placeholder
and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Proceed order?

Export
Filter
Language
Year
  • 1
    Book
    Book
    2011
    ISBN: 9781409418450  ISBN: 1409418456  ISBN: 9781409488965  ISBN: 1409488969 
    Language: English
    Description: Extreme floods cause enormous damage in floodplains, which levees cannot prevent. Therefore, it is vital for spatial planning to provide space for water retention in these areas. Land use planners, water management agencies, landowners, and policymakers all agree on this challenge, but attempts to make the space for rivers to provide retention are generally not very successful. Adopting an innovative interdisciplinary approach, this book examines how society can manage the use of the floodplains along rivers in the face of extreme floods, focusing in particular on the relation between social arrangements and the elemental forces of floods. The book firstly analyses why contemporary floodplain management is so often clumsy and ineffective by looking at various real-life situations in Germany, using Cultural Theory to provide a much-needed, but previously neglected social perspective. These analyses show a pattern of activity resulting from different rationalities which dominate the floodplains in different phases. During extreme floods, it is rational to manage floodplains as dangerous areas; sandbags and disaster management dominate the scene. After some time, the rationality of control takes over the floodplain management; policymakers discuss flood risk and water managers build levees. When public attention diminishes, floodplains become inconspicuous until more and more stakeholders regard floodplains as profitable land. The current system of planning, law, and property rights even encourages stakeholders to act out their plural rationalities. A permanent dynamic imbalance of different rationalities leads to a robust social construction of the floodplains which results in viable but clumsy floodplains. In the course of time, however, the patterns of activity in the floodplains lead to an increase in intensity and frequency of extreme floods, and to more vulnerable potential damages in the floodplains. Risk increases. Coping with this situation needs another kind of floodplain management. This book proposes an innovative concept - Large Areas for Temporary Emergency Retention (LATER) - in "Clumsy Floodplains" as an alternative to levee-based flood protection. The concept aims at reducing damage by extreme floods in a catchment area by inundating less valuable areas to protect places that are more valuable. It finally examines how this LATER concept might be implemented in areas where there is currently a clumsy style of floodplain management, what interventions are required and how these might come about effectively. Again, using Cultural Theory, the book puts forward a valuable land policy solution which aims at implementing LATER in clumsy floodplains and which develops an obligatory insurance against natural hazards as a responsive land policy for LATER. The book represents the author's PhD research, which he conducted as research assistant at the department for Land Policy, Land Management and Municipal Geoinformation at the School of Spatial Planning, TU Dortmund University, Germany.
    Subject(s): Environmental Policy ; Planning ; Housing ; Environmental Management ; Storm surges ; Flood damage prevention ; Floodplains ; Floodplain management
    ISBN: 9781409418450
    ISBN: 1409418456
    ISBN: 9781409488965
    ISBN: 1409488969
    Source: Ebook Central - Academic Complete
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Natural hazards (Dordrecht), 2016-08, Vol.83 (1), p.129-147
    Description: This paper compares the inherent notions of justice in four different approaches to flood risk management in Europe. As protection against flood risks becomes increasingly difficult, dilemmas of justice emerge: some benefits from flood protection measures whereas others loose. Decisions on whom to protect differentiate between upstream and downstream or left and right side of a river. This raises a central but barely discussed conflict: what (or rather who) should be protected against inundations? This question deals in essence with justice. Justice concerns questions over fairness in the allocation of resources, capital and wealth across different members of society. There are different and contradicting concepts of justice, which differ in interpretations of fair resource allocation and distributions. ‘What’s the right thing to protect’ is thus a question of concepts of justice. This contribution is not an attempt to answer this fundamental question, but it offers a debate on how different concepts of justice provide different answers. These answers will then be related to flood risk management approaches in England, the Netherlands, Germany, and Austria.
