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  • 1
    Language: English
    In: Review of economics of the household, 2018-12, Vol.16 (4), p.971-1001
    Description: Previous empirical literature on the relation between intergenerational transfer of assets and services has mostly focused on contemporary exchanges. By contrast, we provide novel evidence showing that parents who helped their adult children in the past are rewarded by higher chances of receiving informal care later in life. To this end we use Italian data containing precise retrospective information about the help with housing that couples received from their parents when they got married, such as a real estate donation or down payment. Our estimates show that this type of past help is positively associated with the current provision of informal care to the parents. This result is robust to controlling for a large set of individual and family characteristics and is only partially due to increased geographical proximity. We suggest that this finding can be explained by mixed self-interest motives, related to theories based on either bilateral exchange or the presence of a third generation (grandchildren), such as the demonstration effect model or the family constitution model.
    Subject(s): Adult children ; Couples ; D10 ; Domestic relations ; Donations ; Dwellings ; Economic aspects ; Economic theory ; Economics ; Elder care ; Families & family life ; Family characteristics ; Geographical proximity ; Grandchildren ; Housing ; Informal care ; Intergenerational relations ; Intergenerational relationships ; Intergenerational transfer ; Intergenerational transfers ; J13 ; J14 ; Labor Economics ; Microeconomics ; Older people ; Parents & parenting ; Population Economics ; Property market ; Proximity ; Selfinterest ; Social aspects ; Social Sciences, general ; Social theories ; Third generation
    ISSN: 1569-5239
    E-ISSN: 1573-7152
    Source: International Bibliography of the Social Sciences (IBSS)
    Source: Alma/SFX Local Collection
    Source: Sociological Abstracts
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  • 2
    Article
    Article
    2018
    ISSN: 8756-6222 
    Language: English
    In: Journal of law, economics, & organization, 2018-05-01, Vol.34 (2), p.272-299
    Description: Abstract We investigate how oil dependence affects the trade of weapons between countries. We argue that oil-dependent economies have incentives to transfer arms to oil-rich countries to reduce their risk of instability and, as a result, the chances of disruption in the oil industry. We employ gravity models of the arms trade and estimate the effect of both a local as well as a global oil dependence. Two key results emerge. First, the volume of arms transfers to a specific country is affected by the degree of dependence on its supply of oil. Second, global oil dependence motivates arms export to oil-rich countries even in absence of a direct bilateral oil-for-weapons exchange. Our results point consistently toward the conclusion that the arms trade is an effective foreign policy tool to securing and maintaining access to oil.
    Subject(s): Economic incentives ; Finance ; Military aspects ; Petroleum industry ; Research
    ISSN: 8756-6222
    E-ISSN: 1465-7341
    Source: Business Source Ultimate
    Source: EconLit with Full Text
    Source: Alma/SFX Local Collection
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  • 3
    Dissertation
    Dissertation
    2016
    Language: English
    Description: This thesis comprises three essays. The first one focuses on the effect of a change in the labour market conditions induced by a trade shock on crime at the US local level. Using US Census data, I provide evidence that the increasing exposure to Chinese competitiveness has indirectly contributed to the change in the propensity to commit crime through a reduction of the expected labour market earnings. The second essay, which is co-authored with Vincenzo Bove and Roberto Nisticó, addresses the reasons why countries decide to transfer weapons only to specific recipients. We present novel empirical models of the arms trade and concentrate on the role of energy dependence, in particular of oil, in explaining the trade of weapons between countries. We find strong empirical support for the hypothesis that oil-dependent economies have incentives to provide security by selling or giving away arms to oil-rich countries and reduce their risk of political instability. Finally, the last essay, joint with Emanuele Ciani, has a specific focus on family economics. We provide evidence that parents who helped their adult children in the past are rewarded by higher chances of receiving informal care later in life. To this purpose we use Italian data containing retrospective information about help with housing received from parents at the time of marriage. We show a positive association with their current provision of informal care to them, which is robust to controlling for a large set of individual and family characteristics, and is confirmed by an IV regression using house prices as instrument. The results are in line with theories based on the presence of a third generation of grandchildren, such as those involving a demonstration effect or a family constitution.
