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  • 1
    Language: English
    In: Zeitschrift für Betriebswirtschaft, 2020-06-01, Vol.90 (5-6), p.845-878
    Description: It has long been recognized in the literature that the Lean and Six Sigma methodologies can complement each other fruitfully. So far, however, researchers have not been able to derive definitive conclusions on how to combine these methods furthermore, there is little research on how to apply them to service firms. We develop a framework for integrating Lean and Six Sigma instruments in the service industry, particularly in the insurance sector, and discuss it in the context of the insights we gained from a large-scale project carried out at a large German insurance company. We show how various instruments drawn from these two methodologies can be (a) adapted to the insurance industry and (b) combined productively to enable a company to achieve its strategy and goals. The conclusions we draw from these insights can help a wide range of companies customize the combination of the Lean and Six Sigma approaches to suit their specific needs.
    Subject(s): Case studies ; Usage ; Services industry ; Lean manufacturing ; Insurance industry ; Six Sigma
    ISSN: 0044-2372
    E-ISSN: 1861-8928
    Source: Hellenic Academic Libraries Link
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: Molecular cancer research, 2007-12-01, Vol.5 (12), p.1232-1240
    Description: Glioblastomas, the most malignant of all brain tumors, are characterized by cellular resistance to apoptosis and a highly invasive growth pattern. These factors contribute to the poor response of glioblastomas to radiochemotherapy and prevent their complete neurosurgical resection. However, the driving force behind the distinct motility of glioma cells is only partly understood. Here, we report that in the absence of cellular stress and proapoptotic stimuli, human glioblastoma cells exhibit a constitutive activation of caspases in vivo and in vitro . The inhibition of caspases by various peptide inhibitors decreases the migration of cells in scrape motility assays and the invasiveness of cells in spheroid assays. Similarly, specific small interfering RNA– or antisense-mediated down-regulation of caspase-3 and caspase-8 results in an inhibition of the migratory potential of glioma cells. The constitutive caspase-dependent motility of glioblastoma cells is independent of CD95 activation and it is not mediated by mitogen-activated protein/extracellular signal-regulated kinase kinase signaling. The basal caspase activity is accompanied by a constant cleavage of the motility-associated gelsolin protein, which may contribute to the caspase-mediated promotion of migration and invasiveness in glioblastoma cells. Our results suggest that the administration of low doses of caspase inhibitors that block glioma cell motility without affecting the execution of apoptotic cell death may be exploited as a novel strategy for the treatment of glioblastomas. (Mol Cancer Res 2007;5(12):1232–40)
    Subject(s): migration ; apoptosis ; brain tumors ; invasion ; gliomas ; caspases ; Brain Neoplasms - enzymology ; Glioblastoma - enzymology ; MAP Kinase Signaling System - physiology ; Gelsolin - metabolism ; Neoplasm Invasiveness ; Humans ; Brain Neoplasms - pathology ; Caspase 3 - metabolism ; Caspase 8 - metabolism ; Enzyme Inhibitors - pharmacology ; fas Receptor - metabolism ; Caspase Inhibitors ; Cell Movement - physiology ; Caspase 8 - genetics ; Glioblastoma - pathology ; Caspase 3 - genetics ; Cell Line, Tumor ; RNA, Small Interfering ; Index Medicus
    ISSN: 1541-7786
    E-ISSN: 1557-3125
    Source: HighWire Press (Free Journals)
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: Apoptosis (London), 2008-03, Vol.13 (3), p.437-447
    Description: The HIPPI (HIP-1 protein interactor) protein is a multifunctional protein that is involved in the regulation of apoptosis. The interaction partners of HIPPI include HIP-1 (Huntingtin-interacting protein-1), Apoptin, Homer1c, Rybp/DEDAF, and BAR (bifunctional apoptosis regulator). In search for other binding partners of HIPPI, we performed a yeast two hybrid screen and identified BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) as a novel HIPPI-interacting protein. In co-immunoprecipitation assays, BLOC1S2 specifically associates with HIPPI, but not with HIP-1. To study the expression of BLOC1S2 on the protein level, we generated a mouse monoclonal antibody specific for BLOC1S2 and a multiple tissue array comprising 70 normal and cancer tissue samples of diverse origin. BLOC1S2 protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. On the subcellular level, BLOC1S2 is expressed in an organellar-like pattern and co-localizes with mitochondria. Over-expression of BLOC1S2 in the presence or absence of HIPPI does not induce apoptosis. However, BLOC1S2 and HIPPI sensitize NCH89 glioblastoma cells to the pro-apoptotic actions of staurosporine and the death ligand TRAIL by enhancing caspase activation, cytochrome c release, and disruption of the mitochondrial membrane potential. Given its interaction with HIPPI and its pro-apoptotic activity, BLOC1S2 might play an important functional role in cancer and neurodegenerative diseases.
