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  • 1
    Language: English
    In: Archives of disease in childhood. Fetal and neonatal edition, 2016-01, Vol.101 (1), p.87
    Subject(s): Chylothorax - congenital ; Chylothorax - drug therapy ; Humans ; Infant, Newborn ; Infant, Premature ; Pleurodesis - methods ; Povidone-Iodine - administration & dosage
    ISSN: 1359-2998
    E-ISSN: 1468-2052
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: Pediatrics and neonatology, 2018-04, Vol.59 (2), p.184-188
    Description: Byline: Bernhard Resch [bernhard.resch@medunigraz.at] (a,b,*), Krisztina Liziczai (b), Friedrich Reiterer (a), Thomas Freidl (a), Michaela Haim (a), Berndt Urlesberger (a) Key Words respiratory syncytial virus; congenital diaphragmatic hernia; respiratory tract infection; hospitalization Background To evaluate the risk of RSV infection in infants and children with congenital diaphragmatic hernia (CDH) over two consecutive RSV seasons. Methods Retrospective, single-center cohort study from southern Austria including infants with CDH born between 1993 and 2012. Infants were retrieved by searching via ICD-10 codes Q79.0 and Q79.1 and by using a local electronic database. Children were followed over 2 years of life including at least two consecutive RSV seasons (November to April). We also defined a group of hypothetical RSV infections with the following criteria: 70% of the admissions due to a respiratory infection (diagnosis of bronchiolitis and/or LRI score [greater than or equal to]3) during the RSV seasons over the first 2 years of life, when no test for RSV was performed. Results Twenty-nine of 45 infants with CDH comprised the study population (6 were lost to follow-up and 10 died) of whom 9 (31%) exhibited 17 hospitalizations due to respiratory illness. Two hospitalized infants (6.9% of the study population) tested RSV positive, one during the first and the other during the second RSV season. Nine of 29 infants (31%) had documentation of palivizumab prophylaxis, none (0%) had proven RSV hospitalization compared to 1 of 20 (5%) without prophylaxis during the first RSV season (p = 0.256). Including the hypothetical cases, we calculated 0 of 9 (0%) in the palivizumab group and 4 of 20 (20%) in the group without prophylaxis (p = 0.079). Conclusions We found a moderate rate of proven RSV hospitalizations in infants with CDH, and palivizumab prophylaxis led to a non-significant reduction of proven and hypothesized RSV hospitalizations. Author Affiliation: (a) Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria (b) Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Austria * Corresponding author. Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34/2, 8036 Graz, Austria. Fax: +43 316 385 12678. Article History: Received 15 March 2017; Revised 26 June 2017; Accepted 11 August 2017
    Subject(s): Children ; Diagnosis ; Diaphragm ; Diseases ; Hernia ; Respiratory syncytial virus ; Respiratory tract infections
    ISSN: 1875-9572
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 3
    Language: English
    In: Neonatology (Basel, Switzerland), 2015-02, Vol.107 (2), p.100-107
    Description: Background: The fetal-to-neonatal transition is a complex process that includes changes in cardiac and respiratory systems. Objective: The aim of this study is to review the different methods of cardiocirculatory monitoring during the immediate neonatal transition period. Methods: A systematic search of PubMed and Ovid Embase was performed using the following terms: infant, newborn, newborn infant, neonate, neonates, heart, cardiac, blood pressure, haemodynamic, hemodynamics, blood circulation, circulation, echocardiography, ultrasonography, sonography, electrocardiography, ECG, oximetry, pulse, pulse oximetry, monitoring, measurement, acclimatization, adaptation, transition, after birth and delivery room. Additional articles were identified by manual search of cited references. Only human studies describing cardiocirculatory monitoring during the first 15 min after birth were included. Results: Thirteen studies were identified that described heart rate (HR). Additional five studies were identified that measured blood pressure. Four studies performed functional echocardiography during neonatal