placeholder
and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Document type
Language
Year
  • 1
    Language: English
    In: Allergology international, 2016-04, Vol.65 (2), p.192-198
    Description: Second hand tobacco smoke (SHS) and overweight/obesity are risk factors for asthma and lower airway respiratory symptoms. We investigated whether SHS or overweight/obesity were also associated with allergic or non-allergic rhinitis. Cross-sectional data were obtained during the second SAPALDIA Study. Interviewer administered questionnaires were completed by 8047 participants from 8 communities in Switzerland. Blood was collected from 5841 participants and tested for allergen specific IgE. Allergic rhinitis was defined as nasal symptoms with detectable IgE. Data were analysed by multinomial logistic regression with four outcome categories defined according to the presence or absence of rhinitis and/or atopy. The prevalence of allergic rhinitis was 885 (15.2%) and non-allergic rhinitis 323 (5.5%). The risk of allergic rhinitis was increased in subjects with physician diagnosed asthma (Relative Risk Ratio 6.81; 95%CI 5.39, 8.6), maternal atopy (1.56; 1.27, 1.92) and paternal atopy (1.41; 1.11, 1.79). Older subjects were at lower risk (0.96; 0.95,0.97 per year), as were those raised on a farm (0.64; 0.49,0.84), with older siblings (0.92; 0.86,0.97 per sib) or from rural areas. The risk of non-allergic rhinitis was also increased in subjects with physician diagnosed asthma (4.02; 2.86, 5.67), reduced in males (0.59; 0.46, 0.77), but not associated with upbringing on a farm or older siblings. There were no significant associations of SHS or overweight/obesity with either form of rhinitis. Allergic and non-allergic rhinitis have different risk factors apart from asthma. There are significant regional variations within Switzerland, which are not explained by the factors examined.
    Subject(s): Adult ; Aged ; Allergic rhinitis ; Asthma - complications ; Asthma - epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Immunoglobulin E - immunology ; Male ; Middle Aged ; Non-allergic rhinitis ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Overweight ; Prevalence ; Rhinitis - epidemiology ; Rhinitis - etiology ; Risk Factors ; Second hand smoke ; Switzerland - epidemiology ; Tobacco Smoke Pollution - adverse effects
    ISSN: 1323-8930
    E-ISSN: 1440-1592
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: European journal of applied physiology, 2013-04-06, Vol.113 (8), p.2025-2037
    Description: Impairment of cognitive performance during and after high-altitude climbing has been described in numerous studies and has mostly been attributed to cerebral hypoxia and resulting functional and structural cerebral alterations. To investigate the hypothesis that high-altitude climbing leads to cognitive impairment, we used of neuropsychological tests and measurements of eye movement (EM) performance during different stimulus conditions. The study was conducted in 32 mountaineers participating in an expedition to Muztagh Ata (7,546 m). Neuropsychological tests comprised figural fluency, line bisection, letter and number cancellation, and a modified pegboard task. Saccadic performance was evaluated under three stimulus conditions with varying degrees of cortical involvement: visually guided pro- and anti-saccades, and visuo-visual interaction. Typical saccade parameters (latency, mean sequence, post-saccadic stability, and error rate) were computed off-line. Measurements were taken at a baseline level of 440 m and at altitudes of 4,497, 5,533, 6,265, and again at 440 m. All subjects reached 5,533 m, and 28 reached 6,265 m. The neuropsychological test results did not reveal any cognitive impairment. Complete eye movement recordings for all stimulus conditions were obtained in 24 subjects at baseline and at least two altitudes and in 10 subjects at baseline and all altitudes. Measurements of saccade performances showed no dependence on any altitude-related parameter and were well within normal limits. Our data indicates that acclimatized climbers do not seem to suffer from significant cognitive deficits during or after climbs to altitudes above 7,500 m. We demonstrated that investigation of EMs is feasible during high-altitude expeditions.
