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  • 1
    Language: English
    In: Personality and Individual Differences, July 2016, Vol.97, pp.289-299
    Description: Most prior studies regarding navigational efficiency of electronic maps mainly investigated map characteristics such as the frame of references of maps (track-up maps vs. north-up maps) and the map dimensionality (2D maps vs. 3D maps). However, relatively little research has been found regarding how user characteristics, especially a user’s cognitive style, affect the effectiveness of navigational displays. The present study examined how individuals’ field dependence-independence, as an essential dimension of cognitive styles, affects user performance in orienting and navigating tasks with 2D and 3D electronic maps. The results suggested field-independent individuals had higher mental rotation ability than field-dependent individuals. The results also indicated significant interactions between field dependence-independence and frame of reference on both orienting and navigating tasks. Field-independent (FI) individuals responded more quickly and with higher accuracy compared to...
    Subject(s): Field Dependence-Independence ; Frame of Reference ; Electronic Maps ; Field Dependence-Independence ; Frame of Reference ; Electronic Maps ; Psychology
    ISSN: 0191-8869
    E-ISSN: 1873-3549
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  • 2
    Language: English
    In: American Journal of Obstetrics and Gynecology, March 2015, Vol.212(3), pp.367.e1-367.e8
    Description: To evaluate the risk of adverse perinatal outcomes among pregnant women previously hospitalized for bipolar disorder. We completed a population-based cohort study of women with a singleton delivery in Ontario, Canada (2003 to 2011). Women previously hospitalized for bipolar disorder (n = 1859) or major depressive disorder (n = 3724) were each compared to women without a documented mental illness (n = 432,358). Main study outcomes were preterm birth, severe small for gestational age 3rd percentile birthweight, and severe large for gestational age 97th percentile birthweight. Secondary outcomes included stillbirth, congenital malformations, neonatal morbidity and readmission to hospital 28 days. Odds ratios (ORs) were adjusted for maternal age, parity, prepregnancy obesity, substance use, and diabetes mellitus or hypertension before or during pregnancy. Bipolar disorder (adjusted OR [AOR], 1.95; 95% confidence interval [CI], 1.68–2.26)...
    Subject(s): Bipolar Disorder ; Gestational Age Birthweight ; Major Depressive Disorder ; Pregnancy ; Preterm Birth ; Bipolar Disorder ; Gestational Age Birthweight ; Major Depressive Disorder ; Pregnancy ; Preterm Birth ; Medicine
    ISSN: 0002-9378
    E-ISSN: 1097-6868
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  • 3
    Language: English
    In: American Journal of Obstetrics and Gynecology, January 2014, Vol.210(1), pp.S255-S255
    Subject(s): Medicine
    ISSN: 0002-9378
    E-ISSN: 1097-6868
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: English
    In: American Journal of Obstetrics and Gynecology, 2015, Vol.213(6), pp.876-877
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2015.08.004 Byline: Marta Serati, Massimiliano Buoli, A. Carlo Altamura Author Affiliation: Department of Psychiatry, University of Milan, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy Article Note: (footnote) A.C.A. has served as a consultant or on Advisory Boards for Roche, Merck, Astra Zeneca, Bristol Myers Squibb, Janssen/Cilag and Lundbeck; M.B. has served as a consultant for Roche; M.S. reports no conflict of interest.
