placeholder
and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Proceed order?

Export
Filter
Language
Year
  • 1
    Language: English
    In: Clinical chemistry and laboratory medicine, 1998, Vol.36 (4), p.235-240
    Description: Conventional laboratory investigations of haemostasis like prothrombin time and activated partial thromboplastin time are not useful in predicting and managing intra-operative bleeding complications. In order to establish a possible "perioperative reference range" for thrombin generation prothrombin fragment F1+2 (F1+2) and fibrin degradation (D-dimer) markers, we measured F1+2 and D-dimer concentrations before surgery (but after induction of anaesthesia), 30 minutes into surgery, 10 minutes after the event expected to induce the maximal activation of the haemostatic systems, 90 minutes after surgery and on postoperative days 1 and 2 in 226 consecutive patients. Samples were collected from arterial lines. Twenty patients developed a clinically defined, intraoperative disorder of haemostasis, 206 did not. Patients with an intraoperative disorder of haemostasis had significantly higher preoperative F1+2 and D-dimer concentrations. Preoperative values for F1+2 and D-dimer concentrations above the 75th percentile of patients without an intraoperative disorder of haemostasis indicated a 2.70 to 2.88 fold risk of developing an intraoperative disorder of haemostasis (odds ratios were 3.04, 3.12 and 3.29 for D-dimer, ELISA, F1+2, and D-dimer latex tests, respectively with 95% confidence intervals from 1.20 to 8.46) with negative predictive values of 94%, but positive predictive values of only 16% to 26%. These data suggest that preoperative determination of molecular markers might be helpful in identifying a group of patients at high risk for intraoperative disorder of haemostasis by exclusion of low risk patients. Validation of such an approach requires a prospective trial.
    Subject(s): Blood coagulation ; Biological and medical sciences ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Blood Loss, Surgical - prevention & control ; Intraoperative Complications - blood ; Blood Coagulation Disorders - prevention & control ; Fibrin Fibrinogen Degradation Products - metabolism ; Blood Coagulation Disorders - etiology ; Humans ; Middle Aged ; Risk Factors ; Intraoperative Complications - prevention & control ; Male ; Biomarkers - blood ; Hemostasis ; Intraoperative Complications - etiology ; Blood Coagulation ; Peptide Fragments - blood ; Aged, 80 and over ; Blood Coagulation Disorders - blood ; Adult ; Female ; Aged ; Prothrombin - metabolism ; Index Medicus
    ISSN: 1434-6621
    E-ISSN: 1437-4331
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Allergy (Copenhagen), 2013-02, Vol.68 (2), p.220-228
    Description: Background Vitamin D levels are known to be associated with atopic disease development; however, existing data are controversial. The aim of this study was to investigate whether corresponding maternal and cord blood vitamin D levels are associated with atopic outcomes in early infancy. Methods Within the LINA cohort study (Lifestyle and environmental factors and their Influence on Newborns Allergy risk), 25(OH)D was measured in blood samples of 378 mother–child pairs during pregnancy and at birth. Information about children's atopic manifestations during the first 2 years of life was obtained from questionnaires filled out by the parents during pregnancy and annually thereafter. Cord blood regulatory T cells (Treg) were detected by methylation‐specific PCR using a Treg‐specific demethylated region in the FOXP3 gene. Results The median maternal 25(OH)D3 level was 22.19 ng/ml (IQR 14.40–31.19 ng/ml); the median cord blood 25(OH)D3 10.95 ng/ml (6.99–17.39 ng/ml). A high correlation was seen between maternal and cord blood 25(OH)D3 levels, both showing a seasonal distribution. Maternal and cord blood 25(OH)D3 was positively associated with children's risk for food allergy within the first 2 years. Further, higher maternal 25(OH)D3 resulted in a higher risk for sensitization against food allergens at the age of two. Cord blood 25(OH)D3 levels were negatively correlated with regulatory T cell numbers. Conclusion Our study demonstrates that high vitamin D levels in pregnancy and at birth may contribute to a higher risk for food allergy and therefore argues against vitamin D supplement to protect against allergy.
