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  • 1
    Language: English
    In: Agricultural and food economics, 2021-03-08, Vol.9 (1), p.1-13
    Description: AbstractThe transition from a linear to a circular economy is a research trend topic, as well as the possibility to measure the degree of circularity of products and systems. In a linear economy, raw materials are taken from nature and transformed into final products, which are subsequently used and become waste. On the contrary, a circular economy is an economic model that is restorative by intent and design. To measure the degree of circularity is fundamental for understanding processes and improving them. Moreover, this kind of measure could be useful for driving policies on the topic and achieving a higher level of sustainability. Until now, only few studies have been focusing on how to effectively measure the circularity level of a product, a supply chain, or a service. Moreover, in the circular economy paradigm, there are two types of cycles: the technical and biological ones. Biological cycles are mainly connected to the agricultural sector, and for this kind of cycle, the lack of measurement is even bigger. However, some agricultural productions, such as intensive meat production processes, have basically a linear structure. Intensive broiler production, for instance, uses a quite high rate of inputs, which is not entirely converted into edible products but instead results in a percentage of wasteful outputs. The aim of this work is to propose a modification of one of the few available tools for measuring the circularity, the Material Circularity Indicator (MCI), for adapting it to biological cycles. The modified MCI was applied to the poultry sector, integrating the results with the Life Cycle Assessment methodology.
    Subject(s): Economics ; Life cycle assessment ; Economic models ; Economic analysis ; Supply chains ; Sustainability ; Life cycle analysis ; Circularity ; Meat production ; Raw materials ; Meat ; Life cycles ; Broiler production system ; Circular economy ; Indicators ; Modified Material Circularity Indicator ; Life Cycle Assessment
    ISSN: 2193-7532
    E-ISSN: 2193-7532
    Source: Directory of Open Access Journals
    Source: Alma/SFX Local Collection
    Source: ProQuest Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2021-03, Vol.56 (3), p.586-595
    Description: T-cell replete hematopoietic stem cell transplantation (HSCT) from a haploidentical donor followed by high doses of cyclophosphamide has been demonstrated to provide the best chances of a cure for many children in need of an allograft but who lack both a sibling and an unrelated donor. In this study we retrospectively compared the outcome of pediatric patients undergoing T-replete haploidentical HSCT (Haplo) for acute leukemia with those undergoing transplantation from unrelated HLA-matched donor (MUD) and HLA mismatched unrelated donor (MMUD) from 2012 to 2017 at our Center. Both univariable and multivariable analyses showed similar 5-year overall survival rates for MUD, MMUD, and Haplo patients: 71% (95% CI 56-86), 72% (95% CI 55-90), and 75% (95% CI 54-94), respectively (p = 0.97). Haplo patients showed reduced event-free survival rates compared to MUD and MMUD patients: 30% (95% CI 12-49) versus 70% (95% CI 55-84) versus 53% (95% CI 35-73), respectively (p = 0.007), but these data were not confirmed by a multivariable analysis. Non-relapse mortality (NRM) and relapse incidence (RI) were similar for the three groups. Therefore, our data confirm that Haplo is a suitable clinical option for pediatric patients needing HSCT when lacking both an MUD and an MMUD donor.
    Subject(s): Pediatrics ; Cyclophosphamide ; Analysis ; Mortality ; Stem cells ; Acute leukemia ; Transplantation of organs, tissues, etc ; Transplantation ; Children ; T cells ; Health aspects ; Hematopoietic stem cells ; Index Medicus
    ISSN: 0268-3369
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: Neurobiology of disease, 2008, Vol.31 (3), p.395-405
    Description: Abstract Amyotrophic lateral sclerosis (ALS) is a lethal disease affecting motoneurons. In familial ALS, patients bear mutations in the superoxide dismutase gene (SOD1). We transplanted human bone marrow mesenchymal stem cells (hMSCs) into the lumbar spinal cord of asymptomatic SOD1G93A mice, an experimental model of ALS. hMSCs were found in the spinal cord 10 weeks after, sometimes close to motoneurons and were rarely GFAP- or MAP2-positive. In females, where progression is slower than in males, astrogliosis and microglial activation were reduced and motoneuron counts with the optical fractionator were higher following transplantation. Motor tests (Rotarod, Paw Grip Endurance, neurological examination) were significantly improved in transplanted males. Therefore hMSCs are a good candidate for ALS cell therapy: they can survive and migrate after transplantation in the lumbar spinal cord, where they prevent astrogliosis and microglial activation and delay ALS-related decrease in the number of motoneurons, thus resulting in amelioration of the motor performance.
