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  • 1
    Language: German
    In: Bibliotheksdienst, 2019-12-01, Vol.53 (12), p.757-767
    Description: Wie kann der digitale Wandel in wissenschaftlichen Bibliotheken personell, organisatorisch und serviceorientiert gestaltet werden? Welche Auswirkungen hat die Digitalisierung für das professionelle Selbstverständnis? Drei Mitarbeiter*innen des Wissenschaftszentrums Berlin für Sozialforschung (WZB) haben renommierte Einrichtungen des US-amerikanischen Wissenschaftssystems in New York City und Boston besucht und Trends, Probleme und Erfahrungen erkundet.
    Subject(s): Digitization ; Librarians ; Academic libraries
    ISSN: 0006-1972
    E-ISSN: 2194-9646
    Source: De Gruyter Online
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: Bibliotheksdienst, 2019-11-01, Vol.53 (12), p.757-767
    Description: Wie kann der digitale Wandel in wissenschaftlichen Bibliotheken personell, organisatorisch und serviceorientiert gestaltet werden? Welche Auswirkungen hat die Digitalisierung für das professionelle Selbstverständnis? Drei Mitarbeiter*innen des Wissenschaftszentrums Berlin für Sozialforschung (WZB) haben renommierte Einrichtungen des US-amerikanischen Wissenschaftssystems in New York City und Boston besucht und Trends, Probleme und Erfahrungen erkundet.
    Subject(s): Wissenschaftliche Bibliothek ; USA ; processes ; Prozesse ; Scientific library ; Digitalisierung ; Trends ; digitisation
    ISSN: 0006-1972
    E-ISSN: 2194-9646
    Source: De Gruyter Online
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  • 3
    Language: English
    In: The FEBS journal, 2018-12, Vol.285 (23), p.4465-4481
    Description: Marine bacteria catabolize carbohydrate polymers of algae, which synthesize these structurally diverse molecules in ocean surface waters. Although algal glycans are an abundant carbon and energy source in the ocean, the molecular details that enable specific recognition between algal glycans and bacterial degraders remain largely unknown. Here we characterized a surface protein, GMSusD from the planktonic Bacteroidetes‐Gramella sp. MAR_2010_102 that thrives during algal blooms. Our biochemical and structural analyses show that GMSusD binds glucose polysaccharides such as branched laminarin and linear pustulan. The 1.8 Å crystal structure of GMSusD indicates that three tryptophan residues form the putative glycan‐binding site. Mutagenesis studies confirmed that these residues are crucial for laminarin recognition. We queried metagenomes of global surface water datasets for the occurrence of SusD‐like proteins and found sequences with the three structurally conserved residues in different locations in the ocean. The molecular selectivity of GMSusD underscores that specific interactions are required for laminarin recognition. In conclusion, our findings provide insight into the molecular details of β‐glucan binding by GMSusD and our bioinformatic analysis reveals that this molecular interaction may contribute to glucan cycling in the surface ocean. Marine bacteria catabolize carbohydrates, which are synthesized by algae in ocean surface waters. Although algal glycans are an abundant carbon and energy source for marine microbes, the molecular details that enable bacteria for specific polysaccharides recognition remain largely unknown. We characterized surface glycan‐binding protein from the planktonic Bacteroidetes‐Gramella that thrives during algal bloom in Helgoland by consuming algal polysaccharides.
    Subject(s): carbohydrate‐binding proteins ; polysaccharides ; microalgae ; laminarin ; Bacteroidetes ; Tryptophan ; Binding proteins ; Analysis ; Protein binding
    ISSN: 1742-464X
    E-ISSN: 1742-4658
    Source: Hellenic Academic Libraries Link
    Source: Academic Search Ultimate
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  • 4
    Language: English
    In: Nature communications, 2021-04-06, Vol.12 (1), p.2048-2048
    Description: Loss of TP53 and RB1 in treatment-naïve small cell lung cancer (SCLC) suggests selective pressure to inactivate cell death pathways prior to therapy. Yet, which of these pathways remain available in treatment-naïve SCLC is unknown. Here, through systemic analysis of cell death pathway availability in treatment-naïve SCLC, we identify non-neuroendocrine (NE) SCLC to be vulnerable to ferroptosis through subtype-specific lipidome remodeling. While NE SCLC is ferroptosis resistant, it acquires selective addiction to the TRX anti-oxidant pathway. In experimental settings of non-NE/NE intratumoral heterogeneity, non-NE or NE populations are selectively depleted by ferroptosis or TRX pathway inhibition, respectively. Preventing subtype plasticity observed under single pathway targeting, combined treatment kills established non-NE and NE tumors in xenografts, genetically engineered mouse models of SCLC and patient-derived cells, and identifies a patient subset with drastically improved overall survival. These findings reveal cell death pathway mining as a means to identify rational combination therapies for SCLC.