    Subject(s): Adult ; Altitude ; Biomedical and Life Sciences ; Biomedicine ; Cognition ; Cognitive function ; Female ; High altitude ; Human Physiology ; Humans ; Hypoxia ; Male ; Middle Aged ; Mountaineering - physiology ; Neuropsychological testing ; Neuropsychological Tests ; Occupational Medicine/Industrial Medicine ; Original Article ; Saccades ; Saccadic eye movement ; Sports Medicine
    ISSN: 1439-6319
    E-ISSN: 1439-6327
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: American journal of respiratory and critical care medicine, 2010, Vol.182 (4), p.562-568
    Description: Quantitative data on ventilation during acclimatization at very high altitude are scant. Therefore, we monitored nocturnal ventilation and oxygen saturation in mountaineers ascending Mt. Muztagh Ata (7,546 m). To investigate whether periodic breathing persists during prolonged stay at very high altitude. A total of 34 mountaineers (median age, 46 yr; 7 women) climbed from 3,750 m within 19-20 days to the summit at 7,546 m. During ascent, repeated nocturnal recordings of calibrated respiratory inductive plethysmography, pulse oximetry, and scores of acute mountain sickness were obtained. Nocturnal oxygen saturation decreased, whereas minute ventilation and the number of periodic breathing cycles increased with increasing altitude. At the highest camp (6,850 m), median nocturnal oxygen saturation, minute ventilation, and the number of periodic breathing cycles were 64%, 11.3 L/min, and 132.3 cycles/h. Repeated recordings within 5-8 days at 4,497 m and 5,533 m, respectively, revealed increased oxygen saturation, but no decrease in periodic breathing. The number of periodic breathing cycles was positively correlated with days of acclimatization, even when controlled for altitude, oxygen saturation, and other potential confounders, whereas symptoms of acute mountain sickness had no independent effect on periodic breathing. Our field study provides novel data on nocturnal oxygen saturation, breathing patterns, and ventilation at very high altitude. It demonstrates that periodic breathing increases during acclimatization over 2 weeks at altitudes greater than 3,730 m, despite improved oxygen saturation consistent with a progressive increase in loop gain of the respiratory control system. Clinical trial registered with www.clinicaltrials.gov (NCT00514826).
    Subject(s): Abridged Index Medicus ; Acclimatization - physiology ; Adult ; Aged ; Altitude Sickness - complications ; Altitude Sickness - diagnosis ; Altitude Sickness - physiopathology ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; China ; Emergency and intensive respiratory care ; Female ; Humans ; Hypoxia - complications ; Hypoxia - diagnosis ; Hypoxia - physiopathology ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Mountaineering - physiology ; Oximetry - methods ; Oxygen Consumption - physiology ; Plethysmography - methods ; Plethysmography - statistics & numerical data ; Polysomnography - methods ; Polysomnography - statistics & numerical data ; Respiration ; Sleep Apnea, Central - complications ; Sleep Apnea, Central - diagnosis ; Sleep Apnea, Central - physiopathology
    ISSN: 1073-449X
    E-ISSN: 1535-4970
    Source: ProQuest Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: International journal of public health, 2013-08-24, Vol.58 (6), p.949-953
    Description: Objectives To determine reference values for the 1-min sit-to-stand (STS) test in an adult population. Methods Cross-sectional study nested within a nationwide health promotion campaign in Switzerland. Adults performed the STS test and completed questions on demographics and health behavior. Results 6,926 out of 7,753 (89.3 %) adults were able to complete the STS test. The median number of repetitions ranged from 50/min (25–75th percentile 41–57/min) in young men and 47/min (39–55/min) in young women aged 20–24 years to 30/min (25–37/min) in older men and 27/min (22–30/min) in older women aged 75–79 years. Conclusions The reference values support the interpretation of 1-min STS test performance and identification of subjects with decreased lower body muscular strength and endurance.
