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  • 1
    Language: English
    In: Fertility and sterility, 2016, Vol.107 (1), p.97-103.e4
    Description: Objective To determine the prognostic impact of the nuclear status at the two-cell stage on intracytoplasmic sperm injection (ICSI) outcomes. Design Retrospective study. Setting Hospital. Patient(s) Only ICSI cycles with time-lapse monitoring of transferred embryos with known implantation/delivery data from November 2012 to December 2014 were included. A total of 2,449 embryos were assessed for multinucleation rates at the two- and four-cell stage, and 608 transferred embryos were studied for ICSI outcomes. Intervention(s) None. Main Outcome Measure(s) Implantation rate (IR) and live birth rate (LBR) according to the number of multinucleated blastomeres at the two-cell stage: none (Without-MNB2cell ), one (MNB1/2cell ), and two (MNB2/2cell ); morphokinetics of MNB2cell embryos. Result(s) Embryos with MNB1/2cell led to lower IR (27.7%) and LBR (22.7%) than embryos Without-MNB2cell (33.4% and 29.8%, respectively). The MNB2/2cell embryos led to significantly lower IR (18.3%) and LBR (13.4%) than embryos Without-MNB2cell . This difference remained significant in multivariate analysis for implantation (odds ratio 0.57; 95% confidence interval 0.34–0.94) and birth (odds ratio 0.46; 95% confidence interval 0.26–0.80), independently of the other significant parameters (women's age, time of two-cell formation, and multinucleation at the four-cell stage). Among implanted MNB2cell , if cleavage into four cells occurred later than 37 hours after insemination, embryos were significantly more likely to lead to birth. Conclusion(s) The presence of multinucleation at the two-cell stage and more specifically in both blastomeres had a significant negative impact on birth potential. Thus, embryo multinucleation at the two-cell stage should be used as an additional noninvasive criterion for embryo selection.
    Subject(s): Internal Medicine ; Obstetrics and Gynecology ; Birth rate ; implantation ; ICSI outcomes ; embryo multinucleation ; time-lapse system ; Multivariate Analysis ; Humans ; Microscopy, Video ; Cleavage Stage, Ovum ; Embryo Transfer - adverse effects ; Fertility ; Female ; Infertility - physiopathology ; Time-Lapse Imaging - methods ; Retrospective Studies ; Odds Ratio ; Infertility - therapy ; Pregnancy Rate ; Live Birth ; Risk Factors ; Logistic Models ; Treatment Outcome ; Blastomeres - cytology ; Chi-Square Distribution ; Embryo Implantation ; Pregnancy ; Infertility - diagnosis ; Embryo, Mammalian - cytology ; Sperm Injections, Intracytoplasmic - adverse effects ; Cell Nucleus ; Embryonic development ; Spermatozoa ; Embryo ; Analysis ; Index Medicus
    ISSN: 0015-0282
    E-ISSN: 1556-5653
    Source: Alma/SFX Local Collection
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  • 2
    Language: English
    In: PloS one, 2016, Vol.11 (3), p.e0150857-e0150857
    Description: In animal studies, extensive data revealed the influence of culture medium on embryonic development, foetal growth and the behaviour of offspring. However, this impact has never been investigated in humans. For the first time, we investigated in depth the effects of embryo culture media on health, growth and development of infants conceived by In Vitro Fertilization until the age of 5 years old. This single-centre cohort study was based on an earlier randomized study. During six months, in vitro fertilization attempts (No. 371) were randomized according to two media (Single Step Medium--SSM group) or Global medium (Global group). This randomized study was stopped prematurely as significantly lower pregnancy and implantation rates were observed in the SSM group. Singletons (No. 73) conceived in the randomized study were included (42 for Global and 31 for SSM). The medical data for gestational, neonatal and early childhood periods were extracted from medical records and parental interviews (256 variables recorded). The developmental profiles of the children in eight domains (social, self-help, gross motor, fine motor, expressive language, language comprehension, letter knowledge and number knowledge--270 items) were compared in relation to the culture medium. The delivery rate was significantly lower in the SSM group than in the Global group (p〈0.05). The culture medium had no significant effect on birthweight, risk of malformation (minor and major), growth and the frequency of medical concerns. However, the children of the Global group were less likely than those of the SSM group to show developmental problems (p = 0.002), irrespective of the different domains. In conclusion, our findings showed that the embryo culture medium may have an impact on further development.