    Subject(s): Biochemistry, general ; Mitochondria ; Biomedicine ; Lysosomes ; Oncology ; Cancer Research ; Huntington’s disease ; Virology ; Cell Biology ; Apoptosis ; Cancer ; Cilia ; Immunohistochemistry ; Apoptosis - drug effects ; Humans ; Caspase 3 - metabolism ; Caspase 8 - metabolism ; Molecular Sequence Data ; Male ; Membrane Potential, Mitochondrial - drug effects ; Tissue Distribution ; Adult ; Female ; Amino Acid Sequence ; Proteins - physiology ; Cytochromes c - secretion ; Mitochondria - metabolism ; Adaptor Proteins, Signal Transducing - physiology ; Sequence Alignment ; Animals ; TNF-Related Apoptosis-Inducing Ligand - physiology ; Glioblastoma - pathology ; Cell Line, Tumor ; Protein Binding ; HeLa Cells ; Neoplasms - pathology ; Staurosporine - pharmacology ; Glioblastoma multiforme ; Index Medicus
    ISSN: 1360-8185
    E-ISSN: 1573-675X
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Research in hospitality management, 2016-01-02, Vol.6 (1), p.69-76
    Description: An increasing number of academic studies indicate that we as humans are exploiting the planet earth to an extent that is no longer bearable. Put differently, we are actively destroying our very own basis of existence, especially considering the generations to come. It is therefore becoming increasingly significant for companies to develop more social and environmentally friendly ways to produce and distribute their products and services. Moreover, this is reinforced by the rising public awareness of sustainability issues. Apart from this, demographic changes make it increasingly difficult to attract and hire enough qualified employees. Besides, many employees all over the world lack a deeper meaning in what they are doing and consequently job-related motivation and engagement is alarmingly low. Such an issue is signally relevant in particular for the hospitality industry, since hospitality jobs are considered to demand a high performance but are rather poorly paid, while at the same time the industry operates with a high labour intensity, which leads to a substantially high staff turnover rate. The combination of the problems mentioned may in fact have a comprehensive solution. The approach is to actively involve employees in sustainability and corporate social responsibility (CSR) issues and in this way lead employees to the perception of their jobs as being meaningful. Consequentially, increased engagement is expected, which in turn is positively related to business performance and profitability. This research proposes an employee-focused process model that companies can exploit as a guideline towards greater sustainability, CSR and engagement.
    Subject(s): corporate social responsibility ; staff engagement ; sustainability ; employee motivation
    ISSN: 2224-3534
    E-ISSN: 2415-5152
    Source: Taylor & Francis Open Access
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  • 5
    Language: English
    In: Zeitschrift fur Au[sz]en- und Sicherheitspolitik, 2015-04-01, Vol.8 (2), p.271
    ISSN: 1866-2188
    Source: Alma/SFX Local Collection
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  • 6
    Language: German
    In: Zeitschrift für Aussen- und sicherheitspolitik, 2015-04, Vol.8 (2), p.271-286
    Subject(s): Social Sciences, general ; Political Science, general
    ISSN: 1866-2188
    E-ISSN: 1866-2196
    Source: Alma/SFX Local Collection
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  • 7
    Language: German
    Description: Provider: Deutsche Digitale Bibliothek - Institution: Deutsche Nationalbibliothek - Data provided by Europeana Collections- Mainz, Univ., Diss., 2012- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
    Subject(s): Medizin, Gesundheit ; Biowissenschaften, Biologie
    Source: Europeana Collections
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  • 8
    Language: English
    In: Earthquake engineering & structural dynamics, 2020-11, Vol.49 (14), p.1388-1405
    Description: Summary Recognizing the beneficial effect of nonlinear soil–foundation response has led to a novel design concept, termed ‘rocking isolation’. The analysis and design of such rocking structures require nonlinear dynamic time history analyses. Analyzing the entire soil–foundation–structure system is computationally demanding, impeding the application of rocking isolation in practice. Therefore, there is an urgent need to develop efficient simplified analysis methods. This paper assesses the robustness of two simplified analysis methods, using (i) a nonlinear and (ii) a bilinear rocking stiffness combined with linear viscous damping. The robustness of the simplified methods is assessed by (i) one‐to‐one comparison with a benchmark finite element (FE) analysis using a selection of ground motions and (ii) statistical comparison of probability distributions of response quantities, which characterize the time history response of rocking systems. A bridge pier (assumed rigid) supported on a square foundation, lying on a stiff clay stratum, is used as an illustrative example. Nonlinear dynamic FE time history analysis serves as a benchmark. Both methods yield reasonably accurate predictions of the maximum rotation θmax. Their stochastic comparison with respect to the empirical cumulative distribution function of θmax reveals that the nonlinear and the bilinear methods are not biased. Thus, both can be used to estimate probabilities of exceeding a certain threshold value of θ. Developed in this paper, the bilinear method is much easier to calibrate than the nonlinear, offering similar performance.