    Source: ProQuest Dissertations & Theses Global
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  • 4
    Language: English
    In: The B.E. journal of economic analysis & policy, 2021-01-22, Vol.21 (2), p.751-792
    Description: In response to the opioid crisis, US states have implemented policies to reduce the dispensing of opioids and curb drug mortality. Exploiting a long panel of county-level data, we analyse the combination of demand- and supply-side state opioid policies and evaluate their effect on opioids per capita dispensed and their unintended fallouts on drug-related crime. We demonstrate that only laws targeting the supply for opioids reduce the volume of prescribed drugs, while demand-side policies are less effective. We also emphasize that within supply-side state regulations, Pain Management Clinics Laws are the most successful in reducing the dispensation of prescription opioids. Remarkably, the drop in opioids distributed due to supply-side regulations is accompanied by negative externalities in the local market for illicit drugs.
    Subject(s): crime ; drugs ; I18 ; K32 ; opioid laws ; prescription opioids
    ISSN: 2194-6108
    E-ISSN: 1935-1682
    Source: De Gruyter Online
    Source: Alma/SFX Local Collection
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  • 5
    Language: English
    In: Hydrology and earth system sciences, 2017-03-09, Vol.21 (3), p.1439-1454
    Description: Saline–freshwater interaction in porous media is a phenomenon of practical interest particularly for the management of water resources in arid and semi-arid environments, where precious freshwater resources are threatened by seawater intrusion and where storage of freshwater in saline aquifers can be a viable option. Saline–freshwater interactions are controlled by physico-chemical processes that need to be accurately modeled. This in turn requires monitoring of these systems, a non-trivial task for which spatially extensive, high-resolution non-invasive techniques can provide key information. In this paper we present the field monitoring and numerical modeling components of an approach aimed at understanding complex saline–freshwater systems. The approach is applied to a freshwater injection experiment carried out in a hyper-saline aquifer near Cagliari (Sardinia, Italy). The experiment was monitored using time-lapse cross-hole electrical resistivity tomography (ERT). To investigate the flow dynamics, coupled numerical flow and transport modeling of the experiment was carried out using an advanced three-dimensional (3-D) density-driven flow-transport simulator. The simulation results were used to produce synthetic ERT inversion results to be compared against real field ERT results. This exercise demonstrates that the evolution of the freshwater bulb is strongly influenced by the system's (even mild) hydraulic heterogeneities. The example also highlights how the joint use of ERT imaging and gravity-dependent flow and transport modeling give fundamental information for this type of study.
    ISSN: 1607-7938
    ISSN: 1027-5606
    E-ISSN: 1607-7938
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 6
    Language: English
    In: World journal of surgical oncology, 2021-04-18, Vol.19 (1), p.126-126
    Description: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor prognosis. Radical surgery is the best option for cure and, nowadays, it is performed by many surgeons also in cases of vascular infiltration. Whether this aggressive approach to a locally advanced PDAC produces a survival benefit is under debate. Most data in the literature come from retrospective comparative studies; therefore, it is still unclear if such an extensive surgery for an advanced cancer is justified. A retrospective review of patients with PDAC treated at our institution over a 12-year period was performed. Data concerning patients' characteristics, operative details, postoperative course, and long-term survival were retrieved from prospective databases and analysed. Factors associated with poor survival were assessed via Cox regression analysis. A total of 173 patients with PDAC were included in the analysis, 41 subjects underwent pancreatectomy with vascular resection for locally advanced disease, and in 132 patients, only a pancreatic resection was undertaken. Demographics, major comorbidities, and tumour characteristics were similar between the two groups. Length of surgery (P=0.0006), intraoperative blood transfusions (P〈0.0001), and overall complications (P〈0.0001) were significantly higher in the vascular resection group. Length of hospital stay (P=0.684) and 90-day mortality (P=0.575) were comparable between groups. Overall median survival (P= 0.717) and survival rates at 1, 3, and 5 years (P=0.964, P=0.500, and P=0.445, respectively) did not differ significantly between groups. Age ≥70 years and postoperative complications were independent predictors of lower survival. Our study confirms that pancreatectomy with vascular resection for a locally advanced PDAC is a complex operation associated with a significant longer operating time that may increase morbidity; however, in selected patients, R0 margins can be obtained with an acceptable long-term survival rate. Older patients are less likely to benefit from surgery.
