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  • 1
    Language: English
    In: Leukemia, 2013-02, Vol.27 (2), p.416-422
    Description: We studied the prognostic value of minimal disseminated disease (MDD) and anti-ALK immune response in children with NPM-ALK-positive anaplastic-large cell lymphoma (ALCL) and evaluated their potential for risk stratification. NPM-ALK transcripts were analyzed by RT-PCR in bone marrow/peripheral blood of 128 ALCL patients at diagnosis, whereas ALK antibody titers in plasma were assessed using an immunocytochemical approach. MDD was positive in 59% of patients and 96% showed an anti-ALK response. Using MDD and antibody titer results, patients could be divided into three biological risk groups (bRG) with different prognosis: high risk (bHR): MDD-positive and antibody titer ≤ 1/750, 26/128 (20%); low risk (bLR): MDD negative and antibody titer 〉1/750, 40/128 (31%); intermediate risk (bIR): all remaining patients, 62/128 (48%). Progression-free survival was 28% (s.e., 9%), 68% (s.e., 6%) and 93% (s.e., 4%) for bHR, bIR and bLR, respectively (P〈0.0001). Survival was 71% (s.e., 9%), 83% (s.e., 5%) and 98% (s.e., 2%) for bHR, bIR and bLR (P=0.02). Only bHR and histology other than common type were predictive of higher risk of failure (hazard ratio 4.9 and 2.7, respectively) in multivariate analysis. Stratification of ALCL patients based on MDD and anti-ALK titer should be considered in future ALCL trials to optimize treatment.
    Subject(s): Lymphoma, Large-Cell, Anaplastic - immunology ; Neoplasm, Residual - metabolism ; Prognosis ; Protein-Tyrosine Kinases - metabolism ; Autoantibodies - blood ; Humans ; Risk Factors ; Child, Preschool ; In Situ Hybridization, Fluorescence ; Infant ; Male ; Survival Rate ; Receptor Protein-Tyrosine Kinases - metabolism ; Lymphoma, Large-Cell, Anaplastic - mortality ; Protein-Tyrosine Kinases - immunology ; Protein-Tyrosine Kinases - genetics ; Lymphoma, Large-Cell, Anaplastic - diagnosis ; Neoplasm, Residual - diagnosis ; Adolescent ; Female ; Neoplasm, Residual - immunology ; Lymphoma, Large-Cell, Anaplastic - classification ; Child ; Antigens ; Care and treatment ; Analysis ; Physiological aspects ; Lymphomas ; Genetic aspects ; Research ; Immunity ; Prevalence studies (Epidemiology) ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: EPJ Web of conferences, 2020, Vol.225, p.2001
    Subject(s): Neutron counters
    ISSN: 2100-014X
    ISSN: 2101-6275
    E-ISSN: 2100-014X
    Source: Academic Search Ultimate
    Source: Directory of Open Access Journals
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2017-07, Vol.52 (7), p.1022-1028
    Description: Chemotherapy and irradiation can affect the gonads, leading to impairment of pubertal development and/or infertility. Fertility preservation (FP) is therefore a crucial endeavor in hematopoietic stem cell transplantation (HSCT) because of the severe impact of infertility on the quality of life of long-term survivors. Despite the existence of different international guidelines, FP counseling and procedures are not routinely implemented as part of patient care. We present herein a survey conducted by the Pediatric Working Party of the European Society for Blood and Marrow Transplantation (EBMT), which aims to analyze and compare different FP practices for children and adolescents across EBMT centers in 2013. A total of 177 pediatric centers reporting to the EBMT were contacted; of this number, 38 centers (21%) located in 16 different countries responded. These centers reported 834 patients receiving HSCT in 2013 (73% prepubertal), corresponding to 22% of all children (n=3789) undergoing HSCT in EBMT reporting centers. Overall, 39% of the reported patients received counseling and 29% received an FP procedure. The increased need for FP programs, extended education for patient-care teams, and more personal resources and funding emerged from this survey as pivotal factors necessary to support and implement such programs.