    Subject(s): rocking structures ; rocking foundations ; simplified analysis methodology ; soil–structure interaction ; seismic isolation ; Analysis ; Distribution (Probability theory) ; Methods
    ISSN: 0098-8847
    E-ISSN: 1096-9845
    Source: Alma/SFX Local Collection
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  • 9
    Language: English
    In: Angewandte Chemie (International ed.), 2018-09-24, Vol.57 (39), p.12950-12955
    Description: Polyanionic silicon clusters are provided by the Zintl phases K4Si4, comprising [Si4]4− units, and K12Si17, consisting of [Si4]4− and [Si9]4− clusters. A combination of solid‐state MAS‐NMR, solution NMR, and Raman spectroscopy, electrospray ionization mass spectrometry, and quantum‐chemical investigations was used to investigate four‐ and nine‐atomic silicon Zintl clusters in neat solids and solution. The results were compared to 29Si isotope‐enriched samples. 29Si‐MAS NMR and Raman shifts of the phase‐pure solids K4Si4 and K12Si17 were interpreted by quantum‐chemical calculations. Extraction of [Si9]4− clusters from K12Si17 with liquid ammonia/222crypt and their transfer to pyridine yields in a red solid containing Si9 clusters. This compound was characterized by elemental and EDX analyses and 29Si‐MAS NMR and Raman spectroscopy. Charged Si9 clusters were detected by 29Si NMR in solution. 29Si and 1H NMR spectra reveal the presence of the [H2Si9]2− cluster anion in solution. Polyanionic silicon clusters are provided by the Zintl phases K4Si4, comprising [Si4]4− units, and K12Si17, consisting of [Si4]4− and [Si9]4− clusters. Charged Si9 clusters were detected for the first time by 29Si NMR spectroscopy in the solid state and in solution. 29Si and 1H NMR spectra reveal the [H2Si9]2− cluster anion in solution and J(29Si—1H) coupling shows these is proton scrambling.
    Subject(s): quantum chemical calculations ; cluster compounds ; silicon ; NMR spectroscopy ; isotope enrichment ; Nuclear magnetic resonance spectroscopy ; Silicon ; Pyridine ; Raman spectroscopy ; Mass spectrometry ; Investigations
    ISSN: 1433-7851
    E-ISSN: 1521-3773
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: Clinical interventions in aging, 2017, Vol.12, p.1503-1513
    Description: Sarcopenic obesity (SO) is a geriatric syndrome characterized by the disproportion between the amount of lean mass and fat mass. Exercise decreases fat and maintains muscle mass; however, older people fail to exercise at doses sufficient to affect musculoskeletal and cardiometabolic risk factors. The aim of this study was to evaluate the effect of whole-body electromyostimulation (WB-EMS), a time-efficient, joint-friendly and highly individualized exercise technology, on sarcopenia and SO in older men. A total of 100 community-dwelling northern Bavarian men aged ≥70 years with sarcopenia and obesity were randomly (1-1-1) assigned to either 16 weeks of 1) WB-EMS and protein supplementation (WB-EMS&P), 2) isolated protein supplementation or 3) nonintervention control. WB-EMS consisted of 1.5×20 min (85 Hz, 350 µs, 4 s of strain to 4 s of rest) applied with moderate-to-high intensity while moving. We further generated a daily protein intake of 1.7-1.8 g/kg/body mass per day. The primary study end point was Sarcopenia Z-Score, and the secondary study end points were body fat rate (%), skeletal muscle mass index (SMI) and handgrip strength. Intention-to-treat analysis determined a significantly favorable effect of WB-EMS&P ( 〈0.001) and protein ( =0.007) vs control. Both groups significantly ( 〈0.001) lost body fat (WB-EMS&P: 2.1%; protein: 1.1%) and differed significantly ( ≤0.004) from control (0.3%). Differences between WB-EMS&P and protein were significant for the Sarcopenia Z-Score ( =0.39) and borderline nonsignificant ( =0.051) for body fat. SMI increased significantly in both groups ( 〈0.001 and =0.043) and decreased significantly in the control group (CG; =0.033); differences between the verum groups and control were significant ( ≤0.009). Handgrip strength increased in the WB-EMS group (1.90 kg; 〈0.001; =0.050 vs control) only. No adverse effects of WB-EMS or protein supplementation were recorded. WB-EMS&P is a safe and efficient method for tackling sarcopenia and SO in older men. However, the suboptimum effect on functional parameters should be addressed by increased voluntary activation during WB-EMS application.
    Subject(s): Sarcopenia - physiopathology ; Transcutaneous Electric Nerve Stimulation ; Sarcopenia - prevention & control ; Humans ; Aged, 80 and over ; Female ; Male ; Obesity - physiopathology ; Aged ; Muscle, Skeletal - physiology ; Hand Strength ; Sarcopenia ; Obesity ; Care and treatment ; Aged men ; Patient outcomes ; Proteins in human nutrition ; Electric stimulation ; Health aspects ; Methods ; Nursing home patients ; Intervention ; Body fat ; Strength training ; Systematic review ; Health physics ; Body composition ; Proteins ; Musculoskeletal system ; Physical fitness ; Hypotheses ; Exercise ; Older people ; Aging ; Fitness training programs ; Index Medicus ; exercise ; electrostimulation ; older people ; sarcopenic obesity ; Original Research ; sarcopenia ; older men ; Electromyostimulation
    ISSN: 1178-1998
    ISSN: 1176-9092
    E-ISSN: 1178-1998
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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