    Subject(s): Adult ; Aged ; Aged, 80 and over ; Arterial infiltration ; Carcinoma, Pancreatic Ductal - mortality ; Carcinoma, Pancreatic Ductal - pathology ; Carcinoma, Pancreatic Ductal - surgery ; Care and treatment ; Development and progression ; Evaluation ; Excision (Surgery) ; Female ; Humans ; Male ; Methods ; Middle Aged ; Neoplasm Metastasis ; Pancreatectomy - methods ; Pancreatectomy - mortality ; Pancreatic cancer ; Pancreatic ductal adenocarcinoma ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Pancreatic surgery ; Patient outcomes ; Postoperative Complications ; Prognosis ; Research ; Retrospective Studies ; Survival ; Survival Analysis ; Survival Rate ; Survivors ; Venous infiltration
    ISSN: 1477-7819
    E-ISSN: 1477-7819
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 7
    Language: English
    In: The breast journal, 2020-09, Vol.26 (9), p.1784-1787
    Description: To evaluate the benefits of pectoral nerve block (PECS block) in breast cancer surgery, we compared outcomes of 100 patients receiving PECS vs 107 without PECS. Intraoperative use of fentanyl (P 〈 .001) acetaminophen (P = .02), morphine (P 〈 .01), and nonsteroidal anti‐inflammatory drugs (NSAIDS) (P 〈 .01) was lower in the PECS group. Occurrence of postoperative nausea and vomiting (PONV) was lower in the PECS group (P = .04). On postoperative day 1, the use of acetaminophen (P = .23), morphine (P = .83), and NSAIDS (P = .4) did not differ. Twenty‐one patients received surgery with PECS block plus sedation alone. PECS block can reduce intraoperative use of opioids and analgesic drugs, and is associated with reduced occurrence of PONV. Selected patients can receive breast‐conserving surgery with PECS plus sedation, avoiding general anesthesia.
    Subject(s): Analysis ; breast conserving surgery ; Lumpectomy ; mastectomy ; PECS block
    ISSN: 1075-122X
    E-ISSN: 1524-4741
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
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  • 8
    Language: English
    In: International journal of environmental research and public health, 2021-05-25, Vol.18 (11), p.5642
    Description: In 2013, in a bid to combat Vaccine Hesitancy (VH) and provide information on vaccines by communicating with the general public and the health community (e.g., healthcare workers and public health operators), the Italian Society of Hygiene and Preventive Medicine (S.It.I.) published the national website “VaccinarSì”. The project was subsequently extended to ten Italian Regions. This led to the creation of the VaccinarSì Network, whose websites are publicly owned. The aim of this work was to present the framework of the websites of the VaccinarSì Network and to analyse user behaviour in the pre-COVID-19-era (dating from each website’s publication until 31 January 2020) and in the COVID-19-era (from 1 February 2020 to 31 January 2021). Some metrics such as the number of visits to the site (sessions, number of users and average session duration), user behaviour (pages viewed, bounce rate and organic search) and the session acquisition path (direct traffic, referrals and social traffic) were searched, extrapolated and processed with Google Analytics. Qualitative and normally distributed quantitative variables were summarised with their absolute (relative) frequencies and means. Statistical differences between the means of the two periods were evaluated through paired t-test. A two-tailed p-value less than 0.05 was considered to be statistically significant. When the total values recorded over the period were compared, an overall increase in metrics was observed—the number of individual users, visits and individual pageviews rose in a statistically significant way. Our study aimed to highlight how combining disciplines such as health education and digital communication via Information and Communication Technologies (ICT) represents the best strategy to support citizens. This approach gives them the tools to become independent and responsible players that are capable of voluntarily and consciously choosing to adhere to vaccination programs. The VaccinarSì Network’s goal for the future is to reach an even wider audience. By building each user’s critical knowledge, this network enables users to be active components of a wider, more empowered community.
