placeholder
and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Document type
Language
Year
  • 1
    Language: English
    In: American journal of respiratory and critical care medicine, 2012-05-15, Vol.185 (10), p.1096-1103
    Description: Rationale: Up to one-third of patients with cystic fibrosis (CF) awaiting lung transplantation (LTX) die while waiting. Inclusion of computed tomography (CT) scores may improve survival prediction models such as the lung allocation score (LAS). Objectives: This study investigated the association between CT and survival in patients with CF screened for LTX. Methods: Clinical data and chest CTs of 411 patients with CF screened for LTX between 1990 and 2005 were collected from 17 centers. CTs were scored with the Severe Advanced Lung Disease (SALD) four-category scoring system, including the components infection/inflammation (INF), air trapping/hypoperfusion (AT), normal/hyperperfusion (NOR), and bulla/cysts (BUL). The volume of each componentwas computed using semiautomated software. Survival analysis included Kaplan-Meier curves and Cox regression models. Measurements and Main Results: Three hundred and sixty-six (186 males) of 411 patients entered the waiting list (median age, 23 yr; range, 5-58 yr). Subsequently, 67 of 366 (18%) died while waiting, 263 of 366 (72%) underwent LTX, and 36 of 366 (10%) were awaiting LTX at the census date. INF and LAS were significantly associated with waiting list mortality in univariate analyses. The multivariate Cox model including INF and LAS grouped in tertiles, and comparing tertiles 2 and 3 with tertile 1, showed waiting list mortality hazard ratios of 1.62 (95% confidence interval [95% CI], 0.78-3.36; P=0.19) and 2.65 (95% CI, 1.35-5.20; P = 0.005) for INF, and 1.42 (95% CI, 0.63-3.24; P=0.40), and 2.32 (95% CI, 1.17-4.60; P=0.016) for LAS, respectively. These results indicated that INF and LAS had significant, independent predictive value for survival. Conclusions: CT score INF correlates with survival, and adds to the predictive value of LAS. Copyright
    Subject(s): Abridged Index Medicus ; Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Cohort Studies ; Cystic fibrosis ; Cystic Fibrosis - diagnostic imaging ; Cystic Fibrosis - mortality ; Cystic Fibrosis - surgery ; Decision Support Techniques ; Female ; Humans ; Intensive care medicine ; Investigative techniques, diagnostic techniques (general aspects) ; Kaplan-Meier Estimate ; Lung disease ; Lung Transplantation ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Prognosis ; Proportional Hazards Models ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Respiratory system ; Severity of Illness Index ; Tomography X-ray computed ; Waiting list survival ; Waiting Lists - mortality ; Young Adult
    ISSN: 1073-449X
    E-ISSN: 1535-4970
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: ProQuest Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: European radiology, 2012-07-20, Vol.22 (12), p.2736-2742
    Description: Objectives To determine the diagnostic accuracy of high-resolution computed tomography (HRCT) for the detection of nontuberculous mycobacterium infection (NTM) in adult cystic fibrosis (CF) patients. Methods Twenty-seven CF patients with sputum-culture-proven NTM (NTM+) underwent HRCT. An age, gender and spirometrically matched group of 27 CF patients without NTM (NTM-) was included as controls. Images were randomly and blindly analysed by two readers in consensus and scored using a modified Bhalla scoring system. Results Significant differences were seen between NTM (+) and NTM (-) patients in the severity of the bronchiectasis subscore [45 % (1.8/4) vs. 35 % (1.4/4), P  = 0.029], collapse/consolidation subscore [33 % (1.3/3 vs. 15 % (0.6/3)], tree-in-bud/centrilobular nodules subscore [43 % (1.7/3) vs. 25 % (1.0/3), P  = 0.002] and the total CT score [56 % (18.4/33) vs. 46 % (15.2/33), P  = 0.002]. Binary logistic regression revealed BMI, peribronchial thickening, collapse/consolidation and tree-in-bud/centrilobular nodules to be predictors of NTM status (R 2  = 0.43). Receiver-operator curve analysis of the regression model showed an area under the curve of 0.89, P  〈 0.0001. Conclusion In adults with CF, seven or more bronchopulmonary segments showing tree-in-bud/centrilobular nodules on HRCT is highly suggestive of NTM colonisation. Key Points • Lung function declines rapidly in cystic fibrosis patients with nontuberculous mycobacterium infection • High-resolution computed tomography can help identify nontuberculous mycobacterium in CF patients • Extensive collapse/consolidation and tree-in-bud/centrilobular nodules are predictive of NTM infection • Multiple bronchopulmonary segments showing tree-in-bud/centrilobular nodules strongly suggest nontuberculous mycobacterium infection
