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  • 1
    Language: English
    In: World journal of hepatology, 2015, Vol.7 (2), p.139-149
    Description: Biomarkers for surveillance, diagnosis and predictionof prognosis in patients with hepatocellular carcinoma(HCC) are currently not ready for introduction intoclinical practice because of limited sensitivity andspecificity. Especially for the early detection of smallHCC novel biomarkers are needed to improve thecurrent effectiveness of screening performed byultrasound. The use of high-throughput technologiesin hepatocellular research allows to identify moleculesinvolved in the complex pathways in hepatocarcinogenesis.Several invasive and non-invasive biomarkershave been identified already and have been evaluatedin different clinical settings. Gene signatures withprognostic potential have been identified by geneexpression profiling from tumor tissue. However, asingle "all-in-one" biomarker that fits all-surveillance,diagnosis, prediction of prognosis-has not been foundso far. The future of biomarkers most probably lies in acombination of non-invasive biomarkers, imaging andclinical parameters in a surveillance setting. Molecularprofiling of tumorous and non-tumorous liver tissuemay allow a prediction of prognosis for the individualpatient and hopefully clear the way for individualtreatment approaches. This article gives an overviewon current developments in biomarker research inHCC with a focus on currently available and novelbiomarkers, in particular on microRNA.
    Subject(s): Biomarker ; Biomarker;Diagnosis ; carcinoma ; Diagnosis ; Hepatocellular ; Hepatocellular carcinoma ; MicroRNA ; Prognosis ; Review
    ISSN: 1948-5182
    E-ISSN: 1948-5182
    Source: PubMed Central
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  • 2
    Lexicon Article
    Lexicon Article
    2021
    ISSN: 0341-4418 
    Language: German
    In: manager magazin, 2021-07-23 (8), p.84-89
    Description: Am Ende der Ära Merkel steht der deutschen Wirtschaft ein Epochenwechsel im China-Geschäft bevor. Grüne, Liberale und auch einige Industrievertreter dringen auf Konfrontation.
    Subject(s): EU-Binnenmarkt ; Internationales Abkommen ; Investition ; Politisches Ziel ; Wirtschaftspolitik
    ISSN: 0341-4418
    Source: Nexis Uni
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  • 3
    Language: German
    Subject(s): Linguistic analysis (Linguistics)
    ISBN: 3732903761
    ISBN: 9783732903764
    Source: Alma/SFX Local Collection
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  • 4
    Book
    Book
    2007
    ISBN: 9783899427172  ISBN: 3899427173 
    Language: German
    Description: Die Soziale Arbeit ist stets darum bemuht, ihre berufliche Identitat im Kampf um Anerkennung und gesellschaftliche Legitimation eindeutig festzulegen. Ihre Suche nach dem Prototyp gelungener und effektiver sozialer Dienstleistung verschleiert dabei nicht selten die Komplexitat diskursiver Praktiken. Am Beispiel des Berufsfeldes der AIDS-Hilfen hebt diese Studie das Potenzial queerer Perspektiven hervor, die sich reflexiv mit der genealogischen Architektur professioneller Performanz auseinandersetzen. Im Anschluss an die Diskussion um den Nutzen von Care-Work-Alternativen des Anders Denkens wird das Konzept der Queer Professionals als Konzept kritischer Sozialer Arbeit gefasst. Dem Ruf nach Klarung identitarer Verunsicherung innerhalb der Disziplin wie auch der Profession Sozialer Arbeit ware damit ein brauchbares, innovatives Konzept an die Hand gegeben.
    Subject(s): AIDS-Hilfen ; body ; Gender Studies ; Gesellschaft ; Körper ; pedagogy ; Professionelle Identität ; Pädagogik ; Queer Theory ; Social Pedagogy ; social work ; Society ; Sozialarbeit ; Sozialpädagogik
    ISBN: 9783899427172
    ISBN: 3899427173
    Source: De Gruyter eBooks
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  • 5
    Language: English
    In: Military medicine, 2010-12, Vol.175 (12), p.947-949
    Description: The Traumatic Brain Injury Screening Instrument (TBISI) was implemented in Veterans Affairs medical facilities in an attempt to identify Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF) veterans with possible mild TBI. Despite its widespread implementation, the reliability and validity of the screening tool has not yet been established. The current study reports preliminary findings on the test-retest reliability of the TBISI in 44 OEF/OIF veterans referred for neuropsychological evaluation following a positive TBI screen. Results suggest overall poor test-retest reliability of the TBI screening tool with regard to type of event, injuries sustained, and resulting sequelae. These findings underscore the importance of further investigation of its psychometric properties to promote accurate identification and referral of veterans with possible TBI.
