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  • 1
    Article
    Article
    2022
    ISSN: 0164-0364 
    Language: English
    In: The American criminal law review, 2022-01-01, Vol.59 (1), p.39
    Description: Federal prosecutors' authority in the U.S. legal system is imperial. When they act, prosecutors speak for the whole of the U.S. government across all policymaking domains. Ideally, their judgments, expressed in many thousands of retail investigative and prosecutive decisions each year, are meant to be insulated from the interests of other Executive Branch actors--even, on many accounts, from the White House. The relevant ideal is expressed not principally as an injunction against self-dealing or "political" influence, but rather as the far broader norm of prosecutorial independence.
    Subject(s): Administrative discretion ; Criminal law ; Criminalization ; Decision making ; Government attorneys ; Influence ; Judgments ; Law enforcement ; Laws, regulations and rules ; Management ; National security ; Powers and duties ; Public prosecutors ; Remedies
    ISSN: 0164-0364
    Source: HeinOnline Law Journal Library
    Source: Nexis Uni
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  • 2
    Language: English
    In: Nature reviews. Molecular cell biology, 2010-01, Vol.11 (1), p.37-49
    Description: The regulated migration of cells is essential for development and tissue homeostasis, and aberrant cell migration can lead to an impaired immune response and the progression of cancer. Primordial germ cells (PGCs), precursors to sperm and eggs, have to migrate across the embryo to reach somatic gonadal precursors, where they carry out their function. Studies of model organisms have revealed that, despite important differences, several features of PGC migration are conserved. PGCs require an intrinsic motility programme and external guidance cues to survive and successfully migrate. Proper guidance involves both attractive and repulsive cues and is mediated by protein and lipid signalling.
    Subject(s): Animals ; Cell migration ; Cell Movement - physiology ; Germ cells ; Germ Cells - physiology ; Homeostasis ; Humans ; Physiological aspects ; Properties ; Signal Transduction
    ISSN: 1471-0072
    E-ISSN: 1471-0080
    Source: Academic Search Ultimate
    Source: Nature Reviews
    Source: Get It Now
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  • 3
    Language: English
    In: Nature (London), 2012, Vol.484 (7392), p.120-124
    Description: The basic unit of skeletal muscle in all metazoans is the multinucleate myofibre, within which individual nuclei are regularly positioned. The molecular machinery responsible for myonuclear positioning is not known. Improperly positioned nuclei are a hallmark of numerous diseases of muscle, including centronuclear myopathies, but it is unclear whether correct nuclear positioning is necessary for muscle function. Here we identify the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes. We find that these proteins interact physically and that expression of the Kif5b motor domain fused to the MAP7 microtubule-binding domain rescues nuclear positioning defects in MAP7-depleted cells. This suggests that MAP7 links Kif5b to the microtubule cytoskeleton to promote nuclear positioning. Finally, we show that myonuclear positioning is physiologically important. Drosophila ens mutant larvae have decreased locomotion and incorrect myonuclear positioning, and these phenotypes are rescued by muscle-specific expression of Ens. We conclude that improper nuclear positioning contributes to muscle dysfunction in a cell-autonomous fashion.
