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  • 1
    Article
    Article
    2014
    ISSN: 0143-781X 
    Language: English
    In: History of political thought, 2014-01-01, Vol.35 (4), p.595-631
    Description: The aim of this paper is to demonstrate how the divide between systematic and historical approaches in political philosophy can be overcome. To this end I use the contemporary debate on cosmopolitanism and show that Plato already gave a philosophical answer to its central beliefs. Since this is meant to be a historical claim I argue (1) that the question of how Plato reacts to the cosmopolitan challenge is not new but one already posed by Plato's contemporaries, (2) that Plato reacted to changing constitutional situations and to the cosmopolitan challenges of the early Sophists through systematic and historical political philosophy. In a more detailed interpretation of the Politeia I show (3) how Plato constructs his dialogue to silence his opponents and make room for something else, namely philosophy. Reading Plato in this way does not offer solutions but instead urges us to reconsider philosophical beliefs.
    Subject(s): Ancient Cosmopolitanism ; Ancient Greece ; Ancient Greek Philosophy ; Beliefs ; Constitution ; Contemporary Cosmopolitanism ; Cosmopolitanism ; Fourth Century ; Global justice ; Greece ; Justice ; Liberalism ; Metaphysics ; Philosophy ; Plato's Letters ; Platonism ; Political Philosophy ; Political science ; Political thought ; Socrates ; Socratic philosophy ; Sophistry ; Soul ; The Republic ; Xenophon
    ISSN: 0143-781X
    E-ISSN: 2051-2988
    Source: International Bibliography of the Social Sciences (IBSS)
    Source: JSTOR Arts & Sciences XV
    Source: Get It Now
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  • 2
    Book
    Book
    2017
    ISBN: 9783319687919  ISBN: 3319687913 
    Language: English
    Description: This book includes the post-conference proceedings of the 20th RoboCup International Symposium, held in Leipzig, Germany, in July 2016. In addition to the 38 contributions to the symposium, selected from 63 submissions, the book also contains 15 champion papers of teams winning individual leagues of the RoboCup 2016 competition, the Amazon Picking Challenge, and the Harting Open Source Award. The papers present current research in the fields of robotics and artificial intelligence with a special focus to robot hardware and software, environment perception, action planning and control, robot learning, multi-robot systems, and human-robot interaction.
    ISBN: 9783319687919
    ISBN: 3319687913
    Source: Springer Lecture Notes in Computer Science eBooks
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  • 3
    Book
    Book
    2010
    ISBN: 0754674681  ISBN: 9780754674689 
    Language: English
    In: The concept of law from a transnational perspective, 2010
    Description: This book brings together the fruits of different traditions in legal philosophy and draws on them to develop a systematic thesis on the concept of law. The work uses a legal model to explore the underlying question of how the current phenomena of transnational law are best understood, in combination with an examination of the traditions of Jürgen Habermas's critical theory and H.L.A. Hart's analytic jurisprudence. This leads the author to conclude that the key to a fruitful dialogue and comprehensive understanding is to appreciate that the concept of law is not state-cantered and must reflect relationships to other legal systems.
    Subject(s): Conceptualization ; Critical theory ; International law ; Jurisprudence ; Jurisprudence & Philosophy of Law ; Law ; Legal systems ; Models ; Philosophy ; Philosophy of law ; Political Philosophy ; Political Theory ; Socio-Legal Studies ; Transnationalism
    ISBN: 0754674681
    ISBN: 9780754674689
    Source: eBook Academic Collection - Worldwide
    Source: International Bibliography of the Social Sciences (IBSS)
    Source: Ebook Central - Academic Complete
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  • 4
    Language: English
    In: Diabetes care, 2017-12-26, Vol.41 (3), p.620-622
    Description: To describe the changes in serum levels of calcitonin in liraglutide- and placebo-treated patients in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial over a 3.5-5-year period. Patients ( = 9,340) with type 2 diabetes and high risk for cardiovascular events were randomized 1:1 to liraglutide or placebo. We analyzed calcitonin levels throughout the trial, and thyroid and C-cell adverse events and neoplasms. At 36 months, patients randomized to liraglutide versus placebo showed no evidence of increase in calcitonin concentrations in male (estimated treatment ratio [ETR] 1.03 [95% CI 1.00, 1.06]; 0.068) and female (ETR 1.00 [95% CI 0.97, 1.02]; 0.671) subgroups. There were no episodes of C-cell hyperplasia or medullary thyroid carcinoma in liraglutide-treated patients. There was no evidence of a difference in calcitonin concentrations between the liraglutide and placebo groups, and no C-cell malignancies occurred in the liraglutide group.
