Proceedings of the National Academy of Sciences of the United States of America, 30 June 2020, Vol.117(26), pp.14769-14778
Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and high resolution is critical for understanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial resolution or electromechanical uncoupling of the beating heart. To overcome this limitation, we herein introduce a scalable method for fabricating a tissue-like, high-density, fully elastic electrode (elastrode) array capable of achieving real-time, stable, cellular level-resolution electrophysiological mapping in vivo. Testing with acute rabbit and porcine models, the device is proven to have robust and intimate tissue coupling while maintaining its chemical, mechanical, and electrical properties during the cardiac cycle. The elastrode array records epicardial atrial signals with comparable efficacy to currently available endocardial-mapping techniques but with 2 times higher atrial-to-ventricular signal...
Atrial Fibrillation ; High-Density Electrophysiology ; in Vivo Cardiac Mapping ; Stretchable Bioelectronics ; Atrial Fibrillation ; Heart Atria ; Electrophysiologic Techniques, Cardiac -- Instrumentation
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