    Subject(s): Animals ; Biological and medical sciences ; C2C12 ; Cell Compartmentation - genetics ; Cell Line ; Cell Nucleus - metabolism ; Cell physiology ; Cell Polarity - genetics ; Cells, Cultured ; Cellular proteins ; Drosophila ; Drosophila melanogaster - cytology ; Drosophila melanogaster - genetics ; Drosophila melanogaster - growth & development ; Fundamental and applied biological sciences. Psychology ; Kinesin ; Kinesin - chemistry ; Kinesin - deficiency ; Kinesin - genetics ; Kinesin - metabolism ; Larva - cytology ; Larva - genetics ; Larva - metabolism ; Life Sciences ; Locomotion - genetics ; Locomotion - physiology ; MAP ; Metazoa ; Mice ; Microtubule-Associated Proteins - chemistry ; Microtubule-Associated Proteins - genetics ; Microtubule-Associated Proteins - metabolism ; Microtubules ; Microtubules - metabolism ; Muscle ; Muscle Fibers, Skeletal - cytology ; Muscle Fibers, Skeletal - metabolism ; Muscle, Skeletal - cytology ; Muscle, Skeletal - physiology ; Muscles ; nuclear movement ; nuclear positioning ; Organ Specificity ; Phenotype ; Physiological aspects ; primary myotubes ; Properties ; Protein Binding ; Protein Structure, Tertiary ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system
    ISSN: 0028-0836
    E-ISSN: 1476-4687
    Source: Academic Search Ultimate
    Source: Get It Now
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  • 4
    Book
    Book
    2020
    ISBN: 9781108477697  ISBN: 1108702538  ISBN: 1108477690  ISBN: 9781108702539 
    Language: English
    Description: During the Italian Renaissance, laywomen and nuns could take part in every stage of the circulation of texts of many kinds, old and new, learned and popular. This first in-depth and integrated analysis of Italian women's involvement in the material textual culture of the period shows how they could publish their own works in manuscript and print and how they promoted the first publication of works composed by others, acting as patrons or dedicatees. It describes how they copied manuscripts and helped to make and sell printed books in collaboration with men, how they received books as gifts and borrowed or bought them, how they commissioned manuscripts for themselves and how they might listen to works in spoken or sung performance. Brian Richardson's richly documented study demonstrates the powerful social function of books in the Renaissance: texts-in-motion helped to shape women's lives and sustain their social and spiritual communities.
    Subject(s): Transmission of texts ; Women ; Women in the book industries and trade ; Women in the book industries and trade-Italy-History
    ISBN: 9781108477697
    ISBN: 1108702538
    ISBN: 1108477690
    ISBN: 9781108702539
    Source: Cambridge Core All Books
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  • 5
    Language: English
    In: The Journal of cell biology, 2010-01-11, Vol.188 (1), p.101-114
    Description: Macroautophagy is a catabolic pathway used for the turnover of long-lived proteins and organelles in eukaryotic cells. The morphological hallmark of this process is the formation of double-membrane autophagosomes that sequester cytoplasm. Autophagosome formation is the most complex part of macroautophagy, and it is a dynamic event that likely involves vesicle fusion to expand the initial sequestering membrane, the phagophore; however, essentially nothing is known about this process including the molecular components involved in vesicle tethering and fusion. In this study, we provide evidence that the subunits of the conserved oligomeric Golgi (COG) complex are required for double-membrane cytoplasm to vacuole targeting vesicle and autophagosome formation. COG subunits localized to the phagophore assembly site and interacted with Atg (autophagy related) proteins. In addition, mutations in the COG genes resulted in the mislocalization of Atg8 and Atg9, which are critical components involved in autophagosome formation.
    Subject(s): Antibodies ; Autophagy ; Autophagy (Cytology) ; Autophagy-Related Protein 8 Family ; Autophagy-Related Proteins ; Biochemistry ; Cogs ; Cytoplasm ; Cytoplasmic Vesicles - metabolism ; Eukaryotes ; Freight ; Genes ; Golgi apparatus ; Golgi Apparatus - metabolism ; Lysosomes ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Microscopy ; Microscopy, Electron, Transmission ; Microscopy, Immunoelectron ; Microtubule-Associated Proteins - genetics ; Microtubule-Associated Proteins - metabolism ; Morphology ; Mutation ; Plasmids ; Properties ; Protein Transport ; Proteins ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - cytology ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Vacuoles ; Vesicular Transport Proteins - genetics ; Vesicular Transport Proteins - metabolism ; Yeasts
    ISSN: 0021-9525
    E-ISSN: 1540-8140
    Source: Rockefeller University Press
    Source: PubMed Central
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  • 6
    Language: English
    In: Developmental cell, 2012-04-17, Vol.22 (4), p.799-810
    Description: Arf GTPases are key regulators of both retrograde and anterograde traffic at the Golgi complex. The Golgi-localized Arf activators, Arf-GEFs (guanine exchange factor) of the BIG/GBF family, are poorly understood in terms of both their regulatory and localization mechanisms. We have performed a detailed kinetic characterization of a functional Golgi Arf-GEF, the trans-Golgi network (TGN)-localized Sec7 protein from yeast. We demonstrate that Sec7 is regulated by both autoinhibition and positive feedback. We show that positive feedback arises through the stable recruitment of Sec7 to membranes via its HDS1 domain by interaction with its product, activated Arf1. This interaction mediates localization of Sec7 to the TGN, because deletion of the HDS1 domain or mutation of the HDS1 domain in combination with deletion of Arf1 significantly increases cytoplasmic localization of Sec7. Our results lead us to propose a model in which Arf-GEF recruitment is linked to Golgi maturation via Arf1 activation. [Display omitted] ► The Golgi Arf-GEF Sec7 is regulated by autoinhibition and positive feedback ► Positive feedback results from stable recruitment of Sec7 to the membrane surface ► Positive feedback arises through interaction between the HDS1 domain and Arf1-GTP ► The HDS1 domain and Arf1 mediate recruitment of Sec7 to the trans-Golgi network Arf guanine exchange factors (GEFs) activate Arf GTPases, key regulators of trafficking at the Golgi complex. Richardson et al. show that the activity and localization of the Arf-GEF Sec7 is controlled through autoinhibition and positive feedback. The authors propose that active Arf1-mediated positive feedback links Arf-GEF recruitment to Golgi maturation.
