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  • 1
    Language: English
    In: Emerging infectious diseases, 2012-05-01, Vol.18 (5), p.869-872
    Description: We screened 1,200 living heart, lung, liver, and kidney transplant recipients for hepatitis E virus infection by reverse transcription PCR. In 12 (1%) patients, hepatitis E virus infection was identified; in 11 patients, chronic infection developed. This immunocompromised population is at risk for hepatitis E virus infection.
    Subject(s): Analysis ; Dispatch ; Genotype ; Health aspects ; heart transplant ; Hepatitis E ; Hepatitis E - diagnosis ; Hepatitis E - epidemiology ; Hepatitis E - virology ; hepatitis E virus ; Hepatitis E virus - classification ; Hepatitis E virus - genetics ; Hepatitis E virus - immunology ; Humans ; Immunocompromised Host ; infection ; kidney transplant ; liver transplant ; lung transplant ; Molecular Sequence Data ; organ transplant ; Organ transplant recipients ; Organ Transplantation - adverse effects ; Phylogeny ; solid organ transplant ; the Netherlands ; Transplantation of organs, tissues, etc ; Viral Proteins - genetics ; virus ; viruses
    ISSN: 1080-6040
    E-ISSN: 1080-6059
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 2
    Language: English
    In: American journal of respiratory and critical care medicine, 2012-05-15, Vol.185 (10), p.1096-1103
    Description: Rationale: Up to one-third of patients with cystic fibrosis (CF) awaiting lung transplantation (LTX) die while waiting. Inclusion of computed tomography (CT) scores may improve survival prediction models such as the lung allocation score (LAS). Objectives: This study investigated the association between CT and survival in patients with CF screened for LTX. Methods: Clinical data and chest CTs of 411 patients with CF screened for LTX between 1990 and 2005 were collected from 17 centers. CTs were scored with the Severe Advanced Lung Disease (SALD) four-category scoring system, including the components infection/inflammation (INF), air trapping/hypoperfusion (AT), normal/hyperperfusion (NOR), and bulla/cysts (BUL). The volume of each componentwas computed using semiautomated software. Survival analysis included Kaplan-Meier curves and Cox regression models. Measurements and Main Results: Three hundred and sixty-six (186 males) of 411 patients entered the waiting list (median age, 23 yr; range, 5-58 yr). Subsequently, 67 of 366 (18%) died while waiting, 263 of 366 (72%) underwent LTX, and 36 of 366 (10%) were awaiting LTX at the census date. INF and LAS were significantly associated with waiting list mortality in univariate analyses. The multivariate Cox model including INF and LAS grouped in tertiles, and comparing tertiles 2 and 3 with tertile 1, showed waiting list mortality hazard ratios of 1.62 (95% confidence interval [95% CI], 0.78-3.36; P=0.19) and 2.65 (95% CI, 1.35-5.20; P = 0.005) for INF, and 1.42 (95% CI, 0.63-3.24; P=0.40), and 2.32 (95% CI, 1.17-4.60; P=0.016) for LAS, respectively. These results indicated that INF and LAS had significant, independent predictive value for survival. Conclusions: CT score INF correlates with survival, and adds to the predictive value of LAS. Copyright
    Subject(s): Abridged Index Medicus ; Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Cohort Studies ; Cystic fibrosis ; Cystic Fibrosis - diagnostic imaging ; Cystic Fibrosis - mortality ; Cystic Fibrosis - surgery ; Decision Support Techniques ; Female ; Humans ; Intensive care medicine ; Investigative techniques, diagnostic techniques (general aspects) ; Kaplan-Meier Estimate ; Lung disease ; Lung Transplantation ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Prognosis ; Proportional Hazards Models ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Respiratory system ; Severity of Illness Index ; Tomography X-ray computed ; Waiting list survival ; Waiting Lists - mortality ; Young Adult
    ISSN: 1073-449X
    E-ISSN: 1535-4970
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: ProQuest Central
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  • 3
    Language: English
    In: The Journal of heart and lung transplantation, 2016, Vol.35 (12), p.1435-1442