    Subject(s): Policy ; Justice ; Earth Sciences ; Natural Hazards ; Property rights ; Civil Engineering ; Geotechnical Engineering & Applied Earth Sciences ; Geophysics/Geodesy ; Hydrogeology ; Allocation ; Flood risk management ; Distribution ; Environmental Management ; Risk management
    ISSN: 0921-030X
    E-ISSN: 1573-0840
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: JAMA : the journal of the American Medical Association, 2013-10-09, Vol.310 (14), p.1473-1481
    Description: IMPORTANCE The prognosis for patients with pancreatic cancer is poor, even after resection with curative intent. Gemcitabine-based chemotherapy is standard treatment for advanced pancreatic cancer, but its effect on survival in the adjuvant setting has not been demonstrated. OBJECTIVE To analyze whether previously reported improvement in disease-free survival with adjuvant gemcitabine therapy translates into improved overall survival. DESIGN, SETTING, AND PATIENTS CONKO-001 (Charité Onkologie 001), a multicenter, open-label, phase 3 randomized trial to evaluate the efficacy and toxicity of gemcitabine in patients with pancreatic cancer after complete tumor resection. Patients with macroscopically completely removed pancreatic cancer entered the study between July 1998 and December 2004 in 88 hospitals in Germany and Austria. Follow-up ended in September 2012. INTERVENTIONS After stratification for tumor stage, nodal status, and resection status, patients were randomly assigned to either adjuvant gemcitabine treatment (1g/m2 d 1, 8, 15, q 4 weeks) for 6 months or to observation alone. MAIN OUTCOMES AND MEASURES The primary end point was disease-free survival. Secondary end points included treatment safety and overall survival, with overall survival defined as the time from date of randomization to death. Patients lost to follow-up were censored on the date of their last follow-up. RESULTS A total of 368 patients were randomized, and 354 were eligible for intention-to-treat-analysis. By September 2012, 308 patients (87.0% [95% CI, 83.1%-90.1%]) had relapsed and 316 patients (89.3% [95% CI, 85.6%-92.1%]) had died. The median follow-up time was 136 months. The median disease-free survival was 13.4 (95% CI, 11.6-15.3) months in the treatment group compared with 6.7 (95% CI, 6.0-7.5) months in the observation group (hazard ratio, 0.55 [95% CI, 0.44-0.69]; P 〈 .001). Patients randomized to adjuvant gemcitabine treatment had prolonged overall survival compared with those randomized to observation alone (hazard ratio, 0.76 [95% CI, 0.61-0.95]; P = .01), with 5-year overall survival of 20.7% (95% CI, 14.7%-26.6%) vs 10.4% (95% CI, 5.9%-15.0%), respectively, and 10-year overall survival of 12.2% (95% CI, 7.3%-17.2%) vs 7.7% (95% CI, 3.6%-11.8%). CONCLUSIONS AND RELEVANCE Among patients with macroscopic complete removal of pancreatic cancer, the use of adjuvant gemcitabine for 6 months compared with observation alone resulted in increased overall survival as well as disease-free survival. These findings provide strong support for the use of gemcitabine in this setting. TRIAL REGISTRATION isrctn.org Identifier: ISRCTN34802808
    Subject(s): Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Biological and medical sciences ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Medical sciences ; Tumors ; Humans ; Middle Aged ; Pancreatic Neoplasms - surgery ; Neoplasm Recurrence, Local ; Male ; Pancreatic Neoplasms - drug therapy ; Antimetabolites, Antineoplastic - therapeutic use ; Deoxycytidine - therapeutic use ; Antimetabolites, Antineoplastic - adverse effects ; Survival Analysis ; Aged, 80 and over ; Adult ; Deoxycytidine - adverse effects ; Female ; Aged ; Pancreatic Neoplasms - mortality ; Chemotherapy, Adjuvant ; Deoxycytidine - analogs & derivatives ; Care and treatment ; Gemcitabine ; Pancreatic cancer ; Patient outcomes ; Adjuvant treatment ; Dosage and administration ; Research ; Health aspects ; Cancer
    ISSN: 0098-7484
    E-ISSN: 1538-3598
    Source: American Medical Association Journals Backfile (through 1997)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Article
    Article
    2016
    ISSN: 0964-0568 
    Language: English
    In: Journal of environmental planning and management, 2016-02-01, Vol.59 (2), p.360-377
    Description: In response to the extreme flood events of recent decades, the European Union has released the Floods Directive (2007/60/EC), which requires the creation of flood risk management plans. These plans do not yet exist in practice, as water management agencies have until 2015 to put them into action. This contribution will discuss two questions regarding the European flood risk management plan: First, how is the new instrument integrated into the various member states, particularly with respect to the scenario approach? Second, how prepared are the institutions for the collaborative planning paradigm of the flood risk management plan, particularly with respect to the river basin districts approach? Citing examples from France, Germany, the Netherlands, and Great Britain, this paper offers both a pessimistic and an optimistic perspective on the implementation of the new flood risk management instrument.
