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1

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Deutsche Flora: Erster Theil, Welcher das in den neun ersten Heften des Botanikers in der kompendiösen Bibliothek angefangene klassificirte Verzeichniß der in Deutschland gefundenen wildwachsenden Gewächse enthält Aus neuern botanischen Schriften zusammengetragen und herausgegeben

Heim, Georg Christoph

1799

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Language: German

Source: Münchener DigitalisierungsZentrum (MDZ)

URL: View record in Münchener DigitalisierungsZentrum (MDZ)$$FView record in $$GMünchener DigitalisierungsZentrum (MDZ)

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Deutsche Flora. Zweyter Theil, oder Fortsetzung des in den neun ersten Heften des Botanikers in der kompendiösen Bibliothek angefangenen klassificirten Verzeichnisses der in Deutschland gefundenen wildwachsenden Gewächse / Aus neuern botanischen Schriften zusammengetragen und herausgegeben von Georg Christoph Heim Pfarrer in Gumpelstadt bey Salzungen in dem Herzogl. Sachsen Meiningschen Amte Altenstein, der Herzogl. Sachsen Gothaischen und Altensteinischen Societät der Fort- und Jogd-Kunde zu Wa

Georg Christoph Heim

1799

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Language: Czech

Description: Provider: Manuscriptorium - National Library of the Czech Republic - Institution: Národní knihovna České republiky - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana

Source: Europeana Collections

URL: View record in Europeana$$FView record in $$GEuropeana

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Deutsche Flora. Zweyten Theils zweyte Abtheilung, enthaltend der neunzehten Classe zweyte Ordenung bis drey und zwanzigste Classe / Aus neuern botanischen Schriften zusammengetragen und herausgegeben von Georg Christoph Heim Pfarrer in Gumpelstadt bey Salzungen in dem Herzogl. Sachsen Meiningschen Amte Altenstein, der Herzogl. Sachsen Gothaischen und Altensteinischen Societät der Fort- und Jogd-Kunde zu Waltershausen ordentlichen, der Jenaischen mineralogischen Societät correspondirendem, der Ch

Georg Christoph Heim

1799

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Language: Czech

Description: Provider: Manuscriptorium - National Library of the Czech Republic - Institution: Národní knihovna České republiky - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana

Source: Europeana Collections

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Deutsche Flora :Aus neuern botanischen Schriften zusammengetragen und herausgegeben. 1, Erster Theil, Welcher das in den neun ersten Heften des Botanikers in der kompendiösen Bibliothek angefangene klassificirte Verzeichniß der in Deutschland gefundenen wildwachsenden Gewächse enthält

1799

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Language: German

Description: Provider: Deutsche Digitale Bibliothek - Institution: Bayerische Staatsbibliothek - Data provided by Europeana Collections- München, Bayerische Staatsbibliothek -- BHS II F 4-1- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana

Source: Europeana Collections

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5

Article

Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation

TICHELLI, André ; BUCHER, Christoph ; BIEDERMANN, Barbara ; [et al.]

2007

ISSN: 0006-4971

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Language: English

In: Blood, 2007, Vol.110 (9), p.3463-3471

Description: We assessed incidence and risk factors of cardiovascular events in 265 patients undergoing allogeneic hematopoietic stem-cell transplantation (HSCT) between 1980 and 2000 and who survived at least 2 years. Results were compared with a cohort of 145 patients treated during the same period with autologous HSCT. The median age of patients with allogeneic HSCT at last follow-up was 39 years, and median follow-up was 9 years. Eighteen (6.8%) patients after allogeneic and 3 (2.1%) patients after autologous HSCT experienced an arterial event. The cumulative incidence of first arterial event after allogeneic HSCT was 22.1% (95% CI, 12.0-40.9) at 25 years. The cumulative incidence 15 years after allogeneic HSCT was 7.5% as compared with 2.3% after autologous HSCT. Adjusting for age, risk of an arterial event was significantly higher after allogeneic HSCT (RR 6.92; P =.009). In multivariate analysis, allogeneic HSCT (RR: 14.5; P =.003), and at least 2 of 4 cardiovascular risk factors (hypertension, dyslipidemia, diabetes, obesity) (RR: 12.4; P =.02) were associated with a higher incidence of arterial events after HSCT. Thus, long-term survivors after allogeneic HSCT are at high risk for premature arterial vascular disease. HSCT might favor the emergence of established risk factors, such as hypertension, diabetes, and dyslipidemia.