    Subject(s): Infertility, Male - prevention & control ; Allografts ; Fertility ; Europe ; Humans ; Adolescent ; Hematopoietic Stem Cell Transplantation ; Female ; Infertility, Female - prevention & control ; Male ; Child ; Cancer patients ; Care and treatment ; Chemotherapy ; Usage ; Transplantation ; Hematopoietic stem cells ; Cancer ; Index Medicus
    ISSN: 0268-3369
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2015-02, Vol.50 (2), p.181-188
    Description: We analyzed the outcome of 243 children with high-risk (HR) AML in first CR1 enrolled in the AIEOP-2002/01 protocol, who were given either allogeneic (ALLO; n=141) or autologous (AUTO; n=102) hematopoietic SCT (HSCT), depending on the availability of a HLA-compatible sibling. Infants, patients with AML-M7, or complex karyotype or those with FLT3-ITD, were eligible to be transplanted also from alternative donors. All patients received a myeloablative regimen combining busulfan, cyclophosphamide and melphalan; [corrected] AUTO-HSCT patients received BM cells in most cases, while in children given ALLO-HSCT stem cell source was BM in 96, peripheral blood in 19 and cord blood in 26. With a median follow-up of 57 months (range 12-130), the probability of disease-free survival (DFS) was 73% and 63% in patients given either ALLO- or AUTO-HSCT, respectively (P=NS). Although the cumulative incidence (CI) of relapse was lower in ALLO- than in AUTO-HSCT recipients (17% vs 28%, respectively; P=0.043), the CI of TRM was 7% in both groups. Patients transplanted with unrelated donor cord blood had a remarkable 92.3% 8-year DFS probability. Altogether, these data confirm that HSCT is a suitable option for preventing leukemia recurrence in HR children with CR1 AML.
    Subject(s): Autografts ; Follow-Up Studies ; Leukemia, Myeloid, Acute - pathology ; Humans ; Child, Preschool ; Hematopoietic Stem Cell Transplantation ; Infant ; Male ; Survival Rate ; Abnormal Karyotype ; Cord Blood Stem Cell Transplantation ; Leukemia, Myeloid, Acute - mortality ; fms-Like Tyrosine Kinase 3 - genetics ; Disease-Free Survival ; Allografts ; Adolescent ; Myeloablative Agonists - administration & dosage ; Female ; Transplantation Conditioning - methods ; Child ; Leukemia, Myeloid, Acute - therapy ; Leukemia, Myeloid, Acute - genetics ; Transplantation ; Health aspects ; Patient outcomes ; Hematopoietic stem cells ; Index Medicus
    ISSN: 0268-3369
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: EPJ Web of conferences, 2021, Vol.247, p.9011
    Description: We compare existing experimental decay heat data sets measured at the JAEA fusion neutron source (FNS), which employed a fast extraction rabbit system that in certain cases allowed the measurements to capture, at short cooling times, the decay profile of 16N in a range of oxides. Focussing on those data points and timescales that can be attributed to 16N, we compare measurements to simulations performed using the FISPACT-II inventory code together with evaluated nuclear data libraries. Making small corrections for other contributions at these short times, we derive integral cross section data estimates for 16O(n,p)16N from 12 oxide sample measurements and compare with previously obtained measurements in the IAEA EXFOR database and evaluations in the nuclear data libraries themselves.
    Subject(s): cross section ; decay heat ; oxide activation
    ISSN: 2100-014X
    E-ISSN: 2100-014X
    Source: Academic Search Ultimate
    Source: Directory of Open Access Journals
    Source: ProQuest Central
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  • 6
    Language: English
    In: Leukemia, 2017-02, Vol.31 (2), p.498-501
    Subject(s): Lymphoma, Large-Cell, Anaplastic - classification ; Protein-Tyrosine Kinases - metabolism ; Child ; Humans ; Lymphoma, Large-Cell, Anaplastic - metabolism ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: IEEE electron device letters, 2016-12, Vol.37 (12), p.1597-1600
    Description: Field-effect transistors (FETs) fabricated on hydrogen-terminated diamond surface have been heavily irradiated with 14.8-MeV neutrons in order to evaluate their possible application in very high neutron fluence environments. The dc performance of the diamond-based FETs, such as drain saturation current and maximum transconductance, has been studied as a function of a 14.8-MeV neutron fluence up to 1014 n/cm 2 , delivered in five steps. The effects on electrical properties of H-terminated diamond surface have also been investigated during the neutron irradiation experiments. The Hall parameters, i.e., sheet hole concentration, hole mobility, and sheet resistance, were monitored before and after each irradiation. The performance remains stable during all the neutron fluence steps, thus assessing a remarkable radiation hardness of diamond-based devices. To the best of our knowledge, this is the first published data on 14-MeV neutron tolerance of diamond FET devices.
