Language:
English
In:
Nutrients, 2020-04-12, Vol.12 (4), p.1067
Description:
Selenoprotein P (SELENOP) is an established biomarker of selenium (Se) status. Serum SELENOP becomes saturated with increasing Se intake, reaching maximal concentrations of 5-7 mg SELENOP/L at intakes of ca. 100-150 µg Se/d. A biomarker for higher Se intake is missing. We hypothesized that SELENOP may also reflect Se status in clinical applications of therapeutic dosages of selenite. To this end, blood samples from two supplementation studies employing intravenous application of selenite at dosages 〉1 mg/d were analyzed. Total Se was quantified by spectroscopy, and SELENOP by a validated ELISA. The high dosage selenite infusions increased SELENOP in parallel to elevated Se concentrations relatively fast to final values partly exceeding 10 mg SELENOP/L. Age or sex were not related to the SELENOP increase. Western blot analyses of SELENOP verified the results obtained by ELISA, and indicated an unchanged pattern of immunoreactive protein isoforms. We conclude that the saturation of SELENOP concentrations observed in prior studies with moderate Se dosages (〈400 µg/d) may reflect an intermediate plateau of expression, rather than an absolute upper limit. Circulating SELENOP seems to be a suitable biomarker for therapeutic applications of selenite exceeding the recommended upper intake levels. Whether SELENOP is also capable of reflecting other supplemental selenocompounds in high dosage therapeutic applications remains to be investigated.
Subject(s):
adjuvant treatment ; Biomarkers - blood ; Cardiovascular Diseases - etiology ; chemotherapy ; Drug Dosage Calculations ; Drug Monitoring - methods ; Female ; Humans ; Infusions, Intravenous ; Male ; Medicin och hälsovetenskap ; monitoring ; Neoplasms - etiology ; Risk Factors ; Selenium - administration & dosage ; Selenium - deficiency ; Selenium - metabolism ; Selenoprotein P - blood ; supplementation ; Thyroiditis, Autoimmune - etiology ; trace element
ISSN:
2072-6643
E-ISSN:
2072-6643
Source:
PubMed Central
Source:
SWEPUB Freely available online
Source:
DOAJ Directory of Open Access Journals - Not for CDI Discovery
URL:
https://www.ncbi.nlm.nih.gov/pubmed/32290626$$D View this record in MEDLINE/PubMed
URL:
http://kipublications.ki.se/Default.aspx?queryparsed=id:143808020$$DView record from Swedish Publication Index
URL:
http://kipublications.ki.se/Default.aspx?queryparsed=id:232290626$$DView record from Swedish Publication Index
Permalink to record