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  • 1
    Language: German
    In: Bibliotheksdienst, 2019-12-01, Vol.53 (12), p.757-767
    Description: Wie kann der digitale Wandel in wissenschaftlichen Bibliotheken personell, organisatorisch und serviceorientiert gestaltet werden? Welche Auswirkungen hat die Digitalisierung für das professionelle Selbstverständnis? Drei Mitarbeiter*innen des Wissenschaftszentrums Berlin für Sozialforschung (WZB) haben renommierte Einrichtungen des US-amerikanischen Wissenschaftssystems in New York City und Boston besucht und Trends, Probleme und Erfahrungen erkundet.
    Subject(s): Digitization ; Librarians ; Academic libraries
    ISSN: 0006-1972
    E-ISSN: 2194-9646
    Source: De Gruyter Online
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: Bibliotheksdienst, 2019-11-01, Vol.53 (12), p.757-767
    Description: Wie kann der digitale Wandel in wissenschaftlichen Bibliotheken personell, organisatorisch und serviceorientiert gestaltet werden? Welche Auswirkungen hat die Digitalisierung für das professionelle Selbstverständnis? Drei Mitarbeiter*innen des Wissenschaftszentrums Berlin für Sozialforschung (WZB) haben renommierte Einrichtungen des US-amerikanischen Wissenschaftssystems in New York City und Boston besucht und Trends, Probleme und Erfahrungen erkundet.
    Subject(s): Wissenschaftliche Bibliothek ; USA ; processes ; Prozesse ; Scientific library ; Digitalisierung ; Trends ; digitisation
    ISSN: 0006-1972
    E-ISSN: 2194-9646
    Source: De Gruyter Online
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  • 3
    Language: English
    In: Clinical oral investigations, 2019-11, Vol.23 (11), p.4145-4156
    Description: Sialolithiasis is the most common cause of chronic sialadenitis of the submandibular gland (SMG). Symptomatic superficial lobe stones are often treated by submandibulectomy. A gland preserving operation allows for transoral stone removal through endoscopically assisted sialolithotomy. Herein, we provide clinical and sonographical follow-up data in patients who underwent sialolithotomy under general anesthesia.Sixty patients treated at the Department of Oral and Maxillofacial Surgery at Düsseldorf University Hospital for superficial lobe sialolithiasis of SMG were included in this study. All received transoral sialolithotomy under general anesthesia. Follow-up was conducted via standardized patient questionnaires, clinical examination, and B-mode and color Doppler sonography.Mean patient age was 48.9 years. 56.6% of right and 43.4% of left SMG were affected. Mean follow-up was 45 months. Fifty-five of 59 detected stones could be removed. Mean operation time was 71 min. 3.3% of patients reported recurrent episodes of postoperative pain and 10% felt recurrent episodes of gland swelling. Persistent postoperative lingual nerve hypesthesia was described in one patient. No facial nerve damages occurred. Salivary flow rates remained reduced in most of the affected glands upon stone removal. Sonographical follow-up data of the previously affected SMG after intraoral endoscopy-assisted sialolithotomy showed a regular gland size in 70.8% of cases, a parenchyma free of inflammation in 93.8%, and without signs of fibrosis in 72.9% of cases. 68.7% of patients showed a regular structure of Wharton’s duct at time of follow-up. In total, 89.6% of patients were diagnosed stone-free within both glands on follow-up. No case required subsequent submandibulectomy.Sialolithotomy of Wharton’s duct for removal of stones from the SMG’s superficial lobe is a promising alternative to submandibulectomy.Reduction of postoperative morbidity through endoscopically assisted sialolithotomy for removal of superficial lobe stones from SMG.Ethics Committee of Heinrich-Heine-University Düsseldorf (no. 5586)
    Subject(s): Sonography ; Submandibular gland ; Superficial lobe ; Endoscopy-assisted sialolithotomy ; Dentistry ; Sialolithiasis ; Salivary Gland Calculi - diagnostic imaging ; Salivary Ducts ; Submandibular Gland - diagnostic imaging ; Humans ; Ultrasonography ; Endoscopy ; Salivary Gland Calculi - surgery ; Lingual nerve ; Surgery ; Maxillofacial ; Fibrosis ; Parenchyma ; Anesthesia ; Facial nerve ; Patients ; Stone ; Morbidity