    Subject(s): Calcitonin ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Clinical trials ; Complications and side effects ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Evaluation ; Health risks ; Hyperplasia ; Malignancy ; Neoplasms ; Patients ; Randomization ; Research design ; Risk factors ; Serum levels ; Subgroups ; Thyroid ; Thyroid carcinoma ; Type 2 diabetes
    ISSN: 0149-5992
    E-ISSN: 1935-5548
    Source: HighWire Press (Free Journals)
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  • 5
    Language: English
    In: Journal of the American College of Cardiology, 2010-05-11, Vol.55 (19), p.2062-2076
    Description: Our purpose was to assess the diagnostic utility of mid-regional pro-atrial natriuretic peptide (MR-proANP) for the diagnosis of acute heart failure (AHF) and the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with AHF. There are some caveats and limitations to natriuretic peptide testing in the acute dyspneic patient. The BACH (Biomarkers in Acute Heart Failure) trial was a prospective, 15-center, international study of 1,641 patients presenting to the emergency department with dyspnea. A noninferiority test of MR-proANP versus B-type natriuretic peptide (BNP) for diagnosis of AHF and a superiority test of MR-proADM versus BNP for 90-day survival were conducted. Other end points were exploratory. MR-proANP (〉 or =120 pmol/l) proved noninferior to BNP (〉 or =100 pg/ml) for the diagnosis of AHF (accuracy difference 0.9%). In tests of secondary diagnostic objectives, MR-proANP levels added to the utility of BNP levels in patients with intermediate BNP values and with obesity but not in renal insufficiency, the elderly, or patients with edema. Using cut-off values from receiver-operating characteristic analysis, the accuracy to predict 90-day survival of heart failure patients was 73% (95% confidence interval: 70% to 77%) for MR-proADM and 62% (95% confidence interval: 58% to 66%) for BNP (difference p 〈 0.001). In adjusted multivariable Cox regression, MR-proADM, but not BNP, carried independent prognostic value (p 〈 0.001). Results were consistent using NT-proBNP instead of BNP (p 〈 0.001). None of the biomarkers was able to predict rehospitalization or visits to the emergency department with clinical relevance. MR-proANP is as useful as BNP for AHF diagnosis in dyspneic patients and may provide additional clinical utility when BNP is difficult to interpret. MR-proADM identifies patients with high 90-day mortality risk and adds prognostic value to BNP. (Biomarkers in Acute Heart Failure [BACH]; NCT00537628).
    Subject(s): Abridged Index Medicus ; Adrenomedullin - blood ; Adult ; Age ; Aged ; Aged, 80 and over ; Atrial Natriuretic Factor - blood ; Automation ; Biomarkers ; Biomarkers - blood ; Dyspnea - blood ; Dyspnea - etiology ; Family medical history ; Female ; Heart attacks ; Heart failure ; Heart Failure - blood ; Heart Failure - complications ; Heart Failure - diagnosis ; Humans ; Male ; Medical prognosis ; Middle Aged ; Mortality ; Patients ; Peptides ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Reproducibility of Results
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Source: Alma/SFX Local Collection
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  • 6
    Language: English
    In: The New England journal of medicine, 2017-07-13, Vol.377 (2), p.122-131
    Description: In this trial, the addition of pertuzumab to trastuzumab and chemotherapy in early-stage HER2-positive breast cancer improved the rate of invasive-disease–free survival at the cost of an increase in diarrhea incidence.