Subject(s): Hematologic and hematopoietic diseases ; Biological and medical sciences ; Medical sciences ; Cardiovascular Diseases - etiology ; Follow-Up Studies ; Humans ; Middle Aged ; Risk Factors ; Child, Preschool ; Male ; Transplantation, Autologous ; Hematopoietic Stem Cell Transplantation - mortality ; Transplantation, Homologous ; Adolescent ; Hematopoietic Stem Cell Transplantation - adverse effects ; Survival Analysis ; Cardiovascular Diseases - epidemiology ; Adult ; Female ; Aged ; Retrospective Studies ; Child ; Cohort Studies ; Index Medicus ; Abridged Index Medicus

ISSN: 0006-4971

E-ISSN: 1528-0020

DOI: 10.1182/blood-2006-10-054080

Source: HighWire Press (Free Journals)

Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Source: American Society of Hematology

URL: http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19211521$$DView record in Pascal Francis

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6

Article

Risk gene variants for nicotine dependence in the CHRNA5–CHRNA3–CHRNB4 cluster are associated with cognitive performance

Winterer, Georg ; Mittelstrass, Kirstin ; Giegling, Ina ; [et al.]

2010

ISSN: 1552-4841

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Language: English

In: American journal of medical genetics. Part B, Neuropsychiatric genetics, 2010-12, Vol.153B (8), p.1448-1458

Description: Recent studies strongly support an association of the nicotinic acetylcholine receptor gene cluster CHRNA5–CHRNA3–CHRNB4 with nicotine dependence (ND). However, the precise genotype–phenotype relationship is still unknown. Clinical and epidemiological data on smoking behavior raise the possibility that the relevant gene variants may indirectly contribute to the development of ND by affecting cognitive performance in some smokers who consume nicotine for reasons of “cognition enhancement.” Here, we tested seven single nucleotide polymorphisms (SNPs) rs684513, rs637137, rs16969968, rs578776, rs1051730, rs3743078, rs3813567 from the CHRNA5–CHRNA3–CHRNB4 gene cluster for association with ND, measures of cognitive performance and gene expression. As expected, we found all SNPs being associated with ND in three independent cohorts (KORA, NCOOP, ESTHER) comprising 5,561 individuals. In an overlapping sample of 2,186 subjects we found three SNPs (rs16969968, rs1051730, rs3743078) being associated with cognitive domains from the Wechsler‐Adult‐Intelligence Scale (WAIS‐R)—most notably in the performance subtest “object assembly” and the verbal subtest “similarities.” In a refined analysis of a subsample of 485 subjects, two of these three SNPs (rs16969968, rs1051730) were associated with n‐back task performance/Continuous Performance Test. Furthermore, two CHRNA5 risk alleles (rs684513, rs637137) were associated with CHRNA5 mRNA expression levels in whole blood in a subgroup of 190 subjects. We here report for the first time an association of CHRNA5–CHRNA3–CHRNB4 gene variants with cognition possibly mediating in part risk for developing ND. The observed phenotype–genotype associations may depend on altered levels of gene expression. © 2010 Wiley‐Liss, Inc.