    Subject(s): e-health ; health communication ; VaccinarSì network ; vaccine hesitancy ; website
    ISSN: 1660-4601
    ISSN: 1661-7827
    E-ISSN: 1660-4601
    Source: PubMed Central
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 9
    Language: English
    In: Aging cell, 2012-06, Vol.11 (3), p.394-400
    Description: Summary We analyzed MBL2 gene variants in two cohorts of centenarians, octo‐nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity. We also assessed in vitro the effect of mannose‐binding lectin (MBL) on various human cells at different stage of senescence. The frequency of high and null activity haplotypes was significantly lower, and the frequency of intermediate activity haplotype significantly higher in centenarians and in subjects between 80 and 99 years from both the cohorts as compared each to the general population from the same geographic area. Furthermore, serum MBL concentration (also after normalization to serum albumin) was significantly lower in centenarians and in octo‐ and nonagenarians as compared to the general population, suggesting that intermediate MBL haplotype/activity may be protective. We also demonstrated that in vitro MBL protein bound to senescent IMR90 fibroblasts thereby causing cell lysis, but not to other types of cycle‐arrested cells not in senescence. This implicates a novel role of MBL in the clearance of senescent cells.
    Subject(s): Age Factors ; Aged, 80 and over ; aging ; Cells, Cultured ; Cohort Studies ; Female ; Haplotypes ; Humans ; innate immunity ; Longevity - genetics ; Longevity - physiology ; Male ; Mannose-Binding Lectins - genetics ; Mannose-Binding Lectins - metabolism ; mannose‐binding lectin ; MBL ; senescence
    ISSN: 1474-9718
    E-ISSN: 1474-9726
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Alma/SFX Local Collection
    Source: DOAJ Directory of Open Access Journals - Not for CDI Discovery
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  • 10
    Language: English
    In: Scientific reports, 2021-07-21, Vol.11 (1), p.14922-14922
    Description: Abstract The GNA15 gene is ectopically expressed in human pancreatic ductal adenocarcinoma cancer cells. The encoded Gα15 protein can promiscuously redirect GPCR signaling toward pathways with oncogenic potential. We sought to describe the distribution of GNA15 in adenocarcinoma from human pancreatic specimens and to analyze the mechanism driving abnormal expression and the consequences on signaling and clinical follow-up. We detected GNA15 expression in pre-neoplastic pancreatic lesions and throughout progression. The analysis of biological data sets, primary and xenografted human tumor samples, and clinical follow-up shows that elevated expression is associated with poor prognosis for G NA 15, but not any other GNA gene. Demethylation of the 5′ GNA15 promoter region was associated with ectopic expression of Gα15 in pancreatic neoplastic cells, but not in adjacent dysplastic or non-transformed tissue. Down-modulation of Gα15 by shRNA or CRISPR/Cas9 affected oncogenic signaling, and reduced adenocarcimoma cell motility and invasiveness. We conclude that de novo expression of wild-type GNA15 characterizes transformed pancreatic cells. The methylation pattern of GNA15 changes in preneoplastic lesions coincident with the release a transcriptional blockade that allows ectopic expression to persist throughout PDAC progression. Elevated GNA15 mRNA correlates with poor prognosis. In addition, ectopic Gα15 signaling provides an unprecedented mechanism in the early steps of pancreas carcinogenesis distinct from classical G protein oncogenic mutations described previously in GNAS and GNAQ/GNA11.
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
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