    Subject(s): Abridged Index Medicus ; Adult ; Aged ; Antibodies, Monoclonal, Humanized - adverse effects ; Antibodies, Monoclonal, Humanized - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - mortality ; Breast Neoplasms - surgery ; Cancer therapies ; CHEMOTHERAPY ; Chemotherapy, Adjuvant ; Complications and side effects ; Death ; Diarrhea ; Diarrhea - chemically induced ; Disease-Free Survival ; Dosage and administration ; Double-Blind Method ; Drug therapy ; EFFICACY ; Epidermal growth factor ; ErbB-2 protein ; Female ; Heart Failure - chemically induced ; Humans ; Immunotherapy ; Invasiveness ; Metastases ; Middle Aged ; Monoclonal antibodies ; Neutropenia ; Oncology ; Patient outcomes ; Patients ; Pertuzumab ; Pharmaceuticals ; PLUS DOCETAXEL ; Receptor, ErbB-2 - analysis ; Risk factors ; Survival ; Survival Rate ; Targeted cancer therapy ; Trastuzumab ; Trastuzumab - adverse effects ; Trastuzumab - therapeutic use ; Tumors
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 7
    Book
    Book
    2013
    ISBN: 9780521897877  ISBN: 0521897874 
    Language: English
    Description: Quantum computation and information is one of the most exciting developments in science and technology of the last twenty years. To achieve large scale quantum computers and communication networks it is essential not only to overcome noise in stored quantum information, but also in general faulty quantum operations. Scalable quantum computers require a far-reaching theory of fault-tolerant quantum computation. This comprehensive text, written by leading experts in the field, focuses on quantum error correction and thoroughly covers the theory as well as experimental and practical issues. The book is not limited to a single approach, but reviews many different methods to control quantum errors, including topological codes, dynamical decoupling and decoherence-free subspaces. Basic subjects as well as advanced theory and a survey of topics from cutting-edge research make this book invaluable both as a pedagogical introduction at the graduate level and as a reference for experts in quantum information science.
    Subject(s): Error-correcting codes (Information theory) ; Quantum computers
    ISBN: 9780521897877
    ISBN: 0521897874
    Source: Cambridge Core All Books
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  • 8
    Book
    Book
    2016
    ISBN: 1118777328  ISBN: 9781118777329  ISBN: 1118777360  ISBN: 9781118777367 
    Language: English
    Description: This unique textbook deals with the variations in the causes, presentations and treatment of neurological disease throughout human populations. International Neurology is an indispensable guide to the full range of neurological conditions you will see in your ever-changing patient population. Comprehensive coverage of neurological diseases and disorders with a clinical approach to diagnosis, treatment and management Truly international authorship distils expert knowledge from around the world Succinct, bite-sized, templated chapters allow for rapid clinical referral Further reading recommendations for each chapter guide readers requiring more depth of information Endorsed by the World Federation of Neurology
    Subject(s): Diseases ; Nervous system ; Neurology
    ISBN: 1118777328
    ISBN: 9781118777329
    ISBN: 1118777360
    ISBN: 9781118777367
    Source: Wiley Online Library UBCM All Obooks
    Source: Ebook Central - Academic Complete
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  • 9
    Language: English
    In: The New England journal of medicine, 2019-11-07, Vol.381 (19), p.1820-1830
    Description: In a randomized trial, 1905 patients with left main coronary artery disease were assigned to either percutaneous coronary intervention (PCI) or coronary-artery bypass grafting (CABG). At 5 years, the rates of the composite of death, stroke, or myocardial infarction were not significantly different between the two groups.
