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  • 1
    Language: English
    In: Annals of oncology, 2015-02, Vol.26 (2), p.325-332
    Description: Five trials assessed lapatinib and trastuzumab (L+T) combined with paclitaxel-containing chemotherapy regimens. They showed high pathological complete response rates, but at the cost of toxicity. This trial assesses L+T combined with docetaxel. The use of docetaxel rather than paclitaxel does not avoid much of the toxicity. Regarding efficacy our results are very consistent with NSABP-B41 trial. Neoadjuvant trials conducted using a double HER2 blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high pathological complete response (pCR) rates, but at the cost of important toxicity. We hypothesised that this toxicity might be due to a specific interaction between paclitaxel and lapatinib. This trial assesses the toxicity and activity of the combination of docetaxel with lapatinib and trastuzumab. Patients with stage IIA to IIIC HER2-positive breast cancer received six cycles of chemotherapy (three cycles of docetaxel followed by three cycles of fluorouracil, epirubicin, cyclophosphamide). They were randomised 1 : 1 : 1 to receive during the first three cycles either lapatinib (1000 mg orally daily), trastuzumab (4 mg/kg loading dose followed by 2 mg/kg weekly), or trastuzumab + lapatinib at the same dose. The primary end point was pCR rate defined as ypT0/is. Secondary end points included safety and toxicity. pCR rate defined as ypT0/is ypN0 was assessed as an exploratory analysis. In June 2012, arm A was closed for futility based on the results from other studies. From October 2010 to January 2013, 128 patients were included in 14 centres. The percentage of the 122 assessable patients with pCR in the breast, and pCR in the breast and nodes, was numerically highest in the lapatinib + trastuzumab group (60% and 56%, respectively), intermediate in the trastuzumab group (52% and 52%), and lowest in the lapatinib group (46% and 36%). Frequency (%) of the most common grade 3–4 toxicities in the lapatinib /trastuzumab/lapatinib + trastuzumab arms were: febrile neutropenia 23/15/10, diarrhoea 9/2/18, infection (other) 9/4/8, and hepatic toxicity 0/2/8. This study demonstrates a numerically modest pCR rate increase with double anti-HER2 blockade plus chemotherapy, but suggests that the use of docetaxel rather than paclitaxel may not reduce toxicity. NCT00450892.
    Subject(s): trastuzumab ; lapatinib ; neoadjuvant chemotherapy ; breast cancer ; HER2 ; pathological response ; Cyclophosphamide - administration & dosage ; Receptor, ErbB-2 - biosynthesis ; Receptor, ErbB-2 - genetics ; Humans ; Middle Aged ; Docetaxel ; Trastuzumab - administration & dosage ; Epirubicin - administration & dosage ; Breast Neoplasms - drug therapy ; Taxoids - administration & dosage ; Anthracyclines - administration & dosage ; Fluorouracil - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Chemotherapy, Adjuvant - methods ; Neoadjuvant Therapy - methods ; Adult ; Female ; Quinazolines - administration & dosage ; Aged ; Lapatinib ; Life Sciences ; Cancer ; Original
    ISSN: 0923-7534
    E-ISSN: 1569-8041
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: EBSCOhost EJS
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
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  • 2
    Language: English
    In: Science (American Association for the Advancement of Science), 2008-06-27, Vol.320 (5884), p.1748-1752
    Description: The synthesis of ordered mesoporous metal composites and ordered mesoporous metals is a challenge because metals have high surface energies that favor low surface areas. We present results from the self-assembly of block copolymers with ligand-stabilized platinum nanoparticles, leading to lamellar CCM-Pt-4 and inverse hexagonal (CCM-Pt-6) hybrid mesostructures with high nanoparticle loadings. Pyrolysis of the CCM-Pt-6 hybrid produces an ordered mesoporous platinum-carbon nanocomposite with open and large pores (≥10 nanometers). Removal of the carbon leads to ordered porous platinum mesostructures. The platinum-carbon nanocomposite has very high electrical conductivity (400 siemens per centimeter) for an ordered mesoporous material fabricated from block copolymer self-assembly.
