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  • 1
    Language: English
    In: Environmental health, 2017-07-28, Vol.16 (1), p.82-82
    Description: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O or NO or PM2.5 or diesel or SO or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved. Both animal and human epidemiological studies support the idea that air pollutants cause defects during gametogenesis leading to a drop in reproductive capacities in exposed populations. Air quality has an impact on overall health as well as on the reproductive function, so increased awareness of environmental protection issues is needed among the general public and the authorities.
    Subject(s): Mammals - metabolism ; Gametogenesis - drug effects ; Animals ; Humans ; Air Pollution - adverse effects ; Air Pollutants - adverse effects ; Female ; Infertility - physiopathology ; Male ; Air Pollutants - toxicity ; Infertility - chemically induced ; Air pollution ; Health aspects ; Infertility ; Risk factors ; Index Medicus ; Air quality ; Reproduction ; Pollutants ; Fertility
    ISSN: 1476-069X
    E-ISSN: 1476-069X
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: Environmental health perspectives, 2019-07, Vol.127 (7), p.77005
    Description: Given its hormonal activity, bisphenol S (BPS) as a substitute for bisphenol A (BPA) could actually increase the risk of endocrine disruption if its toxicokinetic (TK) properties, namely its oral availability and systemic persistency, were higher than those of BPA. The TK behavior of BPA and BPS was investigated by administering the two compounds by intravenous and oral routes in piglet, a known valid model for investigating oral TK. Experiments were conducted in piglets to evaluate the kinetics of BPA, BPS, and their glucuronoconjugated metabolites in plasma and urine after intravenous administration of BPA, BPS, and BPS glucuronide (BPSG) and gavage administration of BPA and BPS. A population semiphysiologically based TK model describing the disposition of BPA and BPS and their glucuronides was built from these data to estimate the key TK parameters that drive the internal exposure to active compounds. The data indicated that almost all the BPS oral dose was absorbed and transported into the liver where only 41% of BPS was glucuronidated, leading to a systemic bioavailability of 57.4%. In contrast, only 77% of the oral dose of BPA was absorbed and underwent an extensive first-pass glucuronidation either in the gut (44%) or in the liver (53%), thus accounting for the low systemic bioavailability of BPA (0.50%). Due to the higher systemic availability of BPS, in comparison with BPA, and its lower plasma clearance (3.5 times lower), the oral BPS systemic exposure was on average about 250 times higher than for BPA for an equal oral molar dose of the two compounds. Given the similar digestive tracts of pigs and humans, our results suggest that replacing BPA with BPS will likely lead to increased internal exposure to an endocrine-active compound that would be of concern for human health. https://doi.org/10.1289/EHP4599.
    Subject(s): Toxicokinetics ; Administration, Intravenous ; Animals ; Sus scrofa - metabolism ; Phenols - pharmacokinetics ; Administration, Oral ; Environmental Pollutants - pharmacokinetics ; Biological Availability ; Female ; Male ; Sulfones - pharmacokinetics ; Benzhydryl Compounds - pharmacokinetics ; Phenols ; Metabolites ; Bisphenol-A ; Swine ; Analysis ; Pharmacology, Experimental ; Endocrine gland diseases ; Development and progression ; Models ; Bioavailability ; Research ; Health aspects ; Risk factors ; Environmental and Society ; Environmental Sciences
    ISSN: 0091-6765
    E-ISSN: 1552-9924
    Source: U.S. Government Documents
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 3
    Language: English
    In: Journal of assisted reproduction and genetics, 2020-05, Vol.37 (5), p.1019-1028
    Description: Monitoring the pH of IVF culture media is a good practice, but the required pH levels have been "arbitrarily" set. Assisted reproductive technology centers around the world are spending time and money on pH monitoring without any consensus to date. The objective of this narrative review was to evaluate the importance of pH monitoring during IVF, discover how the oocyte and embryo regulate their intracellular pH and try to determine the optimal pH to be applied. A narrative literature review was performed on publications in the PubMed database reporting on the impact of pH on cellular function, oocyte and embryo development, IVF outcomes and pathophysiology, or on physiological pH in the female reproductive tract. Intracellular pH regulates many cellular processes such as meiotic spindle stability of the oocyte, cell division and differentiation, embryo enzymatic activities, and blastocoel formation. The internal pH of the human embryo is maintained by regulatory mechanisms (mainly Na /H and HCO /Cl exchangers) that can be exceeded, particularly in the oocyte and early-stage embryos. The opinion that the optimal pH for embryo culture is physiological pH is not correct since several physicochemical parameters specific to IVF culture conditions (temperature, medium composition, duration of culture, or implication of CO ) can modify the intracellular pH of the embryo and change its needs and adaptability. Because correct and stable extracellular pH is essential to embryo health and development, monitoring pH is imperative. However, there is a lack of clinical data on choosing the ideal pH for human IVF culture media.
