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  • 1
    Language: English
    In: Clinical infectious diseases, 2014-12-15, Vol.59 (12), p.1696-1702
    Description: Background. There is a practical need to investigate the performance of the serum galactomannan (GM) assay in hematology patients with a potentially low pretest risk of invasive aspergillosis following effective antimold prophylaxis. Methods. We present a 4-year study with 262 unselected consecutive high-risk episodes, prospectively managed with posaconazole primary prophylaxis and a uniform diagnostic algorithm, including biweekly serum GM quantification for early detection of invasive aspergillosis. Results. A total of 2972 serum GM tests were performed (median, 11 per episode [range, 3–30]); the vast majority were negative (96.7% of tests and 83.6% of episodes). The incidence of breakthrough invasive aspergillosis was 1.9% (5/262), all with true-positive GM test results. Our study identified 30 false-positive GM evaluable episodes (85.7%; 13.8% of all evaluable episodes), validating with real-life data the low positive predictive value of the assay in this setting (12%). In 26 of these 30 episodes (86.7%), the false-positive result(s) occurred in tests performed as preemptive surveillance only. Conversely, in evaluable cases with positive GM tests and a clinical suspicion of invasive fungal disease, the performance of diagnostic-driven GM tests improved, with a positive predictive value of 89.6%. Conclusions. The low pretest risk of invasive aspergillosis in the context of effective antimold prophylaxis renders serum GM surveillance of asymptomatic patients unreliable, as all results would be either negative or false positive. The test remains useful to diagnose patients with a clinical suspicion of invasive fungal disease, calling for a more efficient copositioning of effective prophylaxis and GM testing in this clinical setting.
    Subject(s): Antifungals ; Aspergillus ; Chemotherapy ; Hematology ; Myeloid leukemia ; Screening tests ; Aspergillosis ; Fungal infections ; ARTICLES AND COMMENTARIES ; Consolidation chemotherapy ; Fever ; Mycoses ; Biological and medical sciences ; Human mycoses ; Infectious diseases ; Medical sciences ; Miscellaneous mycoses ; Antigens, Fungal - blood ; Humans ; Mannans - blood ; Aspergillosis - blood ; Antifungal Agents - therapeutic use ; Aspergillosis - drug therapy ; Triazoles - therapeutic use ; Treatment outcome ; Care and treatment ; Analysis ; Antifungal agents ; Dosage and administration ; Risk factors ; Index Medicus
    ISSN: 1058-4838
    E-ISSN: 1537-6591
    Source: Alma/SFX Local Collection
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: Scientific reports, 2018-10-30, Vol.8 (1), p.16028-10
    Description: Camouflage has been a textbook example of natural selection and adaptation since the time of the earliest evolutionists. However, aside from correlational evidence and studies using artificial dummy prey, experiments directly showing that better camouflaged prey to predator vision are at reduced risk of attack are lacking. Here, we show that the level of camouflage achieved through colour adjustments towards the appearance of seaweed habitats is adaptive in reducing predation pressure in the prawn Hippolyte obliquimanus. Digital image analysis and visual modelling of a fish predator (seahorse) predicted that brown prawns would be imperfectly concealed against both brown and red seaweed respectively, whereas pink prawns should be well camouflaged only in red weed. Predation trials with captive seahorses (Hippocampus reidi), coupled with high-speed video analyses, closely matched model predictions: predation rates were similar for brown prawns between seaweed types, but pink individuals were attacked significantly less on red than brown weed. Our work provides some of the clearest direct evidence to date that colour polymorphism and colour change provides a clear adaptive advantage for camouflage, and also highlights how this can be asymmetric across morphs and habitats (i.e. dependent on the specific background-morph combination).
    Subject(s): Prey ; Image processing ; Camouflage ; Algae ; Predation ; Seaweeds ; Natural selection ; Index Medicus
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2020-11, Vol.55 (11), p.2071-2076
    Description: The new coronavirus SARS-CoV-2 has rapidly spread over the world causing the disease by WHO called COVID-19. This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. Risk factors for severe disease include age and predisposing conditions such as cancer. The true impact on stem cell transplant and CAR T-cell recipients in unknown. The European Society for Blood and Marrow Transplantation (EBMT) has therefore developed recommendations for transplant programs and physicians caring for these patients. These guidelines were developed by experts from the Infectious Diseases Working Party and have been endorsed by EBMT's scientific council and board. This work intends to provide guidelines for transplant centers, management of transplant candidates and recipients, and donor issues until the COVID-19 pandemic has passed.
