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  • 1
    Language: English
    In: The New England journal of medicine, 2020-02-20, Vol.382 (8), p.727-733
    Description: The authors report the emergence and isolation of a previously unknown betacoronavirus, the seventh member of the family of coronaviruses that infect humans, in Wuhan, China. Findings in three patients are described.
    Subject(s): Abridged Index Medicus ; Adult ; Bacterial pneumonia ; Betacoronavirus - genetics ; Betacoronavirus - isolation & purification ; Betacoronavirus - ultrastructure ; Bronchoalveolar lavage ; Bronchoalveolar Lavage Fluid - virology ; Care and treatment ; Causes and theories of causation ; Cell culture ; Cells, Cultured ; China ; Cloning ; Coronaviridae ; Coronavirus Infections - diagnostic imaging ; Coronavirus Infections - pathology ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Critical Care ; Diagnosis ; Diagnostics ; Disease ; Diseases ; Emergency Medicine ; Epidemics ; Epidemiologic methods ; Epithelial cells ; Epithelial Cells - pathology ; Epithelial Cells - virology ; Female ; Fever ; Genome, Viral ; Genomes ; Global Health ; Health aspects ; Hospital patients ; Hospitals ; Humans ; Identification and classification ; Illnesses ; Infectious Disease ; Infectious diseases ; Lavage ; Lung - diagnostic imaging ; Lung - pathology ; Lung - virology ; Male ; Medical examination ; Methods ; Microscopy, Electron, Transmission ; Middle Aged ; Original ; Pathogens ; Patients ; Phylogeny ; Physiological aspects ; Pneumonia ; Pneumonia, Viral - diagnostic imaging ; Pneumonia, Viral - pathology ; Pneumonia, Viral - virology ; Pulmonary ; Radiography, Thoracic ; Respiratory diseases ; Respiratory System - pathology ; Respiratory System - virology ; Sarbecovirus ; SARS-CoV-2 ; Seafood ; Transmission electron microscopy ; Usage ; Viral Infections ; Viruses
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 2
    Language: English
    In: Nature communications, 2019-01-08, Vol.10 (1), p.73-73
    Description: Aluminum is a naturally abundant, trivalent charge carrier with high theoretical specific capacity and volumetric energy density, rendering aluminum-ion batteries a technology of choice for future large-scale energy storage. However, the frequent collapse of the host structure of the cathode materials and sluggish kinetics of aluminum ion diffusion have thus far hampered the realization of practical battery devices. Here, we synthesize AlxMnO2 center dot nH(2)O by an in-situ electrochemical transformation reaction to be used as a cathode material for an aluminum-ion battery with a configuration of Al/Al(OTF)(3)-H2O/AlxMnO2 center dot nH(2)O. This cell is not only based on aqueous electrolyte chemistry but also delivers a high specific capacity of 467 mAh g(-1) and a record high energy density of 481 Wh kg(-1). The high safety of aqueous electrolyte, facile cell assembly and the low cost of materials suggest that this aqueous aluminum-ion battery holds promise for large-scale energy applications.
    Subject(s): Aluminum ; Aluminum-ion batteries ; Aqueous electrolytes ; Batteries ; Cathodes ; Chemical synthesis ; Current carriers ; Electrochemistry ; Electrode materials ; Electrolytes ; ENERGY STORAGE ; Flux density ; Ion diffusion ; Kinetics ; Lithium ; Manganese ; Manganese oxides ; Materials selection ; Multidisciplinary Sciences ; Organic chemistry ; Reaction kinetics ; Rechargeable batteries ; Science & Technology ; Science & Technology - Other Topics ; Specific capacity ; Storage batteries ; Transformation
    ISSN: 2041-1723
    E-ISSN: 2041-1723
    Source: Nature Open Access
    Source: Web of Science - Science Citation Index Expanded - 2019〈img src="http://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /〉
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 3
    Language: English
    In: International journal of mechanical engineering education, 2022-01, Vol.50 (1), p.78-88
    Description: The content of noise, vibration, and harshness is an important part of the undergraduate mechanical engineering program education to prepare students ready for their future career, and it has received great attention from educators. Since course content in noise, vibration, and harshness usually requires more mathematical background knowledge and skills such as problem-solving in differential equations and linear algebra, students at the undergraduate level usually experience difficulty in the problem-solving work in noise, vibration, and harshness, though they have already completed the pre-requisite mathematics courses. In this paper, a new schedule and course content design for noise and vibration courses are introduced. By embedding active learning and design during projects, the students were able to obtain a better understanding of the concept of acoustics and vibration, as well as applying the knowledge from lectures to labs so they can connect the learning to real-world applications. Four projects are introduced and explained. To evaluate the effectiveness of the course, student outcomes are assessed and discussed.