    Subject(s): Humans ; Culture Media - pharmacology ; Fertilization in Vitro - methods ; Oocytes - drug effects ; Embryo Culture Techniques - methods ; Embryonic Development ; Culture Media - chemistry ; Blastocyst - drug effects ; Hydrogen-Ion Concentration ; Reproductive Techniques, Assisted - trends ; Index Medicus ; Bicarbonate ; Preimplantation mammalian embryo ; CO2 ; IVF ; Culture media ; Review ; Hydrogen ion
    ISSN: 1058-0468
    E-ISSN: 1573-7330
    Source: PubMed Central
    Source: Alma/SFX Local Collection
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  • 4
    Language: English
    In: Fertility and sterility, 2016, Vol.107 (2), p.365-372.e3
    Description: Objective To investigate current practices for sperm morphology assessment. Design E-mail survey questionnaire. Setting Diagnostic and clinical institutions/laboratories. Patient(s) French biologists and clinicians (n = 225). Intervention(s) None. Main Outcome Measure(s) Answers to 24 questions. Result(s) The survey shows that even now in France there is great inconsistency in the use of sperm morphology assessments. For example, the survey revealed that no fewer than six different staining techniques were in use. Automatic reading is hardly used (used by 2.5% of the biologists replying to the survey). More than 33.6% of biologists use a threshold of normal forms unsuited to their classification, and 20% do not perform any internal quality control in this area. Prescribing doctors seldom trust the tests, likely due to their lack of analytic reliability. Among the biologists surveyed 26% said the percentage of normal forms is either unreliable or not very reliable in analytic terms, and 24% of clinicians stated that it has little clinical relevance. Conclusion(s) The survey reveals a marked lack of uniformity in French laboratories for performing sperm morphology assessment and in the use of the results by physicians. Regular quality control procedures and well-trained personnel, up to date with their training and conversant with the latest techniques as well as harmonized practices, are clearly indispensable. It is time for a consensus on the practice and interpretation of this particular test.
    Subject(s): Internal Medicine ; Obstetrics and Gynecology ; sperm morphology ; quality control ; Analytical reliability ; clinical relevance ; Predictive Value of Tests ; Reproducibility of Results ; Spermatozoa - pathology ; Humans ; Quality Indicators, Health Care ; Male ; Practice Patterns, Physicians ; Consensus ; Quality Improvement ; Cell Shape ; Healthcare Disparities ; Surveys and Questionnaires ; France ; Health Care Surveys ; Semen Analysis - methods ; Quality Control ; Surveys ; Spermatozoa ; Medical care ; Usage ; Physicians ; Quality management ; Index Medicus
    ISSN: 0015-0282
    E-ISSN: 1556-5653
    Source: Alma/SFX Local Collection
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  • 5
    Language: English
    In: Gynecological endocrinology, 2018-08-03, Vol.34 (8), p.664-665
    Description: To detect clinical parameters impacting ovarian reserve, data were analyzed from 573 patients who had an anti-Müllerian hormone (AMH) measurement for infertility treatment. No impact was found on the age at menarche but a significant diminished ovarian reserve was observed when a patient's mother was menopausal before age 50. These data suggest that ovarian reserve must be monitored in such patients to offer them fertility preservation when at risk of premature ovarian insufficiency (POI).