    Subject(s): Coronavirus Infections - prevention & control ; COVID-19 Testing ; Clinical Laboratory Techniques ; Humans ; Pandemics - prevention & control ; Transplantation, Autologous ; Infectious Disease Transmission, Patient-to-Professional - prevention & control ; Transplant Recipients ; COVID-19 ; SARS-CoV-2 ; Allografts ; Coronavirus Infections - epidemiology ; Pneumonia, Viral - epidemiology ; Telemedicine ; Health Personnel ; Betacoronavirus ; Immunotherapy, Adoptive ; Office Visits ; Coronavirus Infections - diagnosis ; Cross Infection - prevention & control ; Europe ; Hematopoietic Stem Cell Transplantation - statistics & numerical data ; Continuity of Patient Care ; Accreditation - organization & administration ; Procedures and Techniques Utilization ; Delivery of Health Care - standards ; Infection Control - standards ; Pneumonia, Viral - prevention & control ; Infectious Disease Transmission, Professional-to-Patient - prevention & control ; Visitors to Patients ; Pneumonia, Viral - diagnosis ; Hematopoietic Stem Cell Transplantation - methods ; Immunocompromised Host ; Tissue Donors ; Epidemics ; Care and treatment ; Communicable diseases ; Stem cells ; Bone marrow ; Transplantation ; Coronaviruses ; T cells ; Health aspects ; Hematopoietic stem cells ; Risk factors ; Index Medicus ; Life Sciences ; Human health and pathology ; Microbiology and Parasitology ; Hematology ; Emerging diseases ; Virology ; Medicin och hälsovetenskap
    ISSN: 0268-3369
    ISSN: 1476-5365
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2018-09, Vol.53 (9), p.1139-1148
    Description: Hematopoietic cell transplantation (HCT) is an established procedure for acquired and congenital disorders of the hematopoietic system. In 2016, there was a tendency for continued activity in this field with 43,636 HCT in 39,313 patients [16,507 allogeneic (42%), 22,806 autologous (58%)] reported by 679 centers in 49 countries in 2016. The main indications were myeloid malignancies 9547 (24%; 96% allogeneic), lymphoid malignancies 25,618 (65%; 20% allogeneic), solid tumors 1516 (4%; 2% allogeneic), and non-malignant disorders 2459 (6%; 85% allogeneic). There was a remarkable leveling off in the use of unrelated donor HCT being replaced by haploidentical HCT. Continued growth in allogeneic HCT for marrow failure, AML, and MPN was seen, whereas MDS appears stable. Allogeneic HCT for lymphoid malignancies vary in trend with increases for NHL and decreases for Hodgkin lymphoma and myeloma. Trends in CLL are not clear, with recent increases after a decrease in activity. In autologous HCT, the use in myeloma continues to expand but is stable in Hodgkin lymphoma. There is a notable increase in autologous HCT for autoimmune disease. These data reflect the most recent advances in the field, in which some trends and changes are likely to be related to development of non-transplant technologies.
    ISSN: 0268-3369
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Article
    Article
    2017
    ISSN: 0034-7329  ISSN: 1983-3121 
    Language: English
    In: Revista brasileira de política internacional, 2017-10-19, Vol.60 (2)
    Description: Abstract Existing research on security governance in South America functions on dichotomous lines. Analysis of Brazil’s security practices is a case in point. On the one hand, scholars point out the balance of power and hegemonic institutions as the main discourse in the security practices between Brazil and its South American neighbors. On the other hand, some other emphasize the importance of democracy, cooperation on defense and security, and peaceful conflict resolution between states in the region as indicators for the emergence of a security community between Brazil and its neighbors in the South American region. The way in which multiple orders coexist is not given adequate attention in empirical research. This article seeks to overcome this dichotomy. By foregrounding Brazil’s regional security practices, particularly during the Lula and Rousseff administration, I show the hybrid and sometimes ambivalent security governance system in Brazil, where mechanisms of balance of power and security community overlap in important ways.
