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  • 1
    Language: English
    In: Folia microbiologica, 2021-04-07, Vol.66 (4), p.579-586
    Description: From 7 to 8 days after the onset of symptoms in COVID-19 infection, the sensitivity of serological tests was found to be higher than that of nucleic acid tests. The aims of this study were to investigate antibody levels in patients with SARS-CoV-2 infection, to examine the relationship between antibody levels and virus load, and to evaluate the performance of 2 different commercial kits. A total of 103 patients with confirmed SARS-CoV-2 infection were included in the study. Antibodies against SARS-CoV-2 in serum samples taken from patients were investigated simultaneously with anti-SARS-CoV-2 IgG and IgA ELISAs (Euroimmun) and COVID-19 (SARS-CoV-2) IgG/IgM (Deep Blue) kits. No positivity was detected with any of the test kits in 18 (17.4%) of the 103 samples. In symptomatic patients, 100% of IgM and IgA tests were found to be positive in the group sampled after 10 days, while 100% of IgG tests were found positive after 20 days. The sensitivity of the Deep Blue COVID-19 IgG antibody kit was calculated as 81.48% and the specificity was 97.96%. While there was no statistically significant difference between the PCR CT and ELISA OD values, a positive correlation was found between the ELISA OD values and the days since the date of symptom initiation. The sensitivity and specificity of the rapid antibody test used in this study were found to be quite high. In conditions where ELISA tests cannot be applied, it is thought that it can give an idea in terms of the presence of antibodies as a simple and fast test. Although ELISA tests are valuable in the diagnosis of COVID-19 during the acute period, they are tests that can be used safely in the diagnosis of previous infections and seroepidemiological studies.
    Subject(s): Analysis ; Antibodies ; Applied Microbiology ; Biological products ; Biomedical and Life Sciences ; Coronaviruses ; COVID-19 ; Diagnosis ; Environmental Engineering/Biotechnology ; Enzyme-linked immunosorbent assay ; Epidemiology ; general ; Health aspects ; IgG antibody ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Immunology ; Infections ; Life Sciences ; Medical research ; Medicine, Experimental ; Microbiology ; Nucleic acids ; Original ; Original Article ; Performance evaluation ; Sensitivity ; Seroepidemiology ; Serological tests ; Serology ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Statistical analysis ; Statistical methods ; Viral antibodies ; Viral diseases ; Viruses
    ISSN: 0015-5632
    E-ISSN: 1874-9356
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: The Canadian journal of infectious diseases & medical microbiology, 2016-08-30, Vol.2016, p.1321487-1321487
    Description: Background. Pseudomonas aeruginosa (P. aeruginosa) is resistant to various antibiotics and can cause serious nosocomial infections with high morbidity and mortality. In this clinical study, we investigated the risk factors in patients who were diagnosed with P. aeruginosa-related nosocomial infection. Methods. A retrospective case control study including patients with P. aeruginosa-related nosocomial infection. Patients who were resistant to any of the six antibiotics (imipenem, meropenem, piperacillin-tazobactam, ciprofloxacin, amikacin, and ceftazidime) constituted the study group. Results. One hundred and twenty isolates were isolated. Various risk factors were detected for each antibiotic in the univariate analysis. In the multivariate analysis, previous cefazolin use was found as an independent risk factor for the development of imipenem resistance (OR = 3.33; CI 95% [1.11–10.0]; p = 0.03), whereas previous cerebrovascular attack (OR = 3.57; CI 95% [1.31–9.76]; p = 0.01) and previous meropenem use (OR = 4.13; CI 95% [1.21–14.07]; p = 0.02) were independent factors for the development of meropenem resistance. For the development of resistance to ciprofloxacin, hospitalization in the neurology intensive care unit (OR = 4.24; CI 95% [1.5–11.98]; p = 0.006) and mechanical ventilator application (OR = 11.7; CI 95% [2.24–61.45]; p = 0.004) were independent risk factors. Conclusion. The meticulous application of contact measures can decrease the rate of nosocomial infections.
    Subject(s): Amikacin ; Analysis ; Antibiotic resistance ; Antibiotics ; Cefazolin ; Ceftazidime ; Ciprofloxacin ; Control methods ; Disease control ; Drug resistance in microorganisms ; Health risk assessment ; Hospitals ; Imipenem ; Infections ; Intensive care ; Meropenem ; Morbidity ; Mortality ; Multivariate analysis ; Neurology ; Nosocomial infection ; Nosocomial infections ; Pathogens ; Piperacillin ; Piperacillin-tazobactam ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa infections ; Research ; Resistance factors ; Risk analysis ; Risk factors ; Tazobactam
    ISSN: 1712-9532
    E-ISSN: 1918-1493
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 3
    Language: English
    In: Metabolic brain disease, 2018-04-07, Vol.33 (4), p.1375-1379
    Description: Hypotonia-cystinuria syndrome is a very rare autosomal recessive contiguous gene deletion syndrome of PREPL and SLC3A1 at 2p21 with neuromuscular and neuroendocrinologic presentation. We report a two-year-six-month-old affected female infant and her five-month-old affected brother with a novel homozygous deletion in SLC3A1 and PREPL gene. Both of siblings had mild facial dysmorphism, hypotonia, feeding problems, failure to thrive, developmental delay. She also had dilated cardiomyopathy which differ from other reported patients. Therefore cardiomyopathy may also be considered one of the features of hypotonia-cystinuria syndrome. With this case report, we present cardiac manifestation of hypotonia-cystinuria syndrome for the first time. Because of two siblings had hyperechogenic bowel in prenatal sonography, it might be a prenatal marker for HCS.
    Subject(s): Aminoaciduria, Renal ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cardiology ; Cardiomyopathy ; Cystinuria ; Dilated cardiomyopathy ; Gene deletion ; general ; Heart ; Heart diseases ; Hypotonia ; Intestine ; Metabolic Diseases ; Neurology ; Neurosciences ; Oncology ; Physiological aspects ; Pregnant women ; Short Communication ; Siblings ; Somatotropin
    ISSN: 0885-7490
    E-ISSN: 1573-7365
    Source: Alma/SFX Local Collection
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  • 4
    Language: English
    In: Metabolic brain disease, 2018-07-31, Vol.33 (6), p.1779-1780
    Description: Byline: Mustafa KA[+ or -]lA[+ or -]c (1), Esra KA[+ or -]lA[+ or -]c (2), Didem Yucel YA[+ or -]lmaz (3), RA[+ or -]za Koksal Ozgul (3) Author Affiliation: (1) Metabolism Unit, Sami Ulus Children Hospital, Babur cad. No: 44, 06080 AltA[+ or -]ndag, Ankara, Turkey (2) Pediatric Genetic Unit, Pediatric Hematology-Oncology Training and Research Hospital, Ankara, Turkey (3) 0000 0001 2342 7339, grid.14442.37, Institute of Child Health, Metabolism Unit, Hacettepe University, Ankara, Turkey Article History: Registration Date: 26/07/2018 Received Date: 26/06/2018 Accepted Date: 26/07/2018 Online Date: 31/07/2018
    Subject(s): Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Children ; Commentary ; general ; Health aspects ; Metabolic Diseases ; Neurology ; Neurosciences ; Oncology ; Phenotypes
    ISSN: 0885-7490
    E-ISSN: 1573-7365
    Source: Alma/SFX Local Collection
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  • 5
    Language: English
    In: American journal of medical genetics. Part A, 2017-12, Vol.173 (12), p.3136-3142
    Description: Frontonasal dysplasias are rare congenital malformations of frontonasal process‐derived structures, characterized by median cleft, nasal anomalies, widely spaced eyes, and cranium bifidum occultum. Several entities of syndromic frontonasal dysplasia have been described, among which, to date, only a few have identified molecular bases. We clinically ascertained a cohort of 124 individuals referred for frontonasal dysplasia. We identified six individuals with a similar phenotype, including one discordant monozygous twin. Facial features were remarkable by nasal deformity with creased ridge and depressed or absent tip, widely spaced eyes, almond‐shaped palpebral fissures, and downturned corners of the mouth. All had apparently normal psychomotor development. In addition, upper limb anomalies, frontonasal encephalocele, corpus callosum agenesis, choanal atresia, and congenital heart defect were observed. We identified five reports in the literature of patients presenting with the same phenotype. Exome sequencing was performed on DNA extracted from blood of two individuals, no candidate gene was identified. In conclusion, we report six novel simplex individuals presenting with a specific frontonasal dysplasia entity associating recognizable facial features, limb and visceral malformations, and apparently normal development. The identification of discordant monozygotic twins supports the hypothesis of a mosaic disorder. Although previous patients have been reported, this is the first series, allowing delineation of a clinical subtype of frontonasal dysplasia, paving the way toward the identification of its molecular etiology.
    Subject(s): Abnormalities, Multiple - genetics ; Agenesis of Corpus Callosum - diagnosis ; Agenesis of Corpus Callosum - genetics ; Birth defects ; Choanal atresia ; Choanal Atresia - diagnosis ; Choanal Atresia - genetics ; Cohort Studies ; Congenital defects ; Corpus callosum ; Craniofacial Abnormalities - classification ; Craniofacial Abnormalities - diagnosis ; Craniofacial Abnormalities - genetics ; Deoxyribonucleic acid ; DNA ; DNA sequencing ; Dysplasia ; Encephalocele ; Encephalocele - diagnosis ; Encephalocele - genetics ; Encephalocele - pathology ; Etiology ; Face - abnormalities ; Facial Bones - abnormalities ; Female ; frontonasal dysplasia ; Genetics ; Heart Defects, Congenital - diagnosis ; Heart Defects, Congenital - genetics ; Human genetics ; Humans ; Infant ; Life Sciences ; Male ; nasal malformation ; nasofrontal encephalocele ; Nose - abnormalities ; Phenotype ; Twins ; Whole Exome Sequencing
    ISSN: 1552-4825
    E-ISSN: 1552-4833
    Source: Hellenic Academic Libraries Link
    Source: Wiley Online Library All Journals
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  • 6
    Language: English
    In: Turkish journal of agriculture and forestry, 2018-04-26, Vol.42 (2)
    ISSN: 1300-011X
    E-ISSN: 1303-6173
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: Journal of infection in developing countries, 2019-10-01, Vol.13 (10), p.886-891
    Description: Introduction: Linezolid is a synthetic antimicrobial agent with a broad spectrum of activity against virtually all Gram-positive bacteria. Although linezolid is generally well tolerated, the prolonged use of linezolid can lead to myelosuppression, including neutropenia, thrombocytopenia, and anemia. The aim of this study was investigating the risk factors for thrombocytopenia in patients who received linezolid therapy. Methodology: This retrospective study was performed on patients who received linezolid therapy between July 2007 and December 2017. Thrombocytopenia was defined as either a platelets count of 〈 100x10(9)/L or a 25% reduction from the baseline platelet count. Results: A total of 371 patients, (198 (53%) male and 173(47%) female were included into the study. Mean duration of therapy was 12.81 +/- 5.19 days. Linezolid-induced thrombocytopenia was detected in a total of 111 patients. Using the univariate analysis advanced sex, serum urea concentration, baseline platelet level and low eGFR value were found to be risk factors for linezolid associated thrombocytopenia (p 〈 0.05). According to a multivariate analysis, patients undergoing carbapenem treatment combination therapy (p = 0.003) and with a baseline platelet level of 〈 200x10(9)/L (p = 0.00) were found to have a high risk of developing thrombocytopenia. Conclusions: Several factors may influence of linezolid associated thrombocytopenia. Platelet count should be monitored during therapy and thrombocytopenia should be kept in mind in patients with baseline platelet level of 〈 200x10(9)/L, low eGFR, linezolid-carbapenem combination therapy.
    Subject(s): Gram-positive bacteria ; Infectious Diseases ; Life Sciences & Biomedicine ; Risk factors ; Science & Technology ; Thrombocytopenia
    ISSN: 1972-2680
    ISSN: 2036-6590
    E-ISSN: 1972-2680
    Source: Academic Search Ultimate
    Source: Web of Science - Science Citation Index Expanded - 2019〈img src="http://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /〉
    Source: ProQuest Central
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  • 8
    Language: English
    In: Journal of bone and mineral metabolism, 2011-02-25, Vol.29 (5), p.621-625
    Description: Hyperphosphatemic familial tumoral calcinosis (HFTC) is known to be caused by mutations in at least three genes: FGF23 , GALNT3 and KL . Two families with two affected members suffering from HFTC were scrutinized for mutations in these candidate genes. We identified in both families homozygous missense mutations affecting highly conserved amino acids in GALNT3 . One of the mutations is a novel mutation, whereas the second mutation was reported before in a compound heterozygous state. Our data expand the spectrum of known mutations in GALNT3 and contribute to a better understanding of the phenotypic manifestations of mutations in this gene.
    Subject(s): Adult ; Anopheles ; Biological and medical sciences ; Calcinosis - genetics ; Dermatology ; Diseases of the osteoarticular system ; Female ; Genetic aspects ; Genetic research ; Humans ; Hypophosphatemia - genetics ; Male ; Medical colleges ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Mutation ; N-Acetylgalactosaminyltransferases - genetics ; Orthopedics ; Short Communication ; Tumors of the skin and soft tissue. Premalignant lesions ; Young Adult
    ISSN: 0914-8779
    E-ISSN: 1435-5604
    Source: Alma/SFX Local Collection
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  • 9
    Language: English
    In: Clinical neurology and neurosurgery, 2005, Vol.107 (4), p.306-309
    Description: To assess and compare the disease severity, the treatment properties and the frequency of motor complications in the patients with Parkinson's disease (PD) having and not having REM sleep behavior disorder (RBD). Based on chart review, patients with Parkinson's disease whose bed partners have reported prominent motor activity while dreaming were identified. Standard questionnaires assessing the presence of RBD have been addressed to these patients and their informants. Obtained data fulfilled clinical diagnostic criteria of probable RBD in 35 patients (RBD group) with the mean age at symptom onset was 61.8 years. Of them 77% were men. Clinical features of these patients concerning Hoehn-Yahr stage of PD, the severity of PD according to the Unified Parkinson's disease rating scale (UPDRS), the mean dose and duration of levodopa (LD) therapy, the presence of motor complications were compared with those of gender and age at PD-onset matched 35 PD patients without RBD (NRBD group). The mean values of PD duration, Hoehn-Yahr stage and UPDRS scores did not differ between groups. The duration of LD therapy was significantly longer in RBD group in comparison to NRBD group (6.2 years versus 3.05 years, respectively, P 〈 0.005) and also mean actual dose of LD was higher (460.3 mg/day versus 320.3 mg/day respectively, P 〈 0.02). The dose and duration of dopamine agonists did not differ between groups. In RBD group, wearing-off phenomenon was significantly common ( P 〈 0.01), its duration was longer ( P 〈 0.005), and LD-related dyskinesias were more frequent ( P 〈 0.01). In the current study, when compared with NRBD group, the patients with RBD required higher doses of LD treatment at an earlier stage of PD which eventually led to motor complications. In these patients, dopaminergic treatment restored UPDRS scores, but did not prevent the occurrence of RBD.
    Subject(s): Age Factors ; Aged ; Antiparkinson Agents - administration & dosage ; Biological and medical sciences ; Case-Control Studies ; Clonazepam - therapeutic use ; Dyskinesias - etiology ; Female ; GABA Modulators - therapeutic use ; Humans ; Levodopa ; Levodopa - administration & dosage ; Male ; Medical sciences ; Mental illness ; Middle Aged ; Motor complications ; Neurosurgery ; Parkinson Disease - complications ; Parkinson Disease - drug therapy ; Parkinson Disease - psychology ; Parkinson's disease ; REM behavior disorder ; REM Sleep Behavior Disorder - drug therapy ; REM Sleep Behavior Disorder - etiology ; Severity of Illness Index ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
    ISSN: 0303-8467
    E-ISSN: 1872-6968
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 10
    Language: English
    In: Journal of infection in developing countries, 2018-07-31, Vol.12 (7), p.508-513
    Description: Infections related to the use of invasive instruments leads to the risk of treatment difficulties, prolonged hospitalization, increased health care costs, and increased mortality and morbidity rates. The present study examines the results of an infection surveillance study that showed an increased incidence of infections related to the use of invasive instruments in the cardiovascular surgery intensive care unit of the Ankara Training and Research Hospital and mitigating measures were taken following the surveillance program. Compared with previous surveillance data, an increase was observed in the incidence of infections related to the use of invasive instruments in cardiovascular surgery intensive care unit (CVS-ICU) during the first six months of 2014. A research team was formed comprising one infectious diseases and microbiology specialist, one cardiovascular surgeon, and two infection-control nurses. Patient data was collected. The compliance of the surgeons, nurses, and other health care professionals to the infection control measures was evaluated. The rate of ventilator-associated pneumonia was 8.20% and the rate of catheter-associated urinary tract infection was 4.47% in the CVS-ICU. There were missing or inadvertent practices regarding antibiotic prophylaxis, asepsis and antisepsis and isolation measures in patient preparation and patient care before and after the operations. The rate of inappropriate antibiotic as prolonged use was 72%. It is one of the basic tasks to take appropriate measures to prevent outbreaks of hospital infections. It is possible to prevent an outbreak of hospital infections only by the accurate analysis of data and establishing strict infection control procedures.
    ISSN: 1972-2680
    E-ISSN: 1972-2680
    Source: Academic Search Ultimate
    Source: ProQuest Central
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