    Subject(s): Food allergy ; LINA ; mother–child pairs ; vitamin D ; Treg ; T-Lymphocytes, Regulatory - metabolism ; Prevalence ; Risk Assessment ; Dermatitis, Atopic - epidemiology ; Humans ; Immunoglobulin E - metabolism ; Male ; Dermatitis, Atopic - physiopathology ; Germany - epidemiology ; T-Lymphocytes, Regulatory - immunology ; Vitamin D - blood ; Immunoglobulin E - immunology ; Dermatitis, Atopic - etiology ; Hypersensitivity - etiology ; Statistics, Nonparametric ; Female ; Hypersensitivity - epidemiology ; Dietary Supplements - adverse effects ; Pregnancy - blood ; Fetal Blood ; Infant, Newborn ; Cohort Studies ; Infants (Newborn) ; Allergens ; Vitamin D ; Analysis ; Calcifediol ; Alfacalcidol ; Children ; T cells ; Health aspects ; Index Medicus
    ISSN: 0105-4538
    E-ISSN: 1398-9995
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: International journal of obesity (2005), 2017-09, Vol.41 (9), p.1440-1446
    Description: The maternal inflammation status during pregnancy has been associated with metabolic imprinting and obesity development in the child. However, the influence of the maternal Th2 cytokines, interleukin-4 (IL4), IL5 and IL13, has not been studied so far. We investigated the relationship between maternal innate (IL6, IL8, IL10 and tumor necrosis factor-α (TNFa)) and adaptive (interferon-γ, IL4, IL5 and IL13) blood cytokine levels at 34 weeks of gestation and children's overweight development until the age of 3 years in 407 children of the German longitudinal LINA (Lifestyle and Environmental Factors and their Influence on Newborns Allergy risk) cohort. Children's body weight and height were measured during the annual clinical visits or acquired from questionnaires. Body mass index (BMI) Z-scores were calculated according to the WHO reference data to adjust for child's age and gender. Cytokine secretion was stimulated with phytohemagglutinin or lipopolysaccharide and measured by cytometric bead assay. Furthermore, we assessed metabolic parameter in blood of 318 children at age 1 using the AbsoluteIDQ p180 Kit (Biocrates LIFE Science AG). Applying logistic regression models, we found that an increase of maternal IL4 and IL13 was associated with a decreased risk for overweight development in 1- and 2-year-old children. This effect was consistent up to the age of 3 years for IL13 and mainly concerns children without maternal history of atopy. Children's acylcarnitine concentrations at 1 year were positively correlated with maternal IL13 levels and inversely associated with the BMI Z-score at age 1. We were able to show for the first time that the maternal Th2 status may be linked inversely to early childhood overweight development accompanied by an altered metabolic profile of the fetus. However, our data do not support a direct mediating role of acylcarnitines on maternal IL13-induced weight development.
    Subject(s): Prospective Studies ; Humans ; Child, Preschool ; Interleukin-13 - immunology ; Infant ; Male ; Th2 Cells - immunology ; Mothers ; Immunity, Innate - physiology ; Tumor Necrosis Factor-alpha - immunology ; Adult ; Female ; Infant, Newborn ; Body Mass Index ; Maternal-Fetal Exchange - immunology ; Adaptive Immunity - physiology ; Genetic Predisposition to Disease - genetics ; Risk Factors ; Metabolome ; Inflammation - immunology ; Interleukin-5 - immunology ; Pregnancy ; Interleukin-4 - immunology ; Longitudinal Studies ; Germany ; Inflammation - physiopathology ; Interleukins ; Maternal-fetal exchange ; Cytokines ; Genetic aspects ; Obesity in children ; Health aspects ; Risk factors ; Index Medicus
    ISSN: 0307-0565
    E-ISSN: 1476-5497
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: The American journal of clinical nutrition, 2015, Vol.102 (4), p.837-47
    Description: Background: It is well known that fish is the major natural source of vitamin D in the diet; therefore, this meta-analysis investigated the influence of fish consumption in randomized controlled trials (RCTs) on serum 25-hydroxyvitamin D [25(OH)D] concentrations. Objective: A literature search was carried out in Medline, Embase, Web of Science, and the Cochrane Library (up to February 2014) for RCTs that investigated the effect of fish consumption on 25(OH)D concentrations in comparison to other dietary interventions. Results: Seven articles and 2 unpublished study data sets with 640 subjects and 14 study groups met the inclusion criteria and were included in this meta-analysis. Compared with controls, the consumption of fish increased 25(OH)D concentrations, on average, by 4.4 nmol/L (95% CI: 1.7, 7.1 nmol/L; P 〉 0.0001, I
