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  • 1
    Article
    Article
    2019
    ISSN: 1687-8450 
    Language: English
    In: Journal of oncology, 2019-09-24, Vol.2019, p.1-9
    Description: Earlier studies on elucidating the role of lymphocytes in tumor immunity predominantly focused on T cells. However, the role of B cells in tumor immunity has increasingly received better attention in recent studies. The B cells that infiltrate tumor tissues are called tumor-infiltrating B cells (TIBs). It is found that TIBs play a multifaceted dual role in regulating tumor immunity rather than just tumor inhibition or promotion. In this article, latest research advances focusing on the relationship between TIBs and tumor complexity are reviewed, and light is shed on some novel ideas for exploiting TIBs as a possible tumor biomarker and potential therapeutic target against tumors.
    Subject(s): T cells ; B cells ; Tumors ; Antigen presentation ; Medical research ; Dendritic cells ; Cytokines ; Antibodies ; Ovarian cancer ; Cell adhesion & migration ; Lymphocytes ; Medical prognosis ; Immunotherapy ; Prostate cancer ; Chemokines
    ISSN: 1687-8450
    E-ISSN: 1687-8450
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: Journal of oncology, 2021-04-20, Vol.2021
    Description: Objective. The aim of this research was to create a new genetic signature of immune checkpoint-associated genes as a prognostic method for pediatric acute myeloid leukemia (AML). Methods. Transcriptome profiles and clinical follow-up details were obtained in Therapeutically Applicable Research to Generate Effective Treatments (TARGET), a database of pediatric tumors. Secondary data was collected from the Gene Expression Omnibus (GEO) to test the observations. In univariate Cox regression and multivariate Cox regression studies, the expression of immune checkpoint-related genes was studied. A three-mRNA signature was developed for predicting pediatric AML patient survival. Furthermore, the GEO cohort was used to confirm the reliability. A bioinformatics method was utilized to identify the diagnostic and prognostic value. Results. A three-gene (STAT1, BATF, EML4) signature was developed to identify patients into two danger categories depending on their OS. A multivariate regression study showed that the immune checkpoint-related signature (STAT1, BATF, EML4) was an independent indicator of pediatric AML. By immune cell subtypes analyses, the signature was correlated with multiple subtypes of immune cells. Conclusion. In summary, our three-gene signature can be a useful tool to predict the OS in AML patients.
    Subject(s): Pediatrics ; Chemotherapy ; Transplants & implants ; Medical prognosis ; Leukemia ; Stem cells ; Clinical trials ; Gene expression ; Patients ; Cancer therapies ; Immune system
    ISSN: 1687-8450
    E-ISSN: 1687-8450
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: Journal of oncology, 2020-09-10, Vol.2020, p.1-13
    Description: The microenvironment plays a vital role in the tumor recurrence of neuroblastoma. This research aimed at exploring prognostic genes that are involved in neuroblastoma microenvironment. We used “estimate” R package to calculate the immune/stromal/ESTIMATE scores of each sample of ArrayExpress dataset E-MTAB-8248 based on the ESTIMATE algorithm. Then we found that immune/stromal/ESTIMATE scores were not correlated with age/chromosome 11q, but tumor stage, MYCN gene amplifications, and chromosome 1p. Samples were then divided into high- and low-score groups, and 280 common differentially expressed genes (DEGs) were identified. 64 potential prognostic genes were harvested through overall survival analysis from the common DEGs. 14 prognostic genes (ABCA6, SEPP1, SLAMF8, GPR171, ABCA9, ARHGAP15, IL7R, HLA-DPB1, GZMA, GPR183, CCL19, ITK, FGL2, and CD1C) were obtained after screening in two independent cohorts. GO and KEGG analysis discovered that common DEGs and 64 potential prognostic genes are mainly involved in T-cell activation, lymphocyte activation regulation, leukocyte migration, and the interaction of cytokines and cytokine receptors. Correlation analysis showed that all prognostic genes were negatively correlated with MYCN amplification. Cox analysis identified 5 independent prognostic genes (ARHGAP15, ABCA9, CCL19, SLAMF8, and CD1C).
