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  • 1
    Language: English
    In: Journal of Geophysical Research: Solid Earth, 08/10/1999, Vol.104(B8), pp.17617-17625
    Description: The northern basin of the Dead Sea is occupied by a approximately 300-m-deep lake. A series of cores in the deep-water part of the lake provide information about the top 365 cm of the sediments. The cores were correlated with high-resolution 3.5-kHz seismic profiles from this area and provide lithologie and age constraints for the high-resolution seismic reflection data. Visual comparison of the two data sets shows that strong surface and shallow subsurface reflectors (A and B) correlate to the massive salt at the seafloor surface and the indurated salt at the base of the cores, respectively. Calculations of an average seismic velocity based on the interval between these reflectors and the corresponding sedimentary thickness yield an average 3500 m/s velocity. This agrees closely with velocities determined from direct measurements of compressional velocities for sediment samples. Ultrasonic wave velocity measurements of salt samples from the cores and dry rock salt cores from the southern basin of the Dead Sea indicate that wave velocities are independent of the burial depth at shallow depths; however, velocities show strong dependence on porosity. At low hydrostatic pressure a reduction in porosity as well as closure of microcracks in the crystals cause an increase in the velocities. This increase disappears at higher stress levels. Synthetic seismograms of the upper 3 ms and the entire 25 ms penetrated by the seismic profiles reinforce the lithologie and seismic stratigraphie correlation and confirm that prominent reflectors in the basin represent the top boundary of halite layers which are separated by laminated sequences of evaporites and elastics. The salt in the upper salt sequence is deposited at a very fast rate of more than 20 mm/yr. However, at shallow depths, considerable compaction takes place. Variations in appearance and velocities of the upper salt sequence and middle salt sequence indicate that the porous, granular, and fine-grained precipitates of the surface salts are diagenetically altered to a coarse and compact crystalline aggregate by re-solution and crystallization with burial. The sedimentary sequences recovered in the cores suggest that significant lake level fluctuations took place in the past in response to climatic changes. The detailed correlation of the cores and seismic profiles makes it possible to extrapolate climatic data from earlier periods beneath the maximum core penetration by analyzing the seismic stratigraphie sequences of the seismic reflection data. Copyright 1999 by the American Geophysical Union.
    Subject(s): Quaternary Geology ; Applied Geophysics ; Active Faults ; Asia ; Bathymetry ; Cenozoic ; Dead Sea ; Faults ; Geophysical Methods ; Geophysical Profiles ; Geophysical Surveys ; High-Resolution Methods ; Holocene ; Middle East ; Quaternary ; Reflection Methods ; Seismic Methods ; Seismic Profiles ; Seismic Stratigraphy ; Strike-Slip Faults ; Surveys;
    ISSN: Journal of Geophysical Research: Solid Earth
    E-ISSN: 01480227
    E-ISSN: 21562202
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  • 2
    In: Clinical Chemistry and Laboratory Medicine, 1998, Vol.36(4), pp.235-240
    Description: Conventional laboratory investigations of haemostasis like prothrombin time and activated partial thromboplastin time are not useful in predicting and managing intra-operative bleeding complications. In order to establish a possible “perioperative reference range” for thrombin generation prothrombin fragment F1+2 (F1+2) and fibrin degradation (D-dimer) markers, we measured F1+2 and D-dimer concentrations before surgery (but after induction of anaesthesia), 30 minutes into surgery, 10 minutes after the event expected to induce the maximal activation of the haemostatic systems, 90 minutes after surgery and on postoperative days 1 and 2 in 226 consecutive patients. Samples were collected from arterial lines. Twenty patients developed a clinically defined, intraoperative disorder of haemostasis, 206 did not. Patients with an intraoperative disorder of haemostasis had significantly higher preoperative F1+2 and D-dimer concentrations. Preoperative values for F1+2 and D-dimer concentrations above the 75th percentile of patients without an intraoperative disorder of haemostasis indicated a 2.70 to 2.88 fold risk of developing an intraoperative disorder of haemostasis (odds ratios were 3.04, 3.12 and 3.29 for D-dimer, ELISA, F1+2, and D-dimer latex tests, respectively with 95% confidence intervals from 1.20 to 8.46) with negative predictive values of 94%, but positive predictive values of only 16% to 26%. These data suggest that preoperative determination of molecular markers might be helpful in identifying a group of patients at high risk for intraoperative disorder of haemostasis by exclusion of low risk patients. Validation of such an approach requires a prospective trial.
