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  • 1
    Language: German
    In: o-bib. Das offene Bibliotheksjournal, 01 October 2015, Vol.2(3), pp.37-62
    Description: Im Zuge der Entwicklung des Fachinformationsdienstes für Medien- und Kommunikationswissenschaft an der Universitätsbibliothek Leipzig hat der Autor eine onlinegestützte Befragung in der Fachcommunity vorgenommen. Ziel der Befragung war es, Bedürfnisse und Gewohnheiten der Wissenschaftlerinnen und Wissenschaftler hinsichtlich der Versorgung mit Literatur zu erfahren. Die Befragung ergab, dass die Mehrheit der Befragten verschiedene Recherchequellen nutzen muss, um relevante Literatur aufzufinden. Obwohl E-Books parallel genutzt werden, betrachten die meisten Befragten gedruckte Literatur als einfacher in der Handhabung. Umgekehrt verhält es sich bei Zeitschriften. Hier wird die elektronische Variante der gedruckten vorgezogen. Leipzig University Library is currently developing an Information Service for Communication and Media Studies. In preparation, the author conducted an online survey amongst academics in the discipline of Communication and Media Studies in order to learn more about their needs and habits when researching literature. For the majority of the academics who were interviewed it is necessary to search different sources to find the literature they need. Although they also use e-books, most academics prefer print publications because the handling is seen as easier. With journals it is the other way round: Electronic journals are preferred over printed journals....
    Subject(s): Fachinformationsdienst ; Medienwissenschaft ; Kommunikationswissenschaft ; Library & Information Science
    E-ISSN: 2363-9814
    Source: Directory of Open Access Journals (DOAJ)
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  • 2
    Language: German
    In: o-bib. Das offene Bibliotheksjournal, 01 December 2015, Vol.2(4), pp.108-118
    Description: Der Beitrag greift den aktuellen Diskussionsstand um die Transformation des bisherigen Systems der Sondersammelgebiete (SSG) zur Förderung von Fachinformationsdiensten (FID) auf und skizziert den Übergang am Beispiel des FID Medien- und Kommunikationswissenschaft an der UB Leipzig. Es werden die Vorteile der neuen Förderrichtlinie, die Ausgestaltung des FID und die noch zu bewältigenden Problemfelder dargestellt. The current state of discussion about transforming the former Special Subject Fields Programme into a funding of Specialized Information Services is presented. The transition is illustrated using the example of the Information Service for Media and Communication Studies of the Leipzig University Library. The paper explains the advantages of the new funding programme as well as the design of the information service and the problem areas which are yet to be mastered.
    Subject(s): Sondersammelgebiet ; Virtuelle Fachbibliothek ; Fachinformationsdienst ; Recherche ; Literaturversorgung ; Medienwissenschaft ; Kommunikationswissenschaft ; Library & Information Science
    E-ISSN: 2363-9814
    Source: Directory of Open Access Journals (DOAJ)
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  • 3
    Language: English
    In: The New England journal of medicine, 08 October 2015, Vol.373(15), pp.1397-407
    Description: Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of ischemic and reperfusion injury in patients undergoing cardiac surgery, but uncertainty about clinical outcomes remains. We conducted a prospective, double-blind, multicenter, randomized, controlled trial involving adults who were scheduled for elective cardiac surgery requiring cardiopulmonary bypass under total anesthesia with intravenous propofol. The trial compared upper-limb RIPC with a sham intervention. The primary end point was a composite of death, myocardial infarction, stroke, or acute renal failure up to the time of hospital discharge. Secondary end points included the occurrence of any individual component of the primary end point by day 90. A total of 1403 patients underwent randomization. The full analysis set comprised 1385 patients (692 in the RIPC group and 693 in the sham-RIPC group). There was no significant between-group difference in the rate of the composite primary end point (99 patients [14.3%] in the RIPC group and 101 [14.6%] in the sham-RIPC group, P=0.89) or of any of the individual components: death (9 patients [1.3%] and 4 [0.6%], respectively; P=0.21), myocardial infarction (47 [6.8%] and 63 [9.1%], P=0.12), stroke (14 [2.0%] and 15 [2.2%], P=0.79), and acute renal failure (42 [6.1%] and 35 [5.1%], P=0.45). The results were similar in the per-protocol analysis. No treatment effect was found in any subgroup analysis. No significant differences between the RIPC group and the sham-RIPC group were seen in the level of troponin release, the duration of mechanical ventilation, the length of stay in the intensive care unit or the hospital, new onset of atrial fibrillation, and the incidence of postoperative delirium.... Upper-limb RIPC performed while patients were under propofol-induced anesthesia did not show a relevant benefit among patients undergoing elective cardiac surgery. (Funded by the German Research Foundation; RIPHeart ClinicalTrials.gov number, NCT01067703.).