    Description: Background Varicella zoster virus (VZV)-specific memory T-cells are significantly lower in transplant recipients than controls. Additionally, VZV-specific IgG titres are significantly lower after than before transplantation. Data on the incidence and timing of herpes zoster (HZ) after lung transplantation is limited. The aim of the study was twofold. First, we investigated the incidence and severity of HZ after lung transplantation. Second, we determined the systemic VZV-specific T-cell and B-cell memory responses before and after HZ. Methods The records of 119 patients who underwent transplantation were analysed for post-transplant HZ. The VZV-specific B- and T-cell memory responses of 5 patients before and after HZ were compared with 5 patients without HZ by Elispot assay and flow cytometry, respectively. Results HZ was clinically diagnosed and confirmed by PCR on blister fluids and/or plasma in 17 transplant recipients. Twelve patients had uncomplicated cutaneous HZ and 5 patients had disseminated HZ of whom one died. The incidence of HZ after transplantation (38.2 cases/1000 PY) was significantly higher than the age-matched healthy population (7-8 cases/1000 PY). Both the frequency of VZV-specific IgG producing B-cells (p=0.06) and the percentage of VZV-specific CD4 and CD8 memory T-cells increased after HZ to higher frequencies than in patients without HZ (p=0.03). This was mainly attributed to VZV-reactive effector memory (EM) CD4 T-cells (p=0.02), and central memory (CM, p=0.02) and EM (p=0.03) CD8 T-cells. Conclusions Lung transplant recipients are highly prone to develop HZ with severe complications. Despite deep immunosuppression, HZ boosted their systemic VZV-specific B- and T-cell memory responses.
    Subject(s): Adaptive Immunity ; B cells ; Chickenpox ; ELISpot ; Enzyme-Linked Immunospot Assay ; Herpes Zoster ; Herpesvirus 3, Human ; Humans ; IFN-γ ; Immune response ; Immunoglobulin G ; Immunotherapy ; Lung Transplantation ; memory cells ; Organ transplant recipients ; Shingles (Disease) ; Surgery ; T cells ; Transplantation of organs, tissues, etc ; VZV
    ISSN: 1053-2498
    E-ISSN: 1557-3117
    Source: Alma/SFX Local Collection
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  • 4
    Language: English
    In: British journal of pharmacology, 2002-01, Vol.135 (2), p.511-519
    Description: We have examined the effects of 12 glucocorticoids as inhibitors of A549 cell growth. Other than cortisone and prednisone, all the glucocorticoids inhibited cell growth and this was strongly correlated (r=0.91) with inhibition of prostaglandin (PG)E2 formation. The molecular mechanism by which the active steroids prevented PGE2 synthesis was examined and three groups were identified. Group A drugs did not inhibit arachidonic acid release but inhibited the induction of COX2. Group B drugs were not able to inhibit the induction of COX2 but inhibited arachidonic acid release through suppression of cPLA2 activation. Group C drugs were apparently able to bring about both effects. The inhibitory actions of all steroids was dependent upon glucocorticoid receptor occupation since RU486 reversed their effects. However, group A acted through the NF‐κB pathway to inhibit COX2 as the response was blocked by the inhibitor geldanamycin which prevents dissociation of GR and the effect was blocked by APDC, the NF‐κB inhibitor. On the other hand, the group B drugs were not inhibited by NF‐κB inhibitors or geldanamycin but their effect was abolished by the src inhibitor PP2. Group C drugs depended on both pathways. In terms of PGE2 generation, there is clear evidence of two entirely separate mechanisms of glucocorticoid action, one of which correlates with NF‐κB mediated genomic actions whilst the other, depends upon rapid effects on a cell signalling system which does not require dissociation of GR. The implications for these findings are discussed. British Journal of Pharmacology (2002) 135, 511–519; doi:10.1038/sj.bjp.0704474
    Subject(s): Arachidonic Acid - antagonists & inhibitors ; Arachidonic Acid - secretion ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cell Division - drug effects ; Cell Division - physiology ; cell signalling ; Cyclooxygenase 2 ; Dexamethasone - pharmacology ; Dinoprostone - antagonists & inhibitors ; Dinoprostone - secretion ; Enzyme Activation - drug effects ; Gene Expression Regulation, Enzymologic - drug effects ; genome-independent ; Glucocorticoids ; Glucocorticoids - pharmacology ; Humans ; Isoenzymes - antagonists & inhibitors ; Isoenzymes - biosynthesis ; Medical sciences ; Membrane Proteins ; non-genomic ; Papers ; Pharmacology. Drug treatments ; Phospholipases A - metabolism ; Prostaglandin-Endoperoxide Synthases - biosynthesis ; Signal Transduction - drug effects ; Tumor Cells, Cultured - cytology ; Tumor Cells, Cultured - drug effects ; Tumor Cells, Cultured - enzymology ; Tumor Cells, Cultured - secretion