    Subject(s): Adult ; Adults ; Afghan War ; Americans ; Assessment Instruments ; Brain Injuries - diagnosis ; Humans ; Iraq War ; Male ; Psychometrics ; Reproducibility of Results ; Survivors ; Traumatic Brain Injury ; United States ; Veterans ; Young Adult
    ISSN: 0026-4075
    E-ISSN: 1930-613X
    Source: Academic Search Ultimate
    Source: PTSDpubs
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  • 6
    Article
    Article
    2005
    ISSN: 2192-4848 
    Language: English
    In: Forschungsjournal soziale Bewegungen, 2005-03-01, Vol.18 (1), p.110-112
    ISSN: 2192-4848
    E-ISSN: 2365-9890
    Source: De Gruyter Online
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  • 7
    Language: English
    In: International journal of neuroscience, 2019-03-04, Vol.129 (3), p.217-224
    Description: Aims: In neuropsychological evaluations, it is often difficult to ascertain whether poor performance on measures of validity is due to poor effort or malingering, or whether there is genuine cognitive impairment. Dunham and Denney created an algorithm to assess this question using the Medical Symptom Validity Test (MSVT). We assessed the ability of their algorithm to detect poor validity versus probable impairment, and concordance of failure on the MSVT with other freestanding tests of performance validity. Methods: Two previously published datasets (n = 153 and n = 641, respectively) from outpatient neuropsychological evaluations were used to test Dunham and Denney's algorithm, and to assess concordance of failure rates with the Test of Memory Malingering and the forced choice measure of the California Verbal Learning Test, two commonly used performance validity tests. Results: In both datasets, none of the four cutoff scores for failure on the MSVT (70%, 75%, 80%, or 85%) identified a poor validity group with proportionally aligned failure rates on other freestanding measures of performance validity. Additionally, the protocols with probable impairment did not differ from those with poor validity on cognitive measures. Conclusions: Despite what appeared to be a promising approach to evaluating failure on the easy MSVT subtests when clinical data are unavailable (as recommended in the advanced interpretation program, or advanced interpretation [AI], of the MSVT), the current findings indicate the AI remains the gold standard for doing so. Future research should build on this effort to address shortcomings in measures of effort in neuropsychological evaluations.
    Subject(s): assessment ; Life Sciences & Biomedicine ; malingering ; Neuropsychology ; Neurosciences ; Neurosciences & Neurology ; performance validity testing ; Science & Technology
    ISSN: 0020-7454
    E-ISSN: 1563-5279
    Source: Academic Search Ultimate
    Source: Web of Science - Science Citation Index Expanded - 2019〈img src="http://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /〉
    Source: Web of Science - Social Sciences Citation Index – 2019〈img src="http://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /〉
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  • 8
    Language: English
    In: International journal of neuroscience, 2010-07, Vol.120 (8), p.551-556
    Description: The presence of alcohol is clearly a risk factor for sustaining a traumatic brain injury (TBI); however, the impact of alcohol on injury severity, and functional or cognitive outcome is unclear, as there is mixed evidence in the literature. This study examined 482 participants in a large urban medical center with documented mild-complicated to severe TBI and blood alcohol testing for functional and cognitive outcome. Functional outcomes were measured by the Functional Independence Measure (FIM) and cognitive outcomes were measured using neuropsychological tests known to be sensitive to the sequelae of TBI. Consistent with the hypotheses, there was a statistically significant negative impact of alcohol intoxication at the time of injury on Glasgow Coma Scale (GCS); however intoxication only lowered GCS by an average of 1.9 points. There was a statistically significant relationship between blood alcohol levels (BAL) and FIM at the time of admission to inpatient rehabilitation, but BAL accounted for only 3% of the variance in FIM total score. There was no relationship between BAL and FIM at discharge from rehabilitation or at 1-year follow-up. There was no statistically significant relationship between BAL at the time of injury and cognitive functioning at 1-year follow-up; however, contrary to the hypotheses GCS failed to show a strong relationship with cognitive outcome.
    Subject(s): alcohol ; Alcohol Drinking - adverse effects ; Alcohol Drinking - blood ; Brain Injuries - blood ; Brain Injuries - complications ; Brain Injuries - etiology ; Cognition Disorders - blood ; Cognition Disorders - etiology ; cognitive recovery ; Ethanol - blood ; Female ; functional recovery ; Glasgow Coma Scale ; Health Status Indicators ; Humans ; Male ; Recovery of Function - physiology ; Regression Analysis ; Time Factors ; Trail Making Test ; traumatic brain injury ; Verbal Learning - physiology
    ISSN: 0020-7454
    E-ISSN: 1563-5279
    Source: Academic Search Ultimate
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  • 9
    Book
    Book
    2015
    ISBN: 9783899427172  ISBN: 3899427173 
    Language: German
    Subject(s): Social service
    ISBN: 9783899427172
    ISBN: 3899427173
    Source: De Gruyter eBooks
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  • 10
    Language: English
    In: Psychological injury and law, 2015-06, Vol.8 (2), p.100-105
    Description: Performance validity testing (PVT) is a standard of practice in situations where there are prominent secondary gain issues; however, it is suggested that their use may benefit neuropsychological evaluations in clinical contexts, as engagement in neuropsychological evaluations can affect the validity of testing and can occur for a variety of reasons outside of secondary gain issues. Several methods of embedded index development, as well as methods to combine them are discussed, including issues related to use of multiple indices. The potential limitations to administration of multiple indices are also explored. It is suggested that neuropsychological evaluations can benefit from PVT in regular clinical practice to assist with reaching firmer diagnostic conclusions by assuring test result validity.
    Subject(s): Clinical Psychology ; Law and Psychology ; Neuropsychological examination ; Performance validity ; Psychology ; Psychology, general ; Symptom validity
    ISSN: 1938-971X
    E-ISSN: 1938-9728
    Source: Alma/SFX Local Collection
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