    Subject(s): Blood Coagulation ; Hemostasis ; Blood Loss, Surgical -- Prevention & Control;
    ISSN: 1434-6621
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  • 3
    Language: English
    In: Naturwissenschaften, 1997, Vol.84(9), pp.398-401
    Description: Der Beitrag berichtet über die Ergebnisse der geologischen Forschungskampagne im Bereich des Toten Meeres aus 1993. Im Sediment des Meeresbodens wurden vierzehn Auskernungsbohrungen mit einer Teuflänge bis zu 4,4 m durchgeführt. Das Ziel des Forschungsprojektes war, durch die Analyse der ausgebohrten Sediment-Bohrkerne die Einflüsse möglicher Klimaänderungen auf die Wüstenbildung dieser geologischen Grenzregion zwischen der arabischen und afrikanischen Platte für die vergangenen 2500 Jahre festzustellen. Die Kernbohrungen wurden mit einem Kolbenbohrentkerner und einem Selcore-Bohrwerkzeug ausgeführt. Die Untersuchung der Sedimentschichtung, der jeweils gefundenen Mineralien, ihrer Dichte, Zusammensetzung und Einlagerungsform (Mergel, Steinsalz, Aragonit) und ihrer Gefügestrukturen sowie die Analyse eingeschlossener Pflanzenpollen ermöglicht Rückschlüsse auf den zeitlichen Verlauf klimatischer Veränderungen zwischen trockenem Wüstenklima und feuchtem Mittelmeerklima, Diese Klimaveränderungen stehen auch im Zusammenhang mit den geschichtlich belegten kulturellen Besiedlungen. Aus der Zusammensetzung unterschiedlicher Sedimentschichten kann auf den Grad der Verdunstung zur Zeit der Sedimentation und dadurch auch auf das Klima geschlossen werden. Die Altersbestimmung der verschiedenen Sedimentanteile erfolgte massenspektrometrisch durch die Radiokarbonmethode (C-14-Methode). Die Abbildungen zeigen eine Tiefenkarte des Gebietes, die geographische Lage des Meßpunktes DS7-1SC, die lithologische Verteilung der Sedimentstrukturen sowie rasterelektronenmikroskopische Aufnahmen kristalliner oder laminierter Mineralschichten.
    Subject(s): Geologie ; Historische Entwicklung ; Klima ; Meteorologie ; Trockenheit ; Bohrloch (Allgemein) ; Biologie ; Vegetation ; Feuchtigkeit ; Radiometrie ; Schichtstoff ; Morphologie ; Witterungseinfluss ; Leitisotop ; Kohlenstoff ; Gestein ; Untersuchungsergebnis ; Radiochemische Analyse ; Sedimentation ; Kernbohrwerkzeug ; Wüste ; Radiokarbonmethode ; Lithologie ; Sciences (General);
    ISSN: 0028-1042
    E-ISSN: 1432-1904
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  • 4
    Language: English
    In: Blood, 11/15/2013, Vol.122(21), pp.5456-5456
    ISSN: 0006-4971
    E-ISSN: 1528-0020
    Source: CrossRef
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  • 5
    Language: English
    In: Physical review letters, 02 September 2016, Vol.117(10), pp.100503
    Description: Digital signatures guarantee the authorship of electronic communications. Currently used "classical" signature schemes rely on unproven computational assumptions for security, while quantum signatures rely only on the laws of quantum mechanics to sign a classical message. Previous quantum signature schemes have used unambiguous quantum measurements. Such measurements, however, sometimes give no result, reducing the efficiency of the protocol. Here, we instead use heterodyne detection, which always gives a result, although there is always some uncertainty. We experimentally demonstrate feasibility in a real environment by distributing signature states through a noisy 1.6 km free-space channel. Our results show that continuous-variable heterodyne detection improves the signature rate for this type of scheme and therefore represents an interesting direction in the search for practical quantum signature schemes. For transmission values ranging from 100% to 10%, but otherwise assuming an ideal...
    Subject(s): Channels ; Security ; Messages ; Feasibility ; Distributing ; Quantum Mechanics ; Signatures ; Electronics ; Plasma Physics (General) (So) ; Physics (General) (Ah);
    ISSN: 0031-9007
    E-ISSN: 1079-7114
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  • 6
    Language: English
    In: Physical review letters, 08 August 2014, Vol.113(6), pp.060502
    Description: Continuous variable quantum states of light are used in quantum information protocols and quantum metrology and known to degrade with loss and added noise. We were able to show the distribution of bright polarization squeezed quantum states of light through an urban free-space channel of 1.6 km length. To measure the squeezed states in this extreme environment, we utilize polarization encoding and a postselection protocol that is taking into account classical side information stemming from the distribution of transmission values. The successful distribution of continuous variable squeezed states is accentuated by a quantum state tomography, allowing for determining the purity of the state.