    ISSN: 0007-1188
    E-ISSN: 1476-5381
    Source: Academic Search Ultimate
    Source: Wiley Online Library All Journals
    Source: PubMed Central
    Source: Alma/SFX Local Collection
    Source: Get It Now
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  • 5
    Language: English
    In: Respiratory research, 2015-03-07, Vol.16 (1), p.32-32
    Description: Although osteoporosis and its related fractures are common in patients with COPD, patients at high risk of fracture are poorly identified, and consequently, undertreated. Since there are no fracture prevention guidelines available that focus on COPD patients, we developed a clinical approach to improve the identification and treatment of COPD patients at high risk of fracture. We organised a round-table discussion with 8 clinical experts in the field of COPD and fracture prevention in the Netherlands in December 2013. The clinical experts presented a review of the literature on COPD, osteoporosis and fracture prevention. Based on the Dutch fracture prevention guideline, they developed a 5-step clinical approach for fracture prevention in COPD. Thereby, they took into account both classical risk factors for fracture (low body mass index, older age, personal and family history of fracture, immobility, smoking, alcohol intake, use of glucocorticoids and increased fall risk) and COPD-specific risk factors for fracture (severe airflow obstruction, pulmonary exacerbations and oxygen therapy). Severe COPD (defined as postbronchodilator FEV1 〈50% predicted) was added as COPD-specific risk factor to the list of classical risk factors for fracture. The 5-step clinical approach starts with case finding using clinical risk factors, followed by risk evaluation (dual energy X-ray absorptiometry and imaging of the spine), differential diagnosis, treatment and follow-up. This systematic clinical approach, which is evidence-based and easy-to-use in daily practice by pulmonologists, should contribute to optimise fracture prevention in COPD patients at high risk of fracture.
    Subject(s): BONE-MINERAL DENSITY ; Comorbidity ; Consensus ; COPD ; Corticosteroids ; Critical Pathways ; Decision Support Techniques ; ECLIPSE COHORT ; EMPHYSEMA ; Evidence-based medicine ; Falls (Accidents) ; Fracture ; Humans ; INHALED CORTICOSTEROIDS ; LUNG-DISEASE ; METAANALYSIS ; OBSTRUCTIVE PULMONARY-DISEASE ; Osteoporosis ; Osteoporosis - diagnosis ; Osteoporosis - epidemiology ; Osteoporosis - therapy ; Osteoporotic Fractures - diagnosis ; Osteoporotic Fractures - epidemiology ; Osteoporotic Fractures - prevention & control ; Predictive Value of Tests ; Prevention ; Prognosis ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - therapy ; Respiratory agents ; Review ; Risk Assessment ; Risk Factors ; SYSTEMIC INFLAMMATION ; Therapy ; VERTEBRAL FRACTURES
    ISSN: 1465-9921
    ISSN: 1465-993X
    E-ISSN: 1465-993X
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 6
    Language: English
    In: Journal of medical case reports, 2008-05-21, Vol.2 (1), p.169-169
    Description: Nitrofurantoin is a commonly used drug in the treatment and prevention of urinary tract infections. Many adverse effects of nitrofurantoin have been documented, including aplastic anemia, polyneuritis, and liver and pulmonary toxicity. We describe the clinical history and the autopsy findings in a 51-year-old woman with lung fibrosis of unknown etiology. She had a history of recurrent urinary tract infections, treated with nitrofurantoin for many years. She was referred to our hospital for screening for lung transplantation because of severe pulmonary restriction and dyspnea. Unfortunately, she died as a result of progressive respiratory insufficiency. At autopsy bilateral patchy, sharply circumscribed fibrotic areas in the upper and lower lobes of the lungs were seen with honeycombing. Microscopically, end-stage interstitial fibrosis with diffuse alveolar damage was observed. Due to the atypical distribution of the fibrosis involving both the lower and upper lobes of the lung, the microscopic pattern of the fibrosis and the history of long-term nitrofurantoin use, we concluded that this drug induced the lung fibrosis. The recurrent urinary tract infections were probably caused by a diverticulum of the urinary bladder, which was discovered at autopsy. This case shows that the use of nitrofurantoin may cause severe pulmonary disease. Patients with long-term use of nitrofurantoin should be monitored regularly for adverse pulmonary effects.
