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  • 1
    Language: English
    In: Chemical communications (Cambridge, England), 14 September 2010, Vol.46(34), pp.6209-31
    Description: The thermodynamic self-assembly of any metallo-supramolecular complex [M(pm)L(pn)] in solution can be dissected into five additive free energy contributions. According to a hierarchical energetic order, the two microscopic describers f(inter) and f(intra), which refer to the hetero-component metal-ligand connections, bring the main driving forces to the complexation process. Combined with the statistical factor omega of the self-assembly, which measures the changes in intrinsic rotational entropies accompanying the complexation process, these three parameters provide a satisfying description of the statistical binding leading to [M(pm)L(pn)] in solution. Deviations from statistics, i.e. cooperativity, has then two different origins. Firstly, the preorganization controlling the intramolecular connection events may vary along the assembly process, thus affecting f(intra). Secondly, the homo-component interactions brought by the specific location of the different components in the final assembly...
    Subject(s): Thermodynamics ; Macromolecular Substances -- Chemical Synthesis ; Organometallic Compounds -- Chemical Synthesis
    ISSN: 1359-7345
    E-ISSN: 1364-548X
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  • 2
    Language: English
    In: Annals of the Association of American Geographers, 01 January 2013, Vol.103(1), pp.148-162
    Description: Beginning with Friedrich Ratzel, the founders of migration studies all mentioned the natural environment as an important determinant of human mobility. As migration theories grew in coherence and complexity over the course of the twentieth century, however, environmental considerations generally...
    Subject(s): Climate Change ; Environment ; Environmental Migration ; Migration Theory ; Refugees ; 气候变化 ; 环境迁移 ; 迁移理论 ; 难民。
    ISSN: 0004-5608
    E-ISSN: 1467-8306
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  • 3
    Language: English
    In: Annals of the Association of American Geographers, 01/2013, Vol.103(1), pp.148-162
    Description: Beginning with Friedrich Ratzel, the founders of migration studies all mentioned the natural environment as an important determinant of human mobility. As migration theories grew in coherence and complexity over the course of the twentieth century, however, environmental considerations generally disappeared from explanations of displacement. They would reappear in a largely unconnected discourse stressing the threat of future waves of “environmental migrants” in the end-of-the-century context of climate change anxiety. This alarmist stance was heavily criticized by several migration scholars during the same period of time as a corpus of empirical studies emerged that reconsidered the possible impact of the environment on migration. The purpose of this article is to analyze the intellectual history of this swing of the pendulum. The first part examines the rationale for the temporary disappearance of the environment from migration studies, as this major shift has not yet been fully or systematically studied. The second part considers the renewal of interest in environmental migration. Finally, the last part argues that although a solid body of new research documents the contemporary migration–environment nexus, additional work is needed to reembed the environment more firmly within migration theories, taking into account the increased focus on the nature–society nexus, which has recently expanded in geography. Article ahead-of-print.
    Subject(s): Climate Change ; Environment ; Environmental Migration ; Migration Theory ; Refugees. ; 气候变化 ; 环境 ; 环境迁移 ; 迁移理论 ; 难民。 ; Cambio Climático ; Medio Ambiente ; Migración Ambiental ; Teoría De La Migración ; Refugiados;
    ISSN: 0004-5608
    E-ISSN: 1467-8306
    Source: Informa - Taylor & Francis (via CrossRef)
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  • 4
    In: Brain, 2012, Vol. 135(3), pp.678-692
    Description: This review offers a critical appraisal of the literature on episodic memory performance in frontotemporal dementia. Historically, description of patients diagnosed with what was then known as Pick's disease included the presence of memory deficits and an underlying amnestic syndrome was noted in some of these patients. Over the last 20 years, however, the clinical view has been that episodic memory processing is relatively intact in the frontotemporal dementia syndrome. In particular, patients with the subtypes of behavioural variant frontotemporal dementia and progressive non-fluent aphasia are reported to perform within normal limits on standard memory tests. In the third clinical presentation of frontotemporal dementia, semantic dementia, relatively intact episodic memory against a significantly impaired semantic memory was regarded as the hallmark. This position was instrumental in the development of clinical diagnostic criteria for frontotemporal dementia in which amnesia was explicitly listed as an exclusion criterion for the disease. The relative intactness of episodic memory, therefore, appeared to be a useful diagnostic marker to distinguish early frontotemporal dementia from Alzheimer's disease, in which early episodic memory disturbance remains the most common clinical feature. We argue that recent evidence questions the validity of preserved episodic memory in frontotemporal dementia, particularly in behavioural variant frontotemporal dementia. In semantic dementia, a complex picture emerges with preservation of some components of episodic memory, notably recognition-based visual memory and recall of recent autobiographical events. We propose a critical synthesis of recent neuropsychological evidence on retrograde and anterograde memory in light of neuroimaging and neuropathological findings, demonstrating involvement of medial temporal structures in frontotemporal dementia, structures known to be critical for episodic memory processing. We further argue that the multifactorial nature of most memory tests commonly used clinically fail to capture the memory deficits in frontotemporal dementia and that sensitive assessment tools of memory are needed. Together, recent clinical and experimental findings and the historical evidence represent a strong case for a re-evaluation of the importance of memory disturbance in the clinical diagnosis of frontotemporal dementia.