    Subject(s): Neurology ; Neuroprotection ; Motoneuron ; Cell therapy ; Astrocyte ; SOD1 ; Microglia ; Microglia - metabolism ; Superoxide Dismutase - genetics ; Amyotrophic Lateral Sclerosis - physiopathology ; Humans ; Nerve Degeneration - physiopathology ; Male ; Gliosis - physiopathology ; Movement Disorders - surgery ; Motor Neurons - pathology ; Mesenchymal Stromal Cells - cytology ; Nerve Degeneration - prevention & control ; Spinal Cord - pathology ; Recovery of Function - physiology ; Female ; Gliosis - surgery ; Cell Survival - physiology ; Mesenchymal Stromal Cells - physiology ; Disease Models, Animal ; Astrocytes - cytology ; Microglia - cytology ; Nerve Degeneration - surgery ; Amyotrophic Lateral Sclerosis - therapy ; Myelitis - physiopathology ; Gliosis - metabolism ; Survival Rate ; Treatment Outcome ; Sex Characteristics ; Mutation - genetics ; Spinal Cord - surgery ; Mesenchymal Stem Cell Transplantation - methods ; Animals ; Movement Disorders - physiopathology ; Movement Disorders - etiology ; Mice ; Spinal Cord - physiopathology ; Superoxide Dismutase-1 ; Myelitis - therapy ; Astrocytes - metabolism ; Superoxide dismutase ; Amyotrophic lateral sclerosis ; Transplantation ; Analysis ; Stem cells ; Index Medicus
    ISSN: 0969-9961
    E-ISSN: 1095-953X
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Gut, 2008-02, Vol.57 (2), p.223-231
    Description: Background and aim:Mesenchymal stem cells from bone marrow (MSCs) may have the potential to differentiate in vitro and in vivo into hepatocytes. We investigated whether transplanted human MSCs (hMSCs) may engraft the liver of non-obese diabetic severe combined immuno-deficient (NOD/SCID) mice and differentiate into cells of hepatic lineage.Methods:Ex vivo expanded, highly purified and functionally active hMSCs from bone marrow were transplanted (caudal vein) in sublethally irradiated NOD/SCID mice that were either exposed or not to acute liver injury or submitted to a protocol of chronic injury (single or chronic intraperitoneal injection of CCl4, respectively). Chimeric livers were analysed for expression of human transcripts and antigens.Results:Liver engraftment of cells of human origin was very low in normal and acutely injured NOD/SCID mice with significantly higher numbers found in chronically injured livers. However, hepatocellular differentiation was relatively rare, limited to a low number of cells (ranging from less than 0.1% to 0.23%) as confirmed by very low or not detectable levels of human transcripts for α-fetoprotein, CK18, CK19 and albumin in either normal or injured livers. Finally, a significant number of cells of human origin exhibited a myofibroblast-like morphology.Conclusions:Transplanted hMSCs have the potential to migrate into normal and injured liver parenchyma, particularly under conditions of chronic injury, but differentiation into hepatocyte-like cells is a rare event and pro-fibrogenic potential of hMSC transplant should be not under-evaluated.
