production of horticultural produce and selling of goods (maputi “dried corn”, sweets, peanut butter, snacks etc...) were pillars to their survival in this collapsing economy. Gender influenced the adoption of cross border trading (χ2 = 4.558; p 〈0.05) and hair dressing (χ2 = 10.102; p 〈0.005). Delivery of extra lesson was significantly associated with job title (χ2 = 5.026; p 〈0.05) constituting 70% teachers and 20% headmasters. It was observed that teachers with higher qualifications had a greater chances of being hired as part time private tutors in private schools. A greater proportion of the respondents (70.91%) agreed that venturing into these survival strategies impacted seriously on pupils’ overall performance. Thus teachers are recommended to balance their profession and private business to ensure that pupils’ performance is not compromised.
    Subject(s): flopping economy, survival strategies, teachers, school, livelihood
    E-ISSN: 2668-7798
    Source: HeinOnline Law Journal Library
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  • 4
    Language: English
    In: Leukemia, 2018-11, Vol.32 (11), p.2316-2325
    Description: The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the outcome of multiply R/R childhood B-ALL treated at 24 TACL institutions between 2005 and 2013. Patient information, treatment, and response were collected. Prognostic factors influencing the complete remission (CR) rate and event-free survival (EFS) were analyzed. The analytic set included 578 salvage treatment attempts among 325 patients. CR rates (mean ± SE) were 51 ± 4% for patients with bone marrow R/R B-ALL who underwent a second salvage attempt, 37 ± 6% for a third attempt, and 31 ± 6% for the fourth through eighth attempts combined. For patients achieving a CR after their second, third, and fourth through eighth attempts, the 2 year EFS was 41 ± 6%, 13 ± 7%, and 27 ± 13% respectively. Our results showed slight improvement when compared to previous studies. This is the largest and most recent study to date that evaluates the outcome of this patient population. Our data will provide detailed reference for the evaluation of new agents being developed for childhood B-ALL.
    Subject(s): Antineoplastic Agents - therapeutic use ; B-Lymphocytes - drug effects ; B-Lymphocytes - pathology ; Bone Marrow - drug effects ; Bone Marrow - pathology ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Infant ; Male ; Neoplasm Recurrence, Local - drug therapy ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology ; Remission Induction - methods ; Retrospective Studies ; Salvage Therapy - methods
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
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  • 5
    Language: English
    In: The New England journal of medicine, 2016-01-07, Vol.374 (1), p.43-53
    Description: Antilymphocyte globulin (ATG) added to the conditioning regimen before allogeneic hematopoietic stem-cell transplantation resulted in a lower rate of chronic graft-versus-host disease at 2 years than the rate without ATG (32% vs. 68%), with no apparent increased risk of relapse. Chronic graft-versus-host disease (GVHD) is a major complication of allogeneic stem-cell transplantation that results in later illness and death and a reduction in quality of life. 1 , 2 Risk factors for chronic GVHD are the use of peripheral blood as a source of stem cells, a history of acute GVHD, and the use of donated stem cells with high numbers of T cells. 3 – 7 In a meta-analysis, the Stem Cell Trialists’ Collaborative Group reported an incidence of extensive chronic GVHD of 47% after peripheral-blood stem-cell transplantation from an HLA-identical sibling. 4 In 2012, more than 70% of the stem-cell transplantations performed in . . .