    Subject(s): Anterograde Memory ; Retrograde Memory ; Semantic Dementia
    ISSN: 0006-8950
    E-ISSN: 1460-2156
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  • 5
    Language: English
    In: The Journal of Chemical Physics, 28 February 2013, Vol.138(8)
    Description: We perform two-dimensional Langevin dynamics simulations of electric-field driven polymer translocation through an attractive nanopore. We investigate the effect of the location of the attractive region using different pore patterns. This is found to have an impact on both the translocation time as a function of the chain length and on the polymer entry frequency. We qualitatively compare our results to available experimental data.
    Subject(s): Articles
    ISSN: 0021-9606
    E-ISSN: 1089-7690
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  • 6
    Language: English
    In: The Journal of biological chemistry, 13 November 2015, Vol.290(46), pp.27723-35
    Description: Lateral diffusion enables efficient interactions between membrane proteins, leading to signal transmission across the plasma membrane. An open question is how the spatiotemporal distribution of cell surface receptors influences the transmembrane signaling network. Here we addressed this issue by studying the mobility of a prototypical G protein-coupled receptor, the neurokinin-1 receptor, during its different phases of cellular signaling. Attaching a single quantum dot to individual neurokinin-1 receptors enabled us to follow with high spatial and temporal resolution over long time regimes the fate of individual receptors at the plasma membrane. Single receptor trajectories revealed a very heterogeneous mobility distribution pattern with diffusion constants ranging from 0.0005 to 0.1 μm(2)/s comprising receptors freely diffusing and others confined in 100-600-nm-sized membrane domains as well as immobile receptors. A two-dimensional representation of mobility and confinement resolved two...
    Subject(s): G Protein-Coupled Receptor (Gpcr) ; Clathrin ; Membrane Domains ; Membrane Protein ; Neurokinin-1 Receptor ; Receptor Endocytosis ; Signaling ; Single Molecule Tracking ; Transmembrane Signaling ; Cell Membrane -- Metabolism ; Receptors, Neurokinin-1 -- Metabolism
    ISSN: 0021-9258
    E-ISSN: 1083-351X
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  • 7
    Article
    Article
    2015
    ISSN: 0022-3050  ISSN: 00223050 
    Language: English
    In: Journal of Neurology, Neurosurgery & Psychiatry, 26 March 2015
    Description: Neurologists often struggle to interpret the results of neuropsychological testing, even though cognitive assessments are an integral component of the diagnostic process in dementia syndromes. This article reviews the principles underlying clinical neuropsychology, background on common neuropsychological tests, and tips on how to interpret the results when assessing patients with dementia. General cognitive screening tools, appropriate for use by general neurologists and psychiatrists, as well as specific cognitive tests examining the main cognitive domains (attention and orientation, memory, visuospatial function, language and executive function) in patients with dementia are considered. Finally, the pattern of deficits, helpful in defining clinical dementia phenotypes and sometimes in predicting the underlying molecular pathology, are outlined. Such clinicopathological associations will become invaluable as disease-modifying treatments for dementia are developed and implemented.
