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  • 1
    Language: German
    In: o-bib, 2015-12-01, Vol.2 (4), p.108-118
    Description: Der Beitrag greift den aktuellen Diskussionsstand um die Transformation des bisherigen Systems der Sondersammelgebiete (SSG) zur Förderung von Fachinformationsdiensten (FID) auf und skizziert den Übergang am Beispiel des FID Medien- und Kommunikationswissenschaft an der UB Leipzig. Es werden die Vorteile der neuen Förderrichtlinie, die Ausgestaltung des FID und die noch zu bewältigenden Problemfelder dargestellt. The current state of discussion about transforming the former Special Subject Fields Programme into a funding of Specialized Information Services is presented. The transition is illustrated using the example of the Information Service for Media and Communication Studies of the Leipzig University Library. The paper explains the advantages of the new funding programme as well as the design of the information service and the problem areas which are yet to be mastered.
    Subject(s): Fachinformationsdienst ; Kommunikationswissenschaft ; Literaturversorgung ; Medienwissenschaft ; Recherche ; Sondersammelgebiet ; Virtuelle Fachbibliothek
    E-ISSN: 2363-9814
    Source: Alma/SFX Local Collection
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  • 2
    Language: German
    In: o-bib, 2015-10-01, Vol.2 (3), p.37-62
    Description: Im Zuge der Entwicklung des Fachinformationsdienstes für Medien- und Kommunikationswissenschaft an der Universitätsbibliothek Leipzig hat der Autor eine onlinegestützte Befragung in der Fachcommunity vorgenommen. Ziel der Befragung war es, Bedürfnisse und Gewohnheiten der Wissenschaftlerinnen und Wissenschaftler hinsichtlich der Versorgung mit Literatur zu erfahren. Die Befragung ergab, dass die Mehrheit der Befragten verschiedene Recherchequellen nutzen muss, um relevante Literatur aufzufinden. Obwohl E-Books parallel genutzt werden, betrachten die meisten Befragten gedruckte Literatur als einfacher in der Handhabung. Umgekehrt verhält es sich bei Zeitschriften. Hier wird die elektronische Variante der gedruckten vorgezogen. Leipzig University Library is currently developing an Information Service for Communication and Media Studies. In preparation, the author conducted an online survey amongst academics in the discipline of Communication and Media Studies in order to learn more about their needs and habits when researching literature. For the majority of the academics who were interviewed it is necessary to search different sources to find the literature they need. Although they also use e-books, most academics prefer print publications because the handling is seen as easier. With journals it is the other way round: Electronic journals are preferred over printed journals.
    Subject(s): Fachinformationsdienst ; Kommunikationswissenschaft ; Medienwissenschaft
    E-ISSN: 2363-9814
    Source: Alma/SFX Local Collection
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  • 3
    Article
    Article
    2012
    ISSN: 1479-4098 
    Language: English
    In: Nineteenth-century music review, 2012-06-01, Vol.9 (1), p.153
    ISSN: 1479-4098
    E-ISSN: 2044-8414
    Source: Hellenic Academic Libraries Link
    Source: Cambridge University Press - SHEDL
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  • 4
    Article
    Article
    2012
    ISSN: 1479-4098 
    Language: English
    In: Nineteenth-century music review, 2012-05-24, Vol.9 (1), p.153-156
    ISSN: 1479-4098
    E-ISSN: 2044-8414
    Source: Hellenic Academic Libraries Link
    Source: Cambridge University Press - SHEDL
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  • 5
    Book chapter
    Book chapter
    2018
    ISBN: 3662574489  ISBN: 9783662574485 
    Language: German
    In: Neue Welten - Star Trek als humanistische Utopie?, 2018-07-26, p.165-204
    Description: Das US-amerikanische Medienfranchise Star Trek ist seit nunmehr über 50 Jahren ein globales Phänomen. Durch diese fortdauernde Präsenz erreichte Star Trek eine große weltweite Bekanntheit in der Populärkultur und einen großen Einfluss über Fernsehen und das Kino hinaus. In diesem Kapitel wird gezeigt, wie im Star Trek-Franchise der Aufbau von politisch-sozialen Strukturen dargestellt wird. Es wird davon ausgegangen, dass Star Trek eine utopische Erzählung darstellt, die eine ideale Gesellschaft skizziert. Aber ist die Vereinte Föderation der Planeten, die vorherrschende politische Struktur bei Star Trek, tatsächlich eine erstrebenswerte Utopie? Welche Rolle nimmt in diesem Kontext die fiktive Rasse der Borg ein, die eine fundamental andere Herrschaftsphilosophie repräsentiert. Und wie geschieht in beiden System die Überführung der Gesellschaft von einem chaotischen Naturzustand in eine sozialpolitische Ordnung?