    Subject(s): Abridged Index Medicus ; Adolescent ; Adult ; Analysis ; Antilymphocyte Serum - therapeutic use ; Bone marrow ; Child ; Child, Preschool ; Chronic Disease ; Disease-Free Survival ; Dosage and administration ; Female ; Globulins ; Graft versus host disease ; Graft versus host reaction ; Graft vs Host Disease - epidemiology ; Graft vs Host Disease - mortality ; Graft vs Host Disease - prevention & control ; Hemopoiesis ; Histocompatibility antigen HLA ; Humans ; Immunoglobulins ; Immunosuppressive Agents - therapeutic use ; Incidence ; Leukemia ; Lymphocytes T ; Male ; Middle Aged ; Peripheral blood ; Prevention ; Preventive medicine ; Proportional Hazards Models ; Prospective Studies ; Risk assessment ; Stem cell transplantation ; Stem cells ; Survival Rate ; T-Lymphocytes - immunology ; Transplantation, Homologous ; Transplants & implants ; Treatment outcome ; Young Adult
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Single Journals
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  • 6
    Language: English
    In: Journal of clinical oncology, 2012-06-10, Vol.30 (17), p.2112-2118
    Description: We compared two chemotherapy regimens that included methotrexate (MTX), cisplatin (CDP), and doxorubicin (ADM) with or without ifosfamide (IFO) in patients with nonmetastatic osteosarcoma of the extremity. Patients age ≤ 40 years randomly received regimens with the same cumulative doses of drugs (ADM 420 mg/m(2), MTX 120 g/m(2), CDP 600 mg/m(2), and IFO 30 g/m(2)) but with different durations (arm A, 44 weeks; arm B, 34 weeks). IFO was given postoperatively when pathologic response to MTX-CDP-ADM was poor (arm A) or given in the primary phase of chemotherapy with MTX-CDP-ADM (arm B). End points of the study included pathologic response to preoperative chemotherapy, toxicity, and survival. Given the feasibility of accrual, the statistical plan only permitted detection of a 15% difference in 5-year overall survival (OS). From April 2001 to December 2006, 246 patients were enrolled. Two hundred thirty patients (94%) underwent limb salvage surgery (arm A, 92%; arm B, 96%; P = .5). Chemotherapy-induced necrosis was good in 45% of patients (48% in arm A, 42% in arm B; P = .3). Four patients died of treatment-related toxicity (arm A, n = 1; arm B, n = 3). A significantly higher incidence of hematologic toxicity was reported in arm B. With a median follow-up of 66 months (range, 1 to 104 months), 5-year OS and event-free survival (EFS) rates were not significantly different between arm A and arm B, with OS being 73% (95% CI, 65% to 81%) in arm A and 74% (95% CI, 66% to 82%) in arm B and EFS being 64% (95% CI, 56% to 73%) in arm A and 55% (95% CI, 46% to 64%) in arm B. IFO added to MTX, CDP, and ADM from the preoperative phase does not improve the good responder rate and increases hematologic toxicity. IFO should only be considered in patients who have a poor histologic response to MTX, CDP, and ADM.
    Subject(s): Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Bone Neoplasms - drug therapy ; Chemotherapy, Adjuvant - methods ; Child ; Child, Preschool ; Cisplatin - administration & dosage ; Disease-Free Survival ; Diseases of the osteoarticular system ; Doxorubicin - administration & dosage ; Female ; Femur - pathology ; Humans ; Humerus - pathology ; Ifosfamide - administration & dosage ; Male ; Medical sciences ; Methotrexate - administration & dosage ; Osteosarcoma - drug therapy ; Tibia - pathology ; Tumors ; Tumors of striated muscle and skeleton
    ISSN: 0732-183X
    E-ISSN: 1527-7755
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 7
    Language: English
    In: Haematologica (Roma), 2013-08-01, Vol.98 (8), p.1273-1281
    Description: Children with high-risk acute lymphoblastic leukemia in first complete remission can benefit from allogeneic hematopoietic stem cell transplantation. We analyzed the outcome of 211 children with high-risk acute lymphoblastic leukemia in first complete remission who were given an allogeneic transplant between 1990 and 2008; the outcome of patients who, despite having an indication for transplantation and a suitable donor, did not receive the allograft for different reasons in the same time period was not analyzed. Sixty-nine patients (33%) were transplanted between 1990 and 1999, 58 (27%) between 2000 and 2005, and 84 (40%) between 2005 and 2008. A matched family donor was employed in 138 patients (65%) and an unrelated donor in 73 (35%). The 10-year probabilities of overall and disease-free survival were 63.4% and 61%, respectively. The 10-year cumulative incidences of transplantation-related mortality and relapse were 15% and 24%, respectively. After 1999, no differences in either disease-free survival or transplant-related mortality were observed in patients transplanted from unrelated or matched family donors. In multivariate analysis, grade IV acute graft-versus-host disease was an independent factor associated with worse disease-free survival. By contrast, grade I acute graft-versus-host disease and age at diagnosis between 1 and 9 years were favorable prognostic variables. Our study, not intended to evaluate whether transplantation is superior to chemotherapy for children with acute lymphoblastic leukemia in first complete remission and high-risk features, shows that the allograft cured more than 60% of these patients; in the most recent period, the outcome of recipients of grafts from matched family and unrelated donors was comparable.