    Subject(s): Adult ; Adults ; Age Factors ; Aged ; Brief Report ; Cross-Sectional Studies ; Endurance ; Environmental Health ; Female ; Health risk assessment ; Humans ; Interpretation ; Lower body strength ; Male ; Medical screening ; Medicine ; Medicine & Public Health ; Medicine, Preventive ; Middle Aged ; Muscle Strength ; Occupational Medicine/Industrial Medicine ; Personal health ; Physical Endurance ; Physical Fitness ; Physicians (General practice) ; Preventive health services ; Public Health ; Reference Values ; Sit-to-stand test ; Surveys and Questionnaires ; Switzerland - epidemiology ; Young Adult
    ISSN: 1661-8556
    E-ISSN: 1661-8564
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Respiratory research, 2017-01-11, Vol.18 (1), p.13-13
    Description: Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on lung function including body plethysmography. This multicentre, randomised, double-blind, single-dose, cross-over, placebo-controlled study evaluated efficacy and safety of the free combination of indacaterol maleate (IND) and glycopyrronium bromide (GLY) versus IND alone on spirometric and body plethysmography parameters, including inspiratory capacity (IC), forced expiratory volume in 1 s (FEV ), forced vital capacity (FVC), total lung capacity (TLC) and airway resistance (Raw) in moderate-to-severe COPD patients. Seventy-eight patients with FEV % pred. (mean ± SD) 56 ± 13% were randomised. The combination of IND + GLY versus IND presented a numerically higher peak-IC (Δ = 0.076 L, 95% confidence interval [CI]: -0.010 - 0.161 L; p = 0.083), with a statistically significant difference in mean IC over 4 h (Δ = 0.054 L, 95%CI 0.022 - 0.086 L; p = 0.001). FEV , FVC and Raw, but not TLC, were consistently significantly improved by IND + GLY compared to IND alone. Safety profiles of both treatments were comparable. The free combination of IND + GLY improved lung function parameters as evaluated by spirometry and body plethysmography, with a similar safety profile compared to IND alone. NCT01699685.
    Subject(s): Adrenergic beta-2 Receptor Agonists - administration & dosage ; Adult ; Aged ; Aged, 80 and over ; Body plethysmography ; Comparative analysis ; COPD ; Cross-Over Studies ; Diagnosis, Computer-Assisted - methods ; Dosage and administration ; Double-Blind Method ; Drug Combinations ; Drug therapy ; Drug therapy, Combination ; Female ; Glycopyrrolate ; Glycopyrrolate - administration & dosage ; Glycopyrronium ; Health aspects ; Humans ; Indacaterol ; Indans - administration & dosage ; Lung diseases, Obstructive ; Male ; Middle Aged ; Muscarinic Antagonists - administration & dosage ; Placebo Effect ; Plethysmography ; Plethysmography, Whole Body - methods ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - drug therapy ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Quinolones - administration & dosage ; Reproducibility of Results ; Research ; Respiratory agents ; Respiratory Function Tests - methods ; Sensitivity and Specificity ; Spirometry ; Spirometry - methods ; Switzerland ; Treatment Outcome
    ISSN: 1465-993X
    ISSN: 1465-9921
    E-ISSN: 1465-993X
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Archives of ophthalmology (1960), 2010-02-01, Vol.128 (2), p.184-189
    Description: OBJECTIVE To investigate the effect of very high altitude and different ascent profiles on central corneal thickness (CCT). METHODS Twenty-eight healthy mountaineers were randomly assigned to 2 different ascent profiles during a medical research expedition to Mount Muztagh Ata (7546 m) in western China. Group 1 was allotted a shorter acclimatization time prior to ascent to 6265 m. The main outcome measure was CCT. Secondary outcome measures were oxygen saturation (SpO2) and symptom assessments of acute mountain sickness (cerebral acute mountain sickness score). Examinations were performed at 490, 4497, 5533, and 6265 m. RESULTS Central corneal thickness increased in both groups with increasing altitude and decreased after descent. In group 1 (with the shorter acclimatization), mean CCT increased from 537 to 572 μm. Mean CCT in group 2 increased from 534 to 563 μm (P = .048). The amount of decrease in SpO2 paralleled the increase in CCT. There was no significant decrease in visual acuity. There was a significant correlation between CCT and cerebral acute mountain sickness score when controlled for SpO2 and age. CONCLUSIONS Corneal swelling during high-altitude climbs is promoted by low SpO2. Systemic delivery of oxygen to the anterior chamber seems to play a greater role in corneal oxygenation than previously thought. Adhering to a slower ascent profile results in less corneal edema. Visual acuity in healthy corneas is not adversely affected by edema at altitudes of up to 6300 m. Individuals with more acute mountain sickness–related symptoms had thicker corneas, possibly due to their higher overall susceptibility to hypoxia.Arch Ophthalmol. 2010;128(2):184-189--〉