transition; two in addition to blood pressure monitoring and three in addition to HR monitoring. Conclusion: Routine HR monitoring using electrocardiography or pulse oximetry is used to evaluate adequate hemodynamic transition, and reference ranges have been established. Measuring blood pressure noninvasively though noncontinuously might be of some value in future, considering that the normative data have been established recently. Echocardiographic monitoring during the immediate transition period will improve the knowledge about cardiac function changes, but introduction in clinical routine remains questionable. © 2014 S. Karger AG, Basel
    Subject(s): Blood Pressure ; Development ; Echocardiography ; Electrocardiography ; Female ; Fetus ; Growth ; Heart Function Tests ; Heart Rate ; Hemodynamic monitoring ; Hemodynamics ; Humans ; Infant, Newborn ; Infants ; Male ; Methods ; Monitoring, Physiologic - methods ; Neonatology ; Oximetry ; Parturition ; Pediatric research ; Research ; Review
    ISSN: 1661-7800
    E-ISSN: 1661-7819
    Source: Alma/SFX Local Collection
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  • 4
    Language: English
    In: Evidence-based complementary and alternative medicine, 2015-04-02, Vol.2015, p.571857-6
    Description: Laser acupuncture bears a potential risk for the skin surface, especially in neonates whose skin has histological and physiological peculiarities. We evaluated thermal changes of skin temperature in neonates during laser acupuncture by using a thermal camera (Flir i5, Flir Systems Inc., Portland, USA). Laserneedles (Laserneedle GmbH, Glienicke/Nordbahn, Germany) were fixed to the skin at Large Intestine 4 (LI 4, Hegu), bilaterally. Before application of laser acupuncture (685 nm, 15 mW, 500 μm), as well as after 1, 5, and 10 min, thermographic pictures of both hands were taken. The measuring was carried out on the 23rd day after birth (20 neonates, mean postmenstrual gestational age 38 + 2, mean weight 2604 g). Compared to the initial temperature of 34.2°C on the right hand, the skin temperature had increased to 35.3°C ( P 〈 0.05 ) after 5 min and up to 36.1°C ( P 〈 0.05 ) after 10 min of stimulation. Equally, on the left hand, an increase of the skin temperature from 34.5°C to 35.9°C ( P 〈 0.05 ) and 35.9°C ( P 〈 0.05 ) was measured. The highest measured skin temperature after 10 min of stimulation amounted to 38.7°C, without any clinically visible changes on the skin surface.
    Subject(s): Acupuncture ; Infants (Newborn) ; Physiological aspects ; Skin
    ISSN: 1741-427X
    E-ISSN: 1741-4288
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 5
    Language: English
    In: Twin research and human genetics, 2011-12, Vol.14 (6), p.573-579
    Description: Objective: To examine the effect of twin-to-twin delivery time (TTDT) on neonatal outcome. Methods: We evaluated twin deliveries 〉34 weeks of gestation. Twin pregnancies with both twins delivered by cesarean section and pregnancies with antenatal complications were excluded. We analyzed TTDT and neonatal outcomes of the second twin (umbilical arterial pH value (pHart), Apgar scores at 1, 5 and 10 minutes, need for intensive care). The study population was divided into two homogenous groups based on the mode of delivery: (A) vertex presentation and vaginal delivery of both twins, (B) vertex presentation and vaginal or vaginal operative delivery of twin I, breech or transverse presentation and vaginal breech delivery or cesarean section (CS) of twin II. Results: A total of 207 twin pairs were included in our study. In Group A (n = 151) there were no significant correlations between TTDT and pHart or Apgar scores at 1,5 and 10 minutes of twin II (p = .156; 0.861; 0.151 and 0.384, respectively). In Group B (n = 56), the mean pHart of twin II was inversely correlated to TTDT, but not significantly (p = .417). TTDT was inversely related to 1-min and 5-min Apgar scores, but not significantly (p = .330; p = .138, respectively). The 10-min Apgar score showed no correlation with TTDT (p = .638). Conclusion: Increasing TTDT was not associated with adverse fetal outcome. Expectant management of the second twin appears possible and elapsed time alone does not appear to be an indication for intervention.