    Subject(s): land and water management ; floods directive ; European legislation ; governance ; Fluid Flow and Transfer Processes ; Geography, Planning and Development ; Water Science and Technology ; Management, Monitoring, Policy and Law ; Environmental Science(all) ; flood risk-management ; european legislation
    ISSN: 0964-0568
    E-ISSN: 1360-0559
    Source: EconLit with Full Text
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Article
    Article
    2012
    ISSN: 1473-0952 
    Language: English
    In: Planning theory (London, England), 2012-08-01, Vol.11 (3), p.242-256
    Description: In 1973, Horst W Rittel and Malvin A Webber introduced the term 'wicked problem' in planning theory. They describe spatial planning as dealing with inherent uncertainty, complexity and inevitable normativity. This contribution picks up the concept of wicked problems, reflects on it from a planning-theoretical perspective, and proposes the use of Cultural Theory's concept of clumsy solutions as a response to wicked planning problems. In discussing public participation processes in spatial planning, it is then shown what clumsy solutions mean for spatial planning. The four rationalities of Cultural Theory are then used to explain why public participation in planning can become wicked, and how these rationalities provide a response that copes with this wickedness.
    Subject(s): Gentrification ; Rationality ; Fatalism ; Urban planning ; Individualism ; Foresters ; Pluralist school ; Egalitarianism ; Reason ; Normativity ; participation ; complexity ; uncertainty ; polyrationality ; expectation management
    ISSN: 1473-0952
    E-ISSN: 1741-3052
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Journal of Chemical Information and Modeling, 2009-09-28, Vol.49 (9), p.2077-2081
    Description: Up to now, publicly available data sets to build and evaluate Ames mutagenicity prediction tools have been very limited in terms of size and chemical space covered. In this report we describe a new unique public Ames mutagenicity data set comprising about 6500 nonconfidential compounds (available as SMILES strings and SDF) together with their biological activity. Three commercial tools (DEREK, MultiCASE, and an off-the-shelf Bayesian machine learner in Pipeline Pilot) are compared with four noncommercial machine learning implementations (Support Vector Machines, Random Forests, k-Nearest Neighbors, and Gaussian Processes) on the new benchmark data set.
    Subject(s): Computational Chemistry ; Mutagens - chemistry ; Mutagens - toxicity ; Salmonella typhimurium - genetics ; Artificial Intelligence ; Computational Biology ; Benchmarking ; Salmonella typhimurium - drug effects ; Structure-Activity Relationship ; Mutagenicity Tests - methods ; Mutagenicity Tests - standards ; Normal Distribution ; Databases, Factual
    ISSN: 1549-9596
    E-ISSN: 1520-5142
    E-ISSN: 1549-960X
    Source: ACS Publications
    Source: Hellenic Academic Libraries Link
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Article
    Article
    2020
    ISSN: 1664-1078 
    Language: English
    In: Frontiers in psychology, 2020-01-01, Vol.11, p.585437-585437
    Description: The Psychophysics Toolbox (PTB) is one of the most popular toolboxes for the development of experimental paradigms. It is a very powerful library, providing low-level, platform independent access to the devices used in an experiment such as the graphics and the sound card. While this low-level design results in a high degree of flexibility and power, writing paradigms that interface the PTB directly might lead to code that is hard to read, maintain, reuse, and debug. Running an experiment in different facilities or organizations further requires it to work with various setups that differ in the availability of specialized hardware for response collection, triggering, and presentation of auditory stimuli. The Objective Psychophysics Toolbox (o_ptb) provides an intuitive, unified, and clear interface, built on top of the PTB that enables researchers to write readable, clean, and concise code. In addition to presenting the architecture of the o_ptb, the results of a timing accuracy test are presented. Exactly the same MATLAB code was run on two different systems, one of those using the VPixx system. Both systems showed sub-millisecond accuracy.
