placeholder
and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Proceed order?

Export
Filter
Document type
Language
Year
  • 1
    Language: English
    In: Journal of cancer research and clinical oncology, 2018-10, Vol.144 (10), p.1921-1932
    Description: Lung cancer is highly prevalent and has an especially poor prognosis. Thus, new diagnostic and therapeutic targets are necessary. Two potential targets are somatostatin receptors (SST), which are overexpressed in well-differentiated neuroendocrine neoplasms, and the chemokine receptor CXCR4, which is present mainly in highly proliferative and advanced tumours. Although their expression is relatively well characterized in small cell lung cancer (SCLC), in non-small cell lung cancer (NSCLC), data on SST and CXCR4 expression are scarce and contradictory.We comparatively evaluated 83 tumour samples from a total of 57 lung cancer patients, of which 22 had adenocarcinoma (ADC), 21 had squamous cell carcinoma (SQC), and 15 had SCLC. Samples were evaluated for SST and CXCR4 expression using immunohistochemistry with well-characterized rabbit monoclonal antibodies.In the samples investigated, the most prominently expressed receptors were CXCR4 and SST5. Specifically, CXCR4 was detected with high expression intensity in more than 60% of ADC samples, about 90% of SQC, and 100% of SCLC. SST5 was present in about 75% of ADC and SQC samples and in more than 90% of SCLC. Although not noticeably expressed in ADC and SQC samples, SST2 was detected in 50% of SCLC cases, with a subset of patients displaying exceptionally high expression. The comparison of the three tumour entities revealed that SCLC samples had higher SST2, SST5, and CXCR4 expression, but lower SST3 and SST1 relative to ADC or SQC samples.CXCR4 may be a promising target for diagnostics and therapy in both SCLC and NSCLC.
    Subject(s): Small cell lung cancer ; Medicine & Public Health ; Hematology ; Non-small cell lung cancer ; Oncology ; Cancer Research ; Internal Medicine ; CXCR4 ; Chemokine receptor ; Somatostatin receptors ; Adenocarcinoma - pathology ; Prognosis ; Follow-Up Studies ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Humans ; Lung Neoplasms - metabolism ; Middle Aged ; Carcinoma, Squamous Cell - surgery ; Lung Neoplasms - pathology ; Male ; Small Cell Lung Carcinoma - metabolism ; Adenocarcinoma - metabolism ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Adult ; Female ; Somatostatin - metabolism ; Signal Transduction ; Small Cell Lung Carcinoma - surgery ; Survival Rate ; Receptors, CXCR4 - metabolism ; Small Cell Lung Carcinoma - pathology ; Lung Neoplasms - surgery ; Aged ; Adenocarcinoma - surgery ; Adenocarcinoma ; Immunohistochemistry ; Squamous cell carcinoma ; Analysis ; Monoclonal antibodies ; Lung cancer, Small cell ; Lung cancer, Non-small cell
    ISSN: 0171-5216
    E-ISSN: 1432-1335
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Scientific reports, 2019-03-13, Vol.9 (1), p.4339
    Description: Somatostatin receptors (SST), especially SST2A, are known for their overexpression in well-differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). The chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced tumors. However, comprehensive data are still lacking on potential differences in SST or CXCR4 expression pattern in GEP-NEN in dependence on the place of origin. Overall, 412 samples from 165 GEP-NEN patients, comprising both primary tumors (PT) and metastases (MTS), originating from different parts of the gastrointestinal tract or the pancreas were evaluated for SST and CXCR4 expression by means of immunohistochemistry using monoclonal antibodies. SST2A was present in 85% of PT with a high intensity of expression, followed by SST5 (23%), CXCR4 (21%), SST3 (10%), SST1 (9%), and SST4 (4%). PT displayed higher SST2A and chromogranin A (CgA) expression levels than MTS. In both PT and MTS lower SST2A and CgA expression levels were found in tumors originating from the appendix or colon, compared to tumors from other origins. Tumors derived from appendix or colon were associated with significantly worse patient outcomes. Positive correlations were noted between SST2A and CgA as well as between CXCR4 and Ki-67 expression levels. SST2A and CgA negativity of the tumors was significantly associated with poor patient outcomes. All in all, SST2A was the most prominent receptor expressed in the GEP-NEN samples investigated. However, expression levels varied considerably depending on the location of the primary tumor.