    Subject(s): Cardiac Surgical Procedures ; Ischemic Preconditioning -- Methods ; Postoperative Complications -- Prevention & Control
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 4
    Language: English
    In: International Journal of Geriatric Psychiatry, April 2008, Vol.23(4), pp.415-421
    Description: Objective By means of a representative follow-up survey, we investigated changes in family physicians' (FPs) attitudes towards cognition enhancers in early dementia during 1993 and 2001. Methods One hundred and twenty-two FPs (response rate 71.8%) in Lower Saxony, Germany, were randomly assigned to one of two written case samples presenting a patient with cognitive decline suggestive of early Alzheimer's disease (DAT; case A: female patient vs case B: male patient). Using a structured face-to-face interview, they were asked to suggest their potential drug treatment. The results were compared to corresponding data from our previous survey in 1993. Results FPs' readiness to start antidementia drug treatment decreased from 70.4% in 1993 to 43.4% at follow-up, although underlying DAT was significantly more frequently suggested (11.0% vs 26.2%, p 〈 0.05). Substances with questionable efficacy such as Piracetame were prescribed less frequently in 2001 whereas evidence-based medication like cholinesterase inhibitors (ChEIs) failed to compensate for this drop. Compared to 1993, when 55.2% of FPs expected no therapeutic impact, at follow-up, 75.4% expected slowdown of disease progression, stabilisation or improvement of symptoms (p 〈 0.05). Conclusions Our results demonstrate a significant decrease of therapeutic nihilism in primary care within eight years. However, in patients with suspicion of DAT, this is not reflected accordingly in potential treatment.
    Subject(s): Primary Care ; Alzheimer'S Disease ; Antidementia Drug Treatment ; Cholinesterase Inhibitors
    ISSN: 0885-6230
    E-ISSN: 1099-1166
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  • 5
    Language: English
    In: International Journal of Geriatric Psychiatry, January 2007, Vol.22(1), pp.23-31
    Description: Objective To investigate whether primary care competency in early diagnosis of dementia might have changed during 1993 and 2001. Method By means of a representative follow-up survey 122 out of 170 (71.8%) family physicians (FPs) in Lower Saxony, Germany, were randomly assigned to two written case samples presenting a patient with mild cognitive impairment (case 1a vs. 1b: female vs. male patient) and moderate dementia (case 2a vs 2b: vascular type (VD) vs Alzheimer's disease (DAT)), respectively. By means of a structured face-to-face interview, they were asked for their diagnostic considerations. Results In comparison to 1993, dementia was significantly more frequently considered. However, there was a striking tendency in overestimating vascular aetiology and under-diagnosing probable DAT (case 1a/1b: DAT: 11.0% in 1993 vs 26.2% in 2001; VD: 2.1% in 1993 vs 17.2% in 2001). As a possible contributor to a dementia syndrome, concomitant medication was considered only exceptionally (case 2a/2b: 4.4% in 1993 vs 2.5% in 2001). Physicians above 50 years of age showed a significantly lower early diagnostic awareness. At follow-up, the presumed interest in geriatric (psychiatric) topics dramatically faded from 66.9% to 35.2%. Conclusions Our results demonstrate a persistent need of training efforts aiming at the early recognition of dementia, especially of DAT, in primary care.