    Subject(s): Fundamental and applied biological sciences. Psychology ; Biological and medical sciences ; Cell physiology ; Molecular and cellular biology ; Cell differentiation, maturation, development, hematopoiesis ; Gene Expression ; Carbon Tetrachloride ; Humans ; Hepatocyte Growth Factor - pharmacology ; Mice, SCID ; Liver Regeneration - physiology ; Regenerative Medicine - methods ; Mesenchymal Stem Cell Transplantation - methods ; Animals ; Bone Marrow Cells ; Graft Survival - physiology ; Mice, Inbred NOD ; Mice ; Mesenchymal Stromal Cells - physiology ; Patient outcomes ; Liver ; Stem cells ; Physiological aspects ; Transplantation ; Research ; Cell differentiation ; Liver cells ; Studies ; Antigens ; Dilution ; Morphology ; Bone marrow ; Gene expression ; Membrane filters ; Cell adhesion & migration ; Index Medicus ; Abridged Index Medicus
    ISSN: 0017-5749
    E-ISSN: 1468-3288
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: Journal of cancer research and clinical oncology, 2016-05, Vol.142 (5), p.1127-1132
    Description: To evaluate the prevalence of gonadal dysfunction and the associated risk factors in a cohort of male childhood cancer survivors (CCS). Gonadal function was evaluated measuring FSH, LH, inhibin B and total testosterone levels. Patients with total testosterone 〈3 ng/dl were considered to have hypogonadism. Patients with FSH 〉10 UI/l and inhibin B 〈100 pg/ml were considered to have spermatogenesis damage (SD). To assess the impact of risk factors, we estimated crude and adjusted OR performing logistic regression models. One hundred and ninety-nine male CCS were enrolled; the median follow-up time was 14.01 years. SD was diagnosed in 68 patients, 16 CCS had primary hypogonadism, and 13 had central hypogonadism. The prevalence of gonadal dysfunction (SD or primary hypogonadism) was 45 %, similar in the three considered periods of pediatric cancer diagnosis (1985-1989, 1990-1999, 〉2000). The adjusted risk of gonadal dysfunction was higher in patients treated with radiotherapy (OR = 8.72; 95 % CI 3.94-19.30) and in those exposed to both alkylating and platinum-derived agents (OR = 9.22; 95 % CI 2.17-39.23). Sarcomas were the cancer diagnosis associated with the higher risk of gonadal dysfunction (OR = 3.69; 95 % CI 1.11-12.22). An extremely high rate of gonadal dysfunction was detected in patients who underwent hematopoietic stem cell transplantation and/or total body irradiation. Gonadal dysfunction still remains a significant late effect of anticancer therapies; thus, it is mandatory to inform patients (and parents) about this risk, and semen cryopreservation should be offered to all boys who are able to produce semen.
    Subject(s): Prognosis ; Follow-Up Studies ; Humans ; Risk Factors ; Survivors ; Child, Preschool ; Neoplasms - mortality ; Infant ; Male ; Survival Rate ; Combined Modality Therapy - adverse effects ; Neoplasms - therapy ; Hypogonadism - mortality ; Adolescent ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hypogonadism - diagnosis ; Hypogonadism - etiology ; Neoplasm Staging ; Neoplasms - pathology ; Child ; Infant, Newborn ; Testosterone ; Sarcoma ; Inhibin ; Transplantation ; Epidemiology ; Hematopoietic stem cells ; Cancer in children ; Index Medicus
    ISSN: 0171-5216
    E-ISSN: 1432-1335
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2015-02, Vol.50 (2), p.181-188
    Description: We analyzed the outcome of 243 children with high-risk (HR) AML in first CR1 enrolled in the AIEOP-2002/01 protocol, who were given either allogeneic (ALLO; n=141) or autologous (AUTO; n=102) hematopoietic SCT (HSCT), depending on the availability of a HLA-compatible sibling. Infants, patients with AML-M7, or complex karyotype or those with FLT3-ITD, were eligible to be transplanted also from alternative donors. All patients received a myeloablative regimen combining busulfan, cyclophosphamide and melphalan; [corrected] AUTO-HSCT patients received BM cells in most cases, while in children given ALLO-HSCT stem cell source was BM in 96, peripheral blood in 19 and cord blood in 26. With a median follow-up of 57 months (range 12-130), the probability of disease-free survival (DFS) was 73% and 63% in patients given either ALLO- or AUTO-HSCT, respectively (P=NS). Although the cumulative incidence (CI) of relapse was lower in ALLO- than in AUTO-HSCT recipients (17% vs 28%, respectively; P=0.043), the CI of TRM was 7% in both groups. Patients transplanted with unrelated donor cord blood had a remarkable 92.3% 8-year DFS probability. Altogether, these data confirm that HSCT is a suitable option for preventing leukemia recurrence in HR children with CR1 AML.