    Subject(s): Science & Technology - Other Topics ; Multidisciplinary Sciences ; Science & Technology ; Neuroendocrine Tumors - pathology ; Pancreatic Neoplasms - metabolism ; Neuroendocrine Tumors - metabolism ; Humans ; Middle Aged ; Pancreatic Neoplasms - pathology ; Male ; Receptors, CXCR4 - metabolism ; Young Adult ; Gastrointestinal Neoplasms - pathology ; Adolescent ; Aged, 80 and over ; Adult ; Female ; Aged ; Receptors, Somatostatin - metabolism ; Child ; Gastrointestinal Neoplasms - metabolism ; Immunohistochemistry ; Gastrointestinal tract ; Appendix ; CXCR4 protein ; Clinical outcomes ; Metastases ; Monoclonal antibodies ; Somatostatin ; Colon ; Pancreas ; Chemokines ; Somatostatin receptors ; Tumors
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Web of Science - Science Citation Index Expanded - 2019〈img src="http://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /〉
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Journal of cancer research and clinical oncology, 2016-11, Vol.142 (11), p.2239-2247
    Description: Whereas the different somatostatin receptor (SSTR) subtypes and the chemokine receptor CXCR4 are known to be expressed in a wide variety of human malignancies, comprehensive data are still lacking for MALT-type lymphomas.Overall, 55 cases of MALT-type lymphoma of both gastric and extragastric origin were evaluated for the SSTR subtype and CXCR4 expression by means of immunohistochemistry using novel monoclonal rabbit antibodies. The stainings were rated by means of the immunoreactive score and correlated with clinical data.While the CXCR4 was detected in 92 % of the cases investigated, the SSTR subtypes were much less frequently present. The SSTR5 was expressed in about 50 % of the cases, followed by the SSTR3, the SSTR2A, the SSTR4 and the SSTR1, which were present in 35, 27, 18 or 2 %, respectively, of the tumors only. Gastric lymphomas displayed a significantly higher SSTR3, SSTR4 and SSTR5 expression than extragastric tumors. A correlation between CXCR4 and Ki-67 expression was seen in gastric lymphomas, whereas primarily in extragastric tumors SSTR5 negativity was associated with poor patient outcome.The CXCR4 may serve as a promising target for diagnostics and therapy of MALT-type lymphomas, while the SSTRs appear not suitable in this respect.