Subject(s): n‐back task ; nicotine dependence ; cognition ; single nucleotide polymorphisms ; gene expression ; CHRNA5–CHRNA3–CHRNB4 ; Biological and medical sciences ; Toxicology ; Medical sciences ; Medical genetics ; Tobacco, tobacco smoking ; Wechsler Scales ; Gene Expression ; Genetic Predisposition to Disease ; Multigene Family ; Genetic Association Studies ; Humans ; Middle Aged ; RNA, Messenger - genetics ; Genotype ; Male ; Risk ; Cognition ; Gene Expression Profiling ; Chromosomes, Human, Pair 15 - genetics ; Nerve Tissue Proteins - genetics ; Genetic Variation ; RNA, Messenger - blood ; Adult ; Female ; Tobacco Use Disorder - genetics ; Aged ; Polymorphism, Single Nucleotide ; Receptors, Nicotinic - genetics ; Index Medicus

ISSN: 1552-4841

E-ISSN: 1552-485X

DOI: 10.1002/ajmg.b.31126

Source: Alma/SFX Local Collection

URL: http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23447634$$DView record in Pascal Francis

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7

Article

High Dose Chemotherapy Using Beam without Autologous Rescue Followed by Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation for Refractory or Relapsing Lymphomas - A Comparison of Delayed Versus Immediate Transplantation

Buser, Andreas S ; Stern, Martin ; Bucher, Christoph ; [et al.]

2006

ISSN: 0006-4971

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Language: English

In: Blood, 2006-11-16, Vol.108 (11), p.5352-5352

Description: Abstract Patients with refractory/relapsing lymphoma are rarely cured by chemotherapy, so that allogeneic Hematopoietic Stem Cell Transplantation (HSCT) is often considered as an alternative despite being associated with substantial mortality. Reduced intensity conditioning (RIC) HSCT can induce a graft-vs-lymphoma (GvL) effect but relapse rate is high in advanced disease. High dose chemotherapy (HDC) for tumor debulking given before RIC HSCT has been advocated as a concept. We prospectively compared in a single center two sequential strategies in patients with refractory or relapsing lymphoma: a first cohort (group A) received BEAM chemotherapy without autologous stem cell support followed by delayed RIC HSCT at day 28. The second cohort (group B) received BEAM followed immediately by RIC HSCT. RIC HSCT was based on fludarabine 3×25 mg/m2 followed by 200 cGy TBI. Pretransplant characteristics were comparable in the two groups: group A included 10 patients, 7m/3f, median age 51 years (range 25–63) with 2 CLL, 3 follicular lymphomas (FL), 1 DLBCL, 2 Hodgkin lymphomas and 2 other B-cell lymphomas. Group B included 11 patients, 5m/6f, median age 48 years (range 31–59) with 4 CLL, 3 FL, 2 DLBCL, and 2 other lymphomas. Donors were HLA identical siblings (8 and 9 in group A and B) or unrelated donors (2 in each group). Three patients died before day 100 in group A (all from acute GvHD), whereas none died in group B. Non-hematological toxicity of the regimen before engraftment was comparable, only gut toxicity was higher in group B. As expected, days in aplasia (36 vs 12 days; A vs B; p〈 0.001), days on antibiotics (61 vs 26 days; p =0.016) and length of hospital stay (36 vs 63 days; p =0.017) were significantly different. Cumulative incidence of acute GvHD ≥ grade II (90% vs 36% p= 0.01) and incidence of cGVHD (7/7 vs 6/11, p= 0.03) was higher in group A; hence we failed to show an advantage of separating RIC HSCT from the cytokine storm induced by BEAM. At last follow up, 7/10 patients in group A (median follow up 51 months) were alive, 6 of them in CR, 1 relapsed 9 months after RIC HSCT. In group B (median follow up 20 months), 9/11 patients were alive, 7 of them in CR, 1 in PR and 1 with no change. The two deaths in group B were related to cGvHD. No significant difference in 3 year overall survival (70% ±14% vs. 76%±14%, p= 0.53) was seen. These data challenge the initial concept of debulking first and delaying allogeneic RIC HSCT. They demonstrate encouraging tumor response and acceptable toxicity in patients with relapsing or refractory lymphoma. We confirm that allogeneic HSCT is a valid alternative for patients with resistant/relapsed lymphoma. These patients should be considered candidates for allogeneic HSCT earlier in the course of their disease and direct standard full conditioning with BEAM should be considered.