    Subject(s): Index Medicus
    E-ISSN: 2041-1723
    Source: Nature Open Access
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: The FEBS journal, 2018-12, Vol.285 (23), p.4465-4481
    ISSN: 1742-464X
    E-ISSN: 1742-4658
    Source: Hellenic Academic Libraries Link
    Source: Academic Search Ultimate
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  • 6
    Language: English
    In: Clinical and Vaccine Immunology, 2007-10-01, Vol.14 (10), p.1349-1355
    Description: Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CVI About CVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1556-6811 Online ISSN: 1556-679X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CVI .asm.org, visit: CVI       
    Subject(s): Antigens, Viral - analysis ; Immunoenzyme Techniques - standards ; Europe ; Humans ; Caliciviridae Infections - diagnosis ; Gastroenteritis - diagnosis ; Norovirus - immunology ; Antigens, Viral - immunology ; Feces - virology ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; Gastroenteritis - immunology ; Caliciviridae Infections - immunology ; Index Medicus ; Norovirus ; Gastroenteritis ; Caliciviridae Infections ; Immunoenzyme Techniques ; Virology ; Life Sciences ; Microbiology and Parasitology ; Antigens, Viral ; Feces ; Clinical and Diagnostic Laboratory Immunology
    ISSN: 1556-6811
    E-ISSN: 1556-679X
    Source: HighWire Press (Free Journals)
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Physica. C, Superconductivity, 1998, Vol.301 (1), p.72-84
    Description: The flux pinning of a 120 nm thick polycrystalline niobium film has been investigated dynamically with the vibrating reed technique and, statically, with torque magnetometry. Weakly temperature dependent maxima were observed by torque magnetometry consistent with the matching fields for formation and splitting of vortex chains. From these measurements, we have determined the volume pinning force as a function of applied field which shows a non-monotonic behavior compatible with different vortex regimes. We found that the formation and splitting of vortex chains has negligible influence on the elastic coupling of the vortex lattice measured with the vibrating reed. Both techniques showed sharp maxima in the angular dependence of the upper critical field in agreement with the appearance of surface superconductivity. The elastic coupling between flux lines and film as well as the energy dissipation are finite at magnetic fields higher than the bulk critical field B c2 suggesting the existence of a vortex structure in this field region.
    Subject(s): Vortex chains ; Niobium thin film ; Elastic coupling ; Magnetic fields ; Surface superconductivity ; Exact sciences and technology ; Superconductivity ; Metals, alloys and compounds (a15, 001c15, laves phases, chevrel phases, borocarbides, etc.) ; Superconducting films and low-dimensional structures ; Condensed matter: electronic structure, electrical, magnetic, and optical properties ; Physics ; Vortex lattices ,flux pinning, flux creep ; Superconducting materials (excluding high-tc compounds) ; Metals. Metallurgy ; Low tc films ; Applied sciences ; Properties of type I and type II superconductors ; Metals; alloys and binary compounds (including A15, Laves phases, etc.)
    ISSN: 0921-4534
    E-ISSN: 1873-2143
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
    Source: Alma/SFX Local Collection
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  • 8
    Language: English
    In: PloS one, 2013-04-04, Vol.8 (4), p.e60542-e60542
    Description: Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (σg2/σP2= 25%, h2= 55%). However, a meta-analysis of genome-wide association studies across sixteen studies comprising 50,627 participants did not identify genome-wide significant SNPs. 58 SNPs with p〈10-5were tested in a replication sample (n = 3,271), but none replicated. Furthermore, a gene-based test shows that none of the genes that were previously suggested in the literature to influence entrepreneurship reveal significant associations. Finally, SNP-based genetic scores that use results from the meta-analysis capture less than 0.2% of the variance in self-employment in an independent sample (p≥0.039). Our results are consistent with a highly polygenic molecular genetic architecture of self-employment, with many genetic variants of small effect. Although self-employment is a multi-faceted, heavily environmentally influenced, and biologically distal trait, our results are similar to those for other genetically complex and biologically more proximate outcomes, such as height, intelligence, personality, and several diseases.
    Subject(s): Models, Theoretical ; Genome-Wide Association Study ; Intelligence ; Humans ; Twins, Dizygotic ; Genotype ; Male ; Personality ; Twins, Monozygotic ; Gene-Environment Interaction ; Multifactorial Inheritance ; Employment ; Female ; Registries ; Polymorphism, Single Nucleotide ; Economic aspects ; Social classes ; Research ; Cardiovascular diseases ; Health aspects ; Risk factors ; Index Medicus ; Medicine ; Biology ; Mathematics ; Social and Behavioral Sciences ; Medicinsk genetik ; Hälsovetenskap ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Medicin och hälsovetenskap ; Medicinska och farmaceutiska grundvetenskaper ; Health sciences ; Laboratories ; Genes ; Genomics ; Genomes ; Single-nucleotide polymorphism ; Epidemiology ; Biological effects ; Genetics ; Physiology ; Public health ; Chronic illnesses ; Economics ; Dopamine ; Architecture ; Environmental health ; Economic conditions ; College campuses ; Morbidity ; Disease prevention ; Genetic variance ; Neurology ; Hospitals ; Entrepreneurship ; Heritability ; Polygenic inheritance
    ISSN: 1932-6203
    E-ISSN: 1932-6203
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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