    Subject(s): menopause ; premature ovarian insufficiency ; AMH ; menarche ; Index Medicus
    ISSN: 0951-3590
    E-ISSN: 1473-0766
    Source: Academic Search Ultimate
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  • 6
    Language: English
    In: Obstetrical & gynecological survey, 2017-12, Vol.72 (12), p.718-719
    Description: (Abstracted from Reprod Biomed Online 2017;35:314–317)While intrauterine insemination (IUI) is one of the first lines of infertility treatments and assisted reproductive techniques, the mean delivery per insemination rate is 10.7% and varies widely from one center to another, according to the French registry. This variation could be attributed to the heterogeneity of the treated population, especially with regard to fallopian tube status.
    ISSN: 0029-7828
    E-ISSN: 1533-9866
    Source: Hellenic Academic Libraries Link
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  • 7
    Language: English
    In: European journal of obstetrics & gynecology and reproductive biology: X, 2019-10, Vol.4, p.100058-100058
    Description: ObjectiveIntra-uterine insemination (IUI) is widely used for different indications. The aim of the present study was to evaluate the efficiency of intra-uterine insemination as a function of indication and origin of the inseminated spermatozoa. Study designThe retrospective study involved 827 first attempts of IUI in 827 couples between January 2011 and July 2017 in the Toulouse university hospital. Of these, 642 used fresh sperm from the husband, 40 frozen sperm from the husband and 145 frozen sperm from donors. The measured outcome parameter was live birth rate per attempt. ResultsWhen comparing couples lacking functional gametes (due to male or female causes), to couples who could potentially conceive spontaneously, i.e. subfertile, the latter were found to have a significantly lower live birth rate (18% vs 26%; P 〈 0.05). Even when adjusted for demographic parameters, which differed significantly between the 2 groups (female age, percentage of women suffering from primary infertility, BMI, number of inseminated motile spermatozoa and stimulation duration), this difference remained statistically significant (OR = 0.639 [0.425-0.961]; P = 0.0316). ConclusionWhen compared to couples lacking functional gametes, subfertile couples have poor IUI outcomes, suggesting a hidden cause of infertility, despite no apparent differences in ovarian reserve, tubal potency, results of ovarian stimulation and normal conventional sperm parameters. Further studies are required to better characterise and identify this subgroup of women with poor IUI outcomes.
    ISSN: 2590-1613
    E-ISSN: 2590-1613
    Source: PubMed Central
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  • 8
    Language: English
    In: European journal of obstetrics & gynecology and reproductive biology: X, 2019-07, Vol.3, p.100043-100043
    Description: To evaluate the impact of age-specific anti-Mullerian (AMH) levels on the cumulative live birth rate after 4 intra uterine inseminations (IUI). The retrospective study study involved 509 couples who underwent their first IUI between January 2011 and July 2017 in the Toulouse University Hospital. All IUI were performed after an ovarian stimulation combining recombinant FSH and GnRH antagonist. The main measure outcome was the cumulative live birth rate (LBR) defined as the number of deliveries with at least one live birth resulting from a maximum of 4 IUI attempts. When compared to normal or high levels, low age-specific AMH (〈25th of the AMH in each age group) was associated to a non-significant lower live birth rate (31%, 38% and 42% respectively for low, normal and high age-specific groups; P = 0.170) and non-significant higher miscarriage rate (26%; 19% and 14% respectively for low, normal and high age-specific groups; P = 0.209). However, it must be pointed out that in low age-specific AMH the initial FSH doses used for stimulation were higher than in the other groups. This study shows that the age-specific levels of AMH have only a slight effect on IUI outcome when adapting the stimulation protocols to their level.