    Subject(s): Immunohistochemistry ; MALT lymphoma ; Medicine & Public Health ; Hematology ; Oncology ; Cancer Research ; Internal Medicine ; CXCR4 ; Chemokine receptor ; Somatostatin receptors ; Amino Acid Sequence ; Humans ; Middle Aged ; Lymphoma, B-Cell, Marginal Zone - immunology ; Stomach Neoplasms - metabolism ; Male ; Somatostatin - biosynthesis ; Stomach Neoplasms - immunology ; Stomach Neoplasms - microbiology ; Receptors, Somatostatin - biosynthesis ; Receptors, CXCR4 - biosynthesis ; Lymphoma, B-Cell, Marginal Zone - metabolism ; Aged, 80 and over ; Adult ; Female ; Helicobacter Infections - metabolism ; Aged ; Helicobacter pylori - isolation & purification ; Autoimmune Diseases - metabolism ; Lymphoma, B-Cell, Marginal Zone - microbiology ; Viral antibodies ; Antibodies ; Non-Hodgkin's lymphomas
    ISSN: 0171-5216
    E-ISSN: 1432-1335
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Endocrine Connections, 2021-02, Vol.10 (2), p.180-190
    Description: Programmed death protein 1 (PD-1) and its ligand, PD-L1, have emerged as promising therapeutic targets for many types of cancer that overexpress PD-L1. However, data on PD-L1 expression levels in bronchopulmonary neuroendocrine neoplasms (BP-NEN) are limited and contradictory. In the present study, a total of 298 archived, formalin-fixed, paraffin-embedded BP-NEN samples from 97 patients diagnosed with typical carcinoid (TC), atypical carcinoid (AC), small cell lung cancer (SCLC), or large cell neuroendocrine carcinoma of the lung (LCNEC) were evaluated for PD-L1 expression by immunohistochemistry using the highly sensitive monoclonal anti-PD-L1 antibody 73-10. PD-L1 expression levels were semiquantitatively estimated by tumour grading. Of the 298 BP-NEN samples, 85% were positive for PD-L1 expression. PD-L1 immunostaining predominantly localized to the plasma membrane of both tumour cells and tumour-infiltrating immune cells. SCLC and LCNEC exhibited significantly higher PD-L1 expression levels than TC or AC. PD-L1 expression levels were also higher in patients with lymph node or distant metastases, in patients who smoked, and in patients who died during the follow-up period. Moreover, PD-L1 expression levels correlated positively with tumour grading, Ki-67 index and the expression of the chemokine receptor CXCR4 and negatively with the levels of somatostatin receptor 1 and chromogranin A. High tumour PD-L1 levels were associated with poor patient outcomes. In conclusion, PD-L1 expression is common in BP-NEN, increases with malignancy, and is associated with poor prognosis. Therefore, targeting the PD-1/PD-L1 axis could be a promising strategy for treating BP-NEN. PD-L1 may also represent a useful prognostic biomarker for this tumour entity.
    Subject(s): lung cancer ; neuroendocrine tumour ; antibody ; pd-l1 ; immunohistochemistry ; small cell lung cancer ; pd-1 ; carcinoid ; large cell neuroendocrine carcinoma
    ISSN: 2049-3614
    E-ISSN: 2049-3614
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Journal of cancer research and clinical oncology, 2017-01, Vol.143 (1), p.187-187
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00432-016-2312-3
    Subject(s): Oncology ; Cancer Research ; Internal Medicine ; Medicine & Public Health ; Hematology ; Lymphomas
    ISSN: 0171-5216
    E-ISSN: 1432-1335
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Oncotarget, 2016-07-05, Vol.7 (27), p.41959-41973
    Description: The classification of bronchopulmonary neuroendocrine neoplasms (BP-NEN) into four tumor entities (typical carcinoids (TC), atypical carcinoids (AC), small cell lung cancers (SCLC), large cell neuroendocrine lung carcinomas (LCNEC)) is difficult to perform accurately, but important for prognostic statements and therapeutic management decisions. In this regard, we compared the expression of three proliferation markers, Ki-67, Topoisomerase II alpha (TOP2A), and RacGAP1, in a series of tumor samples from 104 BP-NEN patients (24 TC, 21 AC, 52 SCLC, 7 LCNEC) using different evaluation methods (immunohistochemistry (IHC): Average evaluation, Hotspot evaluation, digital image analysis; RT-qPCR).The results indicated that all three markers had increased protein and mRNA expression with poorer differentiation and correlated well with each other, as well as with grading, staging, and poor survival. Compared with Ki-67 and TOP2A, RacGAP1 allowed for a clearer prognostic statement. The cut-off limits obtained for Ki-67-Average (IHC) were TC-AC 1.5, AC-SCLC 19, and AC-LCNEC 23.5. The Hotspot evaluation generated equal to higher, the digital image analysis generally lower between-entity cut-off limits.All three markers enabled a clear-cut differentiation between the BP-NEN entities, and all methods evaluated were suitable for marker assessment. However, to define optimal cut-off limits, the Ki-67 evaluation methods should be standardized. RacGAP1 appeared to be a new marker with great potential.