    Subject(s): Autografts ; Follow-Up Studies ; Leukemia, Myeloid, Acute - pathology ; Humans ; Child, Preschool ; Hematopoietic Stem Cell Transplantation ; Infant ; Male ; Survival Rate ; Abnormal Karyotype ; Cord Blood Stem Cell Transplantation ; Leukemia, Myeloid, Acute - mortality ; fms-Like Tyrosine Kinase 3 - genetics ; Disease-Free Survival ; Allografts ; Adolescent ; Myeloablative Agonists - administration & dosage ; Female ; Transplantation Conditioning - methods ; Child ; Leukemia, Myeloid, Acute - therapy ; Leukemia, Myeloid, Acute - genetics ; Transplantation ; Health aspects ; Patient outcomes ; Hematopoietic stem cells ; Index Medicus
    ISSN: 0268-3369
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Water, air, and soil pollution, 2009, Vol.201 (1-4), p.19-31
    Subject(s): Fundamental and applied biological sciences. Psychology ; General aspects ; Synecology ; Fresh water ecosystems ; Animal, plant and microbial ecology ; Biological and medical sciences ; Animal and plant ecology ; Applied ecology ; Ecotoxicology, biological effects of pollution
    ISSN: 0049-6979
    E-ISSN: 1573-2932
    Source: Alma/SFX Local Collection
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  • 8
    Language: English
    In: Leukemia, 2017-01, Vol.31 (1), p.18-25
    Description: Recurrent molecular markers have been routinely used in acute myeloid leukemia (AML) for risk assessment at diagnosis, whereas their post-induction monitoring still represents a debated issue. We evaluated the prognostic value and biological impact of minimal residual disease (MRD) and of the allelic ratio (AR) of FLT3-internal-tandem duplication (ITD) in childhood AML. We retrospectively screened 494 children with de novo AML for FLT3-ITD mutation, identifying 54 harboring the mutation; 51% of them presented high ITD-AR at diagnosis and had worse event-free survival (EFS, 19.2 versus 63.5% for low ITD-AR, 〈0.05). Forty-one percent of children with high levels of MRD after the 1st induction course, measured by a patient-specific real-time-PCR, had worse EFS (22.2 versus 59.4% in low-MRD patients, P〈0.05). Next, we correlated these parameters with gene expression, showing that patients with high ITD-AR or persistent MRD had characteristic expression profiles with deregulated genes involved in methylation and acetylation. Moreover, patients with high CyclinA1 expression presented an unfavorable EFS (20.3 versus 51.2% in low CyclinA1 group, P〈0.01). Our results suggest that ITD-AR levels and molecular MRD should be considered in planning clinical management of FLT3-ITD patients. Different transcriptional activation of epigenetic and oncogenic profiles may explain variability in outcome among these patients, for whom novel therapeutic approaches are desirable.