    Subject(s): Primary Care ; Dementia Diagnosis ; Alzheimer'S Disease ; Vascular Dementia
    ISSN: 0885-6230
    E-ISSN: 1099-1166
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  • 6
    Language: English
    In: Scientific reports, 24 October 2018, Vol.8(1), pp.15702
    Description: Cardiovascular diseases are the main cause of death worldwide, demanding new treatments and interventions. Recently, extracellular vesicles (EVs) came in focus as important carriers of protective molecules such as miRNAs and proteins which might contribute to e.g. improved cardiac function after myocardial infarction. EVs can be secreted from almost every cell type in the human body and can be transferred via the bloodstream in almost every compartment. To provide an all-encompassing overview of studies investigating these beneficial properties of EVs we performed a systematic review/meta-analysis of studies investigating the cardioprotective characteristics of EVs. Forty-three studies were investigated and catalogued according to the EV source. We provide an in-depth analysis of the purification method, size of the EVs, the conducted experiments to investigate the beneficial properties of EVs as well as the major effector molecule encapsulated in EVs mediating protection. This study provides...
    Subject(s): Cardiotonic Agents -- Therapeutic Use ; Extracellular Vesicles -- Physiology
    ISSN: 2045-2322
    E-ISSN: 2045-2322
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  • 7
    Language: English
    In: Nutrients, 01 April 2015, Vol.7(5), pp.3094-3118
    Description: The trace element selenium is of high importance for many of the body’s regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can cause harm. A rapidly increasing number of studies characterizes the wide range of selenium dependent functions in the human body and elucidates the complex and multiple physiological and pathophysiological interactions of selenium and selenoproteins. For the majority of selenium dependent enzymes, several biological functions have already been identified, like regulation of the inflammatory response, antioxidant properties and the proliferation/differentiation of immune cells. Although the potential role of selenium in the development and progression of cardiovascular disease has been investigated for decades, both observational and interventional studies of selenium supplementation remain inconclusive and are considered in this review. This review covers current knowledge of the role of selenium and selenoproteins in the human body and its functional role in the cardiovascular system. The relationships between selenium intake/status and various health outcomes, in particular cardiomyopathy, myocardial ischemia/infarction and reperfusion injury are reviewed. We describe, in depth, selenium as a biomarker in coronary heart disease and highlight the significance of selenium supplementation for patients undergoing cardiac surgery.
    Subject(s): Cardiovascular Disease ; Coronary Heart Disease ; Cardiac Surgery ; Selenium Selenoproteins ; Anatomy & Physiology
    E-ISSN: 2072-6643
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  • 8
    Language: English
    In: Journal of Extracellular Vesicles, 01 December 2017, Vol.6(1)
    Description: Preconditioning is a promising technique to protect the heart from ischaemia-reperfusion injury. In this context, the crosstalk between different cardiac cell types and especially the exchange of cardioprotective mediators has come into the focus of current research. Recently, extracellular vesicles (EVs), nano-sized structures, emerged as possible communication mediators. They are taken up by recipient cells and can alter gene expression or activate intracellular signal cascades. It has been shown that all cardiac cell types are able to secrete EVs, but so far the influence of an in vitro preconditioning stimulus on EV concentration and composition has not been investigated. Therefore, we stimulated primary cardiac myocytes and fibroblasts from neonatal rats, as well as H9c2 cells, with two known in vitro preconditioning stimuli: hypoxia or isoflurane. EVs were isolated from cell culture supernatants 48 h after stimulation by differential centrifugation and size exclusion chromatography....