    Subject(s): Adolescent ; Adult ; Bronchiectasis ; Chest ; Chi-Square Distribution ; Computed tomography ; Cystic fibrosis ; Cystic Fibrosis - diagnostic imaging ; Diagnostic Radiology ; Female ; Humans ; Imaging ; Infection ; Internal Medicine ; Interventional Radiology ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Models ; Mycobacterium ; Mycobacterium Infections, Nontuberculous - diagnostic imaging ; Neuroradiology ; Nodules ; Radiology ; Regression analysis ; ROC Curve ; Severity of Illness Index ; Spirometry ; Sputum - microbiology ; Tomography, X-Ray Computed - methods ; Ultrasound
    ISSN: 0938-7994
    E-ISSN: 1432-1084
    Source: Alma/SFX Local Collection
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Annals of translational medicine, 2016-03, Vol.4 (5), p.87-87
    Description: To evaluate the relationship between lung parenchymal abnormalities on chest CT and health-related quality of life in adult cystic fibrosis (CF). The chest CT scans of 101 consecutive CF adults (mean age 27.8±7.9, 64 males) were prospectively scored by two blinded radiologists in consensus using a modified Bhalla score. Health-related quality of life was assessed using the revised Quittner Cystic Fibrosis Questionnaire (CFQ-R). Multiple regressions were performed with each of the CFQ-R domains and all clinical and imaging findings to assess independent correlations. There were 18 inpatients and 83 outpatients. For the cohort of inpatients, CT abnormalities were significantly (P〈0.005 for all) associated with Respiratory Symptoms (Air Trapping), and also with Social Functioning (Consolidation) and Role Functioning (Consolidation). For outpatients, CT abnormalities were significantly (P〈0.005 for all) associated with Respiratory Symptoms (Consolidation) and also with Physical Functioning (Consolidation), Vitality (Consolidation, Severity of Bronchiectasis), Eating Problems (airway wall thickening), Treatment Burden (Total CT Score), Body Image (Severity of Bronchiectasis) and Role Functioning (Tree-in-bud nodules). Consolidation was the commonest independent CT predictor for both inpatients (predictor for 2 domains) and outpatients (predictor in 3 domains). Several chest CT abnormalities excluded traditional measures such as FEV1 and BMI from the majority of CFQ-R domains. Chest CT abnormalities are significantly associated with quality of life measures in adult CF, independent of clinical or spirometric measurements.
    Subject(s): Computed tomography (CT) ; cystic ; fibrosis ; Original ; pulmonary ; quality of life
    ISSN: 2305-5839
    E-ISSN: 2305-5839
    Source: PubMed Central
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: The European respiratory journal, 2013-09-01, Vol.42 (3), p.844-857
    Description: Clinical trials for the treatment of cystic fibrosis (CF) lung disease are important to test and optimise new therapeutic interventions. To evaluate the effect of these interventions, sensitive and accurate outcome measures are needed. The most commonly used endpoints are spirometric variables such as the forced expiratory volume in 1 s and respiratory tract exacerbations. Unfortunately, these endpoints are relatively insensitive for monitoring progression of CF lung disease, and thus require a large number of patients when used in clinical studies. In addition, these endpoints are not suitable to study CF lung disease in young children. Chest computed tomography (CT) holds great promise for use as a sensitive surrogate endpoint in CF. A large body of
    Subject(s): Biological and medical sciences ; Clinical Trials as Topic - methods ; Cystic Fibrosis - diagnostic imaging ; Cystic Fibrosis - physiopathology ; Cystic Fibrosis - therapy ; Disease Progression ; Errors of metabolism ; Humans ; Image Processing, Computer-Assisted ; Lung - diagnostic imaging ; Medical sciences ; Metabolic diseases ; Miscellaneous hereditary metabolic disorders ; Pneumology ; Quality of Life ; Reproducibility of Results ; Sensitivity and Specificity ; Spirometry ; Tomography, X-Ray Computed ; Treatment Outcome