    Subject(s): Abridged Index Medicus ; Acclimatization ; Adult ; Altitude ; Altitude Sickness - physiopathology ; Altitudes ; Atmospheric Pressure ; Biological and medical sciences ; Cornea ; Cornea - diagnostic imaging ; Cornea - metabolism ; Cornea - physiopathology ; Corneal Edema - diagnostic imaging ; Corneal Edema - metabolism ; Corneal Edema - physiopathology ; Female ; Health aspects ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Mountaineering ; Mountaineering - physiology ; Mountaineers ; Ophthalmology ; Oxygen Consumption - physiology ; Physiological aspects ; Prospective Studies ; Research ; Ultrasonography ; Visual Acuity - physiology
    ISSN: 0003-9950
    E-ISSN: 1538-3601
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    Description: Increased pulmonary artery pressure is a well-known phenomenon of hypoxia and is seen in patients with chronic pulmonary diseases, and also in mountaineers on high altitude expedition. Different mediators are known to regulate pulmonary artery vessel tone. However, exact mechanisms are not fully understood and a multimodal process consisting of a whole panel of mediators is supposed to cause pulmonary artery vasoconstriction. We hypothesized that increased hypoxemia is associated with an increase in vasoconstrictive mediators and decrease of vasodilatators leading to a vasoconstrictive net effect. Furthermore, we suggested oxidative stress being partly involved in changement of these parameters. Oxygen saturation (Sao2) and clinical parameters were assessed in 34 volunteers before and during a Swiss research expedition to Mount Muztagh Ata (7549 m) in Western China. Blood samples were taken at four different sites up to an altitude of 6865 m. A mass spectrometry-based targeted metabolomic platform was used to detect multiple parameters, and revealed functional impairment of enzymes that require oxidation-sensitive cofactors. Specifically, the tetrahydrobiopterin (BH4)-dependent enzyme nitric oxide synthase (NOS) showed significantly lower activities (citrulline-to-arginine ratio decreased from baseline median 0.21 to 0.14 at 6265 m), indicating lower NO availability resulting in less vasodilatative activity. Correspondingly, an increase in systemic oxidative stress was found with a significant increase of the percentage of methionine sulfoxide from a median 6% under normoxic condition to a median level of 30% (p〈0.001) in camp 1 at 5533 m. Furthermore, significant increase in vasoconstrictive mediators (e.g., tryptophan, serotonin, and peroxidation-sensitive lipids) were found. During ascent up to 6865 m, significant altitude-dependent changes in multiple vessel-tone modifying mediators with excess in vasoconstrictive metabolites could be demonstrated. These changes, as well as highly significant increase in systemic oxidative stress, may be predictive for increase in acute mountain sickness score and changes in Sao2.
    Subject(s): Clinic for Pneumology ; Medicine & health ; Public Health, Environmental and Occupational Health, Physiology, General Medicine
    ISSN: 1527-0297
    E-ISSN: 1557-8682
    Source: ZORA
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Archives of ophthalmology (1960), 2008-05-01, Vol.126 (5), p.644-650
    Description: OBJECTIVES To determine the incidence of optic disc swelling as a possible indicator of cerebral edema in a large group of healthy mountaineers exposed to very high altitudes and to correlate these findings with various clinical and environmental factors and occurrence of acute mountain sickness and high-altitude cerebral edema. METHODS This multidisciplinary, prospective, observational cohort study was performed in 2005 within the scope of a medical research expedition to Muztagh Ata (7546 m [24 751 ft]) in Western Xinjiang Province, China. Twenty-seven healthy mountaineers aged 26 to 62 years participated. Medical examinations were performed in Switzerland 1 month before and 4½ months after the expedition. Ophthalmologic examinations were performed at 