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  • 1
    Language: English
    In: Clinical chemistry and laboratory medicine, 1998-04-30, Vol.36 (4), p.235-240
    Description: Conventional laboratory investigations of haemostasis like prothrombin time and activated partial thromboplastin time are not useful in predicting and managing intra-operative bleeding complications. In order to establish a possible “perioperative reference range” for thrombin generation prothrombin fragment F1+2 (F1+2) and fibrin degradation (D-dimer) markers, we measured F1+2 and D-dimer concentrations before surgery (but after induction of anaesthesia), 30 minutes into surgery, 10 minutes after the event expected to induce the maximal activation of the haemostatic systems, 90 minutes after surgery and on postoperative days 1 and 2 in 226 consecutive patients. Samples were collected from arterial lines. Twenty patients developed a clinically defined, intraoperative disorder of haemostasis, 206 did not. Patients with an intraoperative disorder of haemostasis had significantly higher preoperative F1+2 and D-dimer concentrations. Preoperative values for F1+2 and D-dimer concentrations above the 75th percentile of patients without an intraoperative disorder of haemostasis indicated a 2.70 to 2.88 fold risk of developing an intraoperative disorder of haemostasis (odds ratios were 3.04, 3.12 and 3.29 for D-dimer, ELISA, F1+2, and D-dimer latex tests, respectively with 95% confidence intervals from 1.20 to 8.46) with negative predictive values of 94%, but positive predictive values of only 16% to 26%. These data suggest that preoperative determination of molecular markers might be helpful in identifying a group of patients at high risk for intraoperative disorder of haemostasis by exclusion of low risk patients. Validation of such an approach requires a prospective trial.
    Subject(s): Blood coagulation ; Biological and medical sciences ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Blood Loss, Surgical - prevention & control ; Intraoperative Complications - blood ; Blood Coagulation Disorders - prevention & control ; Fibrin Fibrinogen Degradation Products - metabolism ; Blood Coagulation Disorders - etiology ; Humans ; Middle Aged ; Risk Factors ; Intraoperative Complications - prevention & control ; Male ; Biomarkers - blood ; Hemostasis ; Intraoperative Complications - etiology ; Blood Coagulation ; Peptide Fragments - blood ; Aged, 80 and over ; Blood Coagulation Disorders - blood ; Adult ; Female ; Aged ; Prothrombin - metabolism
    ISSN: 1434-6621
    E-ISSN: 1437-4331
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: The American journal of clinical nutrition, 2015, Vol.102 (4), p.837-47
    Description: Background: It is well known that fish is the major natural source of vitamin D in the diet; therefore, this meta-analysis investigated the influence of fish consumption in randomized controlled trials (RCTs) on serum 25-hydroxyvitamin D [25(OH)D] concentrations. Objective: A literature search was carried out in Medline, Embase, Web of Science, and the Cochrane Library (up to February 2014) for RCTs that investigated the effect of fish consumption on 25(OH)D concentrations in comparison to other dietary interventions. Results: Seven articles and 2 unpublished study data sets with 640 subjects and 14 study groups met the inclusion criteria and were included in this meta-analysis. Compared with controls, the consumption of fish increased 25(OH)D concentrations, on average, by 4.4 nmol/L (95% CI: 1.7, 7.1 nmol/L; P 〉 0.0001, I
    Subject(s): Animals ; Diet ; Vitamin D Deficiency - blood ; Fishes ; Humans ; Risk Factors ; Seafood ; Vitamin D - administration & dosage ; Nutritional Status ; Databases, Factual ; Randomized Controlled Trials as Topic ; Vitamin D - blood ; Vitamin D ; Nutritional aspects ; Calcifediol ; Fish as food ; Alfacalcidol ; Biological control systems ; Observations ; Health aspects ; Abridged Index Medicus ; RISK-FACTORS ; 25-HYDROXYVITAMIN-D ; vitamin D ; meta-analysis ; D DEFICIENCY ; SERUM ; randomized controlled trial ; Näringslära ; LIFE-STYLE ; intervention studies ; HEART-RATE-VARIABILITY ; COLORECTAL-CANCER ; DIETARY REQUIREMENT ; DISEASE ; 25(OH)D ; fish intake ; FATTY FISH ; Nutrition and Dietetics ; CONSUMPTION
    ISSN: 0002-9165
    E-ISSN: 1938-3207
    Source: Alma/SFX Local Collection
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  • 3
    Language: English
    In: Nature communications, 2020-02-11, Vol.11 (1), p.561-12
    Description: Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects has been discussed controversially in recent years. Here we investigate the effect of prenatal paraben exposure on childhood overweight by combining epidemiological data from a mother-child cohort with experimental approaches. Mothers reporting the use of paraben-containing cosmetic products have elevated urinary paraben concentrations. For butyl paraben (BuP) a positive association is observed to overweight within the first eight years of life with a stronger trend in girls. Consistently, maternal BuP exposure of mice induces a higher food intake and weight gain in female offspring. The effect is accompanied by an epigenetic modification in the neuronal Pro-opiomelanocortin (POMC) enhancer 1 leading to a reduced hypothalamic POMC expression. Here we report that maternal paraben exposure may contribute to childhood overweight development by altered POMC-mediated neuronal appetite regulation.