ISSN: 0006-4971

E-ISSN: 1528-0020

DOI: 10.1182/blood.V108.11.5352.5352

Source: HighWire Press (Free Journals)

Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Source: American Society of Hematology

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8

Article

Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997-2016

Passweg, Jakob R ; Baldomero, Helen ; Ansari, Marc ; [et al.]

2018

ISSN: 1424-7860

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Language: English

In: Swiss medical weekly, 2018, Vol.148 (910), p.w14589-w14589

Description: In 1997, the Swiss Blood Stem Cell Transplantation Group (SBST) initiated a mandatory national registry for all haematopoietic stem cell transplants (HCTs) in Switzerland. As of 2016, after 20 years, information was available for 7899 patients who had received an HCT (2781 allogeneic [35%] and 5118 autologous [65%]). As some patients had more than one transplant the total number of transplants was 3067 allogeneic and 6448 autologous. We compared patient characteristics and outcome of the first decade (1997-2006) and second decade (2007-2016) of the registry. There were numerous changes over time. For allogeneic HCT, transplant rates, and therefore use of HCT technology, increased from 14 to 21.8 HCTs per 1 million inhabitants per year from the first to the second decade. Likewise autologous HCTs increased from 24.8 to 37.2 annually corrected for population growth. Allogeneic transplant recipients were older (38.4 vs 48.3 years) and more frequently had unrelated donors in the second decade. Similarly, age increased for recipients of autologous HCT (50.8 vs 56.4 years). Analysis of outcome showed that the probabilities of overall and progression-free survival were stable over time, in spite of the treatment of older and higher risk patients. In multivariate analysis, nonrelapse mortality decreased in recipients of allogeneic HCT (relative risk 0.68, 95% confidence interval 0.52-0.87) over the two decades. Improvement in adjusted nonrelapse mortality compensated for the fact that higher risk patients were treated in more recent years, resulting in similar overall survival. Five-year survival probabilities were 56% (53-59%) in the first and 54% (51-57%) in the second decade for allogeneic HCT, and 59% (57-61%) in the first and 61% (59-63%) in the second decade for autologous HCT. Detailed analyses of changes over time are presented. This study included all HCTs performed in Switzerland during the period of observation and the data are useful for quality assurance programmes, healthcare cost estimation and healthcare planning. Between 50 and 60% of patients were long-term survivors after both types of HCT, indicating growing populations of surviving patients requiring long-term care and observation.

Subject(s): Index Medicus

ISSN: 1424-7860

E-ISSN: 1424-3997

DOI: 10.4414/smw.2018.14589

Source: Directory of Open Access Journals

Source: Alma/SFX Local Collection

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9

Article

Preoperative values of molecular coagulation markers identify patients at low risk for intraoperative haemostatic disorders and excessive blood loss

KORTE, W ; TRUTTMANN, B ; HEIM, C ; [et al.]

1998

ISSN: 1434-6621

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Language: English

In: Clinical chemistry and laboratory medicine, 1998, Vol.36 (4), p.235-240

Description: Conventional laboratory investigations of haemostasis like prothrombin time and activated partial thromboplastin time are not useful in predicting and managing intra-operative bleeding complications. In order to establish a possible "perioperative reference range" for thrombin generation prothrombin fragment F1+2 (F1+2) and fibrin degradation (D-dimer) markers, we measured F1+2 and D-dimer concentrations before surgery (but after induction of anaesthesia), 30 minutes into surgery, 10 minutes after the event expected to induce the maximal activation of the haemostatic systems, 90 minutes after surgery and on postoperative days 1 and 2 in 226 consecutive patients. Samples were collected from arterial lines. Twenty patients developed a clinically defined, intraoperative disorder of haemostasis, 206 did not. Patients with an intraoperative disorder of haemostasis had significantly higher preoperative F1+2 and D-dimer concentrations. Preoperative values for F1+2 and D-dimer concentrations above the 75th percentile of patients without an intraoperative disorder of haemostasis indicated a 2.70 to 2.88 fold risk of developing an intraoperative disorder of haemostasis (odds ratios were 3.04, 3.12 and 3.29 for D-dimer, ELISA, F1+2, and D-dimer latex tests, respectively with 95% confidence intervals from 1.20 to 8.46) with negative predictive values of 94%, but positive predictive values of only 16% to 26%. These data suggest that preoperative determination of molecular markers might be helpful in identifying a group of patients at high risk for intraoperative disorder of haemostasis by exclusion of low risk patients. Validation of such an approach requires a prospective trial.