    Subject(s): Radiation effects ; MESFET ; neutron radiation effects ; H-termination ; Neutrons ; Logic gates ; MESFETs ; Diamond ; Radiation hardness
    ISSN: 0741-3106
    E-ISSN: 1558-0563
    Source: IEEE Electronic Library (IEL)
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  • 8
    Language: English
    In: Journal of instrumentation, 2020-03-30, Vol.15 (3), p.P03031-P03031
    ISSN: 1748-0221
    E-ISSN: 1748-0221
    Source: IOPscience extra
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  • 9
    Language: English
    In: Review of scientific instruments, 2013-12, Vol.84 (12), p.123505-123505
    Description: Measurements of the response of LaBr3(Ce) to 2.5 MeV neutrons have been carried out at the Frascati Neutron Generator and at tokamak facilities with deuterium plasmas. The observed spectrum has been interpreted by means of a Monte Carlo model. It is found that the main contributor to the measured response is neutron inelastic scattering on (79)Br, (81)Br, and (139)La. An extrapolation of the count rate response to 14 MeV neutrons from deuterium-tritium plasmas is also presented. The results are of relevance for the design of γ-ray diagnostics of fusion burning plasmas.
    ISSN: 0034-6748
    E-ISSN: 1089-7623
    Source: American Institute of Physics (AIP) Publications
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: EPJ Web of conferences, 2017, Vol.146, p.9004
    Description: A neutronics benchmark experiment on a pure Copper block (dimensions 60 × 70 × 70 cm3) aimed at testing and validating the recent nuclear data libraries for fusion applications was performed in the frame of the European Fusion Program at the 14 MeV ENEA Frascati Neutron Generator (FNG). Reaction rates, neutron flux spectra and doses were measured using different experimental techniques (e.g. activation foils techniques, NE213 scintillator and thermoluminescent detectors). This paper first summarizes the analyses of the experiment carried-out using the MCNP5 Monte Carlo code and the European JEFF-3.2 library. Large discrepancies between calculation (C) and experiment (E) were found for the reaction rates both in the high and low neutron energy range. The analysis was complemented by sensitivity/uncertainty analyses (S/U) using the deterministic and Monte Carlo SUSD3D and MCSEN codes, respectively. The S/U analyses enabled to identify the cross sections and energy ranges which are mostly affecting the calculated responses. The largest discrepancy among the C/E values was observed for the thermal (capture) reactions indicating severe deficiencies in the 63,65Cu capture and elastic cross sections at lower rather than at high energy. Deterministic and MC codes produced similar results. The 14 MeV copper experiment and its analysis thus calls for a revision of the JEFF-3.2 copper cross section and covariance data evaluation. A new analysis of the experiment was performed with the MCNP5 code using the revised JEFF-3.3-T2 library released by NEA and a new, not yet distributed, revised JEFF-3.2 Cu evaluation produced by KIT. A noticeable improvement of the C/E results was obtained with both new libraries.
    Subject(s): Neutron flux ; Sensitivity analysis ; Computer simulation ; Benchmarks ; Foils ; Experiments ; Nuclear fusion ; Covariance ; Scintillation counters ; Mathematical analysis ; Copper ; Absorption cross sections ; Uncertainty analysis ; Nuclear reactions
    ISSN: 2100-014X
    ISSN: 2101-6275
    E-ISSN: 2100-014X
    Source: Academic Search Ultimate
    Source: Directory of Open Access Journals
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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