    Subject(s): Aspectos morales y eticos ; Comunidad ; Casos ; Medidas de seguridad ; Educacion ; Aspectos economicos ; Analisis ; Aprobaciones y respaldos ; Aspectos internacionales ; Informes ; Seguridad ; Administracion ; Aspectos sociales ; Observaciones ; Politica militar ; Innovaciones ; Hybrid security ; Security communities ; Brazilian defense policy ; Balance of power in South America
    ISSN: 0034-7329
    ISSN: 1983-3121
    E-ISSN: 0034-7329
    Source: Academic Search Ultimate
    Source: Directory of Open Access Journals
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  • 6
    Language: English
    In: Aquaculture research, 2021-04, Vol.52 (4), p.1621-1629
    Description: The goal of this study was to evaluate the effect of organic waste from yellowtail kingfish (Seriola lalandi) mariculture on seafloor sediments in Magdalena Bay, Baja California Sur. For the spatial analysis of the benthic macroinvertebrate community, sediment samples were collected below the cage and control areas in 2017. Sandy sediments predominated in the study area; organic matter content ranged from 0.96% to 1.18%, except for the control zone III, where it reached 1.48%. Total nitrogen and total phosphorus concentration showed significant differences between cage and control areas. A total of 63 benthic families were identified, and the highest density corresponded to polychaete annelids. BOPA index values indicate a low disturbance level in the study area; however, the distribution of benthic abundance shows a clear separation between zones, related to differences in total phosphorus and total nitrogen contents. The results obtained indicate that the fish farm generated a spatial differentiation of the benthic macroinvertebrate community, although organic farm waste has had a low impact on the seafloor. Results also show that benthic macrofauna is a good ecological indicator and that benthic indices provide a useful tool to evaluate environmental quality.
    Subject(s): soft sediments ; environmental impact ; organic matter ; mariculture ; bio‐indicators ; benthos ; Mariculture ; Benthos ; Organic farming ; Analysis ; Aquaculture industry
    ISSN: 1355-557X
    E-ISSN: 1365-2109
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2020-01, Vol.55 (1), p.126-136
    Description: Information on incidence, and factors associated with mortality is a prerequisite to improve outcome after hematopoietic stem cell transplantation (HSCT). Therefore, 55'668 deaths in 114'491 patients with HSCT (83.7% allogeneic) for leukemia were investigated in a landmark analysis for causes of death at day 30 (very early), day 100 (early), at 1 year (intermediate) and at 5 years (late). Mortality from all causes decreased from cohort 1 (1980-2001) to cohort 2 (2002-2015) in all post-transplant phases after autologous HSCT. After allogeneic HSCT, mortality from infections, GVHD, and toxicity decreased up to 1 year, increased at 5 years; deaths from relapse increased in all post-transplant phases. Infections of unknown origin were the main cause of infectious deaths. Lethal bacterial and fungal infections decreased from cohort 1 to cohort 2, not unknown or mixed infections. Infectious deaths were associated with patient-, disease-, donor type, stem cell source, center, and country- related factors. Their impact varied over the post-transplant phases. Transplant centres have successfully managed to reduce death after HSCT in the early and intermediate post-transplant phases, and have identified risk factors. Late post-transplant care could be improved by focus on groups at risk and better identification of infections of "unknown origin".