    Subject(s): fMRI ; open source software ; psychophysics ; MATLAB ; EEG ; MEG
    ISSN: 1664-1078
    E-ISSN: 1664-1078
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Basic & clinical pharmacology & toxicology, 2018-09, Vol.123, p.29-36
    Description: The application of read‐across and in silico tools for regulatory decision‐making has been limited for pharmaceutical compounds to the assessment of genotoxic impurity. In contrast, the broad availability of toxicity data for industrial chemicals has triggered regulatory frameworks for read‐across (e.g. ECHA Read‐Across Assessment Framework), software tools and public databases for an automated process of gap filling in the context of safety assessment. This MiniReview provides an overview of the currently existing in silico and read‐across approaches for chemicals together with recent developments for pharmaceutical compounds in these areas. It also highlights the differences and commonalities in the in silico safety assessment of industrial chemicals and drug candidates. Whereas toxicity data collection and sharing is now common practice for chemicals falling under the European REACH regulation (Registration, Evaluation, Authorisation and Restriction of Chemicals), the biggest hurdle for establishing preclinical safety databases for pharmaceutical compounds is the unwillingness to share proprietary data and lack of published data sets. In a recent consortium approach, thirteen pharmaceutical companies, eleven academic partners and six small to medium size enterprises (SMEs) of the bioinformatics sector joined forces over the last 7 years within the European Innovative Medicines Initiative project eTOX (‘electronic toxicity’) to design and implement a strategy for leveraging these preclinical data for small molecules and sharing them across project partners. The eTOX database has evolved as the largest preclinical toxicity database for drugs and drug candidates and currently contains more than 1900 different chemical structures and more than 8000 in vivo toxicity study data sets. It can be foreseen that the development and application of such databases for drugs or drug candidates will in the future also cross‐fertilize the read‐across and the in silico assessment of industrial or consumer chemicals particularly as soon as human safety data from clinical trials are integrated too.
    Subject(s): Drug Evaluation, Preclinical - methods ; Risk Assessment - methods ; Guidelines as Topic ; Animals ; Drug-Related Side Effects and Adverse Reactions - prevention & control ; Drug Evaluation, Preclinical - standards ; Computer Simulation ; Humans ; Computational Biology ; Software ; Databases, Factual ; Risk Assessment - standards
    ISSN: 1742-7835
    E-ISSN: 1742-7843
    Source: Hellenic Academic Libraries Link
    Source: Academic Search Ultimate
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Book
    Book
    2016
    ISBN: 9781138252028  ISBN: 9781409418450  ISBN: 1409418456  ISBN: 1138252026 
    Language: English
    Description: Extreme floods cause enormous damage in floodplains, which levees cannot prevent. Therefore, it is vital for spatial planning to provide space for water retention in these areas. Land use planners, water management agencies, landowners, and policymakers all agree on this challenge, but attempts to make the space for rivers to provide retention are generally not very successful. Adopting an innovative interdisciplinary approach, this book examines how society can manage the use of the floodplains along rivers in the face of extreme floods, focusing in particular on the relation between social arrangements and the elemental forces of floods. The book firstly analyses why contemporary floodplain management is so often clumsy and ineffective by looking at various real-life situations in Germany, using Cultural Theory to provide a much-needed, but previously neglected social perspective. These analyses show a pattern of activity resulting from different rationalities which dominate the floodplains in different phases. During extreme floods, it is rational to manage floodplains as dangerous areas; sandbags and disaster management dominate the scene. After some time, the rationality of control takes over the floodplain management; policymakers discuss flood risk and water managers build levees. When public attention diminishes, floodplains become inconspicuous until more and more stakeholders