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  • 1
  • 2
    Language: German
    Description: Provider: Deutsche Digitale Bibliothek - Institution: Bayerische Staatsbibliothek - Data provided by Europeana Collections- Augsburg, Staats- und Stadtbibliothek -- Th Pr 4984- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
    Source: Europeana Collections
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  • 3
    Language: English
    In: American journal of transplantation, 2017-10, Vol.17 (10), p.2591-2600
    Description: BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1–15% of patients. Because antivirals are lacking, most programs screen for BKPyV‐viremia and, if positive, reduce immunosuppression. To evaluate the relationship of viremia and BKPyV‐specific immunity, we examined prospectively cryopreserved plasma and peripheral blood mononuclear cells at the time of transplantation (T0) and at 6 mo (T6) and 12 mo (T12) after transplant from 28 viremic KT patients and 68 nonviremic controls matched for the transplantation period. BKPyV IgG seroprevalence was comparable between cases (89.3%) and controls (91.2%; p = 0.8635), but cases had lower antibody levels (p = 0.022) at T0. Antibody levels increased at T6 and T12 but were not correlated with viremia clearance. BKPyV‐specific T cell responses to pools of overlapping 15mers (15mer peptide pool [15mP]) or immunodominant CD8 9mers (9mer peptide pool [9mP]) from the early viral gene region were not different between cases and controls at T0; however, clearance of viremia was associated with stronger 9mP responses at T6 (p = 0.042) and T12 (p = 0.048), whereas 15mP responses were not informative (T6 p = 0.359; T12 p = 0.856). BKPyV‐specific T cells could be expanded in vitro from all patients after transplant, permitting identification of 78 immunodominant 9mer epitopes including 50 new ones across different HLA class I. Thus, 9mP‐responses may be a novel marker of reconstituting CD8 T cell function that warrants further study as a complement of plasma BKPyV loads for guiding immunosuppression reduction. Interferon‐γ ELISpot responses of CD8 T cells to immunodominant 9mer epitopes from the BK polyomavirus early viral gene region significantly increased in BK viremic patients but not in nonviremic controls, and are associated with viremia clearance posttransplantation, while standard 15mer T cell responses or antibody levels were uninformative.
    Subject(s): translational research/science ; infectious disease ; antigen presentation/recognition ; kidney transplantation/nephrology ; viral: BK/JC/polyoma ; T cell biology ; infection and infectious agents ; Viremia ; Humans ; Middle Aged ; Male ; Case-Control Studies ; BK Virus - isolation & purification ; Adult ; Female ; Aged ; CD8-Positive T-Lymphocytes - immunology ; BK Virus - physiology ; Cohort Studies ; Kidney Transplantation - adverse effects ; Medical research ; Antiviral agents ; Kidneys ; Peptides ; Immunoglobulin G ; Organ transplant recipients ; Transplantation ; T cells ; Cells ; Analysis ; Immunotherapy ; Medicine, Experimental ; Antigenic determinants ; Index Medicus
    ISSN: 1600-6135
    E-ISSN: 1600-6143
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: American journal of transplantation, 2017-07, Vol.17 (7), p.1813-1822
    Description: We assessed the impact of antiviral preventive strategies on the incidence of herpes simplex virus (HSV) and varicella‐zoster virus (VZV) infections in a nationwide cohort of transplant recipients. Risk factors for the development of HSV or VZV infection were assessed by Cox proportional hazards regression. We included 2781 patients (56% kidney, 20% liver, 10% lung, 7.3% heart, 6.7% others). Overall, 1264 (45%) patients received antiviral prophylaxis (ganciclovir or valganciclovir, n = 1145; acyclovir or valacyclovir, n = 138). Incidence of HSV and VZV infections was 28.9 and 12.1 cases, respectively, per 1000 person‐years. Incidence of HSV and VZV infections at 1 year after transplant was 4.6% (95% confidence interval [CI] 3.5–5.8) in patients receiving antiviral prophylaxis versus 12.3% (95% CI 10.7–14) in patients without prophylaxis; this was observed particularly for HSV infections (3% [95% CI 2.2–4] versus 9.8% [95% CI 8.4–11.4], respectively). A lower rate of HSV and VZV infections was also seen in donor or recipient cytomegalovirus‐positive patients receiving ganciclovir or valganciclovir prophylaxis compared with a preemptive approach. Female sex (hazard ratio [HR] 1.663, p = 0.001), HSV seropositivity (HR 5.198, p 〈 0.001), previous episodes of rejection (HR 1.95, p = 0.004), and use of a preemptive approach (HR 2.841, p = 0.017) were significantly associated with a higher risk of HSV infection. Although HSV and VZV infections were common after transplantation, antiviral prophylaxis significantly reduced symptomatic HSV infections. In this national cohort of solid organ transplant recipients, patients receiving antiviral prophylaxis either with (val)ganciclovir or (val)acyclovir have a lower incidence of herpes simplex virus infections compared to patients managed with a preemptive approach for cytomegalovirus infection or not receiving antiherpes prophylaxis.