    Subject(s): Netherlands ; Mortality ; Analysis ; Leukemia ; Stem cells ; United Kingdom ; Transplantation ; Index Medicus ; Epidemiology ; Risk factors ; Medicin och hälsovetenskap
    ISSN: 0268-3369
    ISSN: 1476-5365
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 8
    Language: English
    In: Bone marrow transplantation (Basingstoke), 2019-10, Vol.54 (10), p.1575-1585
    Description: Hematopoietic cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants done in Europe and associated countries continues to rise with 45,418 HCT in 41,100 patients [(17,155 allogeneic (42%) and 23,945 autologous (58%)] reported by 683 centers in 50 countries in 2017. Main indications were myeloid malignancies 10,147 (25%; 96% allogeneic), lymphoid malignancies 26,488 (64%; 19% allogeneic), solid tumors 1,607 (3.9%; 2% allogeneic), and nonmalignant disorders 2,667 (7%; 81% allogeneic). Trends in donor choice seen before continue, with growing numbers of haploidentical HCT and decreasing use of cord blood. Of interest is that after many years of continued growth, the number of patients receiving an allogeneic HCT for marrow failure is decreasing slightly (p 〈 0.001). Such a change may be explained by the use of thrombopoietin analogs in aplastic anemia patients. Other nonmalignant indications, however continue to grow, most importantly HCT for hemoglobinopathies by 36%, equally for thalassemias and sickle cell disease. Non-HCT cell therapies have increased by 28% since 2015 and genetically modified T cells is type of cell therapy with the fastest growth. These annual reports reflect current activity and trends and are useful for health-care planning.
    Subject(s): Hematology ; Transplantation ; Surveys ; Reports ; Medical societies ; Hematopoietic stem cells ; Homografts ; Index Medicus ; Haematological cancer
    ISSN: 0268-3369
    E-ISSN: 1476-5365
    Source: Nature Open Access
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Leukemia, 2020-06, Vol.34 (6), p.1487-1494
    Description: Since early 2020, the SARS-CoV-2 pandemic has a massive impact on health care systems worldwide. Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. Here, we provide recommendations for the management of patients with malignant disease in the times of COVID-19. These recommendations were prepared by an international panel of experts and then consented by the EHA Scientific Working Group on Infection in Hematology. The primary aim is to enable clinicians to provide optimal cancer care as safely as possible, since the most important protection for patients with malignant disease is the best-possible control of the underlying disease.
    Subject(s): Coronavirus Infections - prevention & control ; Practice Guidelines as Topic - standards ; Humans ; Pandemics - prevention & control ; Patient Care - standards ; Infectious Disease Transmission, Patient-to-Professional - prevention & control ; Infection Control - methods ; COVID-19 ; Coronavirus Infections - transmission ; Pneumonia, Viral - transmission ; Neoplasms - virology ; Neoplasms - therapy ; SARS-CoV-2 ; Infection Control - standards ; Coronavirus Infections - virology ; Pneumonia, Viral - prevention & control ; Betacoronavirus ; Pneumonia, Viral - virology ; Prevention ; Infection ; Epidemics ; Care and treatment ; Cancer patients ; China ; B cells ; Cancer ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: The New England journal of medicine, 2017-12-21, Vol.377 (25), p.2433-2444
    Description: CMV infection is a common complication in patients undergoing hematopoietic-cell transplantation. The incidence of CMV infection was 23 percentage points lower with prophylactic letermovir, a CMV–terminase complex inhibitor, than with placebo, with only low-level toxic effects.
    Subject(s): Cytomegalovirus - genetics ; Cytomegalovirus - isolation & purification ; Acetates - adverse effects ; Double-Blind Method ; Antiviral Agents - therapeutic use ; Cytomegalovirus Infections - epidemiology ; Humans ; Middle Aged ; Kaplan-Meier Estimate ; Male ; DNA, Viral - blood ; Young Adult ; Cytomegalovirus Infections - prevention & control ; Quinazolines - therapeutic use ; Antiviral Agents - adverse effects ; Adolescent ; Hematopoietic Stem Cell Transplantation - adverse effects ; Quinazolines - adverse effects ; Cytomegalovirus Infections - etiology ; Adult ; Female ; Acetates - therapeutic use ; Aged ; Edema ; Cytomegalovirus ; Transplants & implants ; Cyclosporins ; Viremia ; Prophylaxis ; Transplantation ; Preventive medicine ; Terminase ; Hemopoiesis ; Fibrillation ; Vomiting ; Stem cells ; Gene loci ; Deoxyribonucleic acid--DNA ; Medicin och hälsovetenskap
    ISSN: 0028-4793
    ISSN: 1533-4406
    E-ISSN: 1533-4406
    Source: Single Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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