    Subject(s): Parabens - analysis ; Humans ; Child, Preschool ; Male ; Preservatives, Pharmaceutical - analysis ; Overweight - metabolism ; Maternal Exposure - adverse effects ; Female ; Parabens - adverse effects ; Pro-Opiomelanocortin - genetics ; Weight Gain ; Child ; Eating ; Preservatives, Pharmaceutical - adverse effects ; Mice, Inbred C57BL ; Urine - chemistry ; Overweight - genetics ; Overweight - physiopathology ; Prenatal Exposure Delayed Effects - physiopathology ; Prenatal Exposure Delayed Effects - etiology ; Prenatal Exposure Delayed Effects - metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects - genetics ; Pro-Opiomelanocortin - metabolism ; Animals ; Hypothalamus - metabolism ; Overweight - etiology ; Mice ; Endocrine system and metabolic diseases ; Risk factors
    ISSN: 2041-1723
    E-ISSN: 2041-1723
    Source: Nature Open Access
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 4
    Language: English
    In: The journal of clinical endocrinology and metabolism, 2013-11, Vol.98 (11), p.4339-4345
    Description: Background: The bioequivalence of the different forms of vitamin D, ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), has been questioned. Earlier studies have suggested that vitamin D2 is less biologically active than vitamin D3. Objective and Design: In a parallel study, we tested the effects of supplementation with 50-μg/d doses of vitamin D2 or D3 or a placebo over a period of 8 weeks on 25(OH)D2, 25(OH)D3, their sum 25(OH)D (primary outcome variables), and PTH in healthy volunteers applying a double-blind, randomized study design. The study was conducted during the winter of 2012 in Halle (Saale), Germany, at latitude 51°47N, when UVB irradiation is virtually absent. Blood samples for the determinations of vitamin D status and PTH were collected at baseline and after 4 and 8 weeks of supplementation. Results: In the placebo group (n = 19), 25(OH)D3 decreased from 39.4 ± 14.2 to 31.1 ± 12.4 nmol/L after 8 weeks (P 〈 .01). In the vitamin D3 group (n = 42), the concentrations of 25(OH)D3 increased from 41.5 ± 22.8 nmol/L at baseline to 88.0 ± 22.1 nmol/L after 8 weeks (P 〈 .01). In the group receiving vitamin D2 (n = 46), the 25(OH)D2 concentrations increased significantly, whereas the 25(OH)D3 concentration fell from 36.4 ± 13.3 nmol/L at baseline to 16.6 ± 6.3 nmol/L after 8 weeks (P 〈 .01). The total 25(OH)D was not different between the groups at baseline but differed significantly between the groups after 4 and 8 weeks (P 〈 .001). Conclusions: Vitamin D3 increases the total 25(OH)D concentration more than vitamin D2. Vitamin D2 supplementation was associated with a decrease in 25(OH)D3, which can explain the different effect on total 25(OH)D.
    Subject(s): Fundamental and applied biological sciences. Psychology ; Feeding. Feeding behavior ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Biological and medical sciences ; Endocrinopathies ; Medical sciences
    ISSN: 0021-972X
    E-ISSN: 1945-7197
    Source: Oxford Journals A-Z Archive
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  • 5
    Language: English
    In: Journal of allergy and clinical immunology, 2015, Vol.137 (2), p.610-613
    Description: (f) Research Group Genome Organization & Function, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany (h) Children's Hospital, Municipal Hospital "St Georg", Leipzig, Germany
    Subject(s): Allergy and Immunology ; DNA Methylation ; Genome-Wide Association Study ; Disease Susceptibility ; Hypersensitivity - etiology ; Epigenesis, Genetic ; Humans ; Infant ; Risk ; Hypersensitivity - epidemiology ; Odds Ratio ; Infant, Newborn ; Vitamin D - blood ; Allergy ; Epigenetic inheritance ; Vitamin D ; Oncology, Experimental ; Genomics ; Calcifediol ; Research ; Alfacalcidol ; Allergic reaction ; Risk factors ; Cancer ; Abridged Index Medicus
    ISSN: 0091-6749
    E-ISSN: 1097-6825
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 6
    Language: English
    In: European journal of nutrition, 2017-03, Vol.56 (2), p.621-634
    Description: The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D3 for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D3 dose impacts cardiovascular risk markers of adults during the winter months.The study was conducted in Halle (Saale), Germany (51o northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April). A total of 105 apparently healthy subjects (male and female, 20–71 years old) were included. Subjects were randomly allocated to two groups. One group received a daily 20-µg vitamin D3 dose (n = 54), and the other group received a placebo (n = 51) for 12 weeks. Outcome measures included blood pressure, heart rate, concentrations of renin, aldosterone, serum lipids and vascular calcification markers, and haematologic variables such as pro-inflammatory monocytes.Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D3 supplementation, although serum 25-hydroxyvitamin D3 increased from 38 ± 14 to 73 ± 16 nmol/L at week 12. The placebo and vitamin D groups did not differ in their final cardiovascular risk profile.Daily supplementation of 20 µg vitamin D3 during winter is unlikely to change cardiovascular risk profile.
    Subject(s): Vitamin D 3 ; Chemistry ; Nutrition ; Cardiovascular risk ; Adults ; Supplementation ; Monocyte subsets
    ISSN: 1436-6207
    E-ISSN: 1436-6215
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: SPORTDiscus with Full Text
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  • 7
    Language: English
    In: European journal of nutrition, 2017-03, Vol.56 (2), p.621
    Description: The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D dose impacts cardiovascular risk markers of adults during the winter months. The study was conducted in Halle (Saale), Germany (51 northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April). A total of 105 apparently healthy subjects (male and female, 20-71 years old) were included. Subjects were randomly allocated to two groups. One group received a daily 20-µg vitamin D dose (n = 54), and the other group received a placebo (n = 51) for 12 weeks. Outcome measures included blood pressure, heart rate, concentrations of renin, aldosterone, serum lipids and vascular calcification markers, and haematologic variables such as pro-inflammatory monocytes. Blood pressure and systemic cardiovascular risk markers remained unchanged by vitamin D supplementation, although serum 25-hydroxyvitamin D increased from 38 ± 14 to 73 ± 16 nmol/L at week 12. The placebo and vitamin D groups did not differ in their final cardiovascular risk profile. Daily supplementation of 20 µg vitamin D during winter is unlikely to change cardiovascular risk profile.
    Subject(s): Blood Pressure ; Calcifediol - blood ; Double-Blind Method ; Vitamin D Deficiency - complications ; Cardiovascular Diseases - prevention & control ; Humans ; Middle Aged ; Risk Factors ; Male ; Biomarkers - blood ; Cholecalciferol - administration & dosage ; Cardiovascular Diseases - blood ; Placebos ; Adult ; Female ; Aged ; Nutritional Status ; Seasons ; Dietary Supplements ; Germany
    E-ISSN: 1436-6215
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: SPORTDiscus with Full Text
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  • 8
    Language: English
    In: Nephrology, dialysis, transplantation, 2015-05, Vol.30 (suppl_3), p.iii510-iii510
    ISSN: 0931-0509
    E-ISSN: 1460-2385
    Source: Alma/SFX Local Collection
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
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  • 9
    Language: English
    In: European journal of immunology, 2011-09, Vol.41 (9), p.2774-2781
    Description: Coxsackievirus B3 (CVB3)‐infection is a frequent cause of acute myocarditis, which may result in chronic myocarditis and virus persistence. Investigation of the initial immune responses to CVB3 may shed light on the mechanisms that contribute to ongoing disease. DCs, as key professional APCs, were investigated in two MHC‐matched hosts: while C57BL/6 mice are resistant to chronic CVB3‐myocarditis, the A.BY/SnJ mouse strain exhibits susceptibility. DC maturation and activation were critically impaired in A.BY/SnJ mice, as reflected by the failure of DCs to induce co‐stimulatory molecules and cytokine/chemokine responses. MHC class I‐restricted antigen presentation via the cross‐presentation pathway was also affected in DCs from A.BY/SnJ mice. DC maturation involves the accumulation of DC aggresome‐like induced structures (DALISs) and the transient storage of defective ribosomal products (DRiPs). DCs from A.BY/SnJ mice showed permanent DALIS accumulation; the detection of poly‐ubiquitinylated CVB3 proteins in these DALISs suggested a limitation in the MHC class I antigenic supply in this host. In conclusion, ongoing chronic disease in A.BY/SnJ mice due to a failure to clear the virus may be attributed to defects in DC maturation/activation and DC MHC class I antigen processing.
    Subject(s): Myocarditis ; Infectious disease ; Animal models ; Proteasome ; Virology ; Myocarditis - etiology ; Dendritic Cells - immunology ; Mice, Inbred C57BL ; Virulence ; Cells, Cultured ; Cytokines - secretion ; Histocompatibility Antigens Class I - immunology ; Dendritic Cells - pathology ; Mice, Transgenic ; Coxsackievirus Infections - complications ; Histocompatibility Antigens Class I - metabolism ; Enterovirus - pathogenicity ; Ubiquitination ; Animals ; Enterovirus - immunology ; Cross-Priming ; Cell Differentiation ; Mice ; Dendritic Cells - virology ; Coxsackievirus Infections - immunology ; Dendritic Cells - metabolism
    ISSN: 0014-2980
    E-ISSN: 1521-4141
    Source: Wiley Online Library All Backfiles
    Source: Alma/SFX Local Collection
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  • 10
    Language: English
    In: Information technology & tourism, 2015-03, Vol.15 (1), p.1-15
    ISSN: 1098-3058
    E-ISSN: 1943-4294
    Source: Alma/SFX Local Collection
    Source: ProQuest Central
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