    Subject(s): Fertilization in Vitro ; Culture Media ; Growth ; Humans ; Child, Preschool ; Infant ; Health Status ; Infant, Newborn ; Cohort Studies ; Fertilization in vitro ; Culture media (Biology) ; Embryonic development ; Research ; Child development ; Analysis ; Index Medicus ; Life Sciences ; Human health and pathology ; Gynecology and obstetrics ; Cognitive science ; In vitro fertilization ; Neonates ; Fertilization ; Sperm ; Medical records ; Implantation ; Cardiovascular disease ; Infants ; Gene expression ; Pregnancy ; Embryonic growth stage ; Autism ; Embryogenesis ; Offspring ; Randomization ; Language ; DNA methylation ; Culture media ; Epigenetics ; Birth weight ; Reproductive technologies ; Blood pressure ; Children
    ISSN: 1932-6203
    E-ISSN: 1932-6203
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 3
    Language: English
    In: Molecular cytogenetics, 2015, Vol.8 (1), p.42
    Description: Prader-Willi syndrome (PWS) is characterized by hypotonia, delayed neuropsychomotor development, overeating, obesity and mental deficiency. This phenotype is encountered in other conditions, defining Prader-Willi-like syndrome (PWLS). We report a 14-year-old boy with a complex small supernumerary marker chromosome (sSMC) associated with PWLS. The propositus presents clinical features commonly found in patients with PWLS, including growth hormone deficit. Banding karyotype analysis and fluorescence in situ hybridization (FISH) revealed a marker derived from chromosome 6 and a neocentromere as suspected, but array-CGH enabled us to characterize this marker as a der(10)t(6;10)(6qter → 6q23.3::10p11.1 → 10p11.21)dn. As far as we know, this is the first diagnosed case of PWLS associated with a complex sSMC, involving a 30.9 Mb gain in the 6q16.3q23.3 region and a 3.5 Mb gain in the 10p11.21p11.1 region. Several genes have been mapped to the 6q region including the TCBA1 gene, which is associated with developmental delay and recurrent infections, the ENPP1 gene, associated with insulin resistance and susceptibility to obesity and the BMIQ3 gene, associated with body mass index (BMI). No OMIM gene was found in the smallest 10p11.21p11.1 region. We suggest that the duplicated chromosome segment 6q16.3q23.3 may be responsible for the phenotype of our case and may also be a candidate locus of PWLS.
    Subject(s): Somatotropin ; Prader-Willi syndrome ; Genes ; Cytogenetics ; Insulin resistance ; Disease susceptibility ; Genetic aspects
    ISSN: 1755-8166
    E-ISSN: 1755-8166
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 4
    Language: English
    In: Basic and clinical andrology, 2015, Vol.25 (1), p.6-6
    Description: To compare sperm parameters and intracytoplasmic sperm injection (ICSI) outcomes for testicular spermatozoa frozen on the day of the biopsy (DO) with those frozen after 24 h of in vitro culture (D1). In this retrospective study, from 1999 to 2012, forty-nine azoospermic patients were included to compare sperm (motility and viability) and outcomes (fertilization (FR), implantation (IR), pregnancy (PR) and delivery rates (DR)). The in vitro culture increased total motility (+2.8 %, p = 0.0161) but decreased viability (-8.3 %, p = 0.007). After 24 h of culture, the post-thaw changes in motility and viability were not significant. Twenty-six couples underwent ICSI: thirty-four ICSI were performed with spermatozoa cryopreserved at D0 and eighteen with spermatozoa frozen at D1. Cumulated IR and DR were lower for ICSI with D1 spermatozoa than with D0 spermatozoa (IR: 21.6 % with D0 vs. 9.8 % with D1, p = 0.102; DR: 27.5 % with D0 vs. 8.3 % with D1, p = 0.049). Despite improving motility, freezing spermatozoa 24 h after testicular biopsy had a potential negative effect on ICSI outcomes, notably on delivery rates. These results may be related to the detrimental impact of the additional culture on the nuclear integrity of sperm.