    Subject(s): Extracellular Vesicles ; in Vitro Preconditioning ; Cardioprotection ; Volatile Anaesthetics ; Mirna ; Cardiac Cells ; Biology
    E-ISSN: 2001-3078
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  • 9
    Language: English
    In: Nutrients, 01 July 2018, Vol.10(8), p.974
    Description: The pleiotropic biochemical and antioxidant functions of vitamin C have sparked recent interest in its application in intensive care. Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ damage. The current evidence of vitamin C’s effect on pathophysiological reactions during various acute stress events (such as sepsis, shock, trauma, burn and ischemia-reperfusion injury) questions whether the application of vitamin C might be especially beneficial for cardiac surgery patients who are routinely exposed to ischemia/reperfusion and subsequent inflammation, systematically affecting different organ systems. This review covers current knowledge about the role of vitamin C in cardiac surgery patients with focus on its influence on organ dysfunctions. The relationships between vitamin C and clinical health outcomes are reviewed with special emphasis on its application in cardiac surgery. Additionally, this review pragmatically discusses evidence on the administration of vitamin C in every day clinical practice, tackling the issues of safety, monitoring, dosage, and appropriate application strategy.
    Subject(s): Vitamin C ; Ascorbic Acid ; Cardiac Surgery ; Antioxidant Therapy ; Nutrient ; Oxidative Stress ; Organ Dysfunction ; Multi Organ Failure ; Anatomy & Physiology
    E-ISSN: 2072-6643
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  • 10
    Language: English
    In: Critical care (London, England), 05 February 2014, Vol.18(1), pp.R25
    Description: Calibrated arterial pulse contour analysis has become an established method for the continuous monitoring of cardiac output (PCCO). However, data on its validity in hemodynamically instable patients beyond the setting of cardiac surgery are scarce. We performed the present study to assess the validity and precision of PCCO-measurements using the PiCCO™-device compared to transpulmonary thermodilution derived cardiac output (TPCO) as the reference technique in neurosurgical patients requiring high-dose vasopressor-therapy. A total of 20 patients (16 females and 4 males) were included in this prospective observational clinical trial. All of them suffered from subarachnoid hemorrhage (Hunt&Hess grade I-V) due to rupture of a cerebral arterial aneurysm and underwent high-dose vasopressor therapy for the prevention/treatment of delayed cerebral ischemia (DCI). Simultaneous CO measurements by bolus TPCO and PCCO were obtained at baseline as well as 2 h, 6 h, 12 h, 24 h, 48 h and 72 h after inclusion. PCCO- and TPCO-measurements were obtained at baseline as well as 2 h, 6 h, 12 h, 24 h, 48 h and 72 h after inclusion. Patients received vasoactive support with (mean ± standard deviation, SD) 0.57 ± 0.49 μg · kg-1 · min-1 norepinephrine resulting in a mean arterial pressure of 103 ± 13 mmHg and a systemic vascular resistance of 943 ± 248 dyn · s · cm-5. 136 CO-data pairs were analyzed. TPCO ranged from 5.2 to 14.3 l · min-1 (mean ± SD 8.5 ± 2.0 l · min-1) and PCCO ranged from 5.0 to 14.4 l · min-1 (mean ± SD 8.6 ± 2.0 l · min-1). Bias and limits of agreement (1.96 SD of the bias) were -0.03 ± 0.82 l · min-1 and 1.62 l · min-1, resulting in an overall percentage error of 18.8%. The precision of PCCO-measurements was 17.8%. Insufficient trending ability was indicated by concordance rates of 74% (exclusion zone of 15% (1.29 l · min-1)) and 67% (without exclusion zone), as well as by polar plot analysis.
    Subject(s): Clinical Trials As Topic ; Cardiac Output -- Drug Effects ; Norepinephrine -- Therapeutic Use ; Subarachnoid Hemorrhage -- Drug Therapy
    ISSN: 1364-8535
    E-ISSN: 1466-609X
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