Acta Paediatrica, January 2015, Vol.104(1), pp.32-37
To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/apa.12828/abstract Byline: Corinna Binder-Heschl, Berndt Urlesberger, Martin Koestenberger, Bernhard Schwaberger,Georg M. Schmolzer, Gerhard Pichler Keywords: Cardiac biomarker; Cardiac output; Cerebral tissue oxygen saturation; N-terminal probrain natriuretic peptide; Preterm neonates Abstract Aim This prospective observational study investigated if N-terminal probrain natriuretic peptide (NT-proBNP), a cardiac biomarker, correlated with cerebral tissue oxygen saturation (crSO2) in preterm infants on their first day of life. Methods Using near infrared spectroscopy (NIRS), crSO.sub.2 was measured on the right forehead of preterm infants for 24 h. We also recorded arterial oxygen saturation (SpO.sub.2) and calculated fractional tissue oxygen extraction (cFTOE) values. At the end of the NIRS measurement, blood was taken to analyse NT-proBNP. Mean values for the 24-h period were calculated for crSO.sub.2, cFTOE, SpO.sub.2 and these values were correlated to NT-proBNP. An echocardiography was performed in all infants during the measurement period. Results We analysed 35 preterm neonates (33 [+ or -] 2 weeks, 1965 [+ or -] 523 g). NIRS measurements started at 3 [+ or -] 1 h and blood samples were taken at 24 [+ or -] 5 h postnatal. Echocardiography showed an open ductus arteriosus in all infants. Mean NT-proBNP was 4978 [+ or -] 3566 pg/mL, crSO.sub.2 was 76 [+ or -] 8%, and cFTOE was 0.20 [+ or -] 0.08. NT-proBNP correlated negatively with crSO.sub.2 (r = -0.75; p [less than or equal to] 0.001) and positively with cFTOE (r = 0.731; p [less than or equal to] 0.001). Conclusion These results emphasise that crSO2 is influenced by cardiac function, in addition to oxygen consumption, arterial oxygen saturation and vascular resistance, and this can be measured by NT-proBNP.
Cardiac Biomarker ; Cardiac Output ; Cerebral Tissue Oxygen Saturation ; N‐Terminal Probrain Natriuretic Peptide ; Preterm Neonates
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