    Subject(s): Care and treatment ; Case Report ; Case studies ; Complications and side effects ; Diagnosis ; Nitrofurantoin ; Patient outcomes ; Pulmonary fibrosis ; Risk factors
    ISSN: 1752-1947
    E-ISSN: 1752-1947
    Source: BioMedCentral Open Access
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 7
    Language: English
    In: Histopathology, 2012-08, Vol.61 (2), p.324-326
    Description: Byline: Michael A den Bakker(1)(2), Katrien Grunberg(3), Anco Boonstra(4), Peter Th W van Hal(5), Carla E M Hollak(6) Author Affiliation: (1).sub.1Department of Pathology, Erasmus MC, Rotterdam (2).sub.2Department of Pathology, Maasstad Ziekenhuis, Rotterdam (3).sub.3Departments of Pathology (4).sub.4Respiratory Medicine, VU MC, Amsterdam (5).sub.5Department of Respiratory Medicine, Erasmus MC, Rotterdam (6).sub.6Department of Endocrinology and Metabolism, Academic Medical Centre, Amsterdam, The Netherlands
    Subject(s): Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Enzyme Replacement Therapy ; Familial Primary Pulmonary Hypertension ; Female ; Gaucher Disease - classification ; Gaucher Disease - complications ; Gaucher Disease - drug therapy ; Gaucher Disease - pathology ; Glucosylceramidase - therapeutic use ; Humans ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - pathology ; Hypertension, Pulmonary - therapy ; Investigative techniques, diagnostic techniques (general aspects) ; Lung Transplantation ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pneumology ; Pulmonary Artery - pathology ; Pulmonary hypertension ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Recombinant Proteins - therapeutic use
    ISSN: 0309-0167
    E-ISSN: 1365-2559
    Source: Hellenic Academic Libraries Link
    Source: Academic Search Ultimate
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  • 8
    Language: English
    In: Transplant international, 2009-09, Vol.22 (9), p.940-942
    Description: Byline: Hester J. Kan, Marlies E. Heuvers, Karin Grijm, Peter Th.W. van Hal
    Subject(s): Airway Obstruction - etiology ; C-Reactive Protein - metabolism ; Calcineurin Inhibitors ; Dose-Response Relationship, Drug ; Female ; Humans ; Hypoproteinemia - pathology ; Immunosuppressive Agents - adverse effects ; Lung Transplantation - methods ; Middle Aged ; Pleural Effusion - etiology ; Sirolimus - adverse effects ; Tomography, X-Ray Computed - methods ; Transplantation of organs, tissues, etc ; Treatment Outcome
    ISSN: 0934-0874
    E-ISSN: 1432-2277
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 9
    Language: English
    In: Biochemical journal, 2003-11-15, Vol.376 (Pt 1), p.285-290
    Description: Glucocorticoids inhibit the release of eicosanoid pro-inflammatory mediators. The immunosuppressant FK506 is known to enhance many aspects of glucocorticoid action. In the present study we show that FK506 (1 microM or 10 microM) inhibits the release of arachidonic acid and prostaglandin E2 from A549 cells and also inhibits their proliferation. Simultaneous treatment of FK506 together with the glucocorticoids dexamethasone, methyl-prednisolone, fluticasone or mometasone (10 nM) enhances the growth inhibitory effect of these steroids. Furthermore, the simultaneous use of FK506 and these glucocorticoids similarly results in enhanced inhibition of arachidonic acid release. When pretreated for 2 h, FK506 enhances glucocorticoid inhibition of COX2 (cyclo-oxygenase 