American Journal of Obstetrics and Gynecology, March 2015, Vol.212(3), pp.367.e1-367.e8
To evaluate the risk of adverse perinatal outcomes among pregnant women previously hospitalized for bipolar disorder. We completed a population-based cohort study of women with a singleton delivery in Ontario, Canada (2003 to 2011). Women previously hospitalized for bipolar disorder (n = 1859) or major depressive disorder (n = 3724) were each compared to women without a documented mental illness (n = 432,358). Main study outcomes were preterm birth, severe small for gestational age 3rd percentile birthweight, and severe large for gestational age 97th percentile birthweight. Secondary outcomes included stillbirth, congenital malformations, neonatal morbidity and readmission to hospital 28 days. Odds ratios (ORs) were adjusted for maternal age, parity, prepregnancy obesity, substance use, and diabetes mellitus or hypertension before or during pregnancy. Bipolar disorder (adjusted OR [AOR], 1.95; 95% confidence interval [CI], 1.68–2.26)...
Bipolar Disorder ; Gestational Age Birthweight ; Major Depressive Disorder ; Pregnancy ; Preterm Birth ; Bipolar Disorder ; Gestational Age Birthweight ; Major Depressive Disorder ; Pregnancy ; Preterm Birth ; Medicine
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