    ISSN: 2590-1613
    E-ISSN: 2590-1613
    Source: PubMed Central
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  • 9
    Language: English
    In: Journal of assisted reproduction and genetics, 2007-05, Vol.24 (5), p.159-165
    Description: Purpose: The pregnancy outcome and the chances of birth were assessed according to embryo quality after IVF or ICSI. Methods: The implantation rate (IR), the loss of gestational sacs rate (LGSR), and birth rate (BR) were determined according to the cleavage stage and the integrity of blastomeres after day-2 homogeneous embryo transfers (n = 1812). Results: The LGSR was higher after transfers of 2–3-cell or 5–6-cell embryos and was significantly increased when more than 20% of the embryo volume was fragmented in 4-cell embryos. After transfers of 4-cell embryos without fragmentation, the BR was significantly higher than the BR after transfers of 4-cell embryos with 1–20% fragmentation (16.6% vs 13.1%). The difference was the consequence of a higher IR (20.4% vs 17.3%) but also of a lower LGSR (18.9% vs 24.2%). Conclusions: Not only implantation and the ability to give a pregnancy, but also the capacity to give a live birth are dependent on the embryo quality.
    Subject(s): Human Genetics ; IVF/ICSI outcome ; Medicine & Public Health ; Gynecology ; Developmental Biology ; Assisted reproduction ; Embryo development ; Embryo quality ; Pregnancy ; Embryo Disposition - statistics & numerical data ; Sperm Injections, Intracytoplasmic - statistics & numerical data ; Fetal Death ; Humans ; Adult ; Female ; Fertilization in Vitro - statistics & numerical data ; Embryo Implantation ; Infant, Newborn ; Pregnancy Outcome ; Pregnant women ; Embryo ; Index Medicus ; Life Sciences ; Human health and pathology ; IVF ; ICSI outcome ; Assisted Reproduction
    ISSN: 1058-0468
    E-ISSN: 1573-7330
    Source: PubMed Central
    Source: Alma/SFX Local Collection
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  • 10
    Language: English
    In: Physiological Genomics, 2009-01-01, Vol.36 (2), p.98-113
    Description: Early mammalian development is characterized by extensive changes in nuclear functions that result from epigenetic modifications of the newly formed embryonic genome. While the first embryonic cells are totipotent, this status spans only a few cell cycles. At the blastocyst stage, the embryo already contains differentiated trophectoderm cells and pluripotent inner cell mass cells. Concomitantly, the embryonic genome becomes progressively transcriptionally active. During this unique period of development, the gene expression pattern has been mainly characterized in the mouse, in which embryonic genome activation (EGA) spans a single cell cycle after abrupt epigenetic modifications. To further characterize this period, we chose to analyze it in the rabbit, in which, as in most mammals, EGA is more progressive and occurs closer to the first cell differentiation events. In this species, for which no transcriptomic arrays were available, we focused on genes expressed at EGA and first differentiation and established a 2,000-gene dedicated cDNA array. Screening this with pre-EGA, early post-EGA, and blastocyst embryos divided genes into seven clusters of expression according to their regulation during this period and revealed their dynamics of expression during EGA and first differentiation. Our results point to transient properties of embryo transcriptome at EGA, due not only to the transition between maternal and embryonic transcripts but also to the transient expression of a subset of embryonic genes whose functions remained largely uncharacterized. They also provide a first view of the functional consequences of the changes in gene expression program.
    Subject(s): Cell Differentiation - genetics ; Rabbits ; Animals ; Oligonucleotide Array Sequence Analysis ; Gene Expression Regulation, Developmental ; Blastocyst - metabolism ; Female ; Gene Expression Profiling ; Genome ; Morula - metabolism ; Embryo, Mammalian - metabolism ; Index Medicus ; Life Sciences ; Mathematics ; Computer Science
    ISSN: 1094-8341
    E-ISSN: 1531-2267
    Source: HighWire Press (Free Journals)
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