    Subject(s): Adolescent ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Follow-Up Studies ; Graft vs Host Disease - diagnosis ; Graft vs Host Disease - epidemiology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - mortality ; Humans ; Infant ; Italy - epidemiology ; Male ; Original and Brief Reports ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery ; Registries ; Remission Induction ; Risk Factors ; Transplantation, Homologous - adverse effects ; Transplantation, Homologous - mortality ; Treatment Outcome
    ISSN: 0390-6078
    E-ISSN: 1592-8721
    Source: HighWire Press (Free Journals)
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 8
    Language: English
    In: European journal of cancer (1990), 2005, Vol.41 (18), p.2836-2845
    Description: Around 1148 patients with non-metastatic osteosarcoma of the extremity were treated in a single institution between 1972 and 1999 with 4 different protocol of adjuvant and 7 different protocols of neoadjuvant chemotherapy. The rate of limb salvage increased from 20% to 71%. The 5-year event-free survival (EFS) and overall survival (OS) were 57% and 66%, respectively. The 10-year EFS and OS were 52% and 57%, respectively, and the results significantly correlated with serum alkaline phosphatase levels; the type of chemotherapy (adjuvant vs neoadjuvant); and with histologic response to pre-operative treatment. Aggressive chemotherapy and surgery could cure about the 60% of patients with osteosarcoma of the extremity. However, since local or systemic relapses, myocardiopathies and a second malignancy are possible even 5 or more years since the beginning of treatment, a long-term follow-up is recommended.
    Subject(s): Adolescent ; Adult ; Aged ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Bone Neoplasms - drug therapy ; Bone Neoplasms - pathology ; Bone Neoplasms - surgery ; Cancer ; Chemotherapy ; Chemotherapy, Adjuvant ; Child ; Child, Preschool ; Disease-Free Survival ; Extremities ; Female ; Follow-up ; Humans ; Infant ; Infant, Newborn ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasms, Second Primary - drug therapy ; Osteosarcoma ; Osteosarcoma - drug therapy ; Osteosarcoma - pathology ; Osteosarcoma - surgery ; Pharmacology. Drug treatments ; Phosphatases ; Postoperative Complications - etiology ; Retrospective Studies ; Treatment Outcome ; Tumors
    ISSN: 0959-8049
    E-ISSN: 1879-0852
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 9
    Book
    Book
    2013
    ISBN: 0816674299  ISBN: 0816674280  ISBN: 9780816674282  ISBN: 9780816674299 
    Language: English
    Description: In the late 1960s, Indian families in Minneapolis and St. Paul were under siege. Clyde Bellecourt remembers, "We were losing our children during this time; juvenile courts were sweeping our children up, and they were fostering them out, and sometimes whole families were being broken up." In 1972, motivated by prejudice in the child welfare system and hostility in the public schools, American Indian Movement (AIM) organizers and local Native parents came together to start their own community school. For Pat Bellanger, it was about cultural survival. Though established in a moment of crisis, the school fulfilled a goal that she had worked toward for years: to create an educational system that would enable Native children "never to forget who they were." While AIM is best known for its national protests and political demands, the survival schools foreground the movement's local and regional engagement with issues of language, culture, spirituality, and identity. In telling of the evolution and impact of the Heart of the Earth school in Minneapolis and the Red School House in St. Paul, Julie L. Davis explains how the survival schools emerged out of AIM's local activism in education, child welfare, and juvenile justice and its efforts to achieve self-determination over urban Indian institutions. The schools provided informal, supportive, culturally relevant learning environments for students who had struggled in the public schools. Survival school classes, for example, were often conducted with students and instructors seated together in a circle, which signified the concept of mutual human respect. Davis reveals how the survival schools contributed to the global movement for Indigenous decolonization as they helped Indian youth and their families to reclaim their cultural identities and build a distinctive Native community. The story of these schools, unfolding here through the voices of activists, teachers, parents, and students, is also an in-depth history of AIM's founding and early community organizing in the Twin Cities-and evidence of its long-term effect on Indian people's lives.