Subject(s): Blood coagulation ; Biological and medical sciences ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Blood Loss, Surgical - prevention & control ; Intraoperative Complications - blood ; Blood Coagulation Disorders - prevention & control ; Fibrin Fibrinogen Degradation Products - metabolism ; Blood Coagulation Disorders - etiology ; Humans ; Middle Aged ; Risk Factors ; Intraoperative Complications - prevention & control ; Male ; Biomarkers - blood ; Hemostasis ; Intraoperative Complications - etiology ; Blood Coagulation ; Peptide Fragments - blood ; Aged, 80 and over ; Blood Coagulation Disorders - blood ; Adult ; Female ; Aged ; Prothrombin - metabolism ; Index Medicus

ISSN: 1434-6621

E-ISSN: 1437-4331

DOI: 10.1515/CCLM.1998.040

Source: Alma/SFX Local Collection

URL: http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2254046$$DView record in Pascal Francis

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10

Article

Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997-2016

Passweg, Jakob R ; Baldomero, Helen ; Ansari, Marc ; [et al.]

2018

ISSN: 0036-7672

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Language: English

Description: In 1997, the Swiss Blood Stem Cell Transplantation Group (SBST) initiated a mandatory national registry for all haematopoietic stem cell transplants (HCTs) in Switzerland. As of 2016, after 20 years, information was available for 7899 patients who had received an HCT (2781 allogeneic [35%] and 5118 autologous [65%]). As some patients had more than one transplant the total number of transplants was 3067 allogeneic and 6448 autologous. We compared patient characteristics and outcome of the first decade (1997-2006) and second decade (2007-2016) of the registry. There were numerous changes over time. For allogeneic HCT, transplant rates, and therefore use of HCT technology, increased from 14 to 21.8 HCTs per 1 million inhabitants per year from the first to the second decade. Likewise autologous HCTs increased from 24.8 to 37.2 annually corrected for population growth. Allogeneic transplant recipients were older (38.4 vs 48.3 years) and more frequently had unrelated donors in the second decade. Similarly, age increased for recipients of autologous HCT (50.8 vs 56.4 years). Analysis of outcome showed that the probabilities of overall and progression-free survival were stable over time, in spite of the treatment of older and higher risk patients. In multivariate analysis, nonrelapse mortality decreased in recipients of allogeneic HCT (relative risk 0.68, 95% confidence interval 0.52-0.87) over the two decades. Improvement in adjusted nonrelapse mortality compensated for the fact that higher risk patients were treated in more recent years, resulting in similar overall survival. Five-year survival probabilities were 56% (53-59%) in the first and 54% (51-57%) in the second decade for allogeneic HCT, and 59% (57-61%) in the first and 61% (59-63%) in the second decade for autologous HCT. Detailed analyses of changes over time are presented. This study included all HCTs performed in Switzerland during the period of observation and the data are useful for quality assurance programmes, healthcare cost estimation and healthcare planning. Between 50 and 60% of patients were long-term survivors after both types of HCT, indicating growing populations of surviving patients requiring long-term care and observation.

Subject(s): Medicine & health ; Clinic for Oncology and Hematology ; Medical Clinic

ISSN: 0036-7672

DOI: 10.4414/smw.2018.14589

DOI: 10.5167/uzh-153330

Source: ZORA

Source: Alma/SFX Local Collection

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