    Subject(s): Datasets ; Algorithms ; Medical prognosis ; Neuroblastoma ; Gene expression ; Chromosomes ; Age ; Cancer ; Tumors
    ISSN: 1687-8450
    E-ISSN: 1687-8450
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Journal of oncology, 2019-09-08, Vol.2019, p.1-14
    Description: Milk is a heterogeneous lacteal secretion mixture of numerous components that exhibit a wide variety of chemical and functional activities. Casein, the main protein in milk, is composed of α-, β-, and κ-caseins, each of which is important for nutritional value and for promoting the release of cytokines, also are linked to the regulation of haematopoiesis and immune response and inhibit the proliferation and induce the differentiation of leukaemia cells. It has been shown that the digestive process of caseins leads to the release of bioactive peptides that are involved in the regulation of blood pressure and the inhibition or activation of the immune response by serving as agonists or antagonists of opioid receptors, thus controlling the expression of genes that exert epigenetic control. Later, they bind to opioid receptor, block nuclear factor κ-beta, increase the redox potential, and reduce oxidative stress and the pro-inflammatory agents that favour an antioxidant and anti-inflammatory environment. Therefore, the bioactive peptides of casein could be compounds with antileukaemia potential. This review provides a summary of current knowledge about caseins and casein peptides on the immune system as well as their roles in the natural defence against the development of leukaemia and as relevant epigenetic regulators that can help eradicate leukaemia.
    Subject(s): Antioxidants ; Immune response ; Casein ; Cytokines ; Leukemia ; Carbohydrates ; Enzymes ; Peptides ; Dietary minerals ; Amino acids ; Lipids ; Hormones ; Fatty acids ; Lymphoma ; Calcium phosphates ; Proteins ; Nutrition research ; Hypotheses ; Lactose ; Physiology ; Adults ; Potassium ; Cancer ; Immune system ; Milk
    ISSN: 1687-8450
    E-ISSN: 1687-8450
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: Journal of oncology, 2019-10-10, Vol.2019, p.1-9
    Description: Objectives. Portal vein embolization (PVE) stimulates hypertrophy of the future liver remnant (FLR) and improves the safety of extended hepatectomy. This study evaluated the efficacy of PVE, performed with PVA and coils, in relation to its effect on FLR volume and ratio. Secondary endpoints were the assessment of PVE complications, accomplishment of liver surgery, and patient outcome after hepatectomy. Materials and Methods. All patients who underwent PVE before planned major hepatectomy between 2013 and 2017 were retrospectively analyzed, comprising a total of 64 patients. Baseline patient clinical characteristics, imaging records, liver volumetric changes, complications, and outcomes were analyzed. Results. There were 45 men and 19 women with a mean age of 64 years. Colorectal liver metastasis was the most frequent liver tumor. The majority of patients (n = 53) had a right PVE. FLR increased from a mean value of 484 ml ± 242 to 654 ml ± 287 p〈0.001 after PVE. Two major complications were experienced after PVE: 1 case of left hepatic artery branch laceration and 1 case of hemoperitoneum and hemothorax. A total of 44 (69%) patients underwent liver surgery. Twenty-one patients were not taken to surgery due to disease progression (n = 18), liver insufficiency (n = 1), and insufficient FLR volume (n = 1), and one patient declined surgery (n = 1). Conclusions. PVE with PVA and coils was accomplished safely and promoted a high FLR hypertrophy yield, enabling most of our patients to be submitted to the potentially curative treatment of liver tumor resection.
    Subject(s): Liver ; Surgical outcomes ; Chemotherapy ; Medical imaging ; Surgery ; Embolization ; Software ; Patients ; Catheters ; Veins & arteries ; Tumors
    ISSN: 1687-8450
    E-ISSN: 1687-8450
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: Journal of oncology, 2019-05-02, Vol.2019, p.4047617-7
    Description: Acute lymphoblastic leukemia and other aggressive lymphoid malignancies like Burkitt leukemia/lymphoma have high incidence of central nervous system (CNS) involvement. Various solid tumors, most notably breast cancer, can also metastasize into the CNS as a late stage complication causing devastating effects. Intrathecal (IT) chemotherapy consisting of methotrexate, cytarabine, or the two in combination is frequently used for the prophylaxis and treatment of CNS metastasis. Because of the high toxicity of these chemotherapeutic agents, however, their side effect profiles are potentially catastrophic. The incidence of neurotoxicity secondary to IT chemotherapy is well defined in the pediatric literature but is poorly reported in adults. Here, we investigated the incidence of neurologic and nonneurologic side effects secondary to IT chemotherapy in 109 consecutive adult patients over a two-year time period at hospitals associated with our institution. Of 355 IT chemotherapy treatments received by these patients, 11 (3.10%) resulted in paresthesias or paralysis, which we defined as significant neurologic events in our analysis. We also examined minor events that arose after IT chemotherapy, including back pain, headache, fever, vomiting, and asthenia. At least one of these occurred after 30.70% of IT chemotherapy doses. Clinicians involved in the care of patients receiving IT chemotherapy should be aware of these findings and consider treatment options lower rate of neurotoxicity such as high-dose systemic methotrexate.