    Subject(s): Nanoparticles ; Material concentration ; Pyrolysis ; Solvents ; Self assembly ; Copolymers ; Nanocomposites ; Materials ; Ligands ; Reports ; Block copolymers ; Chemistry ; General and physical chemistry ; Physical and chemical studies. Granulometry. Electrokinetic phenomena ; Porous materials ; Colloidal state and disperse state ; Exact sciences and technology ; Surfaces ; Surfaces (Technology) ; Research
    ISSN: 0036-8075
    E-ISSN: 1095-9203
    Source: Single Journals
    Source: Academic Search Ultimate
    Source: EBSCOhost EJS
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: PCCP. Physical chemistry chemical physics (Print), 2013-02-06, Vol.15 (9), p.383-392
    Description: Although the first nanoseconds to microseconds rule the resulting process yield of laser ablation in liquid, a comprehensive view involving combination of time-resolved measurement techniques is still lacking. In this paper, fundamental aspects of laser ablation of metals in water during the production of nanoparticles are discussed. Three fast diagnostic methods have been applied simultaneously. These are Optical Emission Spectroscopy for the plasma characterization, fast shadowgraph for plasma and cavitation bubble dynamics and laser scattering for the mechanisms of delivery of the produced materials in the liquid. Moreover, in order to validate the discussion, the effect on cavitation dynamics of the ablation of bulk and wire-shaped targets has been investigated together with the relative nanoparticles production yield. Unusual arrow-bow ejection phenomena between the cavitation bubble and the wire result in suppressed material back-deposition, causing efficient ejection of ablated matter into the liquid. The presented nanosecond and microsecond-resolved analysis allows estimating the timescale and role of the basic mechanisms involved in laser ablation in liquids as well as the thermodynamic characteristics of the processes. Detailed study of the mechanisms involved during laser ablation in liquids can be useful for improving the NPs production yield.
    Subject(s): General, apparatus, technics of preparation ; Chemistry ; General and physical chemistry ; Physical and chemical studies. Granulometry. Electrokinetic phenomena ; Colloidal state and disperse state ; Exact sciences and technology
    ISSN: 1463-9076
    E-ISSN: 1463-9084
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Optics letters, 2019-09-01, Vol.44 (17), p.4239-4242
    Description: In this work, we design and experimentally demonstrate a novel terahertz (THz) filter exhibiting a flattened spectral response in the atmospheric transmission window around the central frequency of 300 GHz. The innovative concept behind this filter is the coupling of Fabry-Perot and guided mode resonances. The latter arise from a two-dimensional patch array patterned on an aluminum layer deposited on a low loss cyclo-olefin polymer. The filter experimental performance shows high transmittance in the flat-top band, with less than 3 dB losses, and high out-of-band rejection, as theoretically expected. This kind of component provides a cost-effective, functional solution for narrowband filtering in emerging THz devices and systems with possible applications in wireless telecommunications.
    Subject(s): Index Medicus
    ISSN: 0146-9592
    E-ISSN: 1539-4794
    Source: OSA Publishing
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: Mycopathologia (1975), 2004-08, Vol.158 (1), p.73-79
    Description: Aspergillus fumigatus is a pathogenic fungus capable of causing both allergic lung disease and invasive aspergillosis, a serious, life-threatening condition in neutropenic patients. Aspergilli express an array of mycotoxins and enzymes which may facilitate fungal colonisation of host tissue. In this study we investigated the possibility of using the insect, Galleria mellonella, for in vivo pathogenicity testing of Aspergillus species. Four clinical isolates of Aspergillus fumigatus and a single strain of Aspergillus niger were characterised for catalase and elastase activity and for the production of gliotoxin. Gliotoxin is an immunosuppressive agent previously implicated in assisting tissue penetration. Results illustrated a strain dependent difference in elastase activity but no significant difference in catalase activity. Gliotoxin production was detected in vitro and in vivo by Reversed Phase-High Performance Liquid Chromatography, with highest amounts being produced by A. fumigatus ATCC 26933 (350 ng/mg hyphae). Survival probability plots (Kaplan–Meier) of experimental groups infected with Aspergillus conidia indicate that G. mellonella is more susceptible to fungal infection by A. fumigatus ATCC 26933, implicating a critical role for gliotoxin production rather than growth rate or enzymatic activity in the virulence of A. fumigatus in this model.