regard floodplains as profitable land. The current system of planning, law, and property rights even encourages stakeholders to act out their plural rationalities. A permanent dynamic imbalance of different rationalities leads to a robust social construction of the floodplains which results in viable but clumsy floodplains. In the course of time, however, the patterns of activity in the floodplains lead to an increase in intensity and frequency of extreme floods, and to more vulnerable potential damages in the floodplains. Risk increases. Coping with this situation needs another kind of floodplain management. This book proposes an innovative concept - Large Areas for Temporary Emergency Retention (LATER) - in "Clumsy Floodplains" as an alternative to levee-based flood protection. The concept aims at reducing damage by extreme floods in a catchment area by inundating less valuable areas to protect places that are more valuable. It finally examines how this LATER concept might be implemented in areas where there is currently a clumsy style of floodplain management, what interventions are required and how these might come about effectively. Again, using Cultural Theory, the book puts forward a valuable land policy solution which aims at implementing LATER in clumsy floodplains and which develops an obligatory insurance against natural hazards as a responsive land policy for LATER. The book represents the author's PhD research, which he conducted as research assistant at the department for Land Policy, Land Management and Municipal Geoinformation at the School of Spatial Planning, TU Dortmund University, Germany. Thomas Hartmann, Department Human Geography and Urban and Regional Planning, Faculty for Geosciences, Utrecht University, The Netherlands
    Subject(s): Environmental Policy ; Planning ; Housing ; Environmental Management
    ISBN: 9781138252028
    ISBN: 9781409418450
    ISBN: 1409418456
    ISBN: 1138252026
    Source: Ebook Central - Academic Complete
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: BMC neuroscience, 2009-02-19, Vol.10 (1), p.11-11
    Description: Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference is expressed by differential activation of distributed cortical networks. The analysis was based on a sample of 41 participants: 21 patients with chronic tinnitus and 20 healthy control participants. To investigate the architecture of these networks, we used phase locking analysis in the 1-90 Hz frequency range of a minute of resting-state MEG recording. We found: 1) For tinnitus patients: A significant decrease of inter-areal coupling in the alpha (9-12 Hz) band and an increase of inter-areal coupling in the 48-54 Hz gamma frequency range relative to the control group. 2) For both groups: an inverse relationship (r = -.71) of the alpha and gamma network coupling. 3) A discrimination of 83% between the patient and the control group based on the alpha and gamma networks. 4) An effect of manifestation on the distribution of the gamma network: In patients with a tinnitus history of less than 4 years, the left temporal cortex was predominant in the gamma network whereas in patients with tinnitus duration of more than 4 years, the gamma network was more widely distributed including more frontal and parietal regions. In the here presented data set we found strong support for an alteration of long-range coupling in tinnitus. Long-range coupling in the alpha frequency band was decreased for tinnitus patients while long-range gamma coupling was increased. These changes discriminate well between tinnitus and control participants. We propose a tinnitus model that integrates this finding in the current knowledge about tinnitus. Furthermore we discuss the impact of this finding to tinnitus therapies using Transcranial Magnetic Stimulation (TMS).
    Subject(s): Data Interpretation, Statistical ; Magnetoencephalography ; Alpha Rhythm ; Humans ; Middle Aged ; Male ; Cerebral Cortex - physiopathology ; Transcranial Magnetic Stimulation ; Young Adult ; Temporal Lobe - physiopathology ; Adult ; Female ; Tinnitus - therapy ; Aged ; Models, Neurological ; Chronic Disease ; Nerve Net - physiopathology ; Tinnitus - physiopathology ; Care and treatment ; Causes of ; Tinnitus ; Diagnosis ; Research ; Health aspects ; Magnetic brain stimulation ; Index Medicus
    ISSN: 1471-2202
    E-ISSN: 1471-2202
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...