    Subject(s): Bipolar Disorder ; Pregnant Women;
    ISSN: 00029378
    E-ISSN: 10976868
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  • 5
    In: The Journal of Bone and Joint Surgery, 2018, Vol.100(3), pp.205-210
    Description: BACKGROUND:: The purpose of this study was to investigate the effects of femoral version, cam-type femoroacetabular impingement (FAI), and the combination of the 2 on the passive hip range of motion (ROM). METHODS:: We prospectively analyzed a consecutive cohort of 220 patients (440 hips) who presented with unilateral or bilateral hip pain. The passive hip ROM was measured bilaterally with the patient in prone, supine, and lateral positions. Femoral version was measured and the presence of cam-type deformity was determined on preoperative computed tomography (CT) scans. Diagnostic findings of cam-type FAI included an alpha angle of 〉50° on CT radial sequences of the head-neck junction and a femoral head-neck offset ratio of 〈0.18 on both radiographs and CT. RESULTS:: Multivariate linear regression analysis confirmed that femoral version, as compared with the presence of a cam lesion, was a stronger independent predictor of internal rotation ROM. Conversely, the presence of a cam lesion resulted in a significant decrease in the passive hip flexion ROM (p 〈 0.001) with no additional effects due to the degree of femoral version. The passive hip internal rotation ROM in neutral flexion/extension and with the hip in 90° of flexion were maximized in patients with femoral anteversion and decreased significantly with each incremental decrease in femoral version (p 〈 0.001). CONCLUSIONS:: Abnormalities in femoral version significantly outweigh the effect of cam-type impingement on the passive hip internal rotation ROM. In contrast, the presence of a cam lesion significantly decreases the hip flexion ROM, irrespective of the degree of femoral version. These findings help to inform surgical decision-making for patients with cam-type FAI or femoral version abnormalities. CLINICAL RELEVANCE:: It is common clinical practice to ascribe loss of hip internal rotation to the presence of a cam lesion and to assume that arthroscopic femoral osteoplasty will substantially improve internal rotation postoperatively. Our study shows that the cam lesion is more intimately tied to hip flexion than to hip internal rotation. This result directly impacts the clinical assessment of a patient presenting with radiographic findings of FAI.
    Subject(s): Tomography, X-Ray Computed ; Femoracetabular Impingement -- Diagnostic Imaging ; Femur Head -- Diagnostic Imaging ; Range of Motion, Articular -- Physiology;
    ISSN: 0021-9355
    E-ISSN: 15351386
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  • 6
    Language: English
    In: Journal of the American College of Cardiology, 10 March 2018, Vol.71(11), pp.A406-A406
    Description: Two occluders used for rehearsal were selected by comprehensive analysis of the measurements of LAA orifice, which had the same size with the final choice of procedure, and were inserted into 3D printing models with a near perfect fit. Conclusion Comprehensive analysis of the parameters of LAA orifice by ultrasound 3D DICOM data may help to predict optimal device size and promises to improve surgical successful rate.
    Subject(s): Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 7
    Language: English
    In: The American Journal of Sports Medicine, March 2012, Vol.40(3), pp.534-541
    Description: Background: Nonoperative options for osteochondral lesions (OCLs) of the talar dome are limited, and currently, there is a lack of scientific evidence to guide management. Purpose: To evaluate the short-term efficacy and safety of platelet-rich plasma (PRP) compared with hyaluronic acid (HA) in reducing pain and disability caused by OCLs of the ankle. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: Thirty-two patients aged 18 to 60 years were allocated to a treatment by intra-articular injections of either HA (group 1) or PRP (plasma rich in growth factors [PRGF] technique, group 2) for OCLs of the talus. Thirty OCLs, 15 per arm, received 3 consecutive intra-articular therapeutic injections and were followed for 28 weeks. The efficacy of the injections in reducing pain and improving function was assessed at each visit using the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale (AHFS); a visual analog scale (VAS) for pain, stiffness,...
    Subject(s): Osteochondritis Dissecans ; Osteochondral Lesion ; Ankle ; Platelet-Rich Plasma ; Prp ; Hyaluronic Acid ; Medicine
    ISSN: 0363-5465
    E-ISSN: 1552-3365
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  • 8
    Language: English
    In: American Journal of Obstetrics and Gynecology, August 2012, Vol.207(2), pp.141.e1-141.e5
    Description: To determine whether proangiogenic immature myeloid cells are present in human placentas. Biopsies were obtained from 61 placentas of term pregnancies. Percentage of CD45+CD33+LIN2−HLADR− immature myeloid cells of total CD45+ hematopoietic cells was determined by flow cytometry. Location of immature myeloid cells in the placenta was identified using confocal microscopy. The proangiogenic potential of immature myeloid cells was analyzed by endothelial tube formation. Immature myeloid cells comprise ∼25% of human placental CD45+ hematopoietic cells and infiltrate placentas in proximity of blood vessels. The percentage of immature myeloid cells correlated positively with placental weight (r2 = 0.108, P = .01) and birthweight (r2 = 0.087, P = .02). Endothelial tube formation was increased in the presence of immature myeloid cells as compared with the presence of CD45+LIN2+ control cells. Human placentas are populated by immature...