    Subject(s): Prognosis ; Poly-ADP-Ribose Binding Proteins - metabolism ; Humans ; Lung Neoplasms - metabolism ; Ki-67 Antigen - metabolism ; Neuroendocrine Tumors - diagnosis ; GTPase-Activating Proteins - metabolism ; Carcinoid Tumor - metabolism ; Small Cell Lung Carcinoma - metabolism ; Neoplasm Grading ; Biomarkers, Tumor - metabolism ; Lung - radiation effects ; Carcinoma, Large Cell - genetics ; Gene Expression Regulation, Neoplastic - drug effects ; Lung Neoplasms - genetics ; DNA Topoisomerases, Type II - metabolism ; Lung - pathology ; Carcinoma, Large Cell - metabolism ; Carcinoma, Large Cell - diagnosis ; Neuroendocrine Tumors - metabolism ; Kaplan-Meier Estimate ; Poly-ADP-Ribose Binding Proteins - genetics ; Small Cell Lung Carcinoma - genetics ; Neuroendocrine Tumors - genetics ; Carcinoid Tumor - genetics ; Ki-67 Antigen - genetics ; Lung - drug effects ; Small Cell Lung Carcinoma - diagnosis ; DNA Topoisomerases, Type II - genetics ; Biomarkers, Tumor - genetics ; Gene Expression Regulation, Neoplastic - radiation effects ; GTPase-Activating Proteins - genetics ; Lung Neoplasms - diagnosis ; Neoplasm Staging ; Carcinoid Tumor - diagnosis
    E-ISSN: 1949-2553
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Aging clinical and experimental research, 2021-04, Vol.33 (4), p.1133-1144
    Description: Coronavirus disease 2019 (COVID-19) disproportionately affects older people. Observational studies suggest indolent cardiovascular involvement after recovery from acute COVID-19. However, these findings may reflect pre-existing cardiac phenotypes. We tested the association of baseline cardiovascular magnetic resonance (CMR) phenotypes with incident COVID-19. We studied UK Biobank participants with CMR imaging and COVID-19 testing. We considered left and right ventricular (LV, RV) volumes, ejection fractions, and stroke volumes, LV mass, LV strain, native T1, aortic distensibility, and arterial stiffness index. COVID-19 test results were obtained from Public Health England. Co-morbidities were ascertained from self-report and hospital episode statistics (HES). Critical care admission and death were from HES and death register records. We investigated the association of each cardiovascular measure with COVID-19 test result in multivariable logistic regression models adjusting for age, sex, ethnicity, deprivation, body mass index, smoking, diabetes, hypertension, high cholesterol, and prior myocardial infarction. We studied 310 participants (n = 70 positive). Median age was 63.8 [57.5, 72.1] years; 51.0% (n = 158) were male. 78.7% (n = 244) were tested in hospital, 3.5% (n = 11) required critical care admission, and 6.1% (n = 19) died. In fully adjusted models, smaller LV/RV end-diastolic volumes, smaller LV stroke volume, and poorer global longitudinal strain were associated with significantly higher odds of COVID-19 positivity. We demonstrate association of pre-existing adverse CMR phenotypes with greater odds of COVID-19 positivity independent of classical cardiovascular risk factors. Observational reports of cardiovascular involvement after COVID-19 may, at least partly, reflect pre-existing cardiac status rather than COVID-19 induced alterations.