    Subject(s): Apgar Score ; Articles ; Cesarean Section ; Complications ; Delivery, Obstetric - methods ; Female ; Fetal monitoring ; Gestational Age ; Humans ; Hydrogen-Ion Concentration ; Infant, Newborn ; Multiple birth ; Neonatal intensive care ; neonatal outcome ; Pregnancy ; Pregnancy Outcome ; Pregnancy, Twin ; Research ; Time Factors ; twin-to-twin delivery time ; Twins ; umbilical arterial pH
    ISSN: 1832-4274
    E-ISSN: 1839-2628
    Source: Alma/SFX Local Collection
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  • 6
    Language: English
    In: Archives of disease in childhood. Fetal and neonatal edition, 2016-01, Vol.101 (1), p.87-88
    ISSN: 1359-2998
    E-ISSN: 1468-2052
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: Neonatology (Basel, Switzerland), 2017, Vol.111 (1), p.55-60
    Description: Substantial haemodynamic changes occur during the first minutes after birth. Currently, only heart rate (HR) and arterial oxygen saturation are routinely used to monitor haemodynamic transition after birth. The aim of the present study was to continuously assess haemodynamic changes during transition in term infants for the first time by using electrical velocimetry (EV), a new method of non-invasive cardiac output monitoring (NICOM), based on impedance cardiography technology. In this prospective observational study, term neonates delivered by elective caesarean section underwent NICOM measurements within the first 15 min after birth. The beat-to-beat measurement over a 10-second period was used to calculate cardiac output (CO) for each minute after birth. The data of CO were only accepted when the signal quality index (SQI) remained 〉80% during the measurement period of 10 s. 100 term neonates underwent 1,500 NICOM measurements. 1,143 (76.2%) measurements were excluded because of a SQI 〈80%. HR and CO showed a trend to increase within the first minutes, and decreased significantly from minute 3 (HR) and 4 (CO), until minute 12 and 10, respectively. Stroke volume remained stable during the observation period. The present study was the first using EV for NICOM during the transition period in a larger cohort of newborn infants. Results of NICOM were similar to available echocardiography data. The possibility of NICOM offers continuous CO measurement. The present study supports the idea that CO is closely related to HR in newborn infants.
    Subject(s): Cardiography, Impedance - methods ; Cardiovascular equipment ; Cesarean section ; Echocardiography, Doppler ; Female ; Heart beat ; Heart Rate - physiology ; Humans ; Infant, Newborn ; Infants (Newborn) ; Intensive Care Units, Neonatal ; Male ; Monitoring, Physiologic - instrumentation ; Patient monitoring equipment ; Prospective Studies ; Stroke Volume - physiology ; Term Birth ; Time Factors
    ISSN: 1661-7800
    E-ISSN: 1661-7819
    Source: Alma/SFX Local Collection
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  • 8
    Language: English
    In: Klinische Pädiatrie, 2008, Vol.220 (6), p.384-387
    Description: Abstract BACKGROUND: Focal nodular hyperplasia (FNH) is a benign hepatic lesion of unknown etiology. Although uncommon in children, a cumulative incidence is reported in oncologic patients after ending their therapy. Differential diagnosis to other focal liver lesions especially to metastases is often difficult. PATIENTS AND METHODS: We report on four children (female n=2, male n=2; age at initial diagnosis: 9 months, 20 months, 11.5 and 14 years) with different non-hepatic primary tumors (gastrointestinal stroma-tumor, neuroblastoma (n=2) and nephroblastoma) who developed focal liver lesions 2, 2.5, 3 and 8 years after successful treatment of their primary malignancy, respectively. RESULTS: Diagnosis of focal nodular hyperplasia was established by sonography, computed tomography and magnetic resonance imaging. In addition percutaneous needle biopsy was performed in two patients. Median interval from the end of chemotherapy to the onset of FNH was 3.9 years (range 2–8 years). CONCLUSION: Diagnosis of FNH has to be included in the differential diagnosis of uncertain liver lesions. Biopsy might be avoided by using special imaging techniques like MRI, CT and ultrasound. A wait and see strategy is recommended, specific treatment is not necessary.