    ISBN: 3662574489
    ISBN: 9783662574485
    Source: Alma/SFX Local Collection
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  • 6
    Review
    Review
    2016
    ISSN: 0044-3360 
    Language: German
    In: Zeitschrift für Politik, 2016-06-01, Vol.63 (2), p.229-231
    Subject(s): BUCHBESPRECHUNGEN
    ISSN: 0044-3360
    Source: JSTOR Arts & Sciences XIV
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  • 7
    Language: English
    In: Nutrients, 2015-04-27, Vol.7 (5), p.3094-3118
    Description: The trace element selenium is of high importance for many of the body's regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can cause harm. A rapidly increasing number of studies characterizes the wide range of selenium dependent functions in the human body and elucidates the complex and multiple physiological and pathophysiological interactions of selenium and selenoproteins. For the majority of selenium dependent enzymes, several biological functions have already been identified, like regulation of the inflammatory response, antioxidant properties and the proliferation/differentiation of immune cells. Although the potential role of selenium in the development and progression of cardiovascular disease has been investigated for decades, both observational and interventional studies of selenium supplementation remain inconclusive and are considered in this review. This review covers current knowledge of the role of selenium and selenoproteins in the human body and its functional role in the cardiovascular system. The relationships between selenium intake/status and various health outcomes, in particular cardiomyopathy, myocardial ischemia/infarction and reperfusion injury are reviewed. We describe, in depth, selenium as a biomarker in coronary heart disease and highlight the significance of selenium supplementation for patients undergoing cardiac surgery.
    Subject(s): Antioxidants - metabolism ; cardiac surgery ; cardiovascular disease ; Cardiovascular Diseases - diet therapy ; Cardiovascular Diseases - metabolism ; Cardiovascular System - metabolism ; coronary heart disease ; Dietary Supplements ; Humans ; Review ; Selenium - metabolism ; selenium selenoproteins ; Selenoproteins - metabolism ; Trace Elements - metabolism
    ISSN: 2072-6643
    E-ISSN: 2072-6643
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 8
    Language: English
    In: Scientific reports, 2018-10-24, Vol.8 (1), p.15702-14
    Description: Cardiovascular diseases are the main cause of death worldwide, demanding new treatments and interventions. Recently, extracellular vesicles (EVs) came in focus as important carriers of protective molecules such as miRNAs and proteins which might contribute to e.g. improved cardiac function after myocardial infarction. EVs can be secreted from almost every cell type in the human body and can be transferred via the bloodstream in almost every compartment. To provide an all-encompassing overview of studies investigating these beneficial properties of EVs we performed a systematic review/meta-analysis of studies investigating the cardioprotective characteristics of EVs. Forty-three studies were investigated and catalogued according to the EV source. We provide an in-depth analysis of the purification method, size of the EVs, the conducted experiments to investigate the beneficial properties of EVs as well as the major effector molecule encapsulated in EVs mediating protection. This study provides evidence that EVs from different cell types and body fluids provide cardioprotection in different in vivo and in vitro studies. A meta-analysis was performed to estimate the underlying effect size. In conclusion, we demonstrated that EVs from different sources might serve as a promising tool for treating cardiovascular diseases in the future.
    Subject(s): Angina, Stable - blood ; Animals ; Body Fluids ; Cardiotonic Agents - pharmacology ; Cardiotonic Agents - therapeutic use ; Cardiovascular diseases ; Cell Fractionation ; Cell Line ; Drug Evaluation ; Extracellular Vesicles - chemistry ; Extracellular Vesicles - physiology ; Fibroblasts - chemistry ; Fibroblasts - ultrastructure ; Humans ; Ischemic Preconditioning, Myocardial - methods ; Mesenchymal Stem Cells - chemistry ; Mesenchymal Stem Cells - ultrastructure ; Myocardial infarction ; Myocardial Infarction - blood ; Myocardial Infarction - therapy ; Myocytes, Cardiac - chemistry ; Myocytes, Cardiac - ultrastructure ; Organ Specificity ; Oxidative Stress ; Reviews ; Systematic review ; Vesicles
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 9
    Language: English
    In: Critical care (London, England), 2020-08-12, Vol.24 (1), p.499-499
    Description: The goal of nutrition support is to provide the substrates required to match the bioenergetic needs of the patient and promote the net synthesis of macromolecules required for the preservation of lean mass, organ function, and immunity. Contemporary observational studies have exposed the pervasive undernutrition of critically ill patients and its association with adverse clinical outcomes. The intuitive hypothesis is that optimization of nutrition delivery should improve ICU clinical outcomes. It is therefore surprising that multiple large randomized controlled trials have failed to demonstrate the clinical benefit of restoring or maximizing nutrient intake. This may be in part due to the absence of biological markers that identify patients who are most likely to benefit from nutrition interventions and that monitor the effects of nutrition support. Here, we discuss the need for practical risk stratification tools in critical care nutrition, a proposed rationale for targeted biomarker development, and potential approaches that can be adopted for biomarker identification and validation in the field.