    Subject(s): Animals ; Diet ; Vitamin D Deficiency - blood ; Fishes ; Humans ; Risk Factors ; Seafood ; Vitamin D - administration & dosage ; Nutritional Status ; Databases, Factual ; Randomized Controlled Trials as Topic ; Vitamin D - blood ; Vitamin D ; Nutritional aspects ; Calcifediol ; Fish as food ; Alfacalcidol ; Biological control systems ; Observations ; Health aspects ; Index Medicus ; Abridged Index Medicus ; RISK-FACTORS ; 25-HYDROXYVITAMIN-D ; vitamin D ; meta-analysis ; D DEFICIENCY ; SERUM ; randomized controlled trial ; Näringslära ; LIFE-STYLE ; intervention studies ; HEART-RATE-VARIABILITY ; COLORECTAL-CANCER ; DIETARY REQUIREMENT ; DISEASE ; 25(OH)D ; fish intake ; FATTY FISH ; Nutrition and Dietetics ; CONSUMPTION
    ISSN: 0002-9165
    E-ISSN: 1938-3207
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: European heart journal, 2016, Vol.37 (1), p.24-34
    Subject(s): Humans ; Male ; Treatment Outcome ; Cardiovascular Agents - pharmacology ; Hypertension - etiology ; Heart Diseases - diagnosis ; Cardiovascular Agents - therapeutic use ; Heart Diseases - etiology ; Heart Diseases - therapy ; Drug-Related Side Effects and Adverse Reactions ; Cardiovascular Agents - pharmacokinetics ; Sex Factors ; Female ; Hypertension - therapy ; Hypertension - diagnosis ; Needs Assessment ; Index Medicus ; Medicin och hälsovetenskap
    ISSN: 0195-668X
    ISSN: 1522-9645
    E-ISSN: 1522-9645
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: European heart journal, 2018-08-01, Vol.39 (suppl_1)
    ISSN: 0195-668X
    E-ISSN: 1522-9645
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: BMJ open, 2019-06, Vol.9 (5), p.e023826-e023826
    Description: IntroductionMultidisciplinary, complex rehabilitation interventions are an important part of the treatment of chronic diseases. However, little is known about the effectiveness of routine rehabilitation interventions within the German healthcare system. Due to the nature of the social insurance system in Germany, randomised controlled trials examining the effects of rehabilitation interventions are challenging to implement and scarcely accessible. Consequently, alternative pre-post designs can be employed to assess pre-post effects of medical rehabilitation programmes. We present a protocol of systematic review and meta-analysis methods to assess the pre-post effects of rehabilitation interventions in Germany.Methods and analysisThe respective study will be conducted within the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A systematic literature review will be conducted to identify studies reporting the pre-post effects (start of intervention vs end of intervention or later) in German healthcare. Studies investigating the following disease groups will be included: orthopaedics, rheumatology, oncology, pulmonology, cardiology, endocrinology, gastroenterology and psychosomatics. The primary outcomes of interest are physical/mental quality of life, physical functioning and social participation for all disease groups as well as pain (orthopaedic and rheumatologic patients only), blood pressure (cardiac patients only), asthma control (patients with asthma only), dyspnoea (patients with chronic obstructive pulmonary disease only) and depression/anxiety (psychosomatic patients only). We will invite the principal investigators of the identified studies to provide additional individual patient data. We aim to perform the meta-analyses using individual patient data as well as aggregate data. We will examine the effects of both study-level and patient-level moderators by using a meta-regression method.Ethics and disseminationOnly studies that have received institutional approval from an ethics committee and present anonymised individual patient data will be included in the meta-analysis. The results will be presented in a peer-reviewed publication and at research conferences. A declaration of no objection by the ethics committee of the University of Würzburg is available (number 20180411 01).Trial registration numberCRD42018080316.