    ISSN: 1432-6981
    E-ISSN: 1436-3771
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Head & face medicine, 2021-03-01, Vol.17 (1), p.8-8
    Description: Gland preserving techniques in the treatment of sialolithiasis have continuously replaced radical surgery. The aim of this study was to evaluate a multimodal treatment algorithm in the therapy of sialolithiasis and assess improvement of HRQoL perceived by patients. Patients with sialolithiasis were treated by a multimodal treatment algorithm based on multiplicity of stones, stone size, affected gland, and stone position. The therapeutic spectrum ranged from conservative measures, extracorporeal shockwave lithotripsy, interventional sialendoscopy, combined endoscopic-surgical procedures to surgical gland removal as ultima ratio. Outcomes were evaluated by surgeons by means of the electronic patient record and by patients themselves using a standardized questionnaire. 87 patients treated for sialolithiasis were comprised in this study. The submandibular gland (SMG) was affected in 58.6% and the parotid gland (PG) in 41.4% of cases. Mean patient age was 41.67 years for SMG and 48.91 years for PG. In over 80% of cases sialolithiasis was associated with classic meal-related pain and swelling. Type and intensity of symptomatic sialolithiasis were not dependent on patient age or gender, nor could a relation between the affected gland and the occurrence of symptoms be demonstrated. Overall, 86.2% of cases were reported as cured using the multimodal step-by-step treatment algorithm. Resection of the affected gland could be dispensed in 98.9% of cases. According to patients pain could be reduced in 94.3% of cases. The analyzed treatment algorithm of increasing invasiveness is a favorable and effective tool to successfully treat sialolithiasis in 〉 86% of cases. For the first time, the present study shows that patient-perceived improvement of HRQoL due to ease of symptoms has an even higher success rate of 〉 94%.
    Subject(s): Algorithms ; Humans ; Lithotripsy ; Quality of Life ; Adult ; Treatment Outcome ; Retrospective Studies ; Endoscopy ; Salivary Gland Calculi - surgery ; Medical research ; Care and treatment ; Pain ; Analysis ; Medical records ; Medicine, Experimental ; Health aspects ; Intervention ; Ultrasonic imaging ; Patients ; Stone ; Success ; Age ; Index Medicus ; Dentistry ; Submandibular gland ; Minimal-invasive ; Research ; Parotid gland ; Sialolithiasis ; Algorithm
    ISSN: 1746-160X
    E-ISSN: 1746-160X
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: Kidney international, 2019-04, Vol.95 (4), p.983-991
    Description: Mineralocorticoid receptor antagonists have beneficial effects on left ventricular remodeling, cardiac fibrosis, and arrhythmia in heart failure, but efficacy and safety in dialysis patients is less clear. We evaluated the effect of spironolactone on left ventricular mass (LVM), an independent predictor of all-cause and cardiovascular mortality, in hemodialysis patients. In this placebo-controlled, parallel-group trial, 97 hemodialysis patients (23% female; mean age 60.3 years) were randomized to spironolactone 50 mg once daily (n=50) or placebo (n=47). The primary efficacy endpoint was change in LVM index (LVMi) from baseline to 40 weeks as determined by cardiac magnetic resonance imaging. Safety endpoints were development of hyperkalemia and change in residual renal function. There was no significant change in LVMi in participants randomized to spironolactone compared to placebo (-2.86±11.87 vs. 0.41±10.84 g/m2). There was also no difference in the secondary outcomes of mean 24-hour systolic or diastolic ambulatory blood pressure, left ventricular ejection fraction, 6-minute walk test distance, or New York Heart Association functional class. Moderate hyperkalemia (pre-dialysis potassium levels of 6.0-6.5 mmol/L) was more frequent with spironolactone treatment (155 vs. 80 events), but severe hyperkalemia (≥6.5 mmol/L) was not (14 vs. 24 events). Changes in residual urine volume and measured glomerular filtration rate did not differ between groups. There were no deaths in the spironolactone group and 4 deaths in the placebo group. Thus, treatment with 50 mg spironolactone did not change left ventricular mass index, cardiac function, or blood pressure in hemodialysis patients. Spironolactone increased the frequency of moderate hyperkalemia, but did not increase severe hyperkalemia. [Display omitted]