    Subject(s): Neuropsychology ; Dementia ; Alzheimer'S Disease ; Cognitive Neuropsychology ; Cognition
    ISSN: 0022-3050
    ISSN: 00223050
    E-ISSN: 1468-330X
    E-ISSN: 1468330X
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  • 8
    Language: English
    In: Journal of the American Chemical Society, 29 August 2018, Vol.140(34), pp.10820-10828
    Description: We have designed a rigid photocleavable dianthracene-based ligand that reacts with ytterbium as coordination metal ion for the creation of a class of tridimensional light-degradable metal-organic framework (MOF). We demonstrated that we can obtain a high level of control on the disassembly of the MOF formed with this ligand which can be triggered either through light irradiation or temperature increase. The reversible 4π-4π photodimerization is the intrinsic chemical mechanism ruling the ligand and MOF cleavage. In the fields of biology and medicine, MOFs have sparked a strong interest as highly porous vehicles for drug release but have only been explored so far through the passive leakage of their payloads. The designed light-degradable MOFs can potentially overcome this limitation and serve as prototypes for drug delivery and corresponding therapeutic applications.
    Subject(s): Chemical Sciences ; Chemistry;
    ISSN: 0002-7863
    E-ISSN: 1520-5126
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  • 9
    In: Brain, 2014, Vol. 137(4), pp.1241-1253
    Description: Semantic dementia, although conceptualized as a language disorder, may be accompanied by impairments in theory of mind. Using structural MRI, Irish et al. reveal that right anterior temporal lobe degeneration underlies theory of mind disruption in this syndrome. These findings underscore the crucial role of these structures for social cognition. Semantic dementia is a progressive neurodegenerative disorder characterized by the amodal and profound loss of semantic knowledge attributable to the degeneration of the left anterior temporal lobe. Although traditionally conceptualized as a language disorder, patients with semantic dementia display significant alterations in behaviour and socioemotional functioning. Recent evidence points to an impaired capacity for theory of mind in predominantly left-lateralized cases of semantic dementia; however, it remains unclear to what extent semantic impairments contribute to these deficits. Further the neuroanatomical signature of such disturbance remains unknown. Here, we sought to determine the neural correlates of theory of mind performance in patients with left predominant semantic dementia ( n = 11), in contrast with disease-matched cases with behavioural-variant frontotemporal dementia ( n = 10) and Alzheimer’s disease ( n = 10), and healthy older individuals ( n = 14) as control participants. Participants completed a simple cartoons task, in which they were required to describe physical and theory of mind scenarios. Irrespective of subscale, patients with semantic dementia exhibited marked impairments relative to control subjects; however, only theory of mind deficits persisted when we covaried for semantic comprehension. Voxel-based morphometry analyses revealed that atrophy in right anterior temporal lobe structures, including the right temporal fusiform cortex, right inferior temporal gyrus, bilateral temporal poles and amygdalae, correlated significantly with theory of mind impairments in the semantic dementia group. Our results point to the marked disruption of cognitive functions beyond the language domain in semantic dementia, not exclusively attributable to semantic processing impairments. The significant involvement of right anterior temporal structures suggests that with disease evolution, the encroachment of pathology into the contralateral hemisphere heralds the onset of social cognitive deficits in this syndrome.
    Subject(s): Frontotemporal Dementia ; Semantic Memory ; Social Cognition ; Anterior Temporal Lobe ; Theory Of Mind
    ISSN: 0006-8950
    E-ISSN: 1460-2156
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  • 10
    Language: English
    In: Physical review. E, Statistical, nonlinear, and soft matter physics, March 2014, Vol.89(3), pp.030601
    Description: The translocation time of a polymer through a pore under the influence of an external field depends on a number of parameters, the most important of which are the field strength, the interaction with the pore, and the confinement entropy. Experimentally, the translocation is dominated either by the driving force (electrophoretic regime) or by the entropy of confinement or pore interaction (barrier dominated regime). In this Rapid Communication we study a simple model for polymer translocation, loosely based on the asymmetric exclusion process, which shows that it is possible to have what experimentally would be interpreted as barrier dominated, even where there is no barrier to translocation. This effective barrier is interpreted as being due to collaborative effects between the monomers forming the polymer chain.
    Subject(s): Physics;
    ISSN: 1539-3755
    E-ISSN: 1550-2376
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