    Subject(s): Meta-Analysis as Topic ; Humans ; Systematic Reviews as Topic ; Treatment Outcome ; Rehabilitation ; Research Design ; Evaluation Studies as Topic ; Germany ; Literature reviews ; Intervention ; Objectives ; Systematic review ; Quantitative psychology ; Evidence-based medicine ; Asthma ; Meta-analysis ; Index Medicus
    ISSN: 2044-6055
    E-ISSN: 2044-6055
    Source: HighWire Press (Free Journals)
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Echocardiography (Mount Kisco, N.Y.), 2018, Vol.35 (1), p.47-55
    Description: AIM: The aim of our study was to describe right atrial (RA) and right ventricular (RV) function, assessed by Doppler tissue imaging and 2D speckle tracking echocardiography (2DSTE), in women with signs of early impaired left ventricular diastolic function (DD). METHODS AND RESULTS: In a cross-sectional trial, standard parameters of diastolic and right heart function were investigated in 438 women of the Berlin Female Risk Evaluation (BEFRI) study. In a subset of women, average peak systolic RA strain (RAS), as well as the average peak systolic RV strain of the free wall (RVS free wall) and of all RV segments (average RV strain; RVS Avg), was analyzed using 2DSTE. Compared to women with normal diastolic function (DD0), RAS, RVS free wall and RVS Avg were significantly reduced in DD (43.1% +/- 11.9%, -26.7% +/- 5.6%, and -23.3% +/- 3.5% in DD0; vs 35.1% +/- 10.4%, -23.9% +/- 5.5%, and -20.6% +/- 3.8% in DD; P 〈 .01). Peak RV myocardial velocity (RV-IVV) and acceleration during isovolumetric contraction (RV-IVA) were markedly higher in DD (15.0 +/- 3.9 cm/s and 3.1 +/- 1.0 m/s(2) in DD vs 11.9 +/- 3.2 cm/s and 2.8 +/- 0.8 m/s(2) in DD0; P 〈 .05). RAS and RV-IVV were significantly associated with DD after adjustment to age, BMI, and left atrial strain in multivariate regression analysis. CONCLUSION: Systolic right heart function is significantly altered in DD. DTI as well as 2DSTE constitute sensitive echocardiographic tools that enable the diagnosis of impaired right heart mechanics in early-staged DD.
    Subject(s): myocardial strain ; Doppler tissue imaging ; right atrial function ; impaired diastolic function ; 2D speckle tracking echocardiography ; right ventricular function ; Heart ; Echocardiography ; Index Medicus
    ISSN: 0742-2822
    E-ISSN: 1540-8175
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: International journal of nanomedicine, 2018, Vol.13, p.7905-7913
    Description: Optical coherence tomography (OCT) is an intravascular, high-resolution imaging technique that is used to characterize atherosclerotic plaques. However, the identification of macrophages as important markers of inflammation and plaque vulnerability remains difficult. Here, we investigate whether the uptake of very small iron oxide particles (VSOP) in macrophages, that cluster in phagolysosomes and allow high-quality magnetic resonance imaging (MRI) of atherosclerotic plaques, and uptake of ferumoxytol nanoparticles enhance detection of macrophages by OCT. RAW 264.7 macrophage cells were incubated with VSOP (1 and 2 mM Fe) that have been clinically tested and ferumoxytol (8.9 mM Fe) that is approved for iron deficiency treatment and currently investigated as an MRI contrast agent. The light scattering of control macrophages, nanoparticle-labeled macrophages (2,000,000 in 500 µL) and nanoparticle suspensions was measured in synchronous wavelength scan mode using a fluorescence spectrophotometer. For OCT analyses, pellets of 8,000,000 non-labeled, VSOP-labeled and ferumoxytol-labeled RAW 264.7 macrophages were imaged and analyzed on an OPTIS™ OCT imaging system. Incubation with 1 and 2 mM VSOP resulted in uptake of 7.1±1.5 and 12±1.5 pg Fe per cell, which increased the backscattering of the macrophages in spectrophotometry 2.5- and 3.6-fold, whereas incubation with 8.9 mM Fe ferumoxytol resulted in uptake of 6.6±2 pg Fe per cell, which increased the backscattering 1.5-fold at 700 nm. In contrast, backscattering of non-clustered nanoparticles in suspension was negligible. Accordingly, OCT imaging could visualize significantly increased backscattering and signal attenuation of nanoparticle-labeled macrophages in comparison with controls. We conclude that VSOP and, to a lesser extent, ferumoxytol increase light scattering and attenuation when taken up by macrophages and can serve as a multimodal imaging probe for MRI and OCT to improve macrophage detection in atherosclerotic plaques by OCT in the future.