    Subject(s): fms-Like Tyrosine Kinase 3 - genetics ; Disease-Free Survival ; Leukemia, Myeloid, Acute - diagnosis ; Prognosis ; Epigenesis, Genetic - genetics ; Humans ; Child, Preschool ; Retrospective Studies ; Gene Expression Regulation, Leukemic ; Child ; Neoplasm, Residual - genetics ; Leukemia, Myeloid, Acute - genetics ; Molecular targeted therapy ; Gene mutations ; Gene expression ; Health aspects ; Innovations ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Clinical pharmacokinetics, 2020-02-01, Vol.59 (2), p.207-216
    Description: Introduction: The pharmacokinetics (PK) of the 20S proteasome inhibitor bortezomib are characterized by a large volume of distribution and a rapid decline in plasma concentrations within the first hour after administration. An increase in exposure was observed in the second week of treatment, which has previously been explained by extensive binding of bortezomib to proteasome in erythrocytes and peripheral tissues. We characterized the nonlinear population PK and pharmacodynamics (PD) of bortezomib in children with acute lymphoblastic leukemia. Methods: Overall, 323 samples from 28 patients were available from a pediatric clinical study investigating bortezomib at an intravenous dose of 1.3 mg/m2 twice weekly (Dutch Trial Registry number 1881/ITCC021). A semi-physiological PK model for bortezomib was first developed; the PK were linked to the decrease in 20S proteasome activity in the final PK/PD model. Results: The plasma PK data were adequately described using a two-compartment model with linear elimination. Increased concentrations were observed in week 2 compared with week 1, which was described using a Langmuir binding model. The decrease in 20S proteasome activity was best described by a direct effect model with a sigmoidal maximal inhibitory effect, representing the relationship between plasma concentrations and effect. The maximal inhibitory effect was 0.696 pmol AMC/s/mg protein (95% confidence interval 0.664–0.728) after administration. Conclusion: The semi-physiological model adequately described the nonlinear PK and PD of bortezomib in plasma. This model can be used to further optimize dosing of bortezomib.
    Subject(s): Pharmacology (medical) ; Pharmacology ; Proteins ; Pediatrics ; Chemotherapy ; Leukemia ; Population ; Physiology ; Cancer ; Index Medicus
    ISSN: 0312-5963
    E-ISSN: 1179-1926
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2015-09, Vol.50 (9), p.1206-1211
    Description: Fertility after childhood haemopoietic stem cell transplant (HSCT) is a major concern. Conditioning regimens before HSCT present a high risk (〉80%) of ovarian failure. Since 2000, we have proposed cryopreservation of ovarian tissue to female patients undergoing HSCT at our centre, to preserve future fertility. After clinical and haematological evaluation, the patients underwent ovarian tissue collection by laparoscopy. The tissue was analysed by histologic examination to detect any tumour contamination and then frozen following the slow freezing procedure and cryopreserved in liquid nitrogen. From August 2000 to September 2013, 47 patients planned to receive HSCT, underwent ovarian tissue cryopreservation. The median age at diagnosis was 11.1 years and at the time of procedure it was 13 years, respectively. Twenty-four patients were not pubertal at the time of storage, whereas 23 patients had already experienced menarche. The median time between laparoscopy and HSCT was 25 days. Twenty-six out of 28 evaluable patients (93%) developed hypergonadotropic hypogonadism at a median time of 23.3 months after HSCT. One patient required autologous orthotopic transplantation that resulted in one live birth. Results show a very high rate of iatrogenic hypergonadotropic hypogonadism, highlighting the need for fertility preservation in these patients.
    Subject(s): Autografts ; Humans ; Live Birth ; Child, Preschool ; Hematopoietic Stem Cell Transplantation ; Hematologic Diseases - therapy ; Allografts ; Cryopreservation ; Adolescent ; Adult ; Female ; Ovary - transplantation ; Child ; Care and treatment ; Patient outcomes ; Protection and preservation ; Physiological aspects ; Transplantation ; Ovaries ; Health aspects ; Hematopoietic stem cells ; Cancer in children ; Index Medicus
    ISSN: 0268-3369
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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