2) expression. However, when administered simultaneously, FK506 blocks glucocorticoid inhibition of COX2 expression. Nuclear uptake of glucocorticoid receptors mediated by glucocorticoids is also blocked by the simultaneous administration of FK506. These results suggest that the effect of simultaneous treatment of FK506 with glucocorticoids differs significantly from that where pre-treatment of the immunosuppressant is used. Recently, immunophilin interchange has been identified as a first step in glucocorticoid receptor activation following ligand activation. We show here that the FKB51 (FK506-binding protein 51)-FKB52 switch is differentially regulated by glucocorticoid and FK506 treatment strategy.
    Subject(s): Arachidonic Acid - metabolism ; Cell Division - drug effects ; Cell Line, Tumor ; Cyclooxygenase 2 ; Dinoprostone - biosynthesis ; Drug Synergism ; Glucocorticoids - antagonists & inhibitors ; Glucocorticoids - pharmacology ; Humans ; Immunosuppressive Agents - pharmacology ; Isoenzymes - metabolism ; Membrane Proteins ; Prostaglandin-Endoperoxide Synthases - metabolism ; Receptors, Glucocorticoid - metabolism ; Tacrolimus - pharmacology ; Tacrolimus Binding Proteins - metabolism
    ISSN: 0264-6021
    E-ISSN: 1470-8728
    Source: PubMed Central
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  • 10
    Language: English
    In: Lung, 2015-12, Vol.193 (6), p.919-926
    Description: Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients listed for LTX and to investigate the survival after LTX. Methods and Results Data were retrospectively collected from September 1989 until July 2011 of all IPF patients registered for LTX in the Netherlands. Patients were included after revision of the diagnosis based on the criteria set by the ATS/ERS/JRS/ALAT. Trajectory data, clinical data at time of screening, and donor data were collected. In total, 98 IPF patients were listed for LTX. During the waiting list period, 30 % of the patients died. Mean pulmonary artery pressure, 6-min walking distance, and the use of supplemental oxygen were significant predictors of mortality on the waiting list. Fifty-two patients received LTX with a median overall survival after transplantation of 10 years. Conclusions This study demonstrated a 10-year survival time after LTX in IPF. Furthermore, our study demonstrated a significantly better survival after bilateral LTX in IPF compared to single LTX although bilateral LTX patients were significantly younger.
    Subject(s): Article ; BENEFIT ; Cohort Studies ; DIAGNOSIS ; DISEASE ; Exercise Test ; Female ; GUIDELINES ; HEART ; Humans ; Hypertension, Pulmonary - epidemiology ; Idiopathic Pulmonary Fibrosis - epidemiology ; Idiopathic Pulmonary Fibrosis - mortality ; Idiopathic Pulmonary Fibrosis - surgery ; INTERNATIONAL-SOCIETY ; Interstitial lung diseases ; Lung Transplantation ; Lungs ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Netherlands - epidemiology ; Organ transplantation ; Outcomes ; Oxygen Inhalation Therapy - utilization ; PIRFENIDONE ; Pneumology/Respiratory System ; Pulmonary fibrosis ; Pulmonary Wedge Pressure ; Retrospective Studies ; RISK ; SELECTION ; SINGLE ; Survival Rate ; Transplants & implants ; Usual interstitial pneumonia ; Waiting Lists - mortality
    ISSN: 0341-2040
    E-ISSN: 1432-1750
    Source: Alma/SFX Local Collection
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