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  • 1
    Language: English
    In: Langmuir : the ACS journal of surfaces and colloids, 06 December 2011, Vol.27(23), pp.14335-42
    Description: By making dynamic changes to the area of a droplet interface bilayer (DIB), we are able to measure the specific capacitance of lipid bilayers with improved accuracy and precision over existing methods. The dependence of membrane specific capacitance on the chain-length of the alkane oil present in the bilayer is similar to that observed in black lipid membranes. In contrast to conventional artificial bilayers, DIBs are not confined by an aperture, which enables us to determine that the dependence of whole bilayer capacitance on applied potential is predominantly a result of a spontaneous increase in bilayer area. This area change arises from the creation of new bilayer at the three phase interface and is driven by changes in surface tension with applied potential that can be described by the Young-Lippmann equation. By accounting for this area change, we are able to determine the proportion of the capacitance dependence that arises from a change in specific capacitance with applied potential....
    Subject(s): Membranes, Artificial ; Lipid Bilayers -- Chemistry ; Phosphatidylcholines -- Chemistry
    ISSN: 0743-7463
    E-ISSN: 1520-5827
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  • 2
    Language: English
    In: Biophysical Journal, 29 January 2013, Vol.104(2), pp.43a-43a
    Subject(s): Biology
    ISSN: 0006-3495
    E-ISSN: 1542-0086
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: Nano letters, 10 August 2011, Vol.11(8), pp.3324-8
    Description: We form an artificial lipid bilayer between a nanolitre aqueous droplet and a supporting hydrogel immersed in an oil/lipid solution. Manipulation of the axial position of the droplet relative to the hydrogel controls the size of the bilayer formed at the interface; this enables the surface density of integral membrane proteins to be controlled. We are able to modulate the surface density of the β-barrel pore-forming toxin α-hemolysin over a range of 4 orders of magnitude within a time frame of a few seconds. The concentration changes are fully reversible. Membrane protein function and diffusion are unaltered, as measured by single molecule microscopy and single channel electrical recording.
    Subject(s): Lipid Bilayers ; Membrane Proteins -- Analysis
    ISSN: 1530-6984
    E-ISSN: 1530-6992
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  • 4
    Language: English
    In: PQDT - UK & Ireland
    Description: Droplet Interface Bilayers (DIBs) have a number of attributes that distinguish them from conventional artificial lipid bilayers. In particular, the ability to manipulate bilayers mechanically is explored in this thesis. Directed bilayer area changes are used to make precise measurements of the specific capacitance of DIBs and to control the two dimensional concentration of a membrane protein reconstituted in the bilayer. Chapter 1 provides a general introduction to the role of the lipid membrane en- vironment in the function of biological membranes and their integral proteins. An overview of model lipid bilayer systems is given. Chapter 2 introduces work carried out in this laboratory previously and illustrates the experimental setup of DIBs. Some important bilayer biophysical concepts are covered to provide the theoretical background to experiments in this and in later chapters. Results from the characterisation of DIBs are reported, and an account of the development of methods to manipulate...
    Subject(s): Biochemistry ; Biochemistry ; Http://Ora.Ox.Ac.Uk/Objects/Uuid:0b7ffba6-B86d-499c-A93f-3b2fc46a427b ; 558307 ; Pure Sciences
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Source: ProQuest Dissertations & Theses Global: The Sciences and Engineering Collection
    Source: ProQuest Dissertations and Theses Global A&I: The Sciences and Engineering Collection
    Source: ProQuest Dissertations & Theses A&I
    Source: ProQuest Dissertations & Theses: Global
    Source: ProQuest One Academic
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  • 5
    Language: English
    In: PQDT - UK & Ireland
    Description: Droplet Interface Bilayers (DIBs) have a number of attributes that distinguish them from conventional artificial lipid bilayers. In particular, the ability to manipulate bilayers mechanically is explored in this thesis. Directed bilayer area changes are used to make precise measurements of the specific capacitance of DIBs and to control the two dimensional concentration of a membrane protein reconstituted in the bilayer. Chapter 1 provides a general introduction to the role of the lipid membrane en- vironment in the function of biological membranes and their integral proteins. An overview of model lipid bilayer systems is given. Chapter 2 introduces work carried out in this laboratory previously and illustrates the experimental setup of DIBs. Some important bilayer biophysical concepts are covered to provide the theoretical background to experiments in this and in later chapters. Results from the characterisation of DIBs are reported, and an account of the development of methods to manipulate...
