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  • 1
    Language: English
    In: Journal of physical and chemical reference data, 2019-06, Vol.48 (2), p.23101
    Description: Accurate, empirical rovibronic energy levels, with associated uncertainties, are determined for the lowest seven electronic states of the 16O2 molecule using the MARVEL (Measured Active Rotational-Vibrational Energy Levels) algorithm. After careful analysis and validation of 30 671 rovibronic transitions (including 24 376 measured and 6295 artificial transitions), collected from 91 publications, 4279 empirical rovibronic energy levels are determined. The highly accurate empirical (MARVEL) energy database is then augmented with rovibronic energies obtained from accurate effective Hamiltonians for the lowest six electronic states, establishing a hybrid database containing 15 946 rovibronic energy levels. Based on this hybrid database, complete up to the first dissociation limit, 41 260 cm−1, an accurate temperature-dependent ideal-gas partition function, Qint(T), and some related thermochemical functions [isobaric heat capacity, Cpo(T), entropy, So(T), and (absolute) enthalpy, Ho(T)] are derived for 16O2 employing the direct-summation technique. All thermochemical functions are reported, in 1 K increments up to 5000 K, in the supplementary material to this paper.
    Subject(s): Studies ; Superheroes ; Temperature ; Energy ; Entropy ; Heat transfer ; Data bases
    ISSN: 0047-2689
    E-ISSN: 1529-7845
    Source: American Institute of Physics (AIP) Publications
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  • 2
    Language: English
    In: European journal of international law, 2012-02-01, Vol.23 (1), p.97-119
    Subject(s): International law ; Evaluation ; Usage ; Geography, Historical
    ISSN: 0938-5428
    E-ISSN: 1464-3596
    Source: Academic Search Ultimate
    Source: Nexis Uni
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
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  • 3
    Language: English
    In: Cancer, 2019-08-01, Vol.125 (15), p.2693-2703
    Description: Background Desmoid tumors (DTs) are rare and understudied fibroblastic lesions that are frequently recurrent and locally invasive. DT patients often experience chronic pain, organ dysfunction, decrease in quality of life, and even death. Methods Sorafenib has emerged as a promising therapeutic strategy, which has led to the first randomized phase 3 clinical trial devoted to DTs. Concurrently, we conducted a comprehensive analysis of sorafenib efficacy in a large panel of desmoid cell strains to probe for response mechanism. Results We found distinctive groups of higher‐ and lower‐responder cells. Clustering the lower‐responder group, we observed that CTNNB1 mutation was determinant of outcome. Our results revealed that a lower dose of sorafenib was able to inhibit cell viability, migration, and invasion of wild‐type and T41A‐mutated DTs. Apoptosis induction was observed in those cells after treatment with sorafenib. On the other hand, the lower dose of sorafenib was not able to inhibit cell viability, migration, or invasion or to induce apoptosis in the S45F‐mutated DTs. The investigation of autophagy showed the dependency of S45F‐mutated DTs on this pathway as a part of cell survival mechanism. Significantly, when autophagy was inhibited genetically or pharmacologically in the S45F mutant cell strains, sensitivity to sorafenib was restored. Conclusions Our findings suggest that the response to sorafenib differs when comparing S45F‐mutated DTs and T41A‐mutated or wild‐type DTs. Furthermore, the combination of hydroxychloroquine and sorafenib enhances the antiproliferative and proapoptotic effects in S45F‐mutated DT cells, suggesting that profiling β‐catenin status could guide clinical management of desmoid patients who are considering sorafenib treatment. Sorafenib treatment is more effective in wild‐type and T41A‐mutated DT cell strains. The resistance observed in S45F‐mutated cells is driven by elevated basal autophagy and could be reversed by autophagy inhibition.
    Subject(s): therapeutic combination ; autophagy ; desmoid tumors ; sorafenib ; hydroxychloroquine ; Humans ; Female ; Male ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Sorafenib - pharmacology ; Sorafenib - therapeutic use ; Autophagy - drug effects ; Fibromatosis, Aggressive - drug therapy ; Desmoid tumors ; Hydroxychloroquine ; Therapeutic combination ; Autophagy ; Sorafenib
    ISSN: 0008-543X
    E-ISSN: 1097-0142
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 4
    Language: English
    In: Oncogene, 2020-08, Vol.39 (34), p.5589-5600
    Description: Wnt/β-catenin signaling is one of the key cascades regulating embryogenesis and tissue homeostasis; it has also been intimately associated with carcinogenesis. This pathway is deregulated in several tumors, including colorectal cancer, breast cancer, and desmoid tumors. It has been shown that CTNNB1 exon 3 mutations are associated with an aggressive phenotype in several of these tumor types and may be associated with therapeutic tolerance. Desmoid tumors typically have a stable genome with β-catenin mutations as a main feature, making these tumors an ideal model to study the changes associated with different types of β-catenin mutations. Here, we show that the apoptosis mechanism is deregulated in β-catenin S45F mutants, resulting in decreased induction of apoptosis in these cells. Our findings also demonstrate that RUNX3 plays a pivotal role in the inhibition of apoptosis found in the β-catenin S45F mutants. Restoration of RUNX3 overcomes this inhibition in the S45F mutants, highlighting it as a potential therapeutic target for malignancies harboring this specific CTNNB1 mutation. While the regulatory effect of RUNX3 in β-catenin is already known, our results suggest the possibility of a feedback loop involving these two genes, with the CTNNB1 S45F mutation downregulating expression of RUNX3, thus providing additional possible novel therapeutic targets for tumors having deregulated Wnt/β-catenin signaling induced by this mutation.
    Subject(s): Core Binding Factor Alpha 3 Subunit - metabolism ; Fibromatosis, Aggressive - metabolism ; Down-Regulation ; Humans ; Gene Expression Regulation, Neoplastic ; Apoptosis - genetics ; Gene Expression Profiling - methods ; Mutation, Missense ; Adenomatous Polyposis Coli - pathology ; beta Catenin - metabolism ; beta Catenin - genetics ; Adenomatous Polyposis Coli - metabolism ; Abdominal Neoplasms - metabolism ; Fibromatosis, Aggressive - genetics ; Wnt Signaling Pathway - genetics ; Abdominal Neoplasms - genetics ; HEK293 Cells ; Cell Line, Tumor ; Core Binding Factor Alpha 3 Subunit - genetics ; Abdominal Neoplasms - pathology ; Adenomatous Polyposis Coli - genetics ; Fibromatosis, Aggressive - pathology ; Index Medicus
    ISSN: 0950-9232
    E-ISSN: 1476-5594
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
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  • 5
    Language: English
    In: Physical review. B, Condensed matter and materials physics, 2012-04, Vol.85 (15)
    ISSN: 1098-0121
    E-ISSN: 1550-235X
    Source: Single Journals
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  • 6
    Language: English
    In: European journal of international law, 2014-02-01, Vol.25 (1), p.25-29
    Subject(s): International law ; Evaluation ; Globalization ; Geography, Political
    ISSN: 0938-5428
    E-ISSN: 1464-3596
    Source: Academic Search Ultimate
    Source: Nexis Uni
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
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  • 7
    Language: English
    In: Physical review. B, 2017-08, Vol.96 (5)
    ISSN: 2469-9950
    E-ISSN: 2469-9969
    Source: Hellenic Academic Libraries Link
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  • 8
    Language: English
    In: ACM transactions on graphics, 2004-08-01, Vol.23 (3), p.695-703
    Description: Valuable 3D graphical models, such as high-resolution digital scans of cultural heritage objects, may require protection to prevent piracy or misuse, while still allowing for interactive display and manipulation by a widespread audience. We have investigated techniques for protecting 3D graphics content, and we have developed a remote rendering system suitable for sharing archives of 3D models while protecting the 3D geometry from unauthorized extraction. The system consists of a 3D viewer client that includes low-resolution versions of the 3D models, and a rendering server that renders and returns images of high-resolution models according to client requests. The server implements a number of defenses to guard against 3D reconstruction attacks, such as monitoring and limiting request streams, and slightly perturbing and distorting the rendered images. We consider several possible types of reconstruction attacks on such a rendering server, and we examine how these attacks can be defended against without excessively compromising the interactive experience for non-malicious users.
    Subject(s): remote rendering ; security ; 3D models ; digital rights management
    ISSN: 0730-0301
    E-ISSN: 1557-7368
    Source: Hellenic Academic Libraries Link
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  • 9
    Language: English
    In: Cancer cell international, 2018, Vol.18 (1), p.89-89
    Description: Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantly underexpressed in liposarcoma tissues. As this miRNA has recently been shown to be a tumor suppressor in many cancers, the objective of this study was to characterize the biological and molecular consequences of miR-133a underexpression in DDLPS. Real-time PCR was used to evaluate expression levels of miR-133a in human DDLPS tissue, normal fat tissue, and human DDLPS cell lines. DDLPS cells were stably transduced with miR-133a vector to assess the effects in vitro on proliferation, cell cycle, cell death, migration, and metabolism. A Seahorse Bioanalyzer system was also used to assess metabolism in vivo by measuring glycolysis and oxidative phosphorylation (OXPHOS) in subcutaneous xenograft tumors from immunocompromised mice. miR-133a expression was significantly decreased in human DDLPS tissue and cell lines. Enforced expression of miR-133a decreased cell proliferation, impacted cell cycle progression kinetics, decreased glycolysis, and increased OXPHOS. There was no significant effect on cell death or migration. Using an in vivo xenograft mouse study, we showed that tumors with increased miR-133a expression had no difference in tumor growth compared to control, but did exhibit an increase in OXPHOS metabolic respiration. Based on our collective findings, we propose that in DDPLS, loss of miR-133a induces a metabolic shift due to a reduction in oxidative metabolism favoring a Warburg effect in DDLPS tumors, but this regulation on metabolism was not sufficient to affect DDPLS.
    Subject(s): Dedifferentiated liposarcoma ; miR-133a ; Sarcoma ; Metabolism
    ISSN: 1475-2867
    E-ISSN: 1475-2867
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 10
    Language: English
    In: Journal of physics. Condensed matter, 2013-10-30, Vol.25 (43), p.435503-435503
    Description: (Screened) hybrid functionals are being used more and more for solid-state calculations. Usually the fraction α of Hartree-Fock exchange is kept fixed during the calculation; however, there is no single (universal) value for α which systematically leads to satisfying accuracy. Instead, one could use a property of the system under consideration to determine α, and in this way the functional would be more flexible and potentially more accurate. Recently, it was proposed to use the static dielectric constant for the calculation of α (Shimazaki and Asai 2008 Chem. Phys. Lett. 466 91 and Marques et al 2011 Phys. Rev. B 83 035119). We explore this idea further and propose a scheme where the connection between and α is optimized based on experimental band gaps. , and thus α, is recalculated at each iteration of the self-consistent procedure. We present results for the bandgap and lattice constant of various semiconductors and insulators with this procedure. In addition, we show that this approach can also be combined with a non-self-consistent hybrid approximation to speed up the calculations considerably, while retaining an excellent accuracy in most cases.
    Subject(s): Electron states ; Condensed matter: electronic structure, electrical, magnetic, and optical properties ; Methods of electronic structure calculations ; Physics ; Exact sciences and technology
    ISSN: 0953-8984
    E-ISSN: 1361-648X
    Source: IOPscience extra
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