    Subject(s): ADP-Ribosylation Factors - genetics ; ADP-Ribosylation Factors - metabolism ; Analysis ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell Membrane - metabolism ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Feedback, Physiological ; Fundamental and applied biological sciences. Psychology ; G proteins ; Gene Expression Regulation, Fungal ; Guanine Nucleotide Exchange Factors - genetics ; Guanine Nucleotide Exchange Factors - metabolism ; Liposomes ; Molecular and cellular biology ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; trans-Golgi Network - metabolism
    ISSN: 1534-5807
    E-ISSN: 1878-1551
    Source: Cell Press Collection [ECCPC]
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  • 7
    Article
    Article
    2016
    ISSN: 0010-6356  ISSN: 1935-0252 
    Language: English
    In: Conradiana, 2016-12-01, Vol.48 (2/3), p.245-256
    Description: Shakespeare's The Tempest has an abrupt and problematic ending; later authors rewriting the work have tried to either impose a fixed closure or prise the ending open. This is particularly true of Conrad's Victory, which provides an uncharacteristic (for Conrad) closed, definitive ending, and later postcolonial rewritings which often, even typically, insist on unresolved plots—both personal and national. We see this clearly in Aimé Cesaire's Une Tempête, Samuel Beckett's Endgame, and Iris Murdoch's The Sea, the Sea. In Prospero's Daughter, Elizabeth Nunez offers a new alternative by presenting a closed ending with poetic justice; this text's conclusion, however, includes its own defiance of colonial and racial narratives of domination.
    Subject(s): Adaptations ; Aesthetics ; ARTICLES ; Beckett, Samuel ; Beckett, Samuel (1906-1989) ; Cesaire, Aime ; Cesaire, Aime (1913-2008) ; Closure (Rhetoric) ; Conrad, Joseph (1857-1924) ; Conrad, Shakespeare, Joseph, --., William ; Drama ; Justice ; Literary characters ; Literary criticism ; Literary devices ; Literature ; Murdoch, Iris (1919-1999) ; Narrative techniques ; Narratives ; Negotiation ; Novels ; Nunez, Elizabeth ; Plot (Narrative) ; Postcolonialism ; Shakespeare, William (1564-1616) ; Writers
    ISSN: 0010-6356
    ISSN: 1935-0252
    E-ISSN: 1935-0252
    Source: Project MUSE - Premium Collection
    Source: Academic Search Ultimate
    Source: MLA International Bibliography with Full Text
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  • 8
    Book
    Book
    2019
    ISBN: 9780814277348  ISBN: 0814277349  ISBN: 9780814214121  ISBN: 0814214126 
    Language: English
    Description: Story, in the largest sense of the term, is arguably the single most important aspect of narrative. But with the proliferation of antimimetic writing, traditional narrative theory has been inadequate for conceptualizing and theorizing a vast body of innovative narratives. In A Poetics of Plot for the Twenty-First Century: Theorizing Unruly Narratives, Brian Richardson proposes a new model for evaluating literature—returning to the basis of narrative theory to illuminate how authors play with and help clarify the boundaries of narrative theory. While he focuses on late modernist, postmodern, and contemporary narratives, the study also includes many earlier works, spanning from Aristophanes and Shakespeare through James Joyce and Virginia Woolf to Salman Rushdie and Angela Carter.
