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  • 1
    Language: English
    In: Journal of the American Chemical Society, 06 December 2017, Vol.139(48), pp.17508-17517
    Description: Conformational fluctuations within scFv antibodies are characterized by a novel perturbation-response decomposition of molecular dynamics trajectories. Both perturbation and response profiles are stratified into stabilizing and destabilizing conditions. The linker between the VH and VL domains exhibits the dominant dynamical response by being coupled to nearly the entire protein, responding to both stabilizing and destabilizing perturbations. Perturbations within complementarity-determining regions (CDR) induce rich behavior in dynamic response. Among many effects, stabilizing any CDR loop in the VH domain triggers a destabilizing response in all CDR loops in the VL domain and vice versa. Destabilizing residues within the VL domain are likely to stabilize all CDR loops in the VH domain, and, when these residues are not buried, the CDR loops in the VL domain are also likely to be stabilized. These effects, described by shifts in normal mode characteristics, initiate a propensity for dynamic...
    Subject(s): Mutation ; Single-Chain Antibodies -- Chemistry
    ISSN: 0002-7863
    E-ISSN: 1520-5126
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  • 2
    Article
    Article
    2014
    ISSN: 02767783 
    Language: English
    In: MIS Quarterly: Management Information Systems, 1 March 2014, Vol.38(1), pp.101-121
    Description: Motivated by the growing importance of social media, this paper examines the relationship between new media, old media, and sales in the context of the music industry. In particular, we study the interplay between blog buzz, radio play, and music sales at both the album and song levels of analysis. We...
    Subject(s): Blog Buzz ; Music Industry ; Music Sales ; Panel Vector Auto-Regression ; Social Media ; Traditional Media
    ISSN: 02767783
    E-ISSN: 21629730
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  • 3
    Language: English
    In: Journal of Applied Polymer Science, 5 May 2011, Vol.120(3), pp.1729-1735
    Description: Blends of polystyrene/poly (4-vinylpyridine) have been prepared by casting from a common solvent. The compatibility of the blends was studied by using dilute solution viscometry (DSV), differential scanning calorimetery (DSC), Fourier transformation-infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The relative viscosity versus composition plots for the blends are not perfect linear. The corresponding intrinsic viscosity values show negative deviation from ideal behavior when plotted against composition. Also, the modified Krigbaum and Wall interaction parameter, Δb, shows small and negative values for all compositions except for the blend PS/P4VP (25: 75). The results indicate that the polymers are incompatible but small interaction values predict physically miscible blends which eventually show phase separation, as is observed in the present studies. However, the blends as obtained show a single, composition-dependent, glass transition temperature that fits the Fox equation well, indicating the presence of homogeneous phase. The constant, k obtained from Gordon-Taylor equation suggests intermolecular attraction between these polymers. FT-IR and SEM support the results of DSV and DSC.
    Subject(s): Blends ; Compatibility ; Dsc ; Ftir ; Poly (4-Vinylpyridine) ; Polystyrene
    ISSN: 00218995
    E-ISSN: 10974628
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  • 4
    Article
    Article
    2015
    ISSN: 0370-0046 
    Language: English
    In: Proceedings of Indian National Science Academy, 01 February 2015, Vol.32(4A)
    Subject(s): Sciences (General)
    ISSN: 0370-0046
    E-ISSN: 2454-9983
    Source: Directory of Open Access Journals (DOAJ)
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  • 5
    Language: English
    In: Applied Economics, 25 November 2016, Vol.48(55), pp.5329-5339
    Description: In this article, we consider two new independent variables as inputs to the Taylor Rule. These are the equity and housing momentum variables and are introduced to investigate the potential usefulness of these two variables in guiding the Fed to lean against potential bubbles. Such effectiveness cannot adequately be evaluated if the Taylor Rule estimation follows the standard regression methodology that has been criticized in the literature to be econometrically incorrect. Using a time-varying parameter estimation methodology, we find that equity momentum as an input in the Taylor Rule does not contribute to changes in Fed Funds. However, the housing momentum plays an important role econometrically and can be a useful tool in setting Fed Funds rates.
    Subject(s): Monetary Policy Rule ; Nonlinear Model ; Stock Market ; Housing Market ; Time-Varying Coefficient ; Economics
    ISSN: 0003-6846
    E-ISSN: 1466-4283
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  • 6
    Language: English
    In: Applied economics, 0, 2016, Vol.48(55), p.5329
    Description: In this article, we consider two new independent variables as inputs to the Taylor Rule. These are the equity and housing momentum variables and are introduced to investigate the potential usefulness of these two variables in guiding the Fed to lean against potential bubbles. Such effectiveness cannot adequately be evaluated if the Taylor Rule estimation follows the standard regression methodology that has been criticized in the literature to be econometrically incorrect. Using a time-varying parameter estimation methodology, we find that equity momentum as an input in the Taylor Rule does not contribute to changes in Fed Funds. However, the housing momentum plays an important role econometrically and can be a useful tool in setting Fed Funds rates. Reprinted by permission of Routledge, Taylor and Francis Ltd.