    Subject(s): Spermatozoïde testiculaire ; ICSI ; Congélation ; Outcome ; Issues ; Culture ; Freezing ; Testicular sperm
    ISSN: 2051-4190
    ISSN: 1166-2654
    E-ISSN: 2051-4190
    Source: BioMedCentral Open Access
    Source: PubMed Central
    Source: Alma/SFX Local Collection
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  • 5
  • 6
    Language: English
    In: Nature physics, 2017-05-01, Vol.13 (6), p.584-590
    Description: Hypothetical low-mass particles, such as axions, provide a compelling explanation for the dark matter in the universe. Such particles are expected to emerge abundantly from the hot interior of stars. To test this prediction, the CERN Axion Solar Telescope (CAST) uses a 9 T refurbished Large Hadron Collider test magnet directed towards the Sun. In the strong magnetic field, solar axions can be converted to X-ray photons which can be recorded by X-ray detectors. In the 2013–2015 run, thanks to low-background detectors and a new X-ray telescope, the signal-to-noise ratio was increased by about a factor of three. Here, we report the best limit on the axion–photon coupling strength (0.66 × 10-10 GeV-1 at 95% confidence level) set by CAST, which now reaches similar levels to the most restrictive astrophysical bounds.
    Subject(s): ASTRONOMY AND ASTROPHYSICS
    ISSN: 1745-2473
    E-ISSN: 1745-2481
    Source: Single Journals
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  • 7
    Language: English
    In: Journal of cosmology and astroparticle physics, 2019-01-16, Vol.2019 (1), p.32-32
    Description: We report on a new search for solar chameleons with the CERN Axion Solar Telescope (CAST). A GridPix detector was used to search for soft X-ray photons in the energy range from 200 eV to 10 keV from converted solar chameleons. No significant excess over the expected background has been observed in the data taken in 2014 and 2015. We set an improved limit on the chameleon photon coupling, βγ≲#5.7×1010 for 1〈βm〈106 at 95% C.L. improving our previous results by a factor two and for the first time reaching sensitivity below the solar luminosity bound for tachocline magnetic fields up to 12.5 T.
    Subject(s): Soft x rays ; Luminosity ; Photons ; Magnetic fields ; Searching ; Solar magnetic field ; ASTRONOMY AND ASTROPHYSICS ; OTHER INSTRUMENTATION
    ISSN: 1475-7516
    E-ISSN: 1475-7516
    Source: IOPscience extra
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  • 8
    Language: English
    In: Physics letters. B, 2015-10-07, Vol.749 (C), p.172-180
    Description: In this work we present a search for (solar) chameleons with the CERN Axion Solar Telescope (CAST). This novel experimental technique, in the field of dark energy research, exploits both the chameleon coupling to matter (βm) and to photons (βγ) via the Primakoff effect. By reducing the X-ray detection energy threshold used for axions from 1 keV to 400 eV CAST became sensitive to the converted solar chameleon spectrum which peaks around 600 eV. Even though we have not observed any excess above background, we can provide a 95% C.L. limit for the coupling strength of chameleons to photons of βγ≲1011 for 1〈βm〈106.
    Subject(s): CAST ; Tachocline ; SDD ; X-ray ; Dark energy ; Chameleon ; High Energy Physics - Phenomenology ; Astrophysics and Astronomy ; Physics - Instrumentation and Detectors ; Physics ; Astrophysics - Solar and Stellar Astrophysics ; chameleon ; ASTRONOMY AND ASTROPHYSICS ; tachocline ; dark energy
    ISSN: 0370-2693
    E-ISSN: 1873-2445
    Source: SCOAP3 Journals
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  • 9
    Language: English
    In: Journal of Cosmology and Astroparticle Physics, 2019 (6)
    Description: We review the physics potential of a next generation search for solar axions: the International Axion Observatory (IAXO). Endowed with a sensitivity to discover axion-like particles (ALPs) with a coupling to photons as small as g(a gamma) similar to 10(-12) GeV-1, or to electrons g(ae) similar to 10(-13), IAXO has the potential to find the QCD axion in the 1 meV similar to 1 eV mass range where it solves the strong CP problem, can account for the cold dark matter of the Universe and be responsible for the anomalous cooling observed in a number of stellar systems. At the same time, IAXO will have enough sensitivity to detect lower mass axions invoked to explain: 1) the origin of the anomalous transparency of the Universe to gamma-rays, 2) the observed soft X-ray excess from galaxy clusters or 3) some inflationary models. In addition, we review string theory axions with parameters accessible by IAXO and discuss their potential role in cosmology as Dark Matter and Dark Radiation as well as their connections to the above mentioned conundrums.
    Subject(s): axions ; Fysik ; Physical Sciences ; Naturvetenskap ; dark matter experiments ; Natural Sciences ; dark matter detectors
    ISSN: 1475-7516
    E-ISSN: 1475-7516
    Source: IOPscience extra
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