    Subject(s): Life Sciences ; Medical Microbiology ; Microbial Ecology ; gliotoxin ; fungal infection ; Microbiology ; immunosuppression ; Galleria mellonella ; Aspergillus fumigatus ; Plant Sciences ; Aspergillus niger - pathogenicity ; Moths - microbiology ; Humans ; Virulence ; Aspergillus fumigatus - enzymology ; Aspergillus niger - enzymology ; Pancreatic Elastase - metabolism ; Aspergillus fumigatus - pathogenicity ; Catalase - metabolism ; Animals ; Gliotoxin - biosynthesis ; Aspergillosis - microbiology ; Aspergillus fumigatus - metabolism ; Aspergillus niger - metabolism ; Index Medicus
    ISSN: 0301-486X
    E-ISSN: 1573-0832
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: Osteoporosis international, 2021-01, Vol.32 (1), p.199-203
    Description: We report the impact of the COVID-19 pandemic on bone densitometry practice in a Northern Italy Orthopedic Hospital, comparing the first 4 months of 2020 with the corresponding period of 2019. COVID-19 pandemic had a disruptive effect on the daily practice of bone densitometry (about - 50% of examinations). The Coronavirus Disease 2019 (COVID-19) pandemic radically changes hospital organization to guarantee patient and staff safety, with the unavoidable cessation of normal outpatient activities. We report the impact of the COVID-19 pandemic on dual energy x-ray absorptiometry (DXA) testing in a Northern Italy Orthopedic Hospital. We analyzed the number of DXA examinations performed at our Institution before, during the lockdown, and immediately after outpatient practice reopening (January 24th to May 27th, 2020), comparing them with the corresponding period of 2019. The number of DXA examinations showed a tremendous reduction from n = 1247 performed from January to May 2019 to n = 623 of 2020 (- 49.9%). No exams were performed in April 2020 (- 100%). On May 2020, a faint resume was observed, with n = 43 DXA (- 84.4% compared to 2019). COVID-19 pandemic had a disruptive effect on the daily practice of bone densitometry with DXA. After reopening, we observed a persistence of DXA examination reduction, confirming the fact that returning to normality will probably be a slow process.
    Subject(s): Epidemics ; Coronaviruses ; Analysis ; Bone densitometry ; Index Medicus
    ISSN: 0937-941X
    E-ISSN: 1433-2965
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Journal of applied phycology, 2019-10, Vol.31 (5), p.3069-3076
    Description: Understanding the physiological responses of intertidal seaweeds to environmental factors is fundamental to characterize their local physiological adaptation and success in the face of climate change. We measured the photosynthetic activity and the total phenolic content of the intertidal alga Cystoseira compressa and explored their relationship with latitude or local ambient air and seawater temperatures. Our results show that, when submerged, the photosynthetic activity of C. compressa showed values typical for non-stressed thalli, and the seawater temperatures found across sites explained the variability of these values. We observed a decrease in the photosynthetic activity of C. compressa when exposed to air, compared to a submerged condition. This activity remained stationary up to 28 °C and then started to decrease with higher air temperatures. The total phenolic content of C. compressa at the end of low tide changed across the study sites from 0.12 to 0.53 % DW. Phenolic variability was explained by the long-term thermal water conditions experienced by the algae, rather than short-term variations encountered during tidal cycles. Overall, our results suggest a crucial role played by temperature in driving the physiological traits of the intertidal C. compressa.
    Subject(s): Life Sciences ; Cystoseira compressa ; Phaeophyta ; Freshwater & Marine Ecology ; Maximum quantum yield ; Plant Physiology ; Ecology ; Phenolic content ; Plant Sciences ; Intertidal ; Seawater and air temperature
    ISSN: 0921-8971
    E-ISSN: 1573-5176
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: ProQuest Central
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  • 8
    Language: English
    In: Leukemia, 2015-02, Vol.29 (2), p.396-405
    Description: Hematopoietic stem cell transplantation (HSCT) from human leukocyte antigen (HLA) haploidentical family donors is a promising therapeutic option for high-risk hematologic malignancies. Here we explored in 121 patients, mostly with advanced stage diseases, a sirolimus-based, calcineurin-inhibitor-free prophylaxis of graft-versus-host disease (GvHD) to allow the infusion of unmanipulated peripheral blood stem cell (PBSC) grafts from partially HLA-matched family donors (TrRaMM study, Eudract 2007-5477-54). Conditioning regimen was based on treosulfan and fludarabine, and GvHD prophylaxis on antithymocyte globulin Fresenius (ATG-F), rituximab and oral administration of sirolimus and mycophenolate. Neutrophil and platelet engraftment occurred in median at 17 and 19 days after HSCT, respectively, and full donor chimerism was documented in patients' bone marrow since the first post-transplant evaluation. T-cell immune reconstitution was rapid, and high frequencies of circulating functional T-regulatory cells (Treg) were documented during sirolimus prophylaxis. Incidence of acute GvHD grade II-IV was 35%, and occurrence and severity correlated negatively with Treg frequency. Chronic GvHD incidence was 47%. At 3 years after HSCT, transpant-related mortality was 31%, relapse incidence 48% and overall survival 25%. In conclusion, GvHD prophylaxis with sirolimus-mycophenolate-ATG-F-rituximab promotes a rapid immune reconstitution skewed toward Tregs, allowing the infusion of unmanipulated haploidentical PBSC grafts.