    Subject(s): Equity ; Housing Needs ; Studies ; Federal Reserve Monetary Policy ; Parameter Estimation ; United States–Us
    ISSN: 0003-6846
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Source: International Bibliography of the Social Sciences
    Source: International Bibliography of the Social Sciences (IBSS)
    Source: ProQuest Business Collection
    Source: ProQuest Politics Collection
    Source: ProQuest Social Sciences Premium Collection
    Source: ProQuest Sociology Collection
    Source: Social Science Premium Collection
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  • 7
    In: Journal of Applied Polymer Science, 15 July 2011, Vol.121(2), pp.623-633
    Description: In this article, we report a novel method to synthesize polyaniline (PANI) nanocomposite. Chitin and PANI are dissolved in a common solvent, N,N-dimethyl acetamide, with 5% LiCl, and the solution is irradiated with 8 MeV electron beam for different doses, nanoparticles of PANI in chitin is obtained. The characterization of the composite was done by UV-vis absorption spectrum, FTIR, thermogravimetric analysis (TGA), X-ray diffraction, scanning electron microscopic (SEM), and DC conductivity studies. UV-vis studies show conversion of emeraldine base form to leucoemaraldine base. FTIR studies show interaction between chitin and PANI. SEM analysis of irradiated composite shows formation of PANI particulates. Average particle size varies from approximately 40 to approximately 1000 nm. DC conductivity of blend improves on irradiation. One-dimensional variable range hopping conduction mechanism is dominating in the irradiated blend. [copy 2011 Wiley Periodicals, Inc. J Appl...
    Subject(s): Chitin ; Conducting Polymer ; Nanocomposite ; Polyaniline
    ISSN: 00218995
    E-ISSN: 10974628
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  • 8
    Language: English
    In: Management Science, November 2016, Vol.62(11), pp.3100-3122
    Description: The growing popularity of online dating websites is altering one of the most fundamental human activities: finding a date or a marriage partner. Online dating platforms offer new capabilities, such as extensive search, big data–based mate recommendations, and varying levels of anonymity, whose parallels do not exist in the physical world. Yet little is known about the causal effects of these new features. In this study we examine the impact of a particular anonymity feature, which is unique to online environments, on matching outcomes. This feature allows users to browse profiles of other users anonymously, by being able to check out a potential mate’s profile while not leaving any visible online record of the visit. Although this feature may decrease search costs and allow users to search without inhibition, it also eliminates “weak signals” of interest for their potential mates that may play an important role in establishing successful communication. We run a randomized field experiment on a major North American online dating website, where 50,000 of 100,000 randomly selected new users are gifted the ability to anonymously view profiles of other users. Compared with the control group, the users treated with anonymity become disinhibited, in that they view more profiles and are more likely to view same-sex and interracial mates. However, based on our analysis, we demonstrate causally that weak signaling is a key mechanism in achieving higher levels of matching outcomes. Anonymous users, who lose the ability to leave a weak signal, end up having fewer matches compared with their nonanonymous counterparts. This effect of anonymity is particularly strong for women, who tend not to make the first move and instead rely on the counterparty to initiate the communication. Further, the reduction in quantity of matches by anonymous users is not compensated by a corresponding increase in quality of matches. This paper was accepted by Lorin Hitt, information systems .
    Subject(s): online dating ; anonymity ; weak signaling ; randomized trial ; field experiment;
    ISSN: 00251909
    E-ISSN: 15265501
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  • 9
    Language: English
    In: MIS Quarterly: Management Information Systems, September 2018, Vol.42(3), pp.719-735
    Description: Making sustainable profits from a baseline zero price and motivating free consumers to convert to premium subscribers is a continuing challenge for all freemium communities. Prior research has causally established that social engagement (Oestreicher-Singer and Zalmanson 2013) and peer influence (Bapna...
    Subject(s): Freemium ; Monetization ; Premium Subscription ; Social Engagement
    ISSN: 02767783
    E-ISSN: 21629730
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  • 10
    In: Physical Chemistry Chemical Physics, 2015, Vol.17(45), pp.30307-30317
    Description: The complexation of small interfering RNA (siRNA) with positively charged gold nanoclusters has been studied in the present investigation with the help of classical molecular dynamics and steered molecular dynamics simulations accompanied by free energy calculations. The results show that gold nanoclusters form a stable complex with siRNA. The wrapping of siRNA around the gold nanocluster depends on the size and charge on the surface of the gold cluster. The binding pattern of the gold nanocluster with siRNA is also influenced by the presence of another cluster. The interaction between the positively charged amines in the gold nanocluster and the negatively charged phosphate group in the siRNA is responsible for the formation of complexes. The binding free energy value increases with the size of the gold cluster and the number of positive charges present on the surface of the gold nanocluster. The results reveal that the binding energy of small gold nanoclusters increases in the presence of another gold nanocluster while the binding of large gold nanoclusters decreases due to the introduction of another gold nanocluster. Overall, the findings have clearly demonstrated the effect of size and charge of gold nanoclusters on their interaction pattern with siRNA.
    Subject(s): Gold ; Nano-Cluster ; Molekulardynamische Simulation ; Amin ; Phosphat ; Komplexbildung ; Freie Energie ; Größeneffekt ; Bindungsenergie ; Molekulardynamik ; Chemistry;
    ISSN: 1463-9076
    E-ISSN: 1463-9084
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