    Subject(s): 558307
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
    Source: ProQuest Dissertations & Theses A&I
    Source: ProQuest Dissertations & Theses: Global
    Source: ProQuest One Academic
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  • 6
    In: Maternal & Child Nutrition, January 2018, Vol.14(1), pp.n/a-n/a
    Description: The authors examined the relationship of prepregnancy body mass index (BMI) and gestational weight gain (GWG) with child neurodevelopment. Mother–child dyads were a subgroup ( = 2,084) of the Child Health and Development Studies from the Oakland, California, area enrolled during pregnancy from 1959 to 1966 and followed at child age 9 years. Linear regression was used to examine associations between prepregnancy BMI, GWG, and standardized Peabody Picture Vocabulary Test and Raven Progressive Matrices scores and to evaluate effect modification of GWG by prepregnancy BMI. Before pregnancy, 77% of women were normal weight, 8% were underweight, 11% were overweight, and 3% were obese. Associations between GWG and child outcomes did not vary by prepregnancy BMI, suggesting no evidence for interaction. In multivariable models, compared to normal prepregnancy BMI, prepregnancy overweight and obesity were associated with lower Peabody scores (b: −1.29; 95% CI [−2.6, −0.04] and b: −2.7; 95% CI [−5.0, −0.32], respectively). GWG was not associated with child Peabody score [b: −0.03 (95% CI: −0.13, 0.07)]. Maternal BMI and GWG were not associated with child Raven score (all  〉0.05). Maternal prepregnancy overweight and obesity were associated with lower scores for verbal recognition in mid‐childhood. These results contribute to evidence linking maternal BMI with child neurodevelopment. Future research should examine the role of higher prepregnancy BMI values and the pattern of pregnancy weight gain in child cognitive outcomes.
    Subject(s): Child Development ; Cognitive Development ; Maternal Obesity ; Pregnancy
    ISSN: 1740-8695
    E-ISSN: 1740-8709
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  • 7
    Language: English
    Description: The authors examined the relationship of prepregnancy body mass index (BMI) and gestational weight gain (GWG) with child neurodevelopment. Mother-child dyads were a subgroup (n = 2,084) of the Child Health and Development Studies from the Oakland, California, area enrolled during pregnancy from 1959 to 1966 and followed at child age 9 years. Linear regression was used to examine associations between prepregnancy BMI, GWG, and standardized Peabody Picture Vocabulary Test and Raven Progressive Matrices scores and to evaluate effect modification of GWG by prepregnancy BMI. Before pregnancy, 77% of women were normal weight, 8% were underweight, 11% were overweight, and 3% were obese. Associations between GWG and child outcomes did not vary by prepregnancy BMI, suggesting no evidence for interaction. In multivariable models, compared to normal prepregnancy BMI, prepregnancy overweight and obesity were associated with lower Peabody scores (b: -1.29; 95% CI [-2.6, -0.04] and b: -2.7;...
    Subject(s): Humans ; Pregnancy Complications ; Obesity ; Weight Gain ; Thinness ; Body Mass Index ; Prevalence ; Cohort Studies ; Follow-Up Studies ; Prospective Studies ; Child Development ; Recognition (Psychology) ; Verbal Learning ; Fetal Development ; Pregnancy ; Adult ; Child ; California ; Female ; Male
    Source: eScholarship (California Digital Library)
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  • 8
    Language: German
    In: Library ideas, 01 December 2009, Vol.5(2), pp.86-87
    Subject(s): Rezension ; Wikipedia ; Internet ; Medienwissenschaft ; Library & Information Science
    ISSN: 1860-7950
    E-ISSN: 1860-7950
    Source: Directory of Open Access Journals (DOAJ)
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  • 9
    Article
    Article
    2004
    ISSN: 0164-7970 
    Language: English
    In: New Directions for Student Services, 2004, Vol.2004(105), pp.63-77
    Description: For Latino students, career development and planning includes the negotiation of family influences, peer expectations, and challenges as they develop career efficacy in work experiences as undergraduates. The model presented here outlines how students can benefit from a holistic perspective on the intersections of career and cultural identity.
    Subject(s): Career Development ; Holistic Approach ; College Students ; Hispanic Americans ; Career Choice ; Foreign Countries ; Social Influences ; Cuba ; Mexico ; Puerto Rico ; South America ; Higher Education ; Cuba ; Mexico ; Puerto Rico ; South America ; Central America;
    ISSN: 0164-7970
    E-ISSN: 1536-0695
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  • 10
    In: Nature Protocols, 2013, Vol.8(6), p.1048
    Description: We describe a protocol for forming an artificial lipid bilayer by contacting nanoliter aqueous droplets in an oil solution in the presence of phospholipids. A lipid monolayer forms at each oil-water interface, and when two such monolayers touch, a bilayer is created. Droplet interface bilayers (DIBs) are a simple way to generate stable bilayers suitable for single-channel electrophysiology and optical imaging from a wide variety of preparations, ranging from purified proteins to reconstituted eukaryotic cell membrane fragments. Examples include purified proteins from the [alpha]-hemolysin pore from Staphylococcus aureus, the anthrax toxin pore and the 1.2-MDa mouse mechanosensitive channel MmPiezo1. Ion channels and ionotropic receptors can also be reconstituted from membrane fragments without further purification. We describe two approaches for forming DIBs. In one approach, a lipid bilayer is created between two aqueous droplets submerged in oil. In the other approach, a membrane is formed between an aqueous droplet and an agarose hydrogel, which allows imaging in addition to electrical recordings. The protocol takes 〈30 min, including droplet generation, monolayer assembly and bilayer formation. In addition to the main protocol, we also describe the preparation of Ag/AgCl electrodes and sample preparation.
    Subject(s): Lipid Membranes – Physiological Aspects ; Lipid Membranes – Properties ; Lipid Membranes – Research ; Membrane Lipids – Physiological Aspects ; Membrane Lipids – Properties ; Membrane Lipids – Research;
    ISSN: 1754-2189
    E-ISSN: 17502799
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