    Subject(s): Usage ; Chemotherapy ; Care and treatment ; Adults ; Paralysis ; Methotrexate ; Vincristine ; Backache ; Cancer ; Flow cytometry ; Spinal cord ; Leukemia ; Headaches ; Breast cancer ; Patients ; Cancer therapies ; Lymphoma ; Fever ; Neurotoxicity ; Cellular biology ; Magnetic resonance imaging ; Vomiting ; Drug dosages ; Hispanics ; Tumors
    ISSN: 1687-8450
    E-ISSN: 1687-8450
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: World journal of surgical oncology, 2021-01-02, Vol.19 (1), p.1-1
    Description: Acellular dermal matrices are biological materials of porcine, bovine, or human origin used as scaffold for reconstructive purpose in plastic surgery; these materials are well-tolerated and safely integrated in host tissues without causing resorption, contracture, and encapsulation thanks to their low antigenicity.Recently, human acellular dermal matrix has been used as a filler in breast-conserving surgery to improve aesthetic results. Adequate knowledge of biomaterials properties, appropriate skill, and careful compliance with some specific recommendations are mandatory in order to optimize outcomes and obtain a work of success.
    Subject(s): Care and treatment ; Surgery ; Patient outcomes ; Breast ; Breast cancer ; Collagen implants ; Health aspects ; Methods ; Index Medicus ; Acellular dermal matrix ; Reconstructive biomaterial ; Breast-conserving surgery
    ISSN: 1477-7819
    E-ISSN: 1477-7819
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 8
    Language: English
    In: The breast journal, 2019-05, Vol.25 (3), p.564-565
    Subject(s): Decision Making ; BRCA1 Protein - genetics ; Postoperative Complications - etiology ; Prophylactic Mastectomy - adverse effects ; Humans ; Prophylactic Mastectomy - methods ; Female ; Heterozygote ; Mammaplasty ; Mutation ; BRCA2 Protein - genetics ; Breast Neoplasms - prevention & control ; Decision-making ; Surgery ; Index Medicus
    ISSN: 1075-122X
    E-ISSN: 1524-4741
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: ANZ journal of surgery, 2019-06, Vol.89 (6), p.786-786
    Subject(s): Breast Neoplasms - surgery ; Esthetics ; Mammaplasty ; Mastectomy, Segmental ; Humans ; Patient Satisfaction ; Patient satisfaction ; Tumors ; Index Medicus
    ISSN: 1445-1433
    E-ISSN: 1445-2197
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: British journal of haematology, 2019-02, Vol.184 (3), p.337-347
    Description: Summary The scenario of paediatric acute myeloid leukaemia (AML), particularly non‐Down syndrome acute megakaryoblastic leukaemia (non‐DS‐AMKL), has been recently revolutionized by the advent of large‐scale, genomic sequencing technologies. In this changing landscape, a significantly relevant discovery has been represented by the identification of the CBFA2T3‐GLIS2 fusion gene, which is the result of a cryptic inversion of chromosome 16. It is the most frequent chimeric oncogene identified to date in non‐DS‐AMKL, although it seems not to be exclusively restricted to the French‐American‐British M7 subgroup. The CBFA2T3‐GLIS2 fusion gene characterizes a subtype of leukaemia that is specific to paediatrics, having never been identified in adults. It characterizes an extremely aggressive leukaemia, as the presence of this fusion is associated with a grim outcome in almost all of the case series reported, with overall survival rates ranging between 15% and 30%. Although the molecular basis that underlies this leukaemia subtype is still far from being completely elucidated, unique functional properties induced by CBFA2T3‐GLIS2 in the leukaemogenesis driving process have been recently identified. We here review the peculiarities of CBFA2T3‐GLIS2‐positive AML, describing its intriguing clinical and biological behaviour and providing some challenging targeting opportunities.
    Subject(s): childhood leukaemia ; acute megakaryoblastic leukaemia ; leukaemia diagnosis ; CBFA2T3‐GLIS2 ; acute myeloid leukaemia ; Oncogene Proteins, Fusion - metabolism ; Humans ; Leukemia, Myeloid, Acute - metabolism ; Child, Preschool ; Infant ; Male ; Kruppel-Like Transcription Factors - metabolism ; Tumor Suppressor Proteins - genetics ; Female ; Child ; Infant, Newborn ; Leukemia, Myeloid, Acute - therapy ; Repressor Proteins - metabolism ; Chromosomes, Human, Pair 16 - genetics ; Tumor Suppressor Proteins - metabolism ; Chromosomes, Human, Pair 16 - metabolism ; Repressor Proteins - genetics ; Survival Rate ; Leukemia, Myeloid, Acute - mortality ; Disease-Free Survival ; Animals ; Oncogene Proteins, Fusion - genetics ; Adolescent ; Kruppel-Like Transcription Factors - genetics ; Leukemia, Myeloid, Acute - genetics ; Index Medicus ; Reviews ; Review
    ISSN: 0007-1048
    E-ISSN: 1365-2141
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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