4 high camps (maximum elevation, 6865 m [22 517 ft]). Optic disc status was documented using digital photography. Further assessments included arterial oxygen saturation and cerebral acute mountain sickness scores. RESULTS Sixteen of 27 study subjects (59%) exhibited optic disc swelling during their stay at high altitudes, with complete regression on return to lowlands. Significant correlation was noted between optic disc swelling and lower arterial oxygen saturation (odds ratio, 0.86 per percentage of arterial oxygen saturation; 95% confidence interval, 0.81-0.92; P 〈 .001), younger age (odds ratio, 0.95 per year; 95% confidence interval, 0.90-0.99; P = .03), and higher cerebral acute mountain sickness scores (odds ratio, 2.32 per 0.1 point; 95% confidence interval, 1.48-3.63; P 〈 .001). CONCLUSION Optic disc swelling occurs frequently in high-altitude climbers and is correlated with peripheral oxygen saturation and symptoms of acute mountain sickness. It is most likely the result of hypoxia-induced brain volume increase.Arch Ophthalmol. 2008;126(5):644-650--〉
    Subject(s): Abridged Index Medicus ; Adult ; Altitude Sickness - complications ; Altitude Sickness - physiopathology ; Biological and medical sciences ; Brain Edema - etiology ; Brain Edema - physiopathology ; Female ; Health aspects ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Mountain sickness ; Mountaineering ; Ophthalmology ; Optic Disk - pathology ; Oxygen Consumption ; Papilledema - etiology ; Papilledema - physiopathology ; Prospective Studies ; Research
    ISSN: 0003-9950
    E-ISSN: 1538-3601
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: The European respiratory journal, 2005, Vol.26 (1), p.174-177
    Subject(s): Adult ; Biological and medical sciences ; Biopsy, Needle ; Bronchoscopy ; Coccidiosis - diagnosis ; Coccidiosis - drug therapy ; Cough - physiopathology ; Female ; Follow-Up Studies ; Hoarseness - physiopathology ; Humans ; Immunohistochemistry ; Itraconazole - therapeutic use ; Lymph Nodes - pathology ; Lymphatic Diseases - diagnosis ; Lymphatic Diseases - drug therapy ; Medical sciences ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Pneumology ; Radiography, Thoracic ; Respiratory system : syndromes and miscellaneous diseases ; Risk Assessment ; Severity of Illness Index ; Tomography, X-Ray Computed - methods ; Treatment Outcome ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
    ISSN: 0903-1936
    E-ISSN: 1399-3003
    Source: HighWire Press (Free Journals)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: Japanese
    In: Allergology international, 2016, Vol.65 (2), p.192-198
    Description: [ABSTRACT] Background: Second hand tobacco smoke (SHS) and overweight/obesity are risk factors for asthma and lower airway respiratory symptoms. We investigated whether SHS or overweight/obesity were also associated with allergic or non-allergic rhinitis. Methods: Cross-sectional data were obtained during the second SAPALDIA Study. Interviewer administered questionnaires were completed by 8047 participants from 8 communities in Switzerland. Blood was collected from 5841 participants and tested for allergen specific IgE. Allergic rhinitis was defined as nasal symptoms with detectable IgE. Data were analysed by multinomial logistic regression with four outcome categories defined according to the presence or absence of rhinitis and/or atopy. Results: The prevalence of allergic rhinitis was 885 (15.2%) and non-allergic rhinitis 323 (5.5%). The risk of allergic rhinitis was increased in subjects with physician diagnosed asthma (Relative Risk Ratio 6.81; 95%CI 5.39, 8.6), maternal atopy (1.56; 1.27, 1.92) and paternal atopy (1.41; 1.11, 1.79). Older subjects were at lower risk (0.96; 0.95,0.97 per year), as were those raised on a farm (0.64; 0.49,0.84), with older siblings (0.92; 0.86,0.97 per sib) or from rural areas. The risk of non-allergic rhinitis was also increased in subjects with physician diagnosed asthma (4.02; 2.86, 5.67), reduced in males (0.59; 0.46, 0.77), but not associated with upbringing on a farm or older siblings. There were no significant associations of SHS or overweight/obesity with either form of rhinitis. Conclusions: Allergic and non-allergic rhinitis have different risk factors apart from asthma. There are significant regional variations within Switzerland, which are not explained by the factors examined.
    ISSN: 1323-8930
    E-ISSN: 1440-1592
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...