    Subject(s): Busulfan - analogs & derivatives ; Neutrophils - cytology ; Prospective Studies ; Humans ; Immunosuppressive Agents - therapeutic use ; Middle Aged ; Male ; Graft vs Host Disease - immunology ; T-Lymphocytes, Regulatory - immunology ; Young Adult ; Blood Platelets - cytology ; Antilymphocyte Serum - therapeutic use ; Adult ; Female ; Child ; Sirolimus - therapeutic use ; Busulfan - therapeutic use ; Administration, Oral ; HLA Antigens - immunology ; Rituximab ; Treatment Outcome ; Vidarabine - analogs & derivatives ; Vidarabine - therapeutic use ; Mycophenolic Acid - analogs & derivatives ; Mycophenolic Acid - therapeutic use ; Adolescent ; Graft vs Host Disease - prevention & control ; T-Lymphocytes - immunology ; Aged ; Tissue Donors ; Transplantation Conditioning ; Peripheral Blood Stem Cell Transplantation ; Antibodies, Monoclonal, Murine-Derived - therapeutic use ; Prevention ; Complications and side effects ; Care and treatment ; Graft versus host reaction ; Transplantation ; T cells ; Blood diseases ; Health aspects ; Hematopoietic stem cells ; Research ; Drug therapy ; Risk factors ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Osteoporosis international, 2021-01, Vol.32 (1), p.85-91
    Description: A new qualitative index of bone strength, based on finite element analysis and named bone strain index, has been recently developed from lumbar DXA scan. This study shows that BSI predicts subsequent re-fracture in osteoporotic patients affected by fragility fractures. Dual-energy X-ray absorptiometry (DXA) can provide quantitative (bone mineral density, BMD) and qualitative (trabecular bone score, TBS) indexes of bone status, able to predict fragility fractures in most osteoporotic patients. A new qualitative index of bone strength, based on finite element analysis and named bone strain index (BSI), has been recently developed from lumbar DXA scan. This study presents the validation results of BSI prediction for re-fracture in osteoporotic patients with fragility fractures. In three academic hospitals, 234 consecutive fractured patients with primary osteoporosis (209 females) performed a spine X-ray for the calculation of spine deformity index (SDI) and DXA densitometry for BMD, TBS and BSI at the basal time and in the follow-up at each clinical check. A subsequent fracture was considered as one unity increase of SDI. For each unit increase of the investigated indexes, the univariate hazard ratio of re-fracture, 95% CI, p value and proportionality test p value are for age 1.040, 1.017-1.064, 0.0007 and 0.2529, respectively, and for BSI 1.372, 1.038-1.813, 0.0261 and 0.5179, respectively. BSI remained in the final multivariate model as a statistically significant independent predictor of a subsequent re-fracture (1.332, 1.013-1.752 and 0.0399) together with age (1.039, 1.016-1.064 and 0.0009); for this multivariate model proportionality test, p value is 0.4604. BSI appears to be a valid DXA index of prediction of re-fracture, and it can be used for a more refined risk assessment of osteoporotic patients.
    Subject(s): Bone Density ; Cancellous Bone - diagnostic imaging ; Lumbar Vertebrae - diagnostic imaging ; Humans ; Osteoporosis - complications ; Osteoporosis - diagnostic imaging ; Osteoporotic Fractures - diagnostic imaging ; Female ; Osteoporotic Fractures - etiology ; Absorptiometry, Photon ; Medicine, Experimental ; Osteoporosis ; Medical research ; Fractures ; Analysis ; Index Medicus
    ISSN: 0937-941X
    E-ISSN: 1433-2965
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: Scientific reports, 2015-06-09, Vol.5 (1), p.11237-11237
    Description: The sub-wavelength concentration and propagation of electromagnetic energy are two complementary aspects of plasmonics that are not necessarily co-present in a single nanosystem. Here we exploit the strong nanofocusing properties of stacked optical antennas in order to highly concentrate the electromagnetic energy into a 5 nm metal-insulator-metal (MIM) cavity and convert free radiation into guided modes. The proposed nano-architecture combines the concentration properties of optical nanoantennas with the propagation capability of MIM systems, paving the way to highly miniaturized on-chip plasmonic waveguiding.
    Subject(s): Propagation ; Energy
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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