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  • 1
    Language: English
    In: Journal of the American College of Cardiology, 2013, Vol.61 (21), p.2194-2196
    Subject(s): Cardiovascular ; Internal Medicine ; Sects ; Medical colleges ; Hospitals ; Heart beat ; Atrial fibrillation
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: Journal of the American College of Cardiology, 2013-05-28, Vol.61 (21), p.2194-2196
    Subject(s): Humans ; Atrial Fibrillation - etiology ; Cardiac Surgical Procedures - adverse effects ; Postoperative Care - methods ; Postoperative Complications ; Atrial Fibrillation - prevention & control ; Fish Oils - therapeutic use ; Randomized Controlled Trials as Topic ; Index Medicus ; Abridged Index Medicus
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Article
    Article
    2009
    ISSN: 1099-5129 
    Language: English
    In: Europace (London, England), 2009-09, Vol.11 (9), p.1230-1234
    Description: A patient with atrial flutter, intermittent non-sustained wide complex tachycardia and 1:1 AV conduction is reported. Electrophysiology testing showed counterclockwise isthmus-dependant right atrial flutter with conduction via the AV node and an innocent bystander left lateral accessory pathway. This explained the observed intermittent wide complex tachycardia. After successful bidirectional cavotricuspid isthmus conduction block, a sustained wide complex tachycardia with identical counterclockwise right atrial activation and rate occurred. This was due to antidromic AV re-entrant tachycardia with innocent bystander activation of the right atrium mimicking atrial flutter. Accessory pathway ablation effectively stopped tachycardia.
    Subject(s): Tachycardia, Ventricular - therapy ; Atrial Flutter - complications ; Diagnosis, Differential ; Tachycardia, Ventricular - complications ; Atrial Flutter - therapy ; Humans ; Male ; Treatment Outcome ; Aged ; Heart Conduction System - abnormalities ; Heart Conduction System - surgery ; Index Medicus
    ISSN: 1099-5129
    E-ISSN: 1532-2092
    Source: Hellenic Academic Libraries Link
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Journal of cardiovascular translational research, 2011-02, Vol.4 (1), p.27-34
    Description: In patients with heart disease, diabetes and age predict adverse outcomes. It remains unclear whether persons with diabetes who have implantable cardioverter defibrillators (ICDs) have fewer appropriate and inappropriate ICD shocks. The objective of this study is to determine if persons with diabetes who have ICDs receive a similar amount of appropriate and inappropriate shocks compared to persons without diabetes. In a post hoc analysis of 1,528 patients enrolled in the INTRINSIC RV trial, all-cause mortality and ICD shocks between persons with and without diabetes, stratified by age, was compared. The relationship between shock and mortality was also assessed. Mortality 1 year after ICD implant was lower for persons without diabetes vs. persons with diabetes (3.5% vs. 7.9%, p 〈 0.001). Young and old persons with diabetes received a similar number of total and appropriate ICD shocks. However, older persons with diabetes were less likely to receive inappropriate ICD shocks vs. older persons without diabetes (1.9% vs. 6.9%, p 〈 0.01). ICD shocks were not temporally related to mortality regardless of diabetes status. In the INTRINSIC RV trial, persons with diabetes and older persons without diabetes undergoing ICD implant were at a higher risk of death. Older persons with diabetes received less inappropriate shocks and still had a similar amount of appropriate shocks compared to persons without diabetes of similar age.
