Proceedings of the National Academy of Sciences of the United States of America, 27 March 2018, Vol.115(13), pp.3422-3427
The influence of population size () on natural selection acting on alleles that affect fitness has been understood for almost a century. As declines, genetic drift overwhelms selection and alleles with direct fitness effects are rendered neutral. Often, however, alleles experience so-called indirect selection, meaning they affect not the fitness of an individual but the fitness distribution of its offspring. Some of the best-studied examples of indirect selection include alleles that modify aspects of the genetic system such as recombination and mutation rates. Here, we use analytics, simulations, and experimental populations of to examine the influence of on indirect selection acting on alleles that increase the genomic mutation rate (mutators). Mutators experience indirect selection via genomic associations with beneficial and deleterious mutations they generate. We show that, as declines, indirect selection driven by linked beneficial mutations is overpowered by drift before drift...
Experimental Evolution ; Indirect Selection ; Mutation Rate ; Mutators ; Population Size ; Evolution, Molecular ; Mutation ; Mutation Rate ; Population Density ; Selection, Genetic ; Saccharomyces Cerevisiae -- Genetics ; Saccharomyces Cerevisiae Proteins -- Genetics
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