    Subject(s): 21st Century ; American ; Comparative Literature ; English, Irish, Scottish, Welsh ; European ; General ; History and criticism ; Literary Collections ; Literary Criticism ; Literature ; Modern ; Narration (Rhetoric) ; Plots (Drama, novel, etc.) ; Theory, etc
    ISBN: 9780814277348
    ISBN: 0814277349
    ISBN: 9780814214121
    ISBN: 0814214126
    Source: OAPEN
    Source: DOAB: Directory of Open Access Books
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  • 9
    Language: English
    In: The New England journal of medicine, 2013-05-02, Vol.368 (18), p.1675-1684
    Description: This trial compared surgery with physical therapy (followed by surgery as needed) in patients with a meniscal tear and mild-to-moderate knee osteoarthritis. Functional outcomes and pain were similar in the two groups at 6 months; 30% of the PT group crossed over to surgery. Symptomatic, radiographically confirmed osteoarthritis of the knee affects more than 9 million people in the United States. 1 Meniscal tears are also highly prevalent, with imaging evidence of a meniscal tear observed in 35% of persons older than 50 years of age; two thirds of these tears are asymptomatic. 2 Meniscal damage is especially prevalent among persons with osteoarthritis 3 , 4 and is frequently treated surgically with arthroscopic partial meniscectomy. This procedure, in which the surgeon trims the torn meniscus back to a stable rim, is performed for a range of indications in more than 465,000 persons annually in the United States. 5 The . . .
    Subject(s): Abridged Index Medicus ; Arthritis ; Biological and medical sciences ; Bone surgery ; Case studies ; Diseases of the osteoarticular system ; Fees & charges ; Female ; General aspects ; Health aspects ; Humans ; Intention to Treat Analysis ; Knee ; Knee Injuries - surgery ; Knee Injuries - therapy ; Male ; Medical sciences ; Menisci, Tibial - surgery ; Meniscus ; Meniscus (Anatomy) ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Motivation ; NMR ; Nuclear magnetic resonance ; Orthopedics ; Osteoarthritis ; Osteoarthritis, Knee - surgery ; Osteoarthritis, Knee - therapy ; Pain Measurement ; Patents ; Patients ; Physical therapists ; Physical therapy ; Physical Therapy Modalities - adverse effects ; Postoperative Complications ; Professional baseball ; Radiography ; Recovery of Function ; Royalties ; Severity of Illness Index ; Skin diseases ; Surgeons ; Surgery ; Therapeutics, Physiological ; Tibial Meniscus Injuries ; Usage
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 10
    Article
    Article
    2018
    ISSN: 0026-7937 
    Language: English
    In: The Modern language review, 2018-01-01, Vol.113 (1), p.80-106
    Description: When Ludovico Ariosto had his Orlando furioso printed in Ferrara in 1516, he took great care over the first impressions that his poem would make. In the opening pages he juxtaposes elements reflecting his status as a courtier with others representing him as an innovative author who aspires to independence. The edition has a dedication to his employer, Ippolito d'Este. Yet Ariosto stresses the protection of his investment in publication through book-privileges, and he includes an emblem that suggests that authors meet with ingratitude. The typography reflects culturally significant choices: roman types rather than italic, and resources that facilitate reading.
    Subject(s): Ariosto, Ludovico ; Ariosto, Ludovico (1474-1533) ; ARTICLES ; Books ; Criticism and interpretation ; Grammar ; Humanism ; Independence ; Italian literature ; Literary devices ; Lyric poetry ; Medieval literature ; Narrative poetry ; Pastoral poetry ; Poetry ; Poets ; Popes ; Printing ; Punctuation ; Renaissance period ; Stanzas ; Typesetting
    ISSN: 0026-7937
    E-ISSN: 2222-4319
    Source: JSTOR Arts & Sciences VII
    Source: Alma/SFX Local Collection
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