    Subject(s): Biomedical Engineering ; Human Genetics ; Heart failure ; Medicine & Public Health ; Mortality ; ICDs ; Diabetes ; Cardiology ; Medicine/Public Health, general ; Biomedicine general ; Age Factors ; Defibrillators, Implantable - adverse effects ; Risk Assessment ; Humans ; Middle Aged ; Risk Factors ; Kaplan-Meier Estimate ; Proportional Hazards Models ; Male ; Treatment Outcome ; Chi-Square Distribution ; Electric Countershock - adverse effects ; Equipment Design ; Randomized Controlled Trials as Topic ; Heart Diseases - mortality ; Electric Countershock - instrumentation ; Time Factors ; Heart Diseases - therapy ; Heart Diseases - complications ; Female ; Aged ; Retrospective Studies ; Diabetes Mellitus - mortality ; Equipment Failure ; Defibrillators ; Index Medicus
    ISSN: 1937-5387
    E-ISSN: 1937-5395
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: The Journal of Innovations in Cardiac Rhythm Management, 2017-09-01, Vol.8 (9), p.2824-2834
    ISSN: 2156-3977
    E-ISSN: 2156-3993
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: Journal of the American Heart Association, 2012-06, Vol.1 (3), p.e000547-n/a
    Description: Background Omega‐3 polyunsaturated fatty acids (n3‐PUFAs) might have antiarrhythmic properties, but data conflict on whether n3‐PUFAs reduce rates of atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG). We hypothesized that n3‐PUFAs would reduce post‐CABG AF, and we tested this hypothesis in a well‐powered, randomized, double‐blind, placebo‐controlled, multicenter clinical trial. Methods and Results Patients undergoing CABG were randomized to pharmaceutical‐grade n3‐PUFAs 2 g orally twice daily (minimum of 6 g) or a matched placebo ≥24 hours before surgery. Gas chromatography was used to assess plasma fatty acid composition of samples collected on the day of screening, day of surgery, and postoperative day 4. Treatment continued either until the primary end point, clinically significant AF requiring treatment, occurred or for a maximum of 2 weeks after surgery. Two hundred sixty patients were enrolled and randomized. Before surgery, n3‐PUFA dosing increased plasma n3‐PUFA levels from 2.9% to 4% and reduced the n6:n3‐PUFA ratio from 9.1 to 6.4 (both P〈0.001). Similar changes were noted on postoperative day 4. There were no lipid changes in the placebo group. The rate of post‐CABG AF was similar in both groups (30% n3‐PUFAs versus 33% placebo, P=0.67). The post‐CABG AF odds ratio for n3‐PUFAs relative to placebo was 0.89 (95% confidence interval 0.52–1.53). There were no differences in any secondary end points. Conclusions Oral n3‐PUFA supplementation begun 2 days before CABG did not reduce AF or other complications after surgery. Clinical Trial Registration URL: www.clinicaltrials.gov Unique identifier: NCT00446966. (J Am Heart Assoc. 2012;1:e000547 doi: 10.1161/JAHA.111.000547.)
    Subject(s): coronary artery bypass graft surgery ; fatty acids ; atrial fibrillation
    ISSN: 2047-9980
    E-ISSN: 2047-9980
    Source: HighWire Press (Free Journals)
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Circulation (New York, N.Y.), 2018-11-06, Vol.138 (Suppl_1 Suppl 1), p.A11758-A11758
    Description: IntroductionSustained ventricular arrhythmias (VA) are common in heart failure patients receiving continuous flow left ventricular assist devices (LVAD). Available studies evaluating the impact of VA on clinical outcomes in LVAD recipients have been single center and limited by small sample sizeHypothesisWe report the first multicenter study to assess the incidence, predictors, and outcomes associated with VA in LVAD patientsMethodsAnalysis was performed on 408 patients who underwent LVAD implantation at 5 centers from 2007-2015. VA was defined as sustained ventricular tachyarrhythmias lasting 〉30 sec or requiring ICD therapy. Effects of pre- and post-LVAD VA on survival was assessed using Kaplan-Meier analysis.ResultsOf 408 LVAD patients (Age 60 years), 254 (62%) had pre-LVAD VA (PreVA) and 154 (38%) did not (No-PreVA). At baseline, the PreVA group had greater male sex (85 vs 75%, p=0.02), amiodarone use (44 vs 31%, p=0.01), LV diastolic dimensions (7.1 vs 6.8 cm, p=0.01) and atrial arrhythmias (AA) (57 vs 45%, p=0.03). Compared to the No-PreVA group, the PreVA group had significantly higher incidence of post-LVAD VA (73 vs 37%, p〈 0.0001), AA (63 vs 42%, P〈0.0001), and ICD shocks (42 vs 32%, p=0.001) but similar rates of hospitalization (0.5 vs 0.5/100 days, p=0.7). During a median follow-up of 478 days, 35% of patients died in both groups. Kaplan-Meier analysis showed no difference in survival between the groups (Log Rank p=0.1Fig 1). Those who had both pre- and post-LVAD VA had similar survival as patients without any VA (Log rank p=0.1).ConclusionsIn this large, multicenter LVAD cohort, PreVA was associated with a significantly higher incidence of post-LVAD VA and ICD shocks. PreVA was not significantly associated with survival or all-cause hospitalizations.