    Subject(s): Quantum Physics;
    ISSN: 0031-9007
    E-ISSN: 1079-7114
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  • 7
    In: Movement Disorders, September 2013, Vol.28(10), pp.1435-1438
    Description: Byline: Sandra Roeske, Ina Filla, Stefan Heim, Katrin Amunts, Christoph Helmstaedter, Ullrich Wullner, Michael Wagner, Thomas Klockgether, Martina Minnerop Keywords: SCA3; ataxia; cognition; follow-up; cerebellum ABSTRACT Background Although it is well established that there is cognitive dysfunction in spinocerebellar ataxia type 3 (SCA3), it is unknown whether cognition deteriorates with disease progression. We therefore prospectively studied cognitive function in patients with SCA3. Methods Eleven patients with SCA3 were assessed using an extensive neuropsychological test battery and retested after 3.5[+ or -]0.4 years. Results In addition to ataxia and motor control, verbal learning and verbal and figural memory deteriorated significantly during the follow-up period. An increase in depressive symptoms was not observed. Conclusions The observation that memory and learning abilities deteriorated with disease progression suggests that cognitive dysfunction is an integral part of SCA3. Because the applied tests for memory function did not require motor responses, cognitive decline cannot be attributed to progressive cerebellar ataxia. The deterioration of verbal and figural memory can be explained either by extracerebellar pathology or by disruption of cerebellar-cerebral circuitries. [c] 2013 International Parkinson and Movement Disorder Society Article Note: Funding agencies: Data acquisition for this study at baseline was part of a project supported by the Deutsche Forschungs-Gemeinschaft (DFG, WU184/3-1) and BMBF (BICW 01 GO 0515). Data aquisition at follow-up was funded in part by the Maria von Linden-Support Programme of the University of Bonn, Germany (to M.M.). Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
    Subject(s): Sca3 ; Ataxia ; Cognition ; Follow‐Up ; Cerebellum
    ISSN: 0885-3185
    E-ISSN: 1531-8257
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  • 8
    In: Movement Disorders, January 2014, Vol.29(1), pp.157-158
    Description: Byline: Sandra Roeske, Ina Filla, Stefan Heim, Katrin Amunts, Christoph Helmstaedter, Ullrich Wullner, Michael Wagner, Thomas Klockgether, Martina Minnerop ***** No abstract is available for this article. ***** Article Note: Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.
    Subject(s): Cognitive Disorders;
    ISSN: 0885-3185
    E-ISSN: 1531-8257
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  • 9
    Language: English
    In: PLoS ONE, 2012, Vol.7(7), p.e40159
    Description: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. ; Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase ( rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and treatment outcome were analysed. rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response genotypes (15% difference in SVR for rs10877012 genotype AA . CC, p = 0.02, OR = 1.52, 95% CI = 1.061–2.188), but not in patients with favourable genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D〈20 ng/mL) during all seasons, but 25(OH)D serum levels were not associated with treatment outcome. ; Our study suggests a role of bioactive vitamin D (1,25[OH]D, calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D is not a suitable predictor of treatment outcome.
    Subject(s): Research Article ; Biology ; Medicine ; Genetics And Genomics ; Immunology ; Gastroenterology And Hepatology
    E-ISSN: 1932-6203
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  • 10
    Language: English
    In: PloS one, 01 January 2015, Vol.10(11), p.e0143293
    Description: Sleep disturbance is associated with the development of obesity, diabetes and hepatic steatosis in murine models. Hepatic triglyceride accumulation oscillates in a circadian rhythm regulated by clock genes, light-dark cycle and feeding time in mice. The role of the sleep-wake cycle in the pathogenesis of human non-alcoholic fatty liver disease (NAFLD) is indeterminate. We sought to detail sleep characteristics, daytime sleepiness and meal times in relation to disease severity in patients with NAFLD.Basic Sleep duration and latency, daytime sleepiness (Epworth sleepiness scale), Pittsburgh sleep quality index, positive and negative affect scale, Munich Chronotype Questionnaire and an eating habit questionnaire were assessed in 46 patients with biopsy-proven NAFLD and 22 healthy controls, and correlated with biochemical and histological parameters.In NAFLD compared to healthy controls, time to fall asleep was vastly prolonged (26.9 vs. 9.8 min., p = 0.0176) and sleep duration was...
    Subject(s): Sciences (General)
    E-ISSN: 1932-6203
    Source: Directory of Open Access Journals (DOAJ)
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