    ISSN: 0903-1936
    E-ISSN: 1399-3003
    Source: HighWire Press (Free Journals)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Radiology, 2009, Vol.253 (1), p.223-229
    Description: To assess whether chest computed tomography (CT) scores from ultra-low-dose end-expiratory scans alone could suffice for assessment of all cystic fibrosis (CF)-related structural lung abnormalities. In this institutional review board-approved study, 20 patients with CF aged 6-20 years (eight males, 12 females) underwent low-dose end-inspiratory CT and ultra-low-dose end-expiratory CT. Informed consent was obtained. Scans were randomized and scored by using the Brody-II CT scoring system to assess bronchiectasis, airway wall thickening, mucus plugging, and opacities. Scoring was performed by two observers who were blinded to patient identity and clinical information. Mean scores were used for all analyses. Statistical analysis included assessment of intra- and interobserver variability, calculation of intraclass correlation coefficients (ICCs), and Bland-Altman plots. Median age was 12.6 years (range, 6.3-20.3 years), median forced expiratory volume in 1 second was 100% (range, 46%-127%) of the predicted value, and median forced vital capacity was 99% (range, 61%-123%) of the predicted value. Very good agreement was observed between end-inspiratory and end-expiratory CT scores for Brody-II total score (ICC = 0.96), bronchiectasis (ICC = 0.98), airway wall thickening (ICC = 0.94), mucus plugging (ICC = 0.96), and opacities (ICC = 0.90). Intra- and interobserver agreement were good to very good (ICC range, 0.70-0.98). Bland-Altman plots showed that differences in scores were independent of score magnitude. In this pilot study, CT scores from end-expiratory and end-inspiratory CT match closely, suggesting that ultra-low-dose end-expiratory CT alone may be sufficient for monitoring CF-related lung disease. This would help reduce radiation dose for a single investigation by up to 75%.
    Subject(s): Adolescent ; Biological and medical sciences ; Child ; Cystic Fibrosis - diagnostic imaging ; Errors of metabolism ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lung Diseases - diagnostic imaging ; Lung Volume Measurements ; Male ; Medical sciences ; Metabolic diseases ; Miscellaneous hereditary metabolic disorders ; Pilot Projects ; Radiation Dosage ; Tomography, X-Ray Computed - methods ; Young Adult
    ISSN: 0033-8419
    E-ISSN: 1527-1315
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Pediatric pulmonology, 2009-09, Vol.44 (9), p.859-865
    Description: Introduction To date no studies have been published on nocturnal cough frequency in children with stable CF. Aim of the study was to assess nocturnal cough frequency in children with CF. In addition nocturnal cough frequency was correlated with parameters of disease severity. Methods During two nights cough was recorded with a digital audio recorder in 25 patients (mean age 13 years; range 6–19) with clinically stable CF. In addition oxygen saturation was measured. The day following the recording spirometry was carried out. CT scores were obtained from the most recent routine CT scan. Cough was expressed in cough seconds (csec) and in cough seconds per hour (csec/hr). Results Data shown are median values and interquartile range (IQR). First night: 8 csec (IQR 3–52); 0.9 csec/hr (IQR 0.3–6.1) Second night: 6 csec (IQR 2–32); 0.6 csec/hr (IQR 0.1–3.4). Csec in the 1st night did not correlate significantly with csec in the 2nd night. Only for the 2nd night a strong correlation was found between csec/hr and the FEV1%pred (rs = −0.75, P 〈 0.001) and FEF75 %pred (rs = −0.71, P 〈 0.001). Bronchiectasis score correlated borderline with the mean csec/hr of both nights (rs = 0.39, P = 0.08). During both nights cough was significantly higher in the first hour of sleep (P ≤ 0.04). Conclusion Frequency of nocturnal coughing in children with CF was higher than that described for normal children. Nocturnal cough tended to be more severe in children with more advanced CF lung disease. Nocturnal cough was more severe in the first hour of sleep and varied from night‐to‐night. Pediatr Pulmonol. 2009; 44:859–865. © 2009 Wiley‐Liss, Inc.