    ISSN: 0009-7322
    E-ISSN: 1524-4539
    Source: Hellenic Academic Libraries Link
    Source: American Heart Association Journals
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 8
    Language: English
    In: The Journal of heart and lung transplantation, 2001, Vol.20 (9), p.928-934
    Description: Background: We prospectively compared the hybrid capture system (HCS) assay with conventional cell culture and shell vial assay for the detection of cytomegalovirus (CMV) infection and disease in the lung transplant population. Methods: Between January 1999 and February 2000, 34 lung transplant patients at Loyola University Medical Center, who were considered to be at risk for CMV disease, underwent surveillance testing for CMV cell culture, shell vial assay and HCS assay according to a pre-determined schedule. In addition, bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial biopsy were performed at regular intervals and for clinical indications. All BAL samples were sent for CMV cultures and biopsy specimens were analyzed for histopathologic evidence of CMV by immunoperoxidase staining using antibody to early immediate nuclear antigen. Results: Ten patients developed CMV disease/syndrome during the course of the study. The sensitivity, specificity, positive predictive value and negative predictive value were 〉90% for the HCS assay. The sensitivity of the HCS assay (90%) was statistically significantly higher than the sensitivity of either the SV assay (40%) or the cell culture (50%). In addition, the HCS assay was able to detect CMV 50 ± 67 days prior to clinical evidence of CMV disease and an average of 36 days prior to the other detection techniques. Conclusion:The HCS assay is a sensitive diagnostic technique able to reliably detect CMV disease earlier than other diagnostic methods in the lung transplant population. Future studies may be able to evaluate whether pre-emptive anti-viral therapy targeted to specific viral loads using the HCS assay will be beneficial in preventing morbidity associated with CMV disease.
    Subject(s): Biological and medical sciences ; Surgery of the respiratory system ; Medical sciences ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Cytosine - analogs & derivatives ; Predictive Value of Tests ; Prospective Studies ; Humans ; Middle Aged ; Male ; Viral Load ; Cytomegalovirus Infections - mortality ; Lung Transplantation ; Sensitivity and Specificity ; Cytomegalovirus Infections - etiology ; Ganciclovir - therapeutic use ; Adult ; Female ; Cytosine - therapeutic use ; Cell Culture Techniques ; Nucleic Acid Hybridization - methods ; Cytomegalovirus - genetics ; Cytomegalovirus - isolation & purification ; Antiviral Agents - therapeutic use ; Organophosphorus Compounds - therapeutic use ; Cytomegalovirus Infections - diagnosis ; Syndrome ; DNA, Viral - blood ; Organophosphonates ; Illinois ; Reagent Kits, Diagnostic ; Survival Analysis ; Immunization, Passive ; Index Medicus
    ISSN: 1053-2498
    E-ISSN: 1557-3117
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Journal of the American Heart Association, 2018-06-15, Vol.7 (12)
    Description: Many patients with heart failure continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implant. We report the first multicenter study to assess the impact of CRT on clinical outcomes in CF-LVAD patients. Analysis was performed on 488 patients (58±13 years, 81% male) with an implantable cardioverter defibrillator (ICD) (n=223) or CRT-D (n=265) who underwent CF-LVAD implantation at 5 centers from 2007 to 2015. Effects of CRT on mortality, hospitalizations, and ventricular arrhythmia incidence were compared against CF-LVAD patients with an ICD alone. Baseline differences were noted between the 2 groups in age (60±12 versus 55±14, 〈0.001) and QRS duration (159±29 versus 126±34, =0.001). Median biventricular pacing in the CRT group was 96%. During a median follow-up of 478 days, Kaplan-Meier analysis showed no difference in survival between groups (log rank =0.28). Multivariate Cox regression demonstrated no survival benefit with type of device (ICD versus CRT-D; =0.16), whereas use of amiodarone was associated with increased mortality (hazard ratio 1.77, 95% confidence interval 1.1-2.8, =0.01). No differences were noted between CRT and ICD groups in all-cause ( =0.06) and heart failure ( =0.9) hospitalizations, ventricular arrhythmia incidence (43% versus 39%, =0.3), or ICD shocks (35% versus 29%, =0.2). During follow-up, 69 (26%) patients underwent pulse generator replacement in the CRT-D group compared with 36 (15.5%) in the ICD group ( =0.003). In this large, multicenter CF-LVAD cohort, continued CRT was not associated with improved survival, hospitalizations, incidence of ventricular arrhythmia and ICD therapies, and was related to a significantly higher number of pulse generator changes.
    Subject(s): Index Medicus
    ISSN: 2047-9980
    E-ISSN: 2047-9980
    Source: HighWire Press (Free Journals)
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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