    Subject(s): Angiogenesis ; Immature Myeloid Cells ; Placenta ; Angiogenesis ; Immature Myeloid Cells ; Placenta ; Medicine
    ISSN: 0002-9378
    E-ISSN: 1097-6868
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  • 9
    Article
    Article
    2010
    ISSN: 0306-3674  ISSN: 03063674 
    Language: English
    In: British Journal of Sports Medicine, 4 July 2010, Vol.44(9), p.618
    Description: Human blood platelet counts are approx imately 200 000/ml. PRP is an autologous concentration of human platelets above this in a small volume of plasma.2 Reports vary regarding the platelet concentration and different growth factors present in the PRP concentrate. Also, there are many preparation protocols, kits, centrifuges and methods to trigger platelet activation before use. The same is true for application methods, including using injectable activated PRP liquid concentrate versus implanting a fibrin scaffold, optimal timing of injection and the specific volume to use. Almost every major manufacturer in the orthopaedic and sports medicine world markets a different commercial kit. Some claim to produce a better quantity and quality of PRP than their competitors from the same amount of blood from the same patient. Costs vary tremendously: a commercial kit yields a PRP concentrate at the cost of several hundred dollars, but inhouse non-automatised techniques produce a PRP concentrate for approximately US$10. Each method to concentrate platelets leads to a different product with different biology and potential uses,3 with a high variation (3 to 27-fold) in growth factor concentration and in the kinetics of release.3–5 Most techniques yield a PRP concentrate of approximately 10% of the blood volume taken (eg, 20 ml of whole blood would result in approximately 2 ml of PRP). These differences might be of relevance to clinical management,3 although they have not been systematically studied. PRP preparations containing only moderately elevated platelet concentrations may be the ones to induce optimal biological benefit, with lower platelet concentrations leading to suboptimal effects, and higher platelet concentrations to inhibitory effects.6 7 Other authors have stated that the “therapeutic dose” of PRP would be at least four to six times higher than the normal platelet count.8 9 To complicate things, the actual growth factor content is not well correlated with the platelet count in whole blood or in PRP, and there is no evidence that gender or age affects platelet count or growth factor concentrations.10
    Subject(s): Plasma ; Injuries ; Pain ; Studies ; Blood ; Blood Platelets ; Insulin-Like Growth Factors ; Gene Expression ; Extracellular Matrix ; Neutrophils;
    ISSN: 0306-3674
    ISSN: 03063674
    E-ISSN: 1473-0480
    E-ISSN: 14730480
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  • 10
    Language: English
    In: 2012, Vol.7(10), p.e48393
    Description: Acute intensive insulin therapy causes a transient worsening of diabetic retinopathy in type 1 diabetes patients and is related to VEGF expression. Reactive oxygen species (ROS) have been shown to be involved in HIF-1α and VEGF expression induced by insulin, but the role of specific ROS sources has not been fully elucidated. In this study we examined the role of NADPH oxidase subunit 4 (Nox4) in insulin-stimulated HIF-1α and VEGF expression, and angiogenic responses in human microvascular endothelial cells (HMVECs). Here we demonstrate that knockdown of Nox4 by siRNA reduced insulin-stimulated ROS generation, the tyrosine phosphorylation of IR-β and IRS-1, but did not change the serine phosphorylation of IRS-1. Nox4 gene silencing had a much greater inhibitory effect on insulin-induced AKT activation than ERK1/2 activation, whereas it had little effect on the expression of the phosphatases such as MKP-1 and SHIP. Inhibition of Nox4 expression inhibited the transcriptional activity of VEGF through HIF-1. Overexpression of wild-type Nox4 was sufficient to increase VEGF transcriptional activity, and further enhanced insulin-stimulated the activation of VEGF. Downregulation of Nox4 expression decreased insulin-stimulated mRNA and protein expression of HIF-1α, but did not change the rate of HIF-1α degradation. Inhibition of Nox4 impaired insulin-stimulated VEGF expression, cell migration, cell proliferation, and tube formation in HMVECs. Our data indicate that Nox4-derived ROS are essential for HIF-1α-dependent VEGF expression, and angiogenesis in vitro induced by insulin. Nox4 may be an attractive therapeutic target for diabetic retinopathy caused by intensive insulin treatment.
    Subject(s): Research Article ; Biology ; Medicine ; Diabetes And Endocrinology ; Ophthalmology
    E-ISSN: 1932-6203
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