    Subject(s): Nanoparticles ; Iron compounds ; Macrophages ; Ferric oxide ; Contrast media ; Cell culture ; Medical imaging ; Nuclear magnetic resonance--NMR ; Microscopy ; Penicillin ; Cardiology ; Index Medicus ; magnetic resonance imaging ; Original Research ; intravascular ; inflammation ; optical coherence tomography ; vulnerability ; multimodal imaging ; macrophages ; Optical coherence tomography ; Magnetic resonance imaging ; ferumoxytol ; superparamagnetic iron oxide particles ; Atherosclerotic plaques
    ISSN: 1178-2013
    ISSN: 1176-9114
    E-ISSN: 1178-2013
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: European journal of nutrition, 2014-06, Vol.53 (4), p.1115-1122
    Description: In vitro studies discovered intestinal proton-coupled folate transporter (PCFT) as a vitamin D hormone-responsive gene. In vivo effects of vitamin D on PCFT and folate status are currently not available.Three experiments were conducted. At first, vitamin D receptor knockout (VDR−/−) mice and corresponding wild-type (WT) mice were compared for their plasma and hepatic folate concentration and PCFT mRNA expression in intestinal mucosa. In a second experiment with rats, we analyzed the folate status of offspring in response to a maternal vitamin D-adequate (1,000 IU/kg) or vitamin D-deficient (0 IU/kg) diet that was fed for 11 weeks. Finally, the plasma folate concentration of healthy individuals was studied at baseline (in winter) and in response to an oral treatment for 8 weeks with 2,000 IU vitamin D3 per day or a placebo, respectively.Here, we show that folate status and intestinal PCFT mRNA abundance did not differ between the VDR−/− and the WT mice. No effect of vitamin D on folate status was also found in rat dams and their offspring, and plasma folate levels of individuals did not change in response to vitamin D.Current data from studies with model animals and humans provide no indication for a vitamin D effect on intestinal uptake and status of folate.
    Subject(s): Human ; Chemistry ; Nutrition ; Vitamin D ; PCFT ; Rat ; VDR −/− mouse ; Folate ; Fundamental and applied biological sciences. Psychology ; Feeding. Feeding behavior ; Biological and medical sciences ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Intestinal Mucosa - metabolism ; Receptors, Calcitriol - deficiency ; Humans ; Mice, Inbred C57BL ; RNA, Messenger - genetics ; Rats ; Male ; Receptors, Calcitriol - metabolism ; RNA, Messenger - metabolism ; Rats, Sprague-Dawley ; Receptors, Calcitriol - genetics ; Intestinal Mucosa - drug effects ; Mice, Knockout ; Randomized Controlled Trials as Topic ; Vitamin D - blood ; Animals ; Proton-Coupled Folate Transporter - blood ; Proton-Coupled Folate Transporter - genetics ; Vitamin D Deficiency - blood ; Folic Acid - blood ; Female ; Vitamin D - administration & dosage ; Mice ; Animal experimentation ; Messenger RNA ; Analysis ; Calcifediol ; Alfacalcidol ; Folic acid ; Index Medicus
    ISSN: 1436-6207
    E-ISSN: 1436-6215
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: SPORTDiscus with Full Text
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...