    Subject(s): viral: herpes zoster/Varicella ; infection and infectious agents ; viral ; antibiotic: antiviral‐ganciclovir/valganciclovir ; infectious disease ; clinical research/practice ; Prognosis ; Follow-Up Studies ; Cytomegalovirus Infections - epidemiology ; Humans ; Middle Aged ; Male ; Transplant Recipients ; Graft Rejection - virology ; Herpesviridae Infections - prevention & control ; Incidence ; Herpesvirus 3, Human - drug effects ; Graft Rejection - epidemiology ; Cytomegalovirus Infections - virology ; Adult ; Female ; Antiviral Agents - therapeutic use ; Graft Rejection - prevention & control ; Risk Factors ; Graft Survival ; Herpesviridae Infections - virology ; Cytomegalovirus Infections - drug therapy ; Organ Transplantation - adverse effects ; Switzerland - epidemiology ; Cohort Studies ; Cytomegalovirus - drug effects ; Herpesviridae Infections - epidemiology ; Index Medicus
    ISSN: 1600-6135
    E-ISSN: 1600-6143
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: American journal of transplantation, 2018-07, Vol.18 (7), p.1745-1754
    Description: Clostridium difficile infection (CDI) is a leading cause of infectious diarrhea in solid organ transplant recipients (SOT). We aimed to assess incidence, risk factors, and outcome of CDI within the Swiss Transplant Cohort Study (STCS). We performed a case‐control study of SOT recipients in the STCS diagnosed with CDI between May 2008 and August 2013. We matched 2 control subjects per case by age at transplantation, sex, and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors and evaluate outcome of CDI. Two thousand one hundred fifty‐eight SOT recipients, comprising 87 cases of CDI and 174 matched controls were included. The overall CDI rate per 10 000 patient days was 0.47 (95% confidence interval ([CI] 0.38‐0.58), with the highest rate in lung (1.48, 95% CI 0.93‐2.24). In multivariable analysis, proven infections (hazard ratio [HR] 2.82, 95% CI 1.29‐6.19) and antibiotic treatments (HR 4.51, 95% CI 2.03‐10.0) during the preceding 3 months were independently associated with the development of CDI. Despite mild clinical presentations, recipients acquiring CDI posttransplantation had an increased risk of graft loss (HR 2.24, 95% CI 1.15‐4.37; P = .02). These findings may help to improve the management of SOT recipients. The authors demonstrate that despite mild clinical presentations and good clinical responses, Clostridium difficile infections are associated with an increased risk of graft loss in the Swiss Transplant Cohort Study.
    Subject(s): infection and infectious agents – bacterial: Clostridium difficile ; infectious disease ; clinical research/practice ; complication: infectious ; antibiotic: antibacterial ; Medical research ; Communicable diseases ; Analysis ; Medicine, Experimental ; Transplantation of organs, tissues, etc ; Organ transplant recipients ; Health aspects ; Antibacterial agents ; Risk factors ; Index Medicus
    ISSN: 1600-6135
    E-ISSN: 1600-6143
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: Transplant infectious disease, 2020-08, Vol.22 (4), p.e13289-n/a
    Description: Background Infections are an important complication after allogeneic hematopoietic cell transplantation (allo‐HCT). The present study aimed at determining the landscape of infections occurring in a large cohort of allo‐HCT patients, as well as associated risk factors for infections and for one‐year non‐relapse mortality. Methods This is a retrospective cohort study using STCS and EBMT databases to assess the one‐year incidence rate of infection, as well as risk factors for infections and for one‐year non‐relapse mortality among adult allo‐HCT patients transplanted between 2010 and 2014 in Switzerland. Univariable and multivariable quasi‐Poisson and multivariable Cox regression models were used. Results Of 553 patients included, 486 had an infection with a global incidence rate of 3.66 infections per patient‐year. Among a total of 1534 infections analyzed, viral infections were predominant (n = 1138, 74.2%), followed by bacterial (n = 343, 22.4%) and fungal (n = 53, 3.5%) infections. At one year, the cumulative incidence of relapse and non‐relapse mortality was 26% and 16%, respectively. 195 (35.3%) of patients had at least one episode of severe graft‐versus‐host‐disease (GvHD). A center effect was observed, and underlying disease, donor type, cytomegalovirus serological constellation, and GvHD were also associated with the incidence rate of infections. There was an increased risk for one‐year non‐relapse mortality associated with all pathogens, specifically within two months of infection, and this remained true beyond 2 months of a fungal infection. Conclusion Despite advances to limit infections in this population, they still occur in most allo‐HCT patients with a major impact on survival at 1 year.