    ISSN: 0306-4190
    E-ISSN: 2050-4586
    Source: Get It Now
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  • 4
    Language: English
    In: Nature communications, 2020-08-06, Vol.11 (1), p.3910-3910
    Description: SARS-CoV-2, a β-coronavirus, has rapidly spread across the world, highlighting its high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly understood. Here, we characterize the replication dynamics, cell tropism and morphogenesis of SARS-CoV-2 in organotypic human airway epithelial (HAE) cultures. SARS-CoV-2 replicates efficiently and infects both ciliated and secretory cells in HAE cultures. In comparison, HCoV-NL63 replicates to lower titers and is only detected in ciliated cells. SARS-CoV-2 shows a similar morphogenetic process as other coronaviruses but causes plaque-like cytopathic effects in HAE cultures. Cell fusion, apoptosis, destruction of epithelium integrity, cilium shrinking and beaded changes are observed in the plaque regions. Taken together, our results provide important insights into SARS-CoV-2 cell tropism, replication and morphogenesis.
    Subject(s): Apoptosis ; Betacoronavirus - pathogenicity ; Betacoronavirus - physiology ; Cell fusion ; Cell Line ; Cells, Cultured ; Coronaviridae ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Cytopathogenic Effect, Viral ; Electrical resistivity ; Epithelial cells ; Epithelial Cells - pathology ; Epithelial Cells - virology ; Epithelium ; Humans ; Morphogenesis ; Morphogenesis - physiology ; Pandemics ; Pathogenesis ; Pneumonia, Viral - virology ; Replication ; Respiratory System - pathology ; Respiratory System - virology ; Respiratory tract ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Tropism ; Viral diseases ; Viral infection ; Virus Replication
    ISSN: 2041-1723
    E-ISSN: 2041-1723
    Source: Nature Open Access
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 5
    Language: English
    In: Nature communications, 2015-11-16, Vol.6 (1), p.8914-8914
    Description: Extensive efforts have been expended in developing hybrid quantum systems to overcome the short coherence time of superconducting circuits by introducing the naturally long-lived spin degree of freedom. Among all the possible materials, single-crystal yttrium iron garnet has shown up recently as a promising candidate for hybrid systems, and various highly coherent interactions, including strong and even ultrastrong coupling, have been demonstrated. One distinct advantage in these systems is that spins form well-defined magnon modes, which allows flexible and precise tuning. Here we demonstrate that by dissipation engineering, a non-Markovian interaction dynamics between the magnon and the microwave cavity photon can be achieved. Such a process enables us to build a magnon gradient memory to store information in the magnon dark modes, which decouple from the microwave cavity and thus preserve a long lifetime. Our findings provide a promising approach for developing long-lifetime, multimode quantum memories.
    Subject(s): Coherence length ; Hybrid systems ; Magnons ; Markov processes ; Single crystals ; Yttrium ; Yttrium-iron garnet
    ISSN: 2041-1723
    E-ISSN: 2041-1723
    E-ISSN: 2331-8422
    Source: Nature Open Access
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
    Source: ProQuest Central
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  • 6
    Language: English
    In: Physical review letters, 2016-09-16, Vol.117 (12), p.123605-123605
    Description: Magnons in ferrimagnetic insulators such as yttrium iron garnet (YIG) have recently emerged as promising candidates for coherent information processing in microwave circuits. Here we demonstrate optical whispering gallery modes of a YIG sphere interrogated by a silicon nitride photonic waveguide, with quality factors approaching 10^{6} in the telecom c band after surface treatments. Moreover, in contrast to conventional Faraday setups, this implement allows an input photon polarized colinearly to the magnetization to be scattered to a sideband mode of orthogonal polarization. This Brillouin scattering process is enhanced through triply resonant magnon, pump, and signal photon modes within an "optomagnonic cavity." Our results show the potential use of magnons for mediating microwave-to-optical carrier conversion.
    Subject(s): C band ; Data processing ; Ferrimagnetism ; Galleries ; Insulators ; Magnetization ; Magnons ; Microwave circuits ; Photonics ; Photons ; Sidebands ; Signal processing ; Silicon nitride ; Spin waves ; Whispering gallery modes ; Yttrium ; Yttrium-iron garnet
    ISSN: 0031-9007
    E-ISSN: 1079-7114
    E-ISSN: 2331-8422
    Source: Hellenic Academic Libraries Link
    Source: PROLA - Physical Review Online Archive
    Source: ProQuest Central
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  • 7
    Article
    Article
    2021
    ISSN: 1040-0605 
    Language: English
    In: American journal of physiology. Lung cellular and molecular physiology, 2021-11-01, Vol.321 (5), p.L958-L959
    Subject(s): COVID-19
    ISSN: 1040-0605
    E-ISSN: 1522-1504
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 8
    Language: English
    In: Nature (London), 2020-07, Vol.583 (7818), p.830-833
    Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern . Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for severe acute respiratory syndrome coronavirus (SARS-CoV) . Here we infected transgenic mice that express human ACE2 (hereafter, hACE2 mice) with SARS-CoV-2 and studied the pathogenicity of the virus. We observed weight loss as well as virus replication in the lungs of hACE2 mice infected with SARS-CoV-2. The typical histopathology was interstitial pneumonia with infiltration of considerable numbers of macrophages and lymphocytes into the alveolar interstitium, and the accumulation of macrophages in alveolar cavities. We observed viral antigens in bronchial epithelial cells, macrophages and alveolar epithelia. These phenomena were not found in wild-type mice infected with SARS-CoV-2. Notably, we have confirmed the pathogenicity of SARS-CoV-2 in hACE2 mice. This mouse model of SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutic agents and vaccines, as well as understanding the pathogenesis of COVID-19.