    Subject(s): Abridged Index Medicus ; Aged ; Biomarkers ; Cardiovascular disease ; Care and treatment ; Cerebral infarction ; Chromium ; Cobalt ; Comparative analysis ; Coronary artery ; Coronary Artery Bypass ; Coronary Artery Disease - mortality ; Coronary Artery Disease - surgery ; Coronary Artery Disease - therapy ; Coronary heart disease ; Coronary vessels ; Death ; Drug delivery ; Drug-Eluting Stents ; Everolimus - administration & dosage ; Female ; General & Internal Medicine ; Heart attacks ; Heart diseases ; Humans ; Implants ; Ischemia ; Laboratories ; Life Sciences & Biomedicine ; Male ; Manuscripts ; Medicine, General & Internal ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - epidemiology ; Myocardial Ischemia - therapy ; Odds Ratio ; Patient outcomes ; Percutaneous Coronary Intervention ; Science & Technology ; Stents ; Stroke ; Stroke - epidemiology
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Web of Science - Science Citation Index Expanded - 2019〈img src="http://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /〉
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 10
    Language: English
    In: BJOG : an international journal of obstetrics and gynaecology, 2012-06, Vol.119 (7), p.778-787
    Description: Please cite this paper as: Kleinrouweler C, Wiegerinck M, Ris-Stalpers C, Bossuyt P, van der Post J, von Dadelszen P, Mol B, Pajkrt E, for the EBM CONNECT Collaboration. Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis. BJOG 2012;119:778787. Background Biomarkers have been proposed for identification of women at increased risk of developing pre-eclampsia. Objectives To investigate the capacity of circulating placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin (sENG) to predict pre-eclampsia. Search strategy Medline and Embase through October 2010 and reference lists of reviews, without constraints. Selection criteria We included original publications on testing of PlGF, VEGF, sFLT1 and sENG in serum or plasma of pregnant women at 〈30 weeks of gestation and before clinical onset of pre-eclampsia. Data collection and analysis Two reviewers independently identified eligible studies, extracted descriptive and test accuracy data and assessed methodological quality. Summary estimates of discriminatory performance were obtained. Main results We included 34 studies. Concentrations of PlGF (27 studies) and VEGF (three studies) were lower in women who developed pre-eclampsia: standardised mean differences (SMD) -0.56 (95% CI -0.77 to -0.35) and -1.25 (95% CI -2.73 to 0.23). Concentrations of sFLT1 (19 studies) and sENG (ten studies) were higher: SMD 0.48 (95% CI 0.210.75) and SMD 0.54 (95% CI 0.240.84). The summary diagnostic odds ratios were: PlGF 9.0 (95% CI 5.614.5), sFLT1 6.6 (95% CI 3.113.7), sENG 4.2 (95% CI 2.47.2), which correspond to sensitivities of 32%, 26% and 18%, respectively, for a 5% false-positive rate. Authors conclusions PlGF, sFLT1 and sENG showed modest but significantly different concentrations before 30 weeks of gestation in women who developed pre-eclampsia. Test accuracies of all four markers, however, are too poor for accurate prediction of pre-eclampsia in clinical practice
    Subject(s): Abridged Index Medicus ; Antigens, CD - blood ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Diseases of mother, fetus and pregnancy ; Endoglin ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Odds Ratio ; Placenta Growth Factor ; placental growth factor ; pre-eclampsia ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Preeclampsia ; Pregnancy ; Pregnancy Proteins - blood ; Pregnancy. Fetus. Placenta ; Receptors, Cell Surface - blood ; Risk factors ; Sensitivity and Specificity ; soluble endoglin ; soluble fms-like tyrosine kinase-1 ; Systematic review ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor Receptor-1 - blood ; Vascular Endothelial Growth Factors - blood
    ISSN: 1470-0328
    E-ISSN: 1471-0528
    Source: Wiley Online Library All Backfiles
    Source: Wiley Online Library All Journals
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