    Subject(s): Predictive Value of Tests ; Magnetic Resonance Spectroscopy ; Ventricular Function, Left ; COVID-19 Testing ; Humans ; Male ; COVID-19 ; Stroke Volume ; Magnetic Resonance Imaging ; Phenotype ; SARS-CoV-2 ; Biological Specimen Banks ; Aged, 80 and over ; Female ; Aged ; United Kingdom - epidemiology ; Critical care ; Coronaviruses ; COVID-19 diagnostic tests ; Biobanks
    ISSN: 1720-8319
    ISSN: 1594-0667
    E-ISSN: 1720-8319
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Neonatology (Basel, Switzerland), 2014-03, Vol.105 (3), p.175-181
    Description: Background: The amplitude-integrated electroencephalogram (aEEG) is a valuable tool for monitoring brain function in preterm infants. Several studies have discussed sex-related differences regarding neonatal morbidity and mortality. To date, no study has been published specifically evaluating potential sex-related differences in aEEG parameters. Objective: The aim of this study was to assess sex-related differences in aEEG signals in preterm born infants without brain injury in the first 4 weeks of life. Methods: aEEG was performed at seven time points (days 1, 2, 3, weeks 1, 2, 3 and 4) and analyzed for Burdjalov total score, number of bursts per hour and visual background pattern. Patients: One hundred and fifty-six infants (85 male and 71 female) born with a gestational age between 28 and 31 completed weeks were evaluated. Results: Mean total score increased with postnatal age and ranged from 5.4 at day 1 to 11.0 at the end of the study period. The score was higher for girls at every time point, and the mean difference was between 0.3 and 0.9. The number of bursts per hour decreased over time from 8.9 at day 1 to 1.6 at the end of the study period. At week 4, the number of bursts per hour was significantly lower in girls (1.3) than in boys (2.0). Conclusion: Sex-related differences were present in aEEG signals of preterm infants. The lower total score and the higher number of bursts might express delayed brain maturation in male preterm infants.
    Subject(s): Original Paper ; Predictive Value of Tests ; Age Factors ; Brain Waves ; Humans ; Male ; Electroencephalography ; Brain - growth & development ; Gestational Age ; Time Factors ; Infant, Premature ; Sex Factors ; Signal Processing, Computer-Assisted ; Female ; Child Development ; Infant, Newborn
    ISSN: 1661-7800
    E-ISSN: 1661-7819
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Inorganic chemistry, 2014-09-02, Vol.53 (17), p.8859-8873
    Description: We report the synthesis and full characterization of dinuclear complexes with the bridging ligand phenanthroline-5,6-dithiolate (phendt2–) featuring the [Ru(bpy)2]2+ or Ir(ppy)2]+ fragment at the diimine donor center and the [Ni(dppe)]2+ or [Pt(phen)]2+ complex moiety at the dithiolate group. The molecular structures of the mononuclear complexes [(C5H5)2Ti(S,S′-phendt)] and [(ppy)2Ir{N,N′-phendt-(C2H4CN)2}](PF6) as well as the dinuclear complex [(C5H5)(PPh3)Ru(phendt)Ni(dppe)](PF6) determined by X-ray diffraction (XRD) studies are compared. Photophysical studies with mononuclear [(bpy)2Ru{phendt-(C2H4CN)2}]2+ and [(ppy)2Ir{phendt-(C2H4CN)2}]+ as well as dinuclear [(bpy)2Ru(phendt)Ni(dppe)]2+ and [(ppy)2Ir(phendt)Ni(dppe)]+ uncovered an effective luminescence quenching in the dinuclear complexes. Lifetime measurements at room temperature, steady-state measurements at low temperature, electrochemical investigations, and DFT calculations provide evidence for a very efficient energy transfer from the Ru/Ir to the Ni complex moiety with a rate constant k 〉 5 × 109 s–1. In comparison, the [Ru]phendt[Ni] complex displays a higher quenching efficiency with reduced excited state lifetime, whereas the [Ir]phendt[Ni] complex is characterized by an unaltered lifetime of the thermally equilibrated excited state.
    Subject(s): Nickel compounds ; Spectra ; Thiols ; Platinum
    ISSN: 0020-1669
    E-ISSN: 1520-510X
    Source: Hellenic Academic Libraries Link
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Biomaterials science, 2013, Vol.1 (11), p.1160-1165
    ISSN: 2047-4830
    E-ISSN: 2047-4849
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...