    Subject(s): Albumins - analysis ; Biomarker ; Biomarkers ; Biomarkers - analysis ; Biomarkers - blood ; Body composition ; Body Composition - physiology ; Body Mass Index ; C-Reactive Protein - analysis ; Clinical outcomes ; Clinical trials ; Critical care ; Critical Care - methods ; Critical Care - statistics & numerical data ; Cytokines ; Enteral Nutrition - adverse effects ; Enteral Nutrition - methods ; Enteral Nutrition - standards ; Humans ; Inflammation ; Insulin Resistance - physiology ; Interleukin-6 - analysis ; Interleukin-6 - blood ; Medical prognosis ; Metabolism ; Mortality ; Nitrogen ; Nitrogen - analysis ; Nitrogen - blood ; Nutrition ; Nutrition Therapy - adverse effects ; Nutrition Therapy - methods ; Nutrition Therapy - standards ; Nutritional Support - adverse effects ; Nutritional Support - methods ; Nutritional Support - standards ; Parenteral nutrition ; Parenteral Nutrition - adverse effects ; Parenteral Nutrition - methods ; Parenteral Nutrition - standards ; Protein synthesis ; Proteins ; Proteins - analysis ; Review ; Tumor necrosis factor-TNF
    ISSN: 1364-8535
    E-ISSN: 1466-609X
    Source: BioMedCentral Open Access
    Source: PubMed Central
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 10
    Language: English
    In: Nutrients, 2020-04-12, Vol.12 (4), p.1067
    Description: Selenoprotein P (SELENOP) is an established biomarker of selenium (Se) status. Serum SELENOP becomes saturated with increasing Se intake, reaching maximal concentrations of 5-7 mg SELENOP/L at intakes of ca. 100-150 µg Se/d. A biomarker for higher Se intake is missing. We hypothesized that SELENOP may also reflect Se status in clinical applications of therapeutic dosages of selenite. To this end, blood samples from two supplementation studies employing intravenous application of selenite at dosages 〉1 mg/d were analyzed. Total Se was quantified by spectroscopy, and SELENOP by a validated ELISA. The high dosage selenite infusions increased SELENOP in parallel to elevated Se concentrations relatively fast to final values partly exceeding 10 mg SELENOP/L. Age or sex were not related to the SELENOP increase. Western blot analyses of SELENOP verified the results obtained by ELISA, and indicated an unchanged pattern of immunoreactive protein isoforms. We conclude that the saturation of SELENOP concentrations observed in prior studies with moderate Se dosages (〈400 µg/d) may reflect an intermediate plateau of expression, rather than an absolute upper limit. Circulating SELENOP seems to be a suitable biomarker for therapeutic applications of selenite exceeding the recommended upper intake levels. Whether SELENOP is also capable of reflecting other supplemental selenocompounds in high dosage therapeutic applications remains to be investigated.
    Subject(s): adjuvant treatment ; Biomarkers - blood ; Cardiovascular Diseases - etiology ; chemotherapy ; Drug Dosage Calculations ; Drug Monitoring - methods ; Female ; Humans ; Infusions, Intravenous ; Male ; Medicin och hälsovetenskap ; monitoring ; Neoplasms - etiology ; Risk Factors ; Selenium - administration & dosage ; Selenium - deficiency ; Selenium - metabolism ; Selenoprotein P - blood ; supplementation ; Thyroiditis, Autoimmune - etiology ; trace element
    ISSN: 2072-6643
    E-ISSN: 2072-6643
    Source: PubMed Central
    Source: SWEPUB Freely available online
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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