    Subject(s): Adolescent ; Adrenal Gland Neoplasms - pathology ; Adrenal Gland Neoplasms - therapy ; Biopsy, Needle ; Case Report ; Child ; Diagnosis, Differential ; Female ; Focal Nodular Hyperplasia - diagnosis ; Focal Nodular Hyperplasia - pathology ; Follow-Up Studies ; Gastrointestinal Stromal Tumors - pathology ; Gastrointestinal Stromal Tumors - secondary ; Gastrointestinal Stromal Tumors - therapy ; Humans ; Infant ; Kidney Neoplasms - pathology ; Kidney Neoplasms - therapy ; Liver - pathology ; Liver Neoplasms - pathology ; Liver Neoplasms - secondary ; Liver Neoplasms - therapy ; Magnetic Resonance Imaging ; Male ; Neuroblastoma - pathology ; Neuroblastoma - secondary ; Neuroblastoma - therapy ; Stomach Neoplasms - pathology ; Stomach Neoplasms - therapy ; Tomography, X-Ray Computed ; Ultrasonography ; Wilms Tumor - pathology ; Wilms Tumor - secondary ; Wilms Tumor - therapy
    ISSN: 0300-8630
    E-ISSN: 1439-3824
    Source: Thieme-Connect Backfiles
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  • 9
    Language: English
    In: Journal of allergy and clinical immunology, 2016
    Description: Background Fish is a frequent elicitor of severe IgE-mediated allergic reactions. Beside avoidance, there is currently no allergen-specific therapy available. Hypoallergenic variants of the major fish allergen, parvalbumin, for specific immunotherapy based on mutation of the 2 calcium-binding sites have been developed. Objectives This study sought to establish a mouse model of fish allergy resembling human disease and to investigate whether mouse and rabbit IgG antibodies induced by immunization with a hypoallergenic mutant of the major carp allergen protect against allergic symptoms in sensitized mice. Methods C3H/HeJ mice were sensitized with recombinant wildtype Cyp c 1 or carp extract by intragastric gavage. Antibody, cellular immune responses, and epitope specificity in sensitized mice were investigated by ELISA, rat basophil leukemia assay, T-cell proliferation experiments using recombinant wildtype Cyp c 1, and overlapping peptides spanning the Cyp c 1 sequence. Anti-hypoallergenic Cyp c 1 mutant mouse and rabbit sera were tested for their ability to inhibit IgE recognition of Cyp c 1, Cyp c 1–specific basophil degranulation, and Cyp c 1–induced allergic symptoms in the mouse model. Results A mouse model of fish allergy mimicking human disease regarding IgE epitope recognition and symptoms as close as possible was established. Administration of antisera generated in mice and rabbits by immunization with a hypoallergenic Cyp c 1 mutant inhibited IgE binding to Cyp c 1, Cyp c 1–induced basophil degranulation, and allergic symptoms caused by allergen challenge in sensitized mice. Conclusions Antibodies induced by immunization with a hypoallergenic Cyp c 1 mutant protect against allergic reactions in a murine model of fish allergy.
    Subject(s): Allergy and Immunology
    ISSN: 0091-6749
    E-ISSN: 1097-6825
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 10
    Language: English
    In: PloS one, 2015, Vol.10 (4), p.e0124320-e0124320
    Description: Euthanasia remains a controversial topic in both public discourses and legislation. Although some determinants of acceptance of euthanasia and physician-assisted death have been identified in previous studies, there is still a shortage of information whether different forms of euthanasia are supported by the same or different sub-populations and whether authoritarian personality dispositions are linked to attitudes towards euthanasia. A large, representative face-to-face survey was conducted in Austria in 2014 (n = 1,971). Respondents faced three scenarios of euthanasia and one of physician assisted death differing regarding the level of specificity, voluntariness and subject, requiring either approval or rejection: (1) abstract description of euthanasia, (2) abstract description of physician-assisted suicide, (3) the case of euthanasia of a terminally-ill 79-year old cancer patient, and (4) the case of non-voluntary, physician assisted death of a severely disabled or ill neonate. A number of potential determinants for rejection ordered in three categories (socio-demographic, personal experience, orientations) including authoritarianism were tested via multiple logistic regression analyses. Rejection was highest in the case of the neonate (69%) and lowest for the case of the older cancer patient (35%). A consistent negative impact of religiosity on the acceptance across all scenarios and differential effects for socio-economic status, area of residence, religious confession, liberalism, and authoritarianism were found. Individuals with a stronger authoritarian personality disposition were more likely to reject physician-assisted suicide for adults but at the same time also more likely to approve of physician-assisted death of a disabled neonate. Euthanasia in adults was supported by a partially different sub-population than assisted death of disabled neonates.
    Subject(s): Adolescent ; Adult ; Adults ; Aged ; Assisted suicide ; Attitude to Death ; Attitudes ; Austria ; Authoritarianism ; Cancer ; Conformism ; Cross-Sectional Studies ; Death ; Demographics ; Determinants ; Educational attainment ; Epidemiology ; Euthanasia ; Euthanasia - psychology ; Female ; Hostility ; Households ; Humans ; Individualism ; Interviews as Topic ; Legislation ; Male ; Medicine ; Middle Aged ; Mortality ; Multivariate Analysis ; Nazi era ; Neonates ; Personality ; Physicians ; Physicians - psychology ; Public Opinion ; Regression analysis ; Rejection ; Religion ; Right to die ; Studies ; Suicide ; Suicide, Assisted ; Surveys ; Surveys and Questionnaires ; Young Adult
    ISSN: 1932-6203
    E-ISSN: 1932-6203
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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