    Subject(s): Education ; Ethnic Studies ; Geschichte (Histor) ; HISTORY ; Indianer ; Midwest (IA, IL, IN, KS, MI, MN, MO, ND, NE, OH, SD, WI) ; Minnesota ; Native American Studies ; Schule ; SOCIAL SCIENCE ; Sociology ; State & Local ; United States ; Vintners ; Wine industry
    ISBN: 0816674299
    ISBN: 0816674280
    ISBN: 9780816674282
    ISBN: 9780816674299
    Source: Ebook Central - Academic Complete
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  • 10
    Language: English
    In: British journal of haematology, 2015-04, Vol.169 (1), p.103-110
    Description: Summary Umbilical cord blood (UCB) from an human leucocyte antigen (HLA)‐identical sibling can be used for transplantation of patients with malignant and non‐malignant diseases. However, the low cellular content of most UCB units represents a limitation to this approach. An option to increase cell dose is to harvest bone marrow (BM) cells from the same donor and infuse them along with the UCB. We studied 156 children who received such a combined graft between 1992 and 2011. Median age was 7 years and 78% of patients (n = 122) were transplanted for non‐malignant diseases, mainly haemoglobinopathies. Acute leukaemia (n = 26) was the most frequent malignant diagnosis. Most patients (91%) received myeloablative conditioning. Median donor age was 1·7 years, median infused nucleated cell dose was 24·4 × 107/kg and median follow‐up was 41 months. Sixty‐days neutrophil recovery occurred in 96% of patients at a median of 17 d. The probabilities of grade‐II‐IV acute and chronic graft‐versus‐host disease (GVHD) were 19% and 10%, respectively. Four‐year overall survival was 90% (68% malignant; 97% non‐malignant diseases) with 3% probability of death. In conclusion, combined UCB and BM transplantation from an HLA‐identical sibling donor is an effective treatment for children with malignant and non‐malignant disorders with high overall survival and low incidence of GVHD.
    Subject(s): Acute Disease ; Adolescent ; Adult ; Allografts ; Antigens ; Bone marrow ; Bone Marrow Transplantation ; Child ; Child, Preschool ; Children ; Chronic Disease ; cord blood ; Cord Blood Stem Cell Transplantation ; Disease-Free Survival ; Female ; Follow-Up Studies ; Graft vs Host Disease - etiology ; Graft vs Host Disease - mortality ; Graft vs Host Disease - therapy ; haematopoietic stem cell transplantation ; Humans ; Infant ; Leukemia - mortality ; Leukemia - therapy ; Living Donors ; Male ; Medicin och hälsovetenskap ; Survival Rate ; Transplantation ; Transplantation Conditioning
    ISSN: 0007-1048
    ISSN: 1365-2141
    E-ISSN: 1365-2141
    Source: Alma/SFX Local Collection
    Source: SWEPUB Freely available online
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