    Subject(s): Adolescent ; Biological and medical sciences ; Child ; children ; cough ; Cough - diagnosis ; Cough - etiology ; cystic fibrosis ; Cystic Fibrosis - complications ; Errors of metabolism ; Female ; General aspects ; Humans ; Male ; measurement ; Medical sciences ; Metabolic diseases ; Miscellaneous hereditary metabolic disorders ; Monitoring, Ambulatory ; Pneumology ; Polysomnography ; Respiratory Function Tests ; Respiratory system : syndromes and miscellaneous diseases ; Severity of Illness Index ; Sleep Stages
    ISSN: 8755-6863
    E-ISSN: 1099-0496
    Source: Hellenic Academic Libraries Link
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Radiology, 2012-03-01, Vol.262 (3), p.969-976
    Description: Purpose: To estimate the effect of the number of computed tomography (CT) sections on trapped air (TA) assessment in patients with cystic fibrosis (CF) by using an established scoring system and a new quantitative scoring system and to compare CT and pulmonary function test (PFT) estimates of TA in a cross-sectional and longitudinal study. Materials and Methods: In this institutional review board-approved pilot study, 20 subjects aged 6-20 years (12 female and eight male; median age, 12.6 years) contributed two expiratory CT studies (three-section baseline CT, volumetric follow-up CT) and two PFT studies over 2 years after parental informed consent was obtained. From follow-up CT studies, seven sets were composed: Set
    Subject(s): Abridged Index Medicus ; Adolescent ; Air ; Child ; Cross-Sectional Studies ; Cystic Fibrosis - diagnostic imaging ; Cystic Fibrosis - physiopathology ; Exhalation ; Female ; Follow-Up Studies ; Humans ; Linear Models ; Longitudinal Studies ; Male ; Respiratory Function Tests ; Retrospective Studies ; Statistics, Nonparametric ; Tomography, X-Ray Computed - methods
    ISSN: 0033-8419
    E-ISSN: 1527-1315
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Pediatric pulmonology, 2009-09, Vol.44 (9), p.859-865
    ISSN: 8755-6863
    E-ISSN: 1099-0496
    Source: Hellenic Academic Libraries Link
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Radiology, 2009-10-01, Vol.253 (1), p.223
    Description: Purpose: To assess whether chest computed tomography (CT) scores from ultra-low-dose end-expiratory scans alone could suffice for assessment of all cystic fibrosis (CF)-related structural lung abnormalities. Materials and Methods: In this institutional review board–approved study, 20 patients with CF aged 6–20 years (eight males, 12 females) underwent low-dose end-inspiratory CT and ultra-low-dose end-expiratory CT. Informed consent was obtained. Scans were randomized and scored by using the Brody-II CT scoring system to assess bronchiectasis, airway wall thickening, mucus plugging, and opacities. Scoring was performed by two observers who were blinded to patient identity and clinical information. Mean scores were used for all analyses. Statistical analysis included assessment of intra- and interobserver variability, calculation of intraclass correlation coefficients (ICCs), and Bland-Altman plots. Results: Median age was 12.6 years (range, 6.3–20.3 years), median forced expiratory volume in 1 second was 100% (range, 46%–127%) of the predicted value, and median forced vital capacity was 99% (range, 61%–123%) of the predicted value. Very good agreement was observed between end-inspiratory and end-expiratory CT scores for Brody-II total score (ICC = 0.96), bronchiectasis (ICC = 0.98), airway wall thickening (ICC = 0.94), mucus plugging (ICC = 0.96), and opacities (ICC = 0.90). Intra- and interobserver agreement were good to very good (ICC range, 0.70–0.98). Bland-Altman plots showed that differences in scores were independent of score magnitude. Conclusion: In this pilot study, CT scores from end-expiratory and end-inspiratory CT match closely, suggesting that ultra-low-dose end-expiratory CT alone may be sufficient for monitoring CF-related lung disease. This would help reduce radiation dose for a single investigation by up to 75%. © RSNA, 2009
    ISSN: 0033-8419
    E-ISSN: 1527-1315
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: French
    Description: Provider: Bibliothèque nationale de France - Institution: Bibliothèque nationale de France - Data provided by Europeana Collections- Contient : Lettres autographes signées de Charles Nodier ; Lettres adressées à Nodier ; Correspondance de Marie Mennessier Nodier ; Papiers divers- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
    Source: Europeana Collections
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...