    Subject(s): Analysis ; Angiotensin converting enzyme ; Angiotensin-Converting Enzyme 2 ; Animals ; Antigens, Viral - immunology ; Antigens, Viral - metabolism ; Betacoronavirus - immunology ; Betacoronavirus - metabolism ; Betacoronavirus - pathogenicity ; Bronchi - pathology ; Bronchi - virology ; Coronavirus Infections - immunology ; Coronavirus Infections - pathology ; Coronavirus Infections - virology ; COVID-19 ; Disease Models, Animal ; Epithelial Cells - pathology ; Epithelial Cells - virology ; Female ; Genetic aspects ; Genetically modified mice ; Humans ; Immunoglobulin G - immunology ; Lung - immunology ; Lung - pathology ; Lung - virology ; Lymphocytes - immunology ; Macrophages, Alveolar - immunology ; Macrophages, Alveolar - virology ; Male ; Mice ; Mice, Transgenic ; Pandemics ; Peptidyl-Dipeptidase A - genetics ; Peptidyl-Dipeptidase A - metabolism ; Pneumonia, Viral - immunology ; Pneumonia, Viral - pathology ; Pneumonia, Viral - virology ; Receptors, Complement 3d - genetics ; Receptors, Complement 3d - metabolism ; SARS-CoV-2 ; Transgenes ; Viroids ; Virus Replication ; Weight Loss
    ISSN: 0028-0836
    E-ISSN: 1476-4687
    Source: Get It Now
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  • 9
    Language: English
    In: Chinese medical journal, 2022-01-04, Vol.135 (4), p.488-490
    Description: Activated AMPK can enhance mitophagy by activating unc-51-like autophagy activating kinase 1 (ULK1) and inhibiting the mammalian target of rapamycin (mTOR). [...]AMPK also directly phosphorylates mitochondrial fission factor on Ser155 and Ser172, triggering fission and subsequently mitophagy. Activated AMPK can resist oxidative stress by inducing the expression of antioxidative genes, such as catalase and superoxide dismutase 2, and suppressing the production of NADPH oxidase 4 (NOX4), which is the most abundant NOX isoform in the kidney. [...]AMPK plays various roles in the kidney [Figure 1], and it emerges as a promising therapeutic target, but the safety of its agonists needs to be further validated.
    Subject(s): Adenosine Monophosphate - metabolism ; Adenosine triphosphate ; AMP-Activated Protein Kinases - metabolism ; Autophagy ; Biosynthesis ; Diabetes ; Gene expression ; Glucose ; Homeostasis ; Insulin resistance ; Kidney - metabolism ; Kidney diseases ; Kinases ; Metabolism ; Nephrology ; Oxidation ; Oxidative stress ; Phosphorylation ; Proteins ; Roles
    ISSN: 0366-6999
    E-ISSN: 2542-5641
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 10
    Language: English
    In: Scientific reports, 2014-05-23, Vol.4 (1), p.5046-5046
    Description: Large-scale screening of hundreds or even thousands of crystallization conditions while with low sample consumption is in urgent need, in current structural biology research. Here we describe a fully-automated droplet robot for nanoliter-scale crystallization screening that combines the advantages of both automated robotics technique for protein crystallization screening and the droplet-based microfluidic technique. A semi-contact dispensing method was developed to achieve flexible, programmable and reliable liquid-handling operations for nanoliter-scale protein crystallization experiments. We applied the droplet robot in large-scale screening of crystallization conditions of five soluble proteins and one membrane protein with 35-96 different crystallization conditions, study of volume effects on protein crystallization, and determination of phase diagrams of two proteins. The volume for each droplet reactor is only ca. 4-8 nL. The protein consumption significantly reduces 50-500 fold compared with current crystallization stations.
    Subject(s): Automation ; Crystallization ; Crystallization - methods ; Humans ; Membrane proteins ; Membrane Proteins - chemistry ; Microfluidic Analytical Techniques - instrumentation ; Microfluidic Analytical Techniques - methods ; Models, Molecular ; Protein Conformation ; Protein folding ; Proteins ; Robotics ; Robots ; X-Ray Diffraction
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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