    Subject(s): allogeneic cell transplantation ; mortality ; infection ; Index Medicus
    ISSN: 1398-2273
    E-ISSN: 1399-3062
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Transplant infectious disease, 2018-12, Vol.20 (6), p.e12981-n/a
    Description: Contemporary, comprehensive data on epidemiology and outcomes of invasive fungal disease (IFD) including breakthrough IFD among allogeneic hematopoietic stem cell transplantation (HSCT) recipients are scarce. We included 479 allogeneic HSCT recipients with 10 invasive candidiasis (IC) and 31 probable/proven invasive mold disease (IMD) from the Swiss Transplant Cohort Study from 01.2009 to 08.2013. Overall cumulative incidence was 2.3% for IC and 8.5% for probable/proven IMI: 6% for invasive aspergillosis (IA) and 2.5% for non‐AspergillusIMI. Among 41 IFD, 46% IFD were breakthrough, with an overall incidence of 4.6%, more frequently caused by other‐than‐Aspergillus fumigatus molds than primary IFD (47.6% (10/21) vs 13% (3/23), P = 0.04). Twelve‐week mortality among patients with IC was 20% and 58.6% for probable/proven IMD (60% IA and 54.6% non‐Aspergillus). Our results reveal that breakthrough IFD represent a marked burden of probable/proven IFD postallogeneic HSCT and mortality remains above 50% in patients with probable/proven IMD, underscoring the ongoing challenges to prevent and treat IFD in these patients.
    Subject(s): hematopoietic stem cell transplantation ; breakthrough infections ; invasive fungal diseases ; invasive mold disease ; Antifungal Agents - adverse effects ; Prospective Studies ; Candidiasis, Invasive - epidemiology ; Humans ; Middle Aged ; Antibiotic Prophylaxis - methods ; Male ; Antibiotic Prophylaxis - adverse effects ; Candida - isolation & purification ; Switzerland ; Incidence ; Candida - physiology ; Hematopoietic Stem Cell Transplantation - adverse effects ; Adult ; Female ; Candida - drug effects ; Candidiasis, Invasive - prevention & control ; Candidiasis, Invasive - microbiology ; Drug Resistance, Fungal ; Transplantation, Homologous - adverse effects ; Medical research ; Molds (Fungi) ; Analysis ; Mortality ; Stem cells ; Mycoses ; Medicine, Experimental ; Transplantation ; Epidemiology ; Hematopoietic stem cells ; Index Medicus
    ISSN: 1398-2273
    E-ISSN: 1399-3062
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 8
    Language: English
    In: Swiss medical weekly, 2019-05-06, Vol.149, p.w20078-w20078
    Description: In solid organ transplant recipients (sOTRs), 5 years after transplantation cancer is a relevant cause of death. We aimed to report cancer incidence in the Swiss Transplant Cohort Study (STCS) between 2008 and 2014 and conducted a prospective cohort study of kidney, heart, lung, pancreas and liver transplant recipients enrolled into the STCS by retrospective analysis of collected data. The STCS provided data on 2758 solid organ transplants. In total, 134 cases of cancer were observed (30 liver, 21 prostate, 18 lung, 13 kidney, 52 other cancers). Standardised incidence ratios (SIRs) were highest for liver cancer, kidney cancer, thyroid cancer, gastric cancer, bladder cancer, cancer of the oral cavity and the pharynx and for lung cancer. Cancer occurrence differed according to the transplanted organ. Cancers were mainly diagnosed at World Health Organisation (WHO) stages I and IV. Treatment received was mainly surgery and, in some cases, included also radiation and/or chemotherapy. Bladder, kidney, liver, lung and prostate cancer were detected at a younger age compared with the general population. Cumulative hazards for death were increased for transplant recipients with cancer. Solid organ transplant recipients show an organ specific increase of cancer compared with the general Swiss population. Clinical trial registration number: NCT02333279.
    Subject(s): Postoperative Complications - etiology ; Neoplasms - etiology ; Prospective Studies ; Humans ; Middle Aged ; Neoplasms - mortality ; Male ; Postoperative Complications - therapy ; Postoperative Complications - mortality ; Incidence ; Neoplasms - therapy ; Organ Transplantation - adverse effects ; Switzerland - epidemiology ; Adult ; Female ; Retrospective Studies ; Index Medicus
    ISSN: 1424-3997
    E-ISSN: 1424-3997
    Source: Directory of Open Access Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: German
    Description: Provider: Deutsche Digitale Bibliothek - Institution: Bayerische Staatsbibliothek - Data provided by Europeana Collections- München, Bayerische Staatsbibliothek -- 2 J.publ.g. 164- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
    Subject(s): Vertrag
    Source: Europeana Collections
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