    Subject(s): hemodialysis ; blood pressure ; potassium ; left ventricular mass index ; spironolactone ; Spironolactone - administration & dosage ; Humans ; Middle Aged ; Male ; Heart Ventricles - diagnostic imaging ; Heart Failure - prevention & control ; Placebos - adverse effects ; Hyperkalemia - epidemiology ; Female ; Heart Failure - etiology ; Heart Ventricles - pathology ; Placebos - administration & dosage ; Spironolactone - adverse effects ; Mineralocorticoid Receptor Antagonists - administration & dosage ; Double-Blind Method ; Mineralocorticoid Receptor Antagonists - adverse effects ; Stroke Volume - drug effects ; Treatment Outcome ; Kidney Failure, Chronic - therapy ; Magnetic Resonance Imaging ; Kidney Failure, Chronic - complications ; Hyperkalemia - chemically induced ; Aged ; Ventricular Remodeling - drug effects ; Heart Ventricles - drug effects ; Renal Dialysis ; Index Medicus
    ISSN: 0085-2538
    E-ISSN: 1523-1755
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: The international journal of cardiovascular imaging, 2021-02-05
    Description: Heart failure with preserved ejection fraction (HFpEF) is highly prevalent in patients on maintenance haemodialysis (HD) and lacks effective treatment. We investigated the effect of spironolactone on cardiac structure and function with a specific focus on diastolic function parameters. The MiREnDa trial examined the effect of 50 mg spironolactone once daily versus placebo on left ventricular mass index (LVMi) among 97 HD patients during 40 weeks of treatment. In this echocardiographic substudy, diastolic function was assessed using predefined structural and functional parameters including E/e'. Changes in the frequency of HFpEF were analysed using the comprehensive 'HFA-PEFF score'. Complete echocardiographic assessment was available in 65 individuals (59.5 ± 13.0 years, 21.5% female) with preserved left ventricular ejection fraction (LVEF 〉 50%). At baseline, mean E/e' was 15.2 ± 7.8 and 37 (56.9%) patients fulfilled the criteria of HFpEF according to the HFA-PEFF score. There was no significant difference in mean change of E/e' between the spironolactone group and the placebo group (+ 0.93 ± 5.39 vs. + 1.52 ± 5.94, p = 0.68) or in mean change of left atrial volume index (LAVi) (1.9 ± 12.3 ml/m vs. 1.7 ± 14.1 ml/m , p = 0.89). Furthermore, spironolactone had no significant effect on mean change in LVMi (+ 0.8 ± 14.2 g/m vs. + 2.7 ± 15.9 g/m ; p = 0.72) or NT-proBNP (p = 0.96). Treatment with spironolactone did not alter HFA-PEFF score class compared with placebo (p = 0.63). Treatment with 50 mg of spironolactone for 40 weeks had no significant effect on diastolic function parameters in HD patients.The trial has been registered at clinicaltrials.gov (NCT01691053; first posted Sep. 24, 2012).
    Subject(s): Index Medicus
    ISSN: 1569-5794
    E-ISSN: 1875-8312
    E-ISSN: 1573-0743
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Lecture notes in computer science, 2016, Vol.9921 LNCS, p.1012-1022
    Description: PPSN 2016 hosts a total number of 16 tutorials covering a broad range of current research in evolutionary computation. The tutorials range from introductory to advanced and specialized but can all be attended without prior requirements. All PPSN attendees are cordially invited to take this opportunity to learn about ongoing research activities in our field.
    Subject(s): Computer Science(all) ; Theoretical Computer Science ; Evolutionary Algorithm ; Evolutionary Robotic ; Smart City ; Cartesian Genetic Programming ; Genetic Program ; Life Sciences
    ISBN: 3319458221
    ISBN: 9783319458229
    ISBN: 331945823X
    ISBN: 9783319458236
    ISSN: 1611-3349
    ISSN: 0302-9743
    E-ISSN: 1611-3349
    Source: SpringerLINK